Abstract:
:As a chronic and lifelong disease, obesity not only significant impairs health but also dramatically shortens life span (at least 10 years). Obesity requires a life-long effort for the successful treatment because a number of abnormalities would appear in the development of obesity. Nanomaterials possess large specific surface area, strong absorptivity, and high bioavailability, especially the good targeting properties and adjustable release rate, which would benefit the diagnosis and treatment of obesity and obesity-related metabolic diseases. Herein, we discussed the therapy and diagnosis of obesity and obesity-related metabolic diseases by using nanomaterials. Therapies of obesity with nanomaterials include improving intestinal health and reducing energy intake, targeting and treating functional cell abnormalities, regulating redox homeostasis, and removing free lipoprotein in blood. Diagnosis of obesity-related metabolic diseases would benefit the therapy of these diseases. The development of nanomaterials will promote the diagnosis and therapy of obesity and obesity-related metabolic diseases.
journal_name
Biomaterialsjournal_title
Biomaterialsauthors
Li J,Cha R,Luo H,Hao W,Zhang Y,Jiang Xdoi
10.1016/j.biomaterials.2019.119474subject
Has Abstractpub_date
2019-12-01 00:00:00pages
119474eissn
0142-9612issn
1878-5905pii
S0142-9612(19)30573-3journal_volume
223pub_type
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