Processes human umbilical veins as arterial substitutes--evaluation in canine models.

Abstract:

:Human umbilical cord vein segments have been used as vessel substitutes for damaged or occluded arteries, as aorto-coronary by-passes and as arterio-venous fistulae for dialysis. The Dardik-Biograft fixed with glutaraldehyde and the Mindich-Bioflow, fixed with ethanol and dialdehyde starch, are commercially available. They were implanted in dogs as replacements for a segment of the abdominal aorta. Post-implantation status was followed by angiography. They were evaluated after removal from sacrificed animals with the aid of scanning electron microscopy and histological techniques. Attention was focused on vessel patency, dimensional stability, integrity of the anastomosis line, lumen wall microstructure, evidence of suture damage and thrombus deposition pattern. Both types of grafts gave functional by-passes for at least until 6 months post-implantation. The Dardik-Biograft appeared more prone to thrombus formation near the anastomosis. Sparse cellular development was also noted. The Mindich-Bioflow gave rise to a prosthesis of superior thromboresistance which was more subject to mechanical damage.

journal_name

Biomaterials

journal_title

Biomaterials

authors

Guidoin R,Marois M,Martin L,Noël HP,Laroche F,Gosselin CO,Côté R,Bénichoux R,Blais P

doi

10.1016/0142-9612(80)90004-6

subject

Has Abstract

pub_date

1980-04-01 00:00:00

pages

82-8

issue

2

eissn

0142-9612

issn

1878-5905

pii

0142-9612(80)90004-6

journal_volume

1

pub_type

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