当前位置： SCI文献检索 > BIOMATERIALS期刊下所有文献 > Iron oxide nanoparticles promote macrophage autophagy and inflammatory response through activation of toll-like Receptor-4 signaling.

Iron oxide nanoparticles promote macrophage autophagy and inflammatory response through activation of toll-like Receptor-4 signaling.

Abstract：

:Nanoparticle-induced autophagy is crucial for its metabolism, cytotoxicity and therapy potency, but little is known about how the host immune system would respond to it. In this study, we demonstrated that two clinically used superparamagnetic iron oxide nanoparticles (SPIONs) specifically induced macrophage autophagy through activation of TLR4, followed by phosphorylation of p38 and nucleus translocation of Nrf2, leading to upregulation of p62/SQSTM1 and macrophage scavenger receptor SR-AI mRNA expression. Overexpressed p62 conjugated with LC3 to form aggresome-like induced structures (ALIS) and then fused with SPIONs containing endosomes and lysosomes to form autolysosomes for degradation of endocytosed nanoparticles. More importantly, SPIONs also could promote macrophage autophagy in mouse liver which is their imaging target. We also discovered that SPIONs could stimulate the expression of inflammatory cytokines through activation of TLR4 signaling in macrophage. In general, our findings indicate that SPIONs would interact with TLR4 on the macrophage membrane and trigger its downstream signaling pathway, independent of the classic autophagic p62 reduction pathway. The observed autophagy and induced inflammatory responses in macrophages provide unique and novel perspectives in optimizing imaging/therapy nanoparticle performance in addition to analysis by traditional biochemical evaluation methods. It also enriches our understanding of NP/macrophage interaction mechanisms in reticular endothelial system (RES) organs.

journal_name

Biomaterials

journal_title

Biomaterials

authors

Jin R,Liu L,Zhu W,Li D,Yang L,Duan J,Cai Z,Nie Y,Zhang Y,Gong Q,Song B,Wen L,Anderson JM,Ai H

doi

10.1016/j.biomaterials.2019.02.026

subject

Has Abstract

pub_date

2019-05-01 00:00:00

pages

23-30

eissn

0142-9612

issn

1878-5905

pii

S0142-9612(19)30123-1

journal_volume

203

pub_type

杂志文章

相关文献

BIOMATERIALS文献大全
  • Combinatorial co-encapsulation of hydrophobic molecules in poly(lactide-co-glycolide) microparticles.

    abstract：:There is great interest for developing poly(lactide-co-glycolide) (PLGA) based particles for targeted delivery and controlled release of encapsulated biological molecules. These PLGA particles can be used to deliver proteins, small molecule drugs and nucleotides. Furthermore, it has been shown that the co-encapsulatio...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2013.01.032

    authors： Acharya AP,Lewis JS,Keselowsky BG

    更新日期：2013-04-01 00:00:00

  • Biological activities of osteoblasts on poly(methyl methacrylate)/silica hybrid containing calcium salt.

    abstract：:The biological activity of osteoblasts on the newly developed bioactive poly(methyl methacrylate) (PMMA)/silica hybrid containing calcium salt was investigated. The attachment, proliferation, and differentiation of primary cultured mouse calvarial osteoblasts were evaluated by hexosaminase, MTT, and alkaline phosphata...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/s0142-9612(02)00421-0

    authors： Rhee SH,Hwang MH,Si HJ,Choi JY

    更新日期：2003-03-01 00:00:00

  • Charge convertibility and near infrared photon co-enhanced cisplatin chemotherapy based on upconversion nanoplatform.

    abstract：:Optimal nano-sized drug carrier requires long blood circulation, selective extravasation, and efficient cell uptake. Here we develop a charge-convertible nanoplatform based on Pt(IV) prodrug loaded NaYF4:Yb,Tm upconversion nanoparticles (UCNs), followed by coating a layer of PEG-PAH-DMMA polymer (UCNs-Pt(IV)@PEG-PAH-D...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2017.03.041

    authors： Xu J,Kuang Y,Lv R,Yang P,Li C,Bi H,Liu B,Yang D,Dai Y,Gai S,He F,Xing B,Lin J

