Thermal-sensitive hydrogel as adjuvant-free vaccine delivery system for H5N1 intranasal immunization.

abstract：:Targeting delivery system has been widely used in packaging drugs for medical therapies attributed to its high efficiency and efficacy. A Traditional Chinese Medicine (TCM) formula consisting of Herba Epimedii has previously been shown to effectively treat postmenopausal osteoporosis. We have subsequently found that i...

journal_title：Biomaterials

authors： Huang L,Wang X,Cao H,Li L,Chow DH,Tian L,Wu H,Zhang J,Wang N,Zheng L,Yao X,Yang Z,Qin L

更新日期：2018-11-01 00:00:00

abstract：:Mucus layer coating the vaginal epithelium represents a barrier for intravaginally delivered recombined adenoviral (rAd) vectors, but it could be overcome by proper polyethylene glycol (PEG) modification. Here we synthesized two cationic PEG derivatives, amino-(EO)n/(AGE)m-Cyss (APCs). The polymers contained neutral l...

journal_title：Biomaterials

authors： Xie Z,Ji Z,Zhang Z,Gong T,Sun X

更新日期：2014-09-01 00:00:00

abstract：:A series of PLA/PEO/PLA triblock copolymers was prepared by ring opening polymerization of rac-lactide in the presence of various di-hydroxyl poly (ethylene glycol)s, using CaH2 as a biocompatible initiator. Hydrogels were prepared by a phase separation method consisting of introducing small amounts of water over solu...

journal_title：Biomaterials

authors： Molina I,Li S,Martinez MB,Vert M

更新日期：2001-02-01 00:00:00

abstract：:FT-IR analysis was performed for the hydroxyapatite (HAp)/collagen (COL) nanocomposite cross-linked by glutaraldehyde (GA). The amide bands I, II and III from COL matrix, and phosphate and carbonate bands from HAp were identified. The amide B band arising from C-H stretching mode showed a sensitive conformation by the...

journal_title：Biomaterials

authors： Chang MC,Tanaka J

更新日期：2002-12-01 00:00:00

abstract：:Developing repair strategies for osteochondral tissue presents complex challenges due to its interfacial nature and complex zonal structure, consisting of subchondral bone, intermediate calcified cartilage and the superficial cartilage regions. In this study, the long term ability of a multi-layered biomimetic collage...

journal_title：Biomaterials

authors： Levingstone TJ,Ramesh A,Brady RT,Brama PAJ,Kearney C,Gleeson JP,O'Brien FJ

更新日期：2016-05-01 00:00:00

abstract：:A-B-type block copolymers, consisting of polystyrene (PST) or poly(methyl methacrylate) (PMMA) forming segment (A) and poly(gamma-benzyl L-glutamate) (P[Glu(OBzl)]) segment (B), were synthesized and the thrombus formation on these block copolymer films was investigated in relation to the adsorption of plasma proteins ...

journal_title：Biomaterials

authors： Mori A,Ito Y,Sisido M,Imanishi Y

更新日期：1986-09-01 00:00:00

abstract：:The hydrophilic nature of hydrogel matrices makes them disadvantageous to entrap poorly soluble therapeutic agents and greatly restricts their applications as drug-delivery systems. In this study, we demonstrated that sustained delivery of lipophilic drugs in hydrogel-based devices can be readily achieved by enhancing...

journal_title：Biomaterials

authors： Chen MC,Tsai HW,Liu CT,Peng SF,Lai WY,Chen SJ,Chang Y,Sung HW

更新日期：2009-04-01 00:00:00

abstract：:In arterial replacement there is a clear clinical need for a functional substitute possessing appropriate haemocompatible properties to be implanted as small diameter artery. Endothelial cell seeding constitutes an appreciated method to improve blood compatibility on the condition that cells firmly adhere to the suppo...

journal_title：Biomaterials

authors： Rémy M,Durand M,Menu P,Voegel JC,Ponsot JF,Bérard X,Harmand MF,Bordenave L

更新日期：2013-12-01 00:00:00

abstract：:Cyclic RGD peptide-decorated polymeric micellar-like nanoparticles (MNP) based on PEGylated poly (trimethylene carbonate) (PEG-PTMC) were prepared for active targeting to integrin-rich cancer cells. An amphiphilic diblock copolymer, α-carboxyl poly (ethylene glycol)-poly (trimethylene carbonate) (HOOC-PEG-PTMC), was s...

journal_title：Biomaterials

authors： Jiang X,Sha X,Xin H,Chen L,Gao X,Wang X,Law K,Gu J,Chen Y,Jiang Y,Ren X,Ren Q,Fang X

