Immunomodulatory injectable silk hydrogels maintaining functional islets and promoting anti-inflammatory M2 macrophage polarization.

abstract：:Inflammatory bowel disease (IBD) is a chronic inflammatory gastrointestinal disorder that affects more than 1 million individuals in the USA. Local therapy with enema formulations, such as micronized budesonide (Entocort®), is a common strategy for treating patients with distally active IBD. However, we hypothesize th...

journal_title：Biomaterials

authors： Date AA,Halpert G,Babu T,Ortiz J,Kanvinde P,Dimitrion P,Narayan J,Zierden H,Betageri K,Musmanno O,Wiegand H,Huang X,Gumber S,Hanes J,Ensign LM

更新日期：2018-12-01 00:00:00

abstract：:The calcination and natural sintering of calcium deficient hydroxyapatite powders Ca(10-x)(PO4)(6-x)(HPO4)x(OH)(2-x) (with 0 < or = x < or = 1) were studied. For temperature below 700 degrees C, particle coalescence occurs without densification. The particle coalescence is associated with a reduction of the specific s...

journal_title：Biomaterials

authors： Raynaud S,Champion E,Bernache-Assollant D

更新日期：2002-02-01 00:00:00

abstract：:Parkinson's disease (PD) is one of the most common neurodegenerative diseases. Activins are members of the superfamily of transforming growth factors and have many potential neuroprotective effects. Herein, at the first place, we verified activin B's neuroprotective role in a PD model, and revealed that activin B's fa...

journal_title：Biomaterials

authors： Li J,Darabi M,Gu J,Shi J,Xue J,Huang L,Liu Y,Zhang L,Liu N,Zhong W,Zhang L,Xing M,Zhang L

更新日期：2016-09-01 00:00:00

abstract：:During organogenesis groups of differentiating cells self-organize into a series of structural intermediates with defined architectural forms. Evidence is emerging that such architectural forms are important in guiding cell fate, yet in vitro methods to guide cell fate have focused primarily on un-patterned exposure o...

journal_title：Biomaterials

authors： Soleas JP,D'Arcangelo E,Huang L,Karoubi G,Nostro MC,McGuigan AP,Waddell TK

更新日期：2020-09-01 00:00:00

abstract：:The peripheral nerve contains three barriers which include the blood-nerve barrier consisting of endoneurial vessels and the perineurium as well as autotypic junctions in Schwann cells. The perineurium prevents diffusion of perineurally injected drugs that can be used for selective regional pain control. It is compose...

journal_title：Biomaterials

authors： Yang S,Krug SM,Heitmann J,Hu L,Reinhold AK,Sauer S,Bosten J,Sommer C,Fromm M,Brack A,Rittner HL

更新日期：2016-03-01 00:00:00

abstract：:One of the main issues in orthopaedic implant design is the fabrication of scaffolds that closely mimic the biomechanical properties of the surrounding bone. This research reports on a multi-stage rapid prototyping technique that was successfully developed to produce porous titanium scaffolds with fully interconnected...

journal_title：Biomaterials

authors： Ryan GE,Pandit AS,Apatsidis DP

更新日期：2008-09-01 00:00:00

abstract：:Tissue-engineered skin substitutes provided a feasibility to overcome the shortage of skin autograft by culturing keratinocytes and dermal fibroblasts in vitro. In this study, we applied bi-layer gelatin-chondrointin-6-sulfate-hyaluronic acid (gelatin-C6S-HA) biomatrices onto the severe combined immunodeficiency (SCID...

journal_title：Biomaterials

authors： Wang TW,Sun JS,Wu HC,Tsuang YH,Wang WH,Lin FH

更新日期：2006-11-01 00:00:00

abstract：:New crosslinked ionic polyurethanes and copolyurethanes were yielded by reaction of telechelic cis-1,4-oligoisoprenes, bearing a variable number of ammonium and hydroxy groups, with isocyanurate of isophorone diisocyanate (I-IPDI). Aiming for a comparative study, polyurethane elastomers based on non-ionic telechelic o...

journal_title：Biomaterials

authors： Kébir N,Campistron I,Laguerre A,Pilard JF,Bunel C,Jouenne T

更新日期：2007-10-01 00:00:00

abstract：:Protein therapeutics targeting inflammatory mediators have shown great promise for the treatment of autoimmunities such as rheumatoid arthritis (RA). However, a significant challenge in this area has been their low in vivo stability and consequently their severely compromised therapeutic efficacy. One such therapeutic...

journal_title：Biomaterials

authors： Pasi S,Kant R,Gupta S,Surolia A

更新日期：2015-02-01 00:00:00

abstract：:An increasing number of treatments of metastases rely on diagnostics and imaging these days. The facts that the activity of cathepsin B (CB) is markedly linked to the metastatic process and that CB is found highly expressed in the pericellular regions in this process make CB an attractive target for diagnosing metasta...