    更新日期：2017-06-01 00:00:00

  • A chitosan/beta-glycerophosphate thermo-sensitive gel for the delivery of ellagic acid for the treatment of brain cancer.

    abstract：:We report here the development of a chitosan/beta-glycerophosphate(Ch/beta-GP) thermo-sensitive gel to deliver ellagic acid (EA) for cancer treatment. The properties of the Ch/beta-GP gels were characterized regarding chemical structure, surface morphology, and viscoelasticity. In vitro EA release rate from the EA loa...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2010.01.139

    authors： Kim S,Nishimoto SK,Bumgardner JD,Haggard WO,Gaber MW,Yang Y

    更新日期：2010-05-01 00:00:00

  • Pentacyclic triterpenes grafted on CD cores to interfere with influenza virus entry: A dramatic multivalent effect.

    abstract：:Multivalent effect plays an important role in biological processes, particularly in the specific recognition of virus with its host cell during the first step of infection. Here we report the synthesis of multivalent pentacyclic triterpene grafted on cyclodextrin core and potency of against influenza entry activity. N...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2015.11.034

    authors： Xiao S,Si L,Tian Z,Jiao P,Fan Z,Meng K,Zhou X,Wang H,Xu R,Han X,Fu G,Zhang Y,Zhang L,Zhou D

    更新日期：2016-02-01 00:00:00

  • In vitro and in vivo calcification of vascular bioprostheses.

    abstract：:Efficacy of different chemical treatments on calcification of vascular graft in vitro and in vivo was studied. Culture medium-filled rat aortas were separately treated in 0.2% glutaraldehyde and epoxy compound, and photooxidized in 0.01% methylene blue for a shorter period (group 1). Another group of rat aortas were s...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/s0142-9612(98)00038-6

    authors： Chanda J,Kondoh K,Ijima K,Matsukawa M,Kuribayashi R

    更新日期：1998-09-01 00:00:00

  • Mineral evolution of bone.

    abstract：:A study on the evolution with age of the mineral composition of bones was performed on samples belonging to human and other common mammalian species (cattle, sheep, dog). The study was carried out on the ashes obtained by calcination of the bone samples (1 h at 900 degrees C). The calcined powders were carefully exami...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/0142-9612(96)88712-6

    authors： Ravaglioli A,Krajewski A,Celotti GC,Piancastelli A,Bacchini B,Montanari L,Zama G,Piombi L

    更新日期：1996-03-01 00:00:00

  • Programmed degradation of a hierarchical nanoparticle with redox and light responsivity for self-activated photo-chemical enhanced chemodynamic therapy.

    abstract：:Chemodynamic therapy (CDT) has recently emerged as a promising treatment for cancer due to the high specificity of CDT towards tumor microenvironment (TME). However, the low efficiency of reactive oxygen species (ROS) generation and the robust ROS defensive mechanisms in cancer cells remain critical hurdles for curren...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2019.119498

    authors： Wang S,Yang L,Cho HY,Dean Chueng ST,Zhang H,Zhang Q,Lee KB

    更新日期：2019-12-01 00:00:00

  • Effect of resin hydrophilicity and temperature on water sorption of dental adhesive resins.

    abstract：:This study examined the effects of copolymer hydrophilicity and temperature on water sorption and solubility characteristics of five copolymer blends of increasing degree of hydrophilicity using gravimetric measurements. Six resin disks (15 mm in diameter x 1 mm in thickness) were prepared from each copolymer blend an...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2005.09.037

    authors： Yiu CK,King NM,Carrilho MR,Sauro S,Rueggeberg FA,Prati C,Carvalho RM,Pashley DH,Tay FR

    更新日期：2006-03-01 00:00:00

  • Interactions of human platelets with insoluble anticoagulant modified polystyrene resins.

