Albumin adsorption on to aluminium oxide and polyurethane surfaces.

abstract：:To achieve enhanced gene transfection efficiency with ocular eye-drop therapy, a cationic core-shell liponanoparticle (DLCS-NP) was designed by enveloping the plasmid-laden chitosan nanoparticle (CS-NP) into a cationic lipid shell. The cellular uptake of DLCS-NP was up to 1.25-fold and 5-fold higher than that of CS-NP...

journal_title：Biomaterials

authors： Jiang M,Gan L,Zhu C,Dong Y,Liu J,Gan Y

更新日期：2012-10-01 00:00:00

abstract：:We have developed an ion-sensing nanoparticle that is comprised of a superparamagnetic iron oxide (SPIO) core encapsulated with a porous silica shell. The latter can be readily anchored with ligands capable of coordinating with positron-emitting metal. Evidently, this nanoparticle has a great potential for use in cell...

journal_title：Biomaterials

authors： Patel D,Kell A,Simard B,Deng J,Xiang B,Lin HY,Gruwel M,Tian G

更新日期：2010-04-01 00:00:00

abstract：:Hydrogels are a promising type of biomaterial for articular cartilage constructs since they have been shown to enable encapsulated chondrocytes to express their predominant phenotypic marker, type II collagen. Endogenously expressed signaling molecules, such as insulin-like growth factor-1 (IGF-1), are also known to f...

journal_title：Biomaterials

authors： Yoon DM,Hawkins EC,Francke-Carroll S,Fisher JP

更新日期：2007-01-01 00:00:00

abstract：:In this paper, we describe interactions between neural cells and the conducting polymer poly(3,4-ethylenedioxythiophene) (PEDOT) toward development of electrically conductive biomaterials intended for direct, functional contact with electrically active tissues such as the nervous system, heart, and skeletal muscle. We...

journal_title：Biomaterials

authors： Richardson-Burns SM,Hendricks JL,Foster B,Povlich LK,Kim DH,Martin DC

更新日期：2007-03-01 00:00:00

abstract：:Glioblastoma multiforme (GBM) is among the most aggressive cancers associated with massive infiltration of peritumoral parenchyma by migrating tumor cells. The infiltrative nature of GBM cells, the intratumoral heterogeneity concomitant with redundant signaling pathways likely underlie the inability of conventional an...

journal_title：Biomaterials

authors： Cosset E,Petty T,Dutoit V,Tirefort D,Otten-Hernandez P,Farinelli L,Dietrich PY,Preynat-Seauve O

更新日期：2016-11-01 00:00:00

abstract：:Checkpoint blocking antibodies that interfere in the PD-1/PD-L1 axis provide effective cancer immunotherapy for tumors that are immune inflamed or induced to become "hot". It has also been demonstrated that a small molecule inhibitor of the signaling hub kinase GSK3 can interfere in the PD-1/PD-L1 axis in T-cells by s...

journal_title：Biomaterials

authors： Allen SD,Liu X,Jiang J,Liao YP,Chang CH,Nel AE,Meng H

更新日期：2020-12-28 00:00:00

abstract：:For H5N1 influenza immunization, we developed a thermal-sensitive hydrogel as intranasal vaccine delivery system, which was formulated with N-[(2-hydroxy-3-trimethylammonium) propyl] chitosan chloride (HTCC) and α, β-glycerophosphate (α, β-GP). The flowing solution of HTCC/GP under room temperature could gelate rapidl...

journal_title：Biomaterials

authors： Wu Y,Wei W,Zhou M,Wang Y,Wu J,Ma G,Su Z

更新日期：2012-03-01 00:00:00

abstract：:We show here, that the proapoptotic peptide, KLAKLAKKLAKLAK (KLA), which by itself does not penetrate cell membranes, can do so when fused to a protein transduction domain derived from NH(2)-terminus of translationally controlled tumor protein (TCTP-PTD, MIIYRDLISH). Once inside the cell, the conjugated KLA exerts its...

journal_title：Biomaterials

authors： Kim HY,Kim S,Youn H,Chung JK,Shin DH,Lee K

更新日期：2011-08-01 00:00:00

abstract：:Biocompatibility and tissue regenerating capacity are essential characteristics in the design of collagenous biomaterials for tissue engineering. Attachment of glycosaminoglycans (GAGs) to collagen may add to these characteristics by creating an appropriate micro-environment. In this study, porous type I collagen matr...

journal_title：Biomaterials

authors： Pieper JS,van Wachem PB,van Luyn MJA,Brouwer LA,Hafmans T,Veerkamp JH,van Kuppevelt TH

