Abstract：
:Microcontact printing techniques were used to modify silicon substrates with arrays of hexagonal features of N1[3-(trimethoxysilyl) propyl]diethylenetriamine (DETA) surrounded by octadecyltrichlorosilane (OTS), which are hydrophilic, cell-adhesive and hydrophobic, non-adhesive organosilanes, respectively. In the presence of serum proteins, LRM55 cell adhesion and morphology on these modified surfaces were best correlated to the width of the cell-adhesive features. On surfaces modified with small (5 microm in width) cell-adhesive features, LRM55 cells elaborated only thin processes. As feature width was increased, cells on these surfaces exhibited increased cell spreading and elaborated wide processes. On surfaces modified with large (>35 microm in width) features, single cells adhered to and spread upon individual DETA features. In a similar fashion, LRM55 cell adhesion density increased with increasing feature width; this correlation could be represented by a simple, second-order relation, and was independent of all other measures of pattern geometry. The results of this study provide evidence that micro-patterning may be effective in controlling astrocyte interaction with implant materials.
journal_name
Biomaterialsjournal_title
Biomaterialsauthors
Kam L,Shain W,Turner JN,Bizios Rdoi
10.1016/s0142-9612(99)00163-5keywords:
subject
Has Abstractpub_date
1999-12-01 00:00:00pages
2343-50issue
23-24eissn
0142-9612issn
1878-5905pii
S0142-9612(99)00163-5journal_volume
20pub_type
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