    abstract：:The interactions of two insoluble anticoagulant polystyrene derivatives with human platelets were studied in an in vitro system similar to a chromatography column. Blood was pumped through the column and platelets were counted before and after passage through the column. Interaction of platelets with the beads led to ...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/0142-9612(84)90053-x

    authors： Fougnot C,Lindon J,Kirshner L,Salzman EW,Jozefowicz M

    更新日期：1984-05-01 00:00:00

  • Effect of laser therapy on attachment, proliferation and differentiation of human osteoblast-like cells cultured on titanium implant material.

    abstract：:The aim of this in vitro study was to investigate the effect of low-level laser therapy (LLLT) on the attachment, proliferation, differentiation and production of transforming growth factor-ss(1) (TGF-beta(1)) by human osteoblast-like cells (HOB). Cells derived from human mandibular bone were exposed to GaAlAs diode l...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2004.09.033

    authors： Khadra M,Lyngstadaas SP,Haanaes HR,Mustafa K

    更新日期：2005-06-01 00:00:00

  • In vitro degradation of pH-sensitive hydrogels containing aromatic azo bonds.

    abstract：:Biodegradable and pH-sensitive hydrogels containing azoaromatic moieties were synthesized from the same polymeric precursors by two synthetic methods, namely a polymer-polymer reaction and cross-linking of polymeric precursors. The effect of the synthetic route employed and the detailed network structure on in vitro d...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/s0142-9612(97)00007-0

    authors： Ghandehari H,Kopecková P,Kopecek J

    更新日期：1997-06-01 00:00:00

  • Cross-linking of dermal sheep collagen using a water-soluble carbodiimide.

    abstract：:A cross-linking method for collagen-based biomaterials was developed using the water-soluble carbodiimide 1-ethyl-3-(3-dimethyl aminopropyl)carbodiimide hydrochloride (EDC). Cross-linking using EDC involves the activation of carboxylic acid groups to give O-acylisourea groups, which form cross-links after reaction wit...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/0142-9612(96)81413-x

    authors： Olde Damink LH,Dijkstra PJ,van Luyn MJ,van Wachem PB,Nieuwenhuis P,Feijen J

    更新日期：1996-04-01 00:00:00

  • Surface modifications induced by ns and sub-ps excimer laser pulses on titanium implant material.

    abstract：:Medical implants used in oral and orthopaedic surgery are mainly produced from titanium. Their biological behaviour, e.g. osseointegration, essentially depends on both the chemical composition and the morphology of the surface. Modifications achieved by excimer laser irradiation of titanium samples were investigated i...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/s0142-9612(03)00318-1

    authors： Bereznai M,Pelsöczi I,Tóth Z,Turzó K,Radnai M,Bor Z,Fazekas A

    更新日期：2003-10-01 00:00:00

  • Synthesis, characterization and ex vivo evaluation of polydimethylsiloxane polyurea-urethanes.

    abstract：:A series of segmented polydimethylsiloxane (PDMS) polyurea-urethanes was synthesized based on hexane diisocyanate modified polyether-PDMS soft segments. The hard segments consisted of 4,4'-methylene diphenylene diisocyanate, which was chain extended with 1,4-butanediol. The effect of chemical composition of the polyet...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/0142-9612(94)90218-6

    authors： Lim F,Yang CZ,Cooper SL

    更新日期：1994-05-01 00:00:00

  • Transdermal immunization with low-pressure-gene-gun mediated chitosan-based DNA vaccines against Japanese encephalitis virus.

    abstract：:DNA vaccine is a milestone in contemporary vaccine development. It has considerably offset many shortcomings in conventional vaccines. Although DNA vaccines applied through 'traditional' high-pressure gene guns generally elicit high titers of protective immunity, such a practice however requires enormous investment in...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2009.07.029

    authors： Huang HN,Li TL,Chan YL,Chen CL,Wu CJ

    更新日期：2009-10-01 00:00:00

  • Heterogeneous iron-containing fluoridated apatites.