更新日期：2011-12-01 00:00:00

abstract：:A new mathematical model was developed and an exact analytical solution without approximations of previous work was derived for the description of the kinetics and equilibrium characteristics of drug loading from a finite external solution onto ion-exchange microspheres. The influence of important parameters pertinent...

journal_title：Biomaterials

authors： Abdekhodaie MJ,Wu XY

更新日期：2006-07-01 00:00:00

abstract：:In this study, we investigate the molecular mechanisms by which human osteoblasts (HOB) challenged with wear debris promote the differentiation of osteoclast precursors. HOB were obtained from trabecular bone and exposed to alumina (Al(2)O(3)) or 'ultra-high molecular weight polyethylene' (UHMWPE) particles for 24h. T...

journal_title：Biomaterials

authors： Granchi D,Amato I,Battistelli L,Ciapetti G,Pagani S,Avnet S,Baldini N,Giunti A

更新日期：2005-05-01 00:00:00

abstract：:Silk fibers have potential biomedical applications beyond their traditional use as sutures. The physical properties of silk fibers and films make it a promising candidate for tissue engineering scaffold applications, particularly where high mechanical loads or tensile forces are applied or in cases where low rates of ...

journal_title：Biomaterials

authors： Panilaitis B,Altman GH,Chen J,Jin HJ,Karageorgiou V,Kaplan DL

更新日期：2003-08-01 00:00:00

abstract：:Right femoral, cortical bone osteotomies of 42 rabbits were fixed with fibrillated, self-reinforced (SR) poly-L-lactide (PLLA) rods, 4.5 mm in diameter. Follow-up times were from 3 to 48 wk. None of the rods broke during this period. There was one non-union at three weeks and one non-union at 12 weeks. Radiographic, h...

journal_title：Biomaterials

authors： Manninen MJ,Pohjonen T

更新日期：1993-01-01 00:00:00

abstract：:Multiwalled carbon nanotubes (MWCNTs) are cut short and grafted with polyethylenimine (PEI) for further covalent conjugation to fluorescein isothiocyanate (FITC) and prostate stem cell antigen (PSCA) monoclonal antibody (mAb). The in vitro and in vivo toxicity data reveal that the as-prepared CNT-PEI(FITC)-mAb has goo...

journal_title：Biomaterials

authors： Wu H,Shi H,Zhang H,Wang X,Yang Y,Yu C,Hao C,Du J,Hu H,Yang S

更新日期：2014-07-01 00:00:00

abstract：:This article has been withdrawn consistent with Elsevier Policy on Article Withdrawal (http://www.elsevier.com/locate/withdrawalpolicy). The Publisher apologizes for any inconvenience this may cause. ...

journal_title：Biomaterials

authors： Chung BG,Du Y,Navaladi A,Khademhosseini A

更新日期：2008-06-03 00:00:00

abstract：:The hydrolytic degradation of aliphatic polyesters derived from lactic and glycolic acids (PLA/GA polymers) has been previously shown to proceed heterogeneously in the case of large size devices, the rate of degradation being greater inside than at the surface. A qualitative model based on diffusion-reaction phenomena...

journal_title：Biomaterials

authors： Grizzi I,Garreau H,Li S,Vert M

更新日期：1995-03-01 00:00:00

abstract：:Realizing the potential of human pluripotent stem cell (hPSC)-based therapy requires the development of defined scalable culture systems with efficient expansion, differentiation and isolation protocols. We report an engineered 3D microfiber system that efficiently supports long-term hPSCs self-renewal under chemicall...

journal_title：Biomaterials

authors： Lu HF,Narayanan K,Lim SX,Gao S,Leong MF,Wan AC

更新日期：2012-03-01 00:00:00

abstract：:Brain tumors and brain metastases are among the deadliest malignancies of all human cancers, largely due to the cellular blood-brain and blood-tumor barriers that limit the delivery of imaging and therapeutic agents from the systemic circulation to tumors. Thus, improved strategies for brain tumor visualization and ta...

journal_title：Biomaterials

authors： Wu JB,Shi C,Chu GC,Xu Q,Zhang Y,Li Q,Yu JS,Zhau HE,Chung LW

更新日期：2015-10-01 00:00:00

abstract：:Implantation of synthetic material, including vascular grafts, pacemakers, etc. results in the foreign body reaction and the formation of multinucleated giant cells (MGCs) at the exterior surface of the implant. Despite the long-standing premise that fusion of mononucleated macrophages results in the formation of MGCs...

