Controlling the kinetics of thiol-maleimide Michael-type addition gelation kinetics for the generation of homogenous poly(ethylene glycol) hydrogels.

abstract：:Cartilage engineering is one of the most challenging issue in regenerative medicine, due to its limited self-ability to repair. Here, we assessed engineering of cartilage tissue starting from human bone marrow (hBM) stem cells under hypoxic environment and delineated the mechanism whereby chondrogenesis could be condu...

journal_title：Biomaterials

authors： Duval E,Baugé C,Andriamanalijaona R,Bénateau H,Leclercq S,Dutoit S,Poulain L,Galéra P,Boumédiene K

更新日期：2012-09-01 00:00:00

abstract：:To achieve enhanced gene transfection efficiency with ocular eye-drop therapy, a cationic core-shell liponanoparticle (DLCS-NP) was designed by enveloping the plasmid-laden chitosan nanoparticle (CS-NP) into a cationic lipid shell. The cellular uptake of DLCS-NP was up to 1.25-fold and 5-fold higher than that of CS-NP...

journal_title：Biomaterials

authors： Jiang M,Gan L,Zhu C,Dong Y,Liu J,Gan Y

更新日期：2012-10-01 00:00:00

abstract：:The advancement in gene therapy relies upon the discovery of safe and efficient delivery agents and methods. In this study, we report the design and synthesis of a cationic bolaamphiphile as a non-viral gene delivery agent. The bolaamphiphile is composed of 1,12-diaminododecane as the central hydrophobic unit linked t...

journal_title：Biomaterials

authors： Khan M,Ang CY,Wiradharma N,Yong LK,Liu S,Liu L,Gao S,Yang YY

更新日期：2012-06-01 00:00:00

abstract：:This work reports the development of new non-thrombogenic polymers based on the linear polymers of polyamidoamines (PAAs), having heparin binding ability, obtained by polyaddition of secondary amines to N,N'-methylene bis-acrylamide. PAAs could not be used directly in the making of blood-contacting materials due to th...

journal_title：Biomaterials

authors： Dey RK,Ray AR

更新日期：2003-08-01 00:00:00

abstract：:Peripherally inserted central catheters (PICCs) are hollow polymeric tubes that transport nutrients, blood and medications to neonates. To determine proper PICC placement, frequent X-ray imaging of neonates is performed. Because X-rays pose severe health risks to neonates, safer alternatives are needed. We hypothesize...

journal_title：Biomaterials

authors： Stevenson AT Jr,Reese LM,Hill TK,McGuire J,Mohs AM,Shekhar R,Bickford LR,Whittington AR

更新日期：2015-06-01 00:00:00

abstract：:In this study, we report the systematic comparison of different poly(ethylene glycol) (PEG) self-assembled monolayers on glass with respect to their protein adsorption and cell adhesion resistance. Combining PEGylation with micellar nanolithography allowed the formation of gold nanoparticle arrays on glass and selecti...

journal_title：Biomaterials

authors： Blümmel J,Perschmann N,Aydin D,Drinjakovic J,Surrey T,Lopez-Garcia M,Kessler H,Spatz JP

更新日期：2007-11-01 00:00:00

abstract：:Islet transplantation is considered the most promising treatment for type 1 diabetes. However, the clinical success is limited by islet dysfunction in long-term culture. In this study, we have utilized the rapid self-gelation and injectability offered by blending of mulberry silk (Bombyx mori) with non-mulberry (Anthe...

journal_title：Biomaterials

authors： Kumar M,Gupta P,Bhattacharjee S,Nandi SK,Mandal BB

更新日期：2018-12-01 00:00:00

abstract：:Mesoporous silica nanoshell (MSN) coating has been demonstrated as a versatile surface modification strategy for various kinds of inorganic functional nanoparticles, such as gold nanorods (GNRs), to achieve not only improved nanoparticle stability but also concomitant drug loading capability. However, limited drug loa...

journal_title：Biomaterials

authors： Xu C,Chen F,Valdovinos HF,Jiang D,Goel S,Yu B,Sun H,Barnhart TE,Moon JJ,Cai W

更新日期：2018-05-01 00:00:00

abstract：:Following intravenous injection of anti-cancer nanomedicines, many barriers need to be overcome en route to the tumor. Cell-mediated delivery of nanoparticles (NPs) is promising in terms of overcoming several of these barriers based on the tumoritropic migratory properties of particular cell types. This guided transpo...

journal_title：Biomaterials

authors： Wayteck L,Dewitte H,De Backer L,Breckpot K,Demeester J,De Smedt SC,Raemdonck K

更新日期：2016-01-01 00:00:00

abstract：:Cerium oxide nanoparticles (nanoceria) are promising materials for intracellular oxygen free radical scavenging providing a potential therapy for reactive oxygen species (ROS)-mediated inflammatory processes. In this study rhombohedral-shaped nanoceria were synthesized by flame spray pyrolysis with tuneable particle d...