    abstract：:The iron-containing fluoridated hydroxyapatites Fe-FeFAp and FeF-FeAp were synthesized heterogeneously in the presence of ferrous ions at 80 degrees C and pH 7.4 in two different types of solution, i.e. fluoride-free solution during the initial half of the experimental period and fluoride-containing solution during th...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/s0142-9612(96)00094-4

    authors： Okazaki M,Takahashi J

    更新日期：1997-01-01 00:00:00

  • The effect of keratinocytes on the biomechanical characteristics and pore microstructure of tissue engineered skin using deep dermal fibroblasts.

    abstract：:Fibrosis affects most organs, it results in replacement of normal parenchymal tissue with collagen-rich extracellular matrix, which compromises tissue architecture and ultimately causes loss of function of the affected organ. Biochemical pathways that contribute to fibrosis have been extensively studied, but the role ...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2014.07.048

    authors： Varkey M,Ding J,Tredget EE,Wound Healing Research Group.

    更新日期：2014-12-01 00:00:00

  • Water absorption and surface properties of novel poly(ethylmethacrylate) polymer systems for use in bone and cartilage repair.

    abstract：:The surface and bulk properties of novel methacrylate polymers prepared by gelling poly(ethyl methacrylate) (PEMA) powder with different ratios of tetrahydrofurfuryl methacrylate (THFMA) and hydroxyethyl methacrylate (HEMA) monomers were investigated. The water adsorption and desorption characteristics of these polyme...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/s0142-9612(00)00229-5

    authors： Hutcheon GA,Messiou C,Wyre RM,Davies MC,Downes S

    更新日期：2001-04-01 00:00:00

  • Cationic lipid bilayer coated gold nanoparticles-mediated transfection of mammalian cells.

    abstract：:Here, we demonstrated dimethyldioctadecylammonium bromide (DODAB), a cationic lipid, bilayer coated Au nanoparticles (AuNPs) could efficiently deliver two types of plasmid DNA into human embryonic kidney cells (HEK 293) in the presence of serum. The transfection efficiency of AuNPs was about five times higher than tha...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2008.05.020

    authors： Li P,Li D,Zhang L,Li G,Wang E

    更新日期：2008-09-01 00:00:00

  • Immunomodulatory properties of chitosan polymers.

    abstract：:The introduction of vaccines is regarded as one of the most successful medical interventions to date. However, there is a clear need for the development of new vaccines for diseases which require the induction of a potent cellular immune response. Advancements in the field of vaccine research have resulted in a move a...

    journal_title：Biomaterials

    pub_type： 杂志文章,评审

    doi：10.1016/j.biomaterials.2018.08.054

    authors： Moran HBT,Turley JL,Andersson M,Lavelle EC

    更新日期：2018-11-01 00:00:00

  • Odontogenic differentiation of human dental pulp stem cells induced by preameloblast-derived factors.

    abstract：:The differentiation of odontoblasts is initiated by the organization of differentiating ameloblasts during tooth formation. However, the exact roles of ameloblast-derived factors in odontoblast differentiation have not yet been characterized. We investigated the effects of preameloblast-conditioned medium (PA-CM) on t...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2011.09.007

    authors： Lee JH,Lee DS,Choung HW,Shon WJ,Seo BM,Lee EH,Cho JY,Park JC

    更新日期：2011-12-01 00:00:00

  • The use of biotinylated-EGF-modified gelatin nanoparticle carrier to enhance cisplatin accumulation in cancerous lungs via inhalation.

    abstract：:To develop a polymer-anticancer drug conjugate, we employed gelatin nanoparticles (GPs) as carriers of cisplatin (CDDP) with anticipated improved therapeutic effect and reduced side effects. The anticancer activities of CDDP-incorporated in GPs (GP-Pt) with biotinylated-EGF (bEGF) modification (GP-Pt-bEGF) were studie...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2009.03.010

    authors： Tseng CL,Su WY,Yen KC,Yang KC,Lin FH

    更新日期：2009-07-01 00:00:00

  • Electrodeposited platinum-iridium coating improves in vivo recording performance of chronically implanted microelectrode arrays.