journal_title：Biomaterials

authors： Ryu JH,Na JH,Ko HK,You DG,Park S,Jun E,Yeom HJ,Seo DH,Park JH,Jeong SY,Kim IS,Kim BS,Kwon IC,Choi K,Kim K

更新日期：2014-02-01 00:00:00

abstract：:We have prepared a fraction of commercial fetal calf serum whose major component comprises proteins of apparent molecular mass 65-80 kDa. These preparations elicit cell spreading responses in serum-free medium at concentrations similar to those reported for human vitronectin. In addition, we have identified (by a prot...

journal_title：Biomaterials

authors： Lydon MJ,Foulger CA

更新日期：1988-11-01 00:00:00

abstract：:Cationic polymer PEI-CyD is doped with Nd by plasma technology to produce the gene vector: Nd@PEI-CyD. Luciferase expression and EGFP transfection experiments performed in vitro reveal that Nd@PEI-CyD has significantly higher transfection efficiency than lipofectamine 2000 and PEI-CyD and the mechanism is studied and ...

journal_title：Biomaterials

authors： Wang Q,Jin W,Wu G,Zhao Y,Jin X,Hu X,Zhou J,Tang G,Chu PK

更新日期：2014-01-01 00:00:00

abstract：:Collagenous xenografts made from kangaroo tail tendon cross-linked with glutaraldehyde have a potential application in the reconstruction of massive digital tendon deficits. However, a limitation to the clinical use of these xenografts has been the optimization of collagen cross-linking, and subsequent bio-incorporati...

journal_title：Biomaterials

authors： Johnson KA,Rogers GJ,Roe SC,Howlett CR,Clayton MK,Milthorpe BK,Schindhelm K

更新日期：1999-06-01 00:00:00

abstract：:Motivated by the necessity to engineer appropriately stratified cartilage, the shear mechanics of layered, bovine chondrocyte-seeded 20mg/mL alginate scaffolds were investigated and related to the structure and biochemical composition. Chondrocyte-seeded alginate scaffolds were exposed to a calcium-chelating solution,...

journal_title：Biomaterials

authors： Lee CS,Gleghorn JP,Won Choi N,Cabodi M,Stroock AD,Bonassar LJ

更新日期：2007-07-01 00:00:00

abstract：:Human cell therapy applications in tissue engineering, such as the ex vivo production of hematopoietic cells for transplantation, have recently entered the clinic. Although considerable effort has been focused on the development of biological processes to generate therapeutic cells, little has been published on the de...

journal_title：Biomaterials

authors： Koller MR,Palsson MA,Manchel I,Maher RJ,Palsson BO

更新日期：1998-11-01 00:00:00

abstract：:Successful cell-based tissue engineering requires a rapid and thorough vascularization in order to ensure long-term implant survival and tissue integration. The vascularization of a scaffold is a complex process, and is modulated by the presence of transplanted cells, exogenous and endogenous signaling proteins, and t...

journal_title：Biomaterials

authors： Ghanaati S,Unger RE,Webber MJ,Barbeck M,Orth C,Kirkpatrick JA,Booms P,Motta A,Migliaresi C,Sader RA,Kirkpatrick CJ

更新日期：2011-11-01 00:00:00

abstract：:Surface properties of implanted biomaterials can cause fibrotic tissue reactions by stimulating differentiation of host fibroblasts into contractile myofibroblasts. Silk fibroin (SF) protein has been used as biomaterial in pure and blended form. however, its effect on myofibroblast differentiation remains elusive. We ...

journal_title：Biomaterials

authors： Acharya C,Hinz B,Kundu SC

更新日期：2008-12-01 00:00:00

abstract：:The hypothesis that E-selectin on activated endothelial cells could be exploited to selectively target drug delivery systems to tumor vasculature was investigated. HPMA copolymer-doxorubicin (DOX) conjugates displaying the high affinity E-selectin binding peptide (Esbp, primary sequence DITWDQLWDLMK) as targeting liga...

journal_title：Biomaterials

authors： Shamay Y,Paulin D,Ashkenasy G,David A

更新日期：2009-11-01 00:00:00

abstract：:Microcontact printing (mCP) is employed to generate discontinuous microscale gradients of active fractalkine, a chemokine expressed by endothelial cells near sites of inflammation where it is believed to form concentration gradients descending away from the inflamed area. In vivo, fractalkine is a transmembrane molecu...

journal_title：Biomaterials

authors： Hjortø GM,Hansen M,Larsen NB,Kledal TN

更新日期：2009-10-01 00:00:00

abstract：:Intracellular reactive sulfur species and reactive oxygen species play vital roles in immunologic mechanism. As an emerging signal transmitter, SO2 can be generated as the anti-oxidant, while SO2 is also a potential oxidative stress-inducer in organism. Aiming to elucidate in-depth the dichotomous role of SO2 under ox...