journal_title：Biomaterials

authors： Lord MS,Jung M,Teoh WY,Gunawan C,Vassie JA,Amal R,Whitelock JM

更新日期：2012-11-01 00:00:00

abstract：:Cancer therapeutics are developed through extensive screening; however, many therapeutics evaluated with 2D in vitro cultures during pre-clinical trials suffer from lower efficacy in patients. Replicating the in vivo tumor microenvironment in vitro with three-dimensional (3D) porous scaffolds offers the possibility of...

journal_title：Biomaterials

authors： Florczyk SJ,Wang K,Jana S,Wood DL,Sytsma SK,Sham J,Kievit FM,Zhang M

更新日期：2013-12-01 00:00:00

abstract：:The development of three-dimensional (3D) biomimetic scaffolds which provide an optimal environment for cells adhesion, proliferation and differentiation, and guide new tissue formation has been one of the major goals in tissue engineering. In this work, a processing technique has been developed to create 3D nanofibro...

journal_title：Biomaterials

authors： Liu X,Ma PX

更新日期：2009-09-01 00:00:00

abstract：:Nanoparticle-induced autophagy is crucial for its metabolism, cytotoxicity and therapy potency, but little is known about how the host immune system would respond to it. In this study, we demonstrated that two clinically used superparamagnetic iron oxide nanoparticles (SPIONs) specifically induced macrophage autophagy...

journal_title：Biomaterials

authors： Jin R,Liu L,Zhu W,Li D,Yang L,Duan J,Cai Z,Nie Y,Zhang Y,Gong Q,Song B,Wen L,Anderson JM,Ai H

更新日期：2019-05-01 00:00:00

abstract：:Isolated hepatocytes in spheroid configuration exhibit a high degree of cell-cell contacts, which are important in the maintenance of viability and liver specific functions. In the absence of a vascular network, the cells in a large spheroid size experience mass transfer limitations of metabolites and oxygen in the co...

journal_title：Biomaterials

authors： Curcio E,Salerno S,Barbieri G,De Bartolo L,Drioli E,Bader A

更新日期：2007-12-01 00:00:00

abstract：:Hydrogels have been widely used for 3-dimensional (3D) cell culture and tissue regeneration due to their tunable biochemical and physicochemical properties as well as their high water content, which resembles the aqueous microenvironment of the natural extracellular matrix. While many properties of natural hydrogel ma...

journal_title：Biomaterials

authors： Zhang S,Liu X,Barreto-Ortiz SF,Yu Y,Ginn BP,DeSantis NA,Hutton DL,Grayson WL,Cui FZ,Korgel BA,Gerecht S,Mao HQ

更新日期：2014-03-01 00:00:00

abstract：:Nitric oxide is a cell signaling molecule that can be a potent inducer of cell death in cancers at elevated concentrations. However, NO is also toxic to normal tissues and chronic exposure at low levels can induce tumor growth. We have designed a polymeric carrier system to deliver nitric oxide locoregionally to tumor...

journal_title：Biomaterials

authors： Duan S,Cai S,Yang Q,Forrest ML

更新日期：2012-04-01 00:00:00

abstract：:Tissue engineering generally utilizes natural or synthetic scaffolds to repair or replace damaged tissues. However, due to the lack of guidance of biological signals, most of the implanted scaffolds have always suffered from poor in vivo cellularization. Herein, we demonstrate a bio-orthogonal reaction-based strategy ...

journal_title：Biomaterials

authors： Mao D,Zhang C,Kenry,Liu J,Wang X,Li B,Yan H,Hu F,Kong D,Wang Z,Liu B

更新日期：2020-02-01 00:00:00

abstract：:In the present study, we evaluated, in mice, the efficacy of the tetrafunctional block copolymer 704 as a nonviral gene delivery vector to the lungs. SPECT/CT molecular imaging of gene expression, biochemical assays, and immunohistochemistry were used. Our dataset shows that the formulation 704 resulted in higher leve...

journal_title：Biomaterials

authors： Richard-Fiardo P,Hervouet C,Marsault R,Franken PR,Cambien B,Guglielmi J,Warnez-Soulie J,Darcourt J,Pourcher T,Colombani T,Haudebourg T,Peuziat P,Pitard B,Vassaux G

更新日期：2015-03-01 00:00:00

abstract：:Chemotherapy is a popular treatment approach against cancer but significant uptake of drugs by normal tissues is still a major limitation. Magnetic drug targeting (MDT) has been used to improve localized drug delivery to interstitial tumor targets. MDT is now being developed to improve drug delivery to tumor vessels. ...

journal_title：Biomaterials

authors： Dandamudi S,Campbell RB

更新日期：2007-11-01 00:00:00

abstract：:Vaccine efficacy is improved upon specific delivery to professional antigen (Ag) presenting cells, such as dendritic cells (DCs). Antigenicity and adjuvanticity of vaccine components can be enhanced by encapsulation within nanoparticle (NP) vaccine carriers that are targeted to the human DC-specific C-type lectin rece...