更新日期：2000-08-01 00:00:00

abstract：:We have prepared a fraction of commercial fetal calf serum whose major component comprises proteins of apparent molecular mass 65-80 kDa. These preparations elicit cell spreading responses in serum-free medium at concentrations similar to those reported for human vitronectin. In addition, we have identified (by a prot...

journal_title：Biomaterials

authors： Lydon MJ,Foulger CA

更新日期：1988-11-01 00:00:00

abstract：:For chronic non-viral gene therapy, biodegradable carriers with low cytotoxicity are essential. To create a series of non-toxic and biodegradable gene carriers, hyperbranched polymers based on 2,2-bis-(methylol)propionic acid (bis-MPA); (Boltorn H) were modified by introducing tertiary amines. The terminal OH groups w...

journal_title：Biomaterials

authors： Reul R,Nguyen J,Kissel T

更新日期：2009-10-01 00:00:00

abstract：:Multiblock, high molecular weight, linear, backbone degradable HPMA copolymer-prostaglandin E1 (PGE1) conjugate has been synthesized by RAFT polymerization mediated by a new bifunctional chain transfer agent (CTA), which contains an enzymatically degradable oligopeptide sequence flanked by two dithiobenzoate groups, f...

journal_title：Biomaterials

authors： Pan H,Sima M,Miller SC,Kopečková P,Yang J,Kopeček J

更新日期：2013-09-01 00:00:00

abstract：:We report here the study of the biocompatibility of a bone graft material, the Pyrost, using a previously established in vitro model of human osteoblasts. The effect of this material on cell proliferation was evaluated by the MTS assay. Results indicated the absolute absence of cytotoxic or cytostatic effect of Pyrost...

journal_title：Biomaterials

authors： Josset Y,Oum'hamed Z,Zarrinpour A,Lorenzato M,Adnet JJ,Laurent-Maquin D

更新日期：1998-10-01 00:00:00

abstract：:There is a growing demand for the production of a DNA biosensor with applications in medicine, the food industry, agriculture, veterinary science and environmental science. In this paper we describe methods for the optical and electrochemical detection of DNA using the enzyme horseradish peroxidase (EC 1.11.1.7) and g...

journal_title：Biomaterials

authors： Downs ME,Warner PJ,Turner AP,Fothergill JC

更新日期：1988-01-01 00:00:00

abstract：:Nanotherapeutics have been investigated for years, but only modest survival benefits were observed clinic. This is partially attributed to the short and rapid elimination of nanodrug after intravenous administration. In this study, a long circulation single wall carbon nanotube (SWCNT) complex was successfully fabrica...

journal_title：Biomaterials

authors： Xie L,Wang G,Zhou H,Zhang F,Guo Z,Liu C,Zhang X,Zhu L

更新日期：2016-10-01 00:00:00

abstract：:A series of mesoporous silica nanoparticles (MSNs) were synthesized using the co-structure directing method. A non-cytotoxic anionic surfactant, undec-1-en-11-yltetra(ethylene glycol) phosphate monoester surfactant (PMES), was used as a structure directing agent (SDA) together with aminopropyltrimethoxysilane that fun...

journal_title：Biomaterials

authors： Tsai CH,Vivero-Escoto JL,Slowing II,Fang IJ,Trewyn BG,Lin VS

更新日期：2011-09-01 00:00:00

abstract：:A graft copolymer having poly(L-lysine) (PLL) as the backbone and monomethoxy poly(ethylene glycol) (MPEG) as pendent chains was synthesized. This polycationic copolymer was used to form microcapsules with sodium alginate, a polyanion. Microcapsules and model surfaces formed with PLL-graft-MPEG demonstrated reduced pr...

journal_title：Biomaterials

authors： Sawhney AS,Hubbell JA

更新日期：1992-01-01 00:00:00

abstract：:This paper is concerned with the entrapment of an enzyme within an aggregated metallic matrix and the development of a bioactive enzyme-metal composite. Whereas the use of organic polymers and metal oxides for the preparation of enzymatically active materials is well developed, the third principle enzyme-material comb...

journal_title：Biomaterials

authors： Ben-Knaz R,Avnir D

更新日期：2009-03-01 00:00:00

abstract：:We report the stimulation of neurogenesis and myogenesis of human mesenchymal stem cells (hMSCs) on the surfaces of biodegradable hydrogels with different stiffness. The hydrogels were composed of gelatin-hydroxyphenylpropionic acid (Gtn-HPA) conjugate were formed using the oxidative coupling of phenol moieties cataly...

journal_title：Biomaterials

authors： Wang LS,Boulaire J,Chan PP,Chung JE,Kurisawa M

更新日期：2010-11-01 00:00:00

abstract：:Autologous melanocyte transplantation for vitiligo treatment by use of melanocyte suspension has drawbacks including cell damage in cell preparation and transportation, difficult manipulation and low engraftment rate in acral vitiligious lesions. We have proposed the concept of cellular patch as an alternative solutio...

