Analysis of the risk of transmitting bovine spongiform encephalopathy through bone grafts derived from bovine bone.

abstract：:A surface functionalization strategy that produces substrates with well-controlled ligand density is critical to investigating the role of cell-substrate interactions in regulating cell adhesion, viability, migration, proliferation and differentiation. Towards this end, we have designed and synthesized a triblock prot...

journal_title：Biomaterials

authors： Fischer SE,Liu X,Mao HQ,Harden JL

更新日期：2007-08-01 00:00:00

abstract：:Morphological changes of human polymorphonuclear neutrophils (PMN) adhering to hydrophilic (glass) and hydrophobic (FEP-Teflon, polyethylene, polypropylene) surfaces were studied in a parallel-plate flow chamber at the light and scanning electron microscopical levels. The PMN were exposed to a shear stress of 0.19 Pa ...

journal_title：Biomaterials

authors： Tomczok J,Sliwa-Tomczok W,Klein CL,van Kooten TG,Kirkpatrick CJ

更新日期：1996-07-01 00:00:00

abstract：:The water-soluble, low toxic and less biodegradable chitosan derivative N-succinyl-chitosan (Suc-chitosan) was investigated for body distribution and urinary excretion on a long-time scale (24-72 h after i.v. injection) using a fluorescein-labeling technique. Fluorescein isothiocyanate (FITC)-labeled Suc-chitosan (Suc...

journal_title：Biomaterials

authors： Kato Y,Onishi H,Machida Y

更新日期：2000-08-01 00:00:00

abstract：:The degradation of poly[bis(glycine ethyl ester)phosphazene] in aqueous media was studied by following the appearance of some of its expected by-products in solution. Disc-shaped polymer slabs of 12 mm diameter and 1.2 mm thickness were prepared by compression moulding, followed by incubation in aqueous media under ca...

journal_title：Biomaterials

authors： Ruiz EM,Ramírez CA,Aponte MA,Barbosa-Cánovas GV

更新日期：1993-06-01 00:00:00

abstract：:Two new absorbable monofilament suture materials polydioxanone and Maxon are being employed increasingly in abdominal surgery because of increased strength retention and decreased tissue reactivity compared with previously available materials. As part of our investigation of the behaviour of suture materials, 3-0 sutu...

journal_title：Biomaterials

authors： Metz SA,Chegini N,Masterson BJ

更新日期：1990-01-01 00:00:00

abstract：:The in vivo properties of a new kind of calcium phosphate cement were investigated in this study. Calcium phosphate cement was implanted as paste into femoral bone and dorsal muscle of dogs for 3 and 6 months, and as prehardened form into thigh muscles of dogs for 1, 2 and 6 months. Histology was performed on thin un-...

journal_title：Biomaterials

authors： Yuan H,Li Y,de Bruijn JD,de Groot K,Zhang X

更新日期：2000-06-01 00:00:00

abstract：:Microcontact printing techniques were used to modify silicon substrates with arrays of hexagonal features of N1[3-(trimethoxysilyl) propyl]diethylenetriamine (DETA) surrounded by octadecyltrichlorosilane (OTS), which are hydrophilic, cell-adhesive and hydrophobic, non-adhesive organosilanes, respectively. In the prese...

journal_title：Biomaterials

authors： Kam L,Shain W,Turner JN,Bizios R

更新日期：1999-12-01 00:00:00

abstract：:Hydrogels have been widely used for 3-dimensional (3D) cell culture and tissue regeneration due to their tunable biochemical and physicochemical properties as well as their high water content, which resembles the aqueous microenvironment of the natural extracellular matrix. While many properties of natural hydrogel ma...

journal_title：Biomaterials

authors： Zhang S,Liu X,Barreto-Ortiz SF,Yu Y,Ginn BP,DeSantis NA,Hutton DL,Grayson WL,Cui FZ,Korgel BA,Gerecht S,Mao HQ

更新日期：2014-03-01 00:00:00

abstract：:Silver nanoparticles (AgNPs) have anti-cancer effect. However, whether and how these particles could inhibit the growth of acute myeloid leukemia (AML) cells is unclear. In the present study, we prepared AgNPs with various sizes and investigated their cytotoxic effect on AML cells. We found that AgNPs could inhibit th...

journal_title：Biomaterials

authors： Guo D,Zhu L,Huang Z,Zhou H,Ge Y,Ma W,Wu J,Zhang X,Zhou X,Zhang Y,Zhao Y,Gu N

更新日期：2013-10-01 00:00:00

abstract：:The advancement in gene therapy relies upon the discovery of safe and efficient delivery agents and methods. In this study, we report the design and synthesis of a cationic bolaamphiphile as a non-viral gene delivery agent. The bolaamphiphile is composed of 1,12-diaminododecane as the central hydrophobic unit linked t...