    abstract：:Reliable single unit neuron recordings from chronically implanted microelectrode arrays (MEAs) are essential tools in the field of neural engineering. However, following implantation, MEAs undergo a foreign body response that functionally isolates them from the brain and reduces the useful longevity of the array. We t...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2019.03.017

    authors： Cassar IR,Yu C,Sambangi J,Lee CD,Whalen JJ 3rd,Petrossians A,Grill WM

    更新日期：2019-06-01 00:00:00

  • Cytotoxicity and MMP-9 activation induced in human mononuclear cells by UHMWPE oxidation.

    abstract：:Ultra high molecular weight polyethylene (UHMWPE) used in orthopedic prosthesis can be oxidized during sterilization processes such as gamma-ray irradiation. Oxidation alters UHMWPE structure and mechanical properties and it has been suggested that this alteration is the first step in the loosening process. Direct eff...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/s0142-9612(02)00097-2

    authors： Renò F,Bracco P,Costa L,Cannas M

    更新日期：2002-09-01 00:00:00

  • Breast cancer cells and macrophages in a paracrine-juxtacrine loop.

    abstract：:Breast cancer cells (BCC) and macrophages are known to interact via epidermal growth factor (EGF) produced by macrophages and colony stimulating factor-1 (CSF-1) produced by BCC. Despite contradictory findings, this interaction is perceived as a paracrine loop. Further, the underlying mechanism of interaction remains ...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2020.120412

    authors： Onal S,Turker-Burhan M,Bati-Ayaz G,Yanik H,Pesen-Okvur D

    更新日期：2021-01-01 00:00:00

  • Microwave CO2 plasma-initiated vapour phase graft polymerization of acrylic acid onto polytetrafluoroethylene for immobilization of human thrombomodulin.

    abstract：:The functionalization of polytetrafluoroethylene (PTFE) for human thrombomodulin (hTM) binding has been achieved by CO2 plasma activation and subsequent vapour phase graft polymerization of acrylic acid (AA). The PTFE surfaces after CO2 plasma treatment, AA grafting and hTM immobilization were characterized by attenua...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/s0142-9612(97)00045-8

    authors： Vasilets VN,Hermel G,König U,Werner C,Müller M,Simon F,Grundke K,Ikada Y,Jacobasch HJ

    更新日期：1997-09-01 00:00:00

  • Synthesis of creatinine-imprinted poly(beta-cyclodextrin) for the specific binding of creatinine.

    abstract：:An artificial receptor for creatinine was synthesized by the method of molecularly imprinted polymer (MIP). beta-Cyclodextrin was used as a monomer cross-linked with epichlorohydrin in the presence of creatinine, which was a template for the imprinting. Different molar ratios of monomer to template were used to synthe...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2004.07.037

    authors： Tsai HA,Syu MJ

    更新日期：2005-05-01 00:00:00

  • Optimized phospholipid-based nanoparticles for inner ear drug delivery and therapy.

    abstract：:To develop efficient carriers for inner ear drug delivery, we prepared four kinds of phospholipid-based nanoparticles: neutral, anionic, cationic, and cationic-PEG (polyethyleneglycol) particles. PEG was used to maintain long-term particle circulation in the perilymph, avoiding non-specific binding of particles to pro...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2018.04.038

    authors： Yang KJ,Son J,Jung SY,Yi G,Yoo J,Kim DK,Koo H

    更新日期：2018-07-01 00:00:00

  • Nanomaterials for the theranostics of obesity.

    abstract：:As a chronic and lifelong disease, obesity not only significant impairs health but also dramatically shortens life span (at least 10 years). Obesity requires a life-long effort for the successful treatment because a number of abnormalities would appear in the development of obesity. Nanomaterials possess large specifi...

    journal_title：Biomaterials

    pub_type： 杂志文章,评审

    doi：10.1016/j.biomaterials.2019.119474

    authors： Li J,Cha R,Luo H,Hao W,Zhang Y,Jiang X

    更新日期：2019-12-01 00:00:00