Abstract：
:Cytokines, chemokines, and growth factors were analyzed periodically over eight weeks from the wound exudate fluid surrounding biomaterials implanted subcutaneously within stainless steel mesh cages. TNF-alpha, MCP-1, MIP-1alpha, IL-2, IL-6, IL-1beta, VEGF, IL-4, and IL-10 were measured from exudate samples collected from cages containing specimens of polyethylene (PE), polyurethane (PU), or organotin polyvinyl chloride (ot-PVC). Empty cages served as negative controls, and lipopolysaccharide (LPS) served as a positive control. Cytokine, chemokine, and growth factor concentrations decreased from the time of implantation to eight weeks post-implantation, and there was an overall increase in cytokine, chemokine, and growth factor production for material-containing cages compared to empty cages. However, cytokine production was only modestly affected by the different surface chemistries of the three implanted polymeric materials.
journal_name
Biomaterialsjournal_title
Biomaterialsauthors
Schutte RJ,Xie L,Klitzman B,Reichert WMdoi
10.1016/j.biomaterials.2008.09.026subject
Has Abstractpub_date
2009-01-01 00:00:00pages
160-8issue
2eissn
0142-9612issn
1878-5905pii
S0142-9612(08)00675-3journal_volume
30pub_type
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