journal_title：Biomaterials

authors： Dou K,Fu Q,Chen G,Yu F,Liu Y,Cao Z,Li G,Zhao X,Xia L,Chen L,Wang H,You J

更新日期：2017-07-01 00:00:00

abstract：:Cationic solid lipid nanoparticles (cSLNs) are promising nanoparticles for controlled drug delivery. Increasing surface charge and/or reducing PEG density enhance cellular uptake of cSLNs in vitro, but for unknown reasons fail to improve drug delivery in vivo. Herein, we show that cSLNs present a risk for systemic pla...

journal_title：Biomaterials

authors： Wu X,Chen H,Wu C,Wang J,Zhang S,Gao J,Wang H,Sun T,Yang YG

更新日期：2018-02-01 00:00:00

abstract：:The ability to restore heart function by replacement of diseased myocardium is one of the great challenges in biomaterials and regenerative medicine. Brown adipose derived stem cells (BADSCs) present a new source of cardiomyocytes to regenerate the myocardium after infarction. In this study, we explored an injectable ...

journal_title：Biomaterials

authors： Wang H,Shi J,Wang Y,Yin Y,Wang L,Liu J,Liu Z,Duan C,Zhu P,Wang C

更新日期：2014-04-01 00:00:00

abstract：:This study describes a family of hollow nanoscale constructs able to display a large and reversible change in size, within a narrow temperature interval. These thermoresponsive nanostructures are generated by crosslinking functionalized amphiphilic molecules, such as poly(ethylene oxide)-poly(propylene oxide)-poly(eth...

journal_title：Biomaterials

authors： Cohn D,Sagiv H,Benyamin A,Lando G

更新日期：2009-07-01 00:00:00

abstract：:Nitric oxide (NO) is an important biological messenger involved in the treatment of bacterial infections, but its controlled and targeted release in bacterial infections remains a major challenge. Herein, an intelligent NO nanogenerator triggered by near-infrared (NIR) light is constructed for targeted treatment of P....

journal_title：Biomaterials

authors： Wu Y,Deng G,Jiang K,Wang H,Song Z,Han H

更新日期：2021-01-01 00:00:00

abstract：:Gold nanoparticles hold great promise as anti-cancer theranostic agents against cancer by actively targeting the tumor cells. As this potential has been supported numerously during in vitro experiments, the effective application is hampered by our limited understanding and control of the interactions within complex in...

journal_title：Biomaterials

authors： D'Hollander A,Jans H,Velde GV,Verstraete C,Massa S,Devoogdt N,Stakenborg T,Muyldermans S,Lagae L,Himmelreich U

更新日期：2017-04-01 00:00:00

abstract：:The differentiation of odontoblasts is initiated by the organization of differentiating ameloblasts during tooth formation. However, the exact roles of ameloblast-derived factors in odontoblast differentiation have not yet been characterized. We investigated the effects of preameloblast-conditioned medium (PA-CM) on t...

journal_title：Biomaterials

authors： Lee JH,Lee DS,Choung HW,Shon WJ,Seo BM,Lee EH,Cho JY,Park JC

更新日期：2011-12-01 00:00:00

abstract：:The adhesion of osteoblasts to substrates is mediated through proteins that have adsorbed to the substrate, providing integrins on the cell membrane with ligands to connect to. The integrins regulate cell behavior through bi-directional signaling pathways. This critical review has the purpose to consider the research ...

journal_title：Biomaterials

authors： Siebers MC,ter Brugge PJ,Walboomers XF,Jansen JA

更新日期：2005-01-01 00:00:00

abstract：:Pituitary adenylate cyclase activating polypeptide (PACAP) is a neuroendocrine factor that activates both the receptor VPAC1 and VPAC2. Although PACAP possesses insulinotropic activity, its therapeutic application is limited by the extremely short acting half-life and the stimulatory effects on glucagon production via...

journal_title：Biomaterials

authors： Ma Y,Fang S,Zhao S,Wang X,Wang D,Ma M,Luo T,Hong A

更新日期：2015-05-01 00:00:00

abstract：:Doxorubicin (DOX) is a well-known anticancer drug used for the treatment of a wide variety of cancers. However, undesired toxicity of DOX limits its uses. To address the issue of minimizing toxicity of DOX by making it targeted towards cancer cells, DOX was entrapped in self-assembled 6-O-(3-hexadecyloxy-2-hydroxyprop...

journal_title：Biomaterials

authors： Ray L,Kumar P,Gupta KC

更新日期：2013-04-01 00:00:00

abstract：:The aim of this study was to develop an effective drug delivery system for the simultaneous topical delivery of two anti-inflammatory drugs, spantide II (SP) and ketoprofen (KP). To achieve this primary goal, we have developed a skin permeating nanogel system (SPN) containing surface modified polymeric bilayered nanop...

journal_title：Biomaterials

authors： Shah PP,Desai PR,Patel AR,Singh MS

更新日期：2012-02-01 00:00:00