journal_title：Biomaterials

authors： Khan M,Ang CY,Wiradharma N,Yong LK,Liu S,Liu L,Gao S,Yang YY

更新日期：2012-06-01 00:00:00

abstract：:Although a variety of nanoparticles (NPs) functionalized with amphotericin B, an antifungal agent widely used in the clinic, have been studied in the last years their cytotoxicity profile remains elusive. Here we show that human endothelial cells take up high amounts of silica nanoparticles (SNPs) conjugated with amph...

journal_title：Biomaterials

authors： Paulo CS,Lino MM,Matos AA,Ferreira LS

更新日期：2013-07-01 00:00:00

abstract：:Space experimentation of cardiomyocyte differentiation from human induced pluripotent stem cells offers an exciting opportunity to explore the potential of these cells for disease modeling, drug discovery and regenerative medicine. Previous studies on the International Space Station were done with 2D non-cryopreserved...

journal_title：Biomaterials

authors： Rampoldi A,Jha R,Fite J,Boland G,Xu C

更新日期：2021-01-11 00:00:00

abstract：:The interaction of three cell types important to the wound repair process with collagen/glycosaminoglycan (GAG) dermal regeneration matrices covalently modified with an Arg-Gly-Asp (RGD)-containing peptide was characterized. Function-blocking monoclonal antibodies directed against various integrin subunits were used t...

journal_title：Biomaterials

authors： Grzesiak JJ,Pierschbacher MD,Amodeo MF,Malaney TI,Glass JR

更新日期：1997-12-01 00:00:00

abstract：:Very elastic poly(L-lactide-co-epsilon-caprolactone) (PLCL) (50:50) copolymer blended with gelatin was electrospun into microfibers from a hexafluoroisopropanol solution. PLCL fiber sheet exhibited the unique soft and flexible behavior while gelatin fiber was hard and brittle. As the gelatin content of PLCL/gelatin fi...

journal_title：Biomaterials

authors： Lee J,Tae G,Kim YH,Park IS,Kim SH,Kim SH

更新日期：2008-04-01 00:00:00

abstract：:Carbon nanotubes have shown great potential in various areas of biomedicine. Herein, we synthesize a series of amphiphilic polymers by anchoring polyethylene glycol (PEG) of different lengths at various densities on poly(maleic anhydride-alt-1-octadecene) (PMHC(18)). The blood circulation and biodistribution of those ...

journal_title：Biomaterials

authors： Liu X,Tao H,Yang K,Zhang S,Lee ST,Liu Z

更新日期：2011-01-01 00:00:00

abstract：:Despite its long history and some preliminary work in tissue engineering nearly 30 years ago, electrospinning has not gained widespread interest as a potential polymer processing technique for applications in tissue engineering and drug delivery until the last 5-10 years. This renewed interest can be attributed to ele...

journal_title：Biomaterials

authors： Sill TJ,von Recum HA

更新日期：2008-05-01 00:00:00

abstract：:A simple route for synthesizing nano-sized beta-tricalcium phosphate (beta-TCP) at room temperature has been developed in methanol solvent. The phase evolution from CaHPO4, intermediate amorphous calcium phosphate (ACP) phases (including ACP1 and ACP2 with different structures) to final beta-TCP with increasing aging ...

journal_title：Biomaterials

authors： Bow JS,Liou SC,Chen SY

更新日期：2004-07-01 00:00:00

abstract：:Cancer vaccines are designed to elicit an endogenous adaptive immune response that can successfully recognize and eliminate residual or recurring tumors. Such approaches can potentially overcome shortcomings of passive immunotherapies by generating long-lived therapeutic effects and immune memory while limiting system...

journal_title：Biomaterials

authors： Shukla S,Myers JT,Woods SE,Gong X,Czapar AE,Commandeur U,Huang AY,Levine AD,Steinmetz NF

更新日期：2017-03-01 00:00:00

abstract：:Myocardial infarction (MI) leads to the mass death of cardiomyocytes accompanying with the unfavorable alternation of microenvironment, a fibrosis scar deprived of electrical communications, and the lack of blood supply in the infarcted myocardium. The three factors are inextricably intertwined and thus result in a co...

journal_title：Biomaterials

authors： Wang W,Tan B,Chen J,Bao R,Zhang X,Liang S,Shang Y,Liang W,Cui Y,Fan G,Jia H,Liu W

更新日期：2018-04-01 00:00:00

abstract：:Disruption of peripheral nerves due to trauma is a frequently occurring clinical problem. Gaps in the nerve are bridged by guiding the regenerating nerves along autologous grafts or artificial guides. This review gives an overview on the different methods of nerve repair techniques. Conventional suturing techniques ar...