journal_title：Biomaterials

authors： Lin SJ,Jee SH,Hsiao WC,Yu HS,Tsai TF,Chen JS,Hsu CJ,Young TH

更新日期：2006-03-01 00:00:00

abstract：:A "room-temperature" injection molding approach combined with particulate leaching (RTIM/PL) has been, for the first time, developed in this work to fabricate three-dimensional porous scaffolds composed of biodegradable polyesters for tissue engineering. In this approach, a "wet" composite of particulate/polymer/solve...

journal_title：Biomaterials

authors： Wu L,Jing D,Ding J

更新日期：2006-01-01 00:00:00

abstract：:Three critical aspects of searching for and understanding how to find highly resistant surfaces to protein adhesion are addressed here with specific application to synthetic membrane filtration. They include the (i) discovery of a series of previously unreported monomers from a large library of monomers with high prot...

journal_title：Biomaterials

authors： Gu M,Kilduff JE,Belfort G

更新日期：2012-02-01 00:00:00

abstract：:The limited intrinsic repair capacity of articular cartilage has stimulated continuing efforts to develop tissue engineered analogues. Matrices composed of type II collagen and chondroitin sulfate (CS), the major constituents of hyaline cartilage, may create an appropriate environment for the generation of cartilage-l...

journal_title：Biomaterials

authors： Pieper JS,van der Kraan PM,Hafmans T,Kamp J,Buma P,van Susante JL,van den Berg WB,Veerkamp JH,van Kuppevelt TH

更新日期：2002-08-01 00:00:00

abstract：:Tissue-engineered muscle is a viable option for tissue repair, though presently technologies are not developed enough to produce tissue in vitro identical to that in vivo. One important step in generating accurate engineered muscle is to mimic natural muscle architecture. Skeletal muscle is composed of fibrils whose o...

journal_title：Biomaterials

authors： Lam MT,Sim S,Zhu X,Takayama S

更新日期：2006-08-01 00:00:00

abstract：:Using the recently developed surface modification technique, free amino groups have been introduced onto polyester-type polyurethane (PU) scaffolds. The introduction of these free amino groups increases the surface energy and provides a convenient way to further immobilize bioactive species such as gelatin, collagen o...

journal_title：Biomaterials

authors： Zhu Y,Gao C,He T,Shen J

更新日期：2004-02-01 00:00:00

abstract：:We investigated the morphological effect of phase-separated block copolymer surfaces composed of poly(2-methacryloyloxyethyl phosphorylcholine (MPC)) (PMPC) and poly(dimethylsiloxane) (PDMS) on protein adsorption and cell adhesion behavior. We observed three different types of phase-separated surface morphologies by T...

journal_title：Biomaterials

authors： Seo JH,Matsuno R,Takai M,Ishihara K

更新日期：2009-10-01 00:00:00

abstract：:A series of latex particles, having different sizes and surface structures, were prepared and the dependence of phagocytosis of latex particles by leucocytes on the particle size and surface potential was investigated by measuring the oxygen consumption of leucocytes. Most of the phagocytic behaviour in the initial st...

journal_title：Biomaterials

authors： Kawaguchi H,Koiwai N,Ohtsuka Y,Miyamoto M,Sasakawa S

更新日期：1986-01-01 00:00:00

abstract：:An ideal approach for bone tissue engineering allows for osteoconductivity, osteoinductivity, and cell transplantation. In this study, we examined coprecipitation and surface adsorption schemes with respect to their abilities to control the spatial quantity and localization of a model protein, bovine serum albumin (BS...

journal_title：Biomaterials

authors： Luong LN,Hong SI,Patel RJ,Outslay ME,Kohn DH

更新日期：2006-03-01 00:00:00

abstract：:The emergence of combinatorial chemistries and the increased discovery of natural compounds have led to the production of expansive libraries of drug candidates and vast numbers of compounds with potentially interesting biological activities. Despite broad interest in high throughput screening (HTS) across varied fiel...

journal_title：Biomaterials

authors： Wu J,Wheeldon I,Guo Y,Lu T,Du Y,Wang B,He J,Hu Y,Khademhosseini A

更新日期：2011-01-01 00:00:00

abstract：:It has been widely accepted that lymph nodes (LNs) are critical targets of cancer vaccines and particles sized between 10 and 100 nm with a neutral or negative surface charge are preferred for lymphatic transfer after subcutaneous or intradermal injection. However their limited uptake by antigen presenting cells (APCs...

journal_title：Biomaterials

authors： Zeng Q,Li H,Jiang H,Yu J,Wang Y,Ke H,Gong T,Zhang Z,Sun X

更新日期：2017-04-01 00:00:00