journal_title：Biomaterials

authors： Cruz LJ,Tacken PJ,Pots JM,Torensma R,Buschow SI,Figdor CG

更新日期：2012-06-01 00:00:00

abstract：:This animal experiment compared the regenerative processes within defined bony defects of the porcine skull after delivery of routinely utilized bone graft materials: anorganic bone matrix (ABM) and an identical ABM carrying the cell binding peptide P-15. Particulated autogenous bone was used as a control group. The c...

journal_title：Biomaterials

authors： Thorwarth M,Schultze-Mosgau S,Wehrhan F,Kessler P,Srour S,Wiltfang J,Andreas Schlegel K

更新日期：2005-10-01 00:00:00

abstract：:A cardiomyocyte-targeted Fas siRNA delivery system was developed using prostaglandin E(2) (PGE(2))-modified siRNA polyplexes formed by a reducible poly(amido amine) to inhibit cardiomyocyte apoptosis. PGE(2), which was used as a specific ligand for cardiomyocyte targeting, was conjugated to the terminal-end of the sen...

journal_title：Biomaterials

authors： Kim SH,Jeong JH,Ou M,Yockman JW,Kim SW,Bull DA

更新日期：2008-11-01 00:00:00

abstract：:In this paper we report a method for biomaterial surface modification that utilizes the self-assembly of block copolymers of poly(styrene-block-ethylene oxide) (PS-PEO) to generate micro-phase separated surfaces with varying density PEO domains. These PS-PEO self-assembled surfaces showed a significant reduction in pr...

journal_title：Biomaterials

authors： George PA,Donose BC,Cooper-White JJ

更新日期：2009-05-01 00:00:00

abstract：:Mesenchymal stromal cells (hMSCs) are advancing into the clinic but the therapeutic efficacy of hMSCs faces the problem of donor variability. In bone tissue engineering, no reliable markers have been identified which are able to predict the bone-forming capacity of hMSCs prior to implantation. To this end, we isolated...

journal_title：Biomaterials

authors： Mentink A,Hulsman M,Groen N,Licht R,Dechering KJ,van der Stok J,Alves HA,Dhert WJ,van Someren EP,Reinders MJ,van Blitterswijk CA,de Boer J

更新日期：2013-06-01 00:00:00

abstract：:Retinal pigment epithelial (RPE) cellular morphology and function are vital to the health of the retina. In age-related macular degeneration, RPE dysfunction and changes in Bruch's membrane occur. Thus, a potential cure is a dual-layer biomimetic transplant consisting of a layer of healthy RPE cells cultured on a supp...

journal_title：Biomaterials

authors： Lee CJ,Fishman HA,Bent SF

更新日期：2007-04-01 00:00:00

abstract：:The management of trauma-associated nerve defects is difficult because of the absence of autologous donor motor or sensory nerves. Pre-clinical development and clinical experience has shown that damaged nerves can be surgically repaired using a tubular conduit interposed across the defect. Acceptable patient outcomes ...

journal_title：Biomaterials

authors： Sierpinski P,Garrett J,Ma J,Apel P,Klorig D,Smith T,Koman LA,Atala A,Van Dyke M

更新日期：2008-01-01 00:00:00

abstract：:Our focus was to develop a three-dimensional (3D) human dynamic in vitro tissue model that mimics the natural microenvironment of the small intestine. We co-cultured human Caco-2 cells with primary-isolated human microvascular endothelial cells (hMECs) on decellularized porcine jejunal segments within a custom-made dy...

journal_title：Biomaterials

authors： Pusch J,Votteler M,Göhler S,Engl J,Hampel M,Walles H,Schenke-Layland K

更新日期：2011-10-01 00:00:00

abstract：:Experimental and histological studies on the reaction of surrounding gingiva to permucosal implants of dense calcium hydroxyapatite were carried out in dogs. Epithelial attachment and connection of supra-alveolar collagen fibres to the implant surface seemed to form a biological seal around implants similar to that ar...

journal_title：Biomaterials

authors： Kurashina K,de Lange GL,de Putter C,de Groot K

更新日期：1984-07-01 00:00:00

abstract：:Platinum nanoparticle-doped chitosan (CHIT) solution can be easily prepared by treating the CHIT solution with aqueous H2PtCl6 solution followed by chemical reduction of Pt(IV) with NaBH4. Multiwalled carbon nanotubes (MWCNT) are then dispersed in the nanoparticle-doped solution. The resulting Pt-CNT-CHIT material bri...

journal_title：Biomaterials

authors： Yang M,Yang Y,Yang H,Shen G,Yu R

更新日期：2006-01-01 00:00:00

abstract：:Valvular interstitial cells (VICs) actively maintain and repair heart valve tissue; however, persistent activation of VICs to a myofibroblast phenotype can lead to aortic stenosis. To better understand and quantify how microenvironmental cues influence VIC phenotype and myofibroblast activation, we compared expression...

journal_title：Biomaterials

authors： Mabry KM,Payne SZ,Anseth KS

更新日期：2016-01-01 00:00:00