journal_title：Biomaterials

authors： IJkema-Paassen J,Jansen K,Gramsbergen A,Meek MF

更新日期：2004-04-01 00:00:00

abstract：:Stem cell therapy is a promising therapeutic method for the treatment of ischemic heart diseases; however, some challenges prohibit the efficacy after cell delivery due to hostile microenvironment of the injured myocardium. 3D printed pre-vascularized stem cell patch can enhance the therapeutic efficacy for cardiac re...

journal_title：Biomaterials

authors： Jang J,Park HJ,Kim SW,Kim H,Park JY,Na SJ,Kim HJ,Park MN,Choi SH,Park SH,Kim SW,Kwon SM,Kim PJ,Cho DW

更新日期：2017-01-01 00:00:00

abstract：:Inherent neuronal and circulating progenitor cells play important roles in facilitating neuronal and functional recovery post stroke. However, this endogenous repair process is rather limited, primarily due to unfavorable conditions in the infarcted brain involving reactive oxygen species (ROS)-mediated oxidative stre...

journal_title：Biomaterials

authors： Petro M,Jaffer H,Yang J,Kabu S,Morris VB,Labhasetwar V

更新日期：2016-03-01 00:00:00

abstract：:Periosteal derived bovine osteoblast-like cells migrated in culture onto an ionomeric cement. Cell cultures were maintained for 4 weeks and used to study the in vitro behaviour of cells on the ionomeric bone cement (IC). The cells produced bone matrix proteins (osteocalcin, bone sialoprotein II) and were osteoblast-li...

journal_title：Biomaterials

authors： Meyer U,Szulczewski DH,Barckhaus RH,Atkinson M,Jones DB

更新日期：1993-10-01 00:00:00

abstract：:The optimal ratio of the polycation's amine to DNA phosphate group (N:P) for efficient polymer-based transfection always employs excess polycation versus DNA. Most of the excess polycation remains free in solution, unassociated with the polyplexes, but is essential for efficient transfection. The mechanism by which ex...

journal_title：Biomaterials

authors： Thibault M,Astolfi M,Tran-Khanh N,Lavertu M,Darras V,Merzouki A,Buschmann MD

更新日期：2011-07-01 00:00:00

abstract：:Safety and high efficacy of vectors are essential requirements for gene therapy. To address these challenges, poly(carboxy betaine methacrylate ethyl ester)-poly(carboxy betaine methacrylate) (PCBMAEE-PCBMA) diblock copolymers were synthesized to form core-shell vector for gene delivery. The hydrophobic PCBMAEE segmen...

journal_title：Biomaterials

authors： Zhang J,Wang Z,Lin W,Chen S

更新日期：2014-09-01 00:00:00

abstract：:Current prosthetic small diameter vascular grafts show poor long-term patency rates, leading to the pursuit of a biological alternative. Hyaff-11 is a hyaluronan-based biodegradable polymer developed for tissue-engineering applications. This study aimed to determine whether human vascular endothelial cells attach to H...

journal_title：Biomaterials

authors： Turner NJ,Kielty CM,Walker MG,Canfield AE

更新日期：2004-12-01 00:00:00

abstract：:We report here the study of the biocompatibility of a bone graft material, the Pyrost, using a previously established in vitro model of human osteoblasts. The effect of this material on cell proliferation was evaluated by the MTS assay. Results indicated the absolute absence of cytotoxic or cytostatic effect of Pyrost...

journal_title：Biomaterials

authors： Josset Y,Oum'hamed Z,Zarrinpour A,Lorenzato M,Adnet JJ,Laurent-Maquin D

更新日期：1998-10-01 00:00:00

abstract：:Although PEGylated liposome-based drug delivery systems hold great promising applications for cancer therapy due to their prolonged blood circulation time, PEGylation significantly reduces their cellular uptake, which markedly impairs the in vivo tumor retention and antitumor efficiency of drug-loaded liposomes. Most ...

journal_title：Biomaterials

authors： Li Y,Liu R,Yang J,Shi Y,Ma G,Zhang Z,Zhang X

更新日期：2015-02-01 00:00:00

abstract：:The clinical usefulness of brain machine interfaces that employ penetrating silicon microelectrode arrays is limited by inconsistent performance at chronic time points. While it is widely believed that elements of the foreign body response (FBR) contribute to inconsistent single unit recording performance, the relatio...

journal_title：Biomaterials

authors： Nolta NF,Christensen MB,Crane PD,Skousen JL,Tresco PA

更新日期：2015-01-01 00:00:00

abstract：:Self-assembling peptides and peptide derivatives bearing cell-binding ligands are increasingly being investigated as defined cell culture matrices and as scaffolds for regenerative medicine. In order to systematically refine such scaffolds to elicit specific desired cell behaviors, ligand display should ideally be ach...

journal_title：Biomaterials

authors： Jung JP,Nagaraj AK,Fox EK,Rudra JS,Devgun JM,Collier JH

更新日期：2009-04-01 00:00:00