journal_title：Biomaterials

authors： Faust JJ,Christenson W,Doudrick K,Ros R,Ugarova TP

更新日期：2017-06-01 00:00:00

abstract：:Regeneration of the damaged myocardium is one of the most challenging fronts in the field of tissue engineering due to the limited capacity of adult heart tissue to heal and to the mechanical and structural constraints of the cardiac tissue. In this study we demonstrate that an engineered acellular scaffold comprising...

journal_title：Biomaterials

authors： Serpooshan V,Zhao M,Metzler SA,Wei K,Shah PB,Wang A,Mahmoudi M,Malkovskiy AV,Rajadas J,Butte MJ,Bernstein D,Ruiz-Lozano P

更新日期：2013-12-01 00:00:00

abstract：:Mandibular reconstruction requires functional and aesthetic repair and is further complicated by contamination from oral and skin flora. Antibiotic-releasing porous space maintainers have been developed for the local release of vancomycin and to promote soft tissue attachment. In this study, mandibular defects in six ...

journal_title：Biomaterials

authors： Watson E,Smith BT,Smoak MM,Tatara AM,Shah SR,Pearce HA,Hogan KJ,Shum J,Melville JC,Hanna IA,Demian N,Wenke JC,Bennett GN,van den Beucken JJJP,Jansen JA,Wong ME,Mikos AG

更新日期：2020-10-01 00:00:00

abstract：:To avoid the overheating effect of excitation light and improve the efficacy of photodynamic therapy (PDT) of upconversion nanoplatform, a novel nanoprobe based on 808 nm-excited upconversion nanocomposites (T-UCNPs@Ce6@mSiO2) with low heating effect and deep penetration has been successfully constructed for targeted ...

journal_title：Biomaterials

authors： Zeng L,Pan Y,Zou R,Zhang J,Tian Y,Teng Z,Wang S,Ren W,Xiao X,Zhang J,Zhang L,Li A,Lu G,Wu A

更新日期：2016-10-01 00:00:00

abstract：:The aim of this study was to investigate the effects of alginate and agarose on the response of bone marrow stromal cells (BMSCs) to chondrogenic stimuli. Rat BMSCs were expanded in monolayer culture with or without FGF-2 supplementation. Cells were then seeded in 2% alginate and agarose gels and cultured in media wit...

journal_title：Biomaterials

authors： Coleman RM,Case ND,Guldberg RE

更新日期：2007-04-01 00:00:00

abstract：:Nanomedicine options for colon cancer therapy have been limited by the lack of suitable carriers capable of delivering sufficient drug into tumors to cause lethal toxicity. To circumvent this limitation, we fabricated a camptothecin (CPT)-loaded poly(lactic-co-glycolic acid) nanoparticle (NP) with dual-surface functio...

journal_title：Biomaterials

authors： Xiao B,Zhang M,Viennois E,Zhang Y,Wei N,Baker MT,Jung Y,Merlin D

更新日期：2015-04-01 00:00:00

abstract：:Culture of seeded osteoblastic cells in three-dimensional osteoconductive scaffolds in vitro is a promising approach to produce an osteoinductive material for repair of bone defects. However, culture of cells in scaffolds sufficiently large to bridge critical-sized defects is a challenge for tissue engineers. Diffusio...

journal_title：Biomaterials

authors： Goldstein AS,Juarez TM,Helmke CD,Gustin MC,Mikos AG

更新日期：2001-06-01 00:00:00

abstract：:Bioactive glasses are potentially useful as bone defect fillers, and vascular endothelial growth factor (VEGF) has demonstrated benefit in bone regeneration as well. We hypothesized that the specific combination of prolonged localized VEGF presentation from a matrix coated with a bioactive glass may enhance bone regen...

journal_title：Biomaterials

authors： Leach JK,Kaigler D,Wang Z,Krebsbach PH,Mooney DJ

更新日期：2006-06-01 00:00:00

abstract：:Elemental metal nanoparticles like cadmium and silver are known to cause oxidative stress and are also highly toxic. Yet for gold nanoparticles (AuNPs), it is not well established whether these particles are biologically toxic. Here we show that AuNPs, which were taken up by MRC-5 human lung fibroblasts in vitro, indu...

journal_title：Biomaterials

authors： Li JJ,Hartono D,Ong CN,Bay BH,Yung LY

更新日期：2010-08-01 00:00:00

abstract：:The use of bone cement to treat vertebral compression fractures in a percutaneous manner requires placement of the cement under fluoroscopic image guidance. To enhance visualization of the flow during injection and to monitor and prevent leakage beyond the confines of the vertebral body, the orthopedic community has d...

journal_title：Biomaterials

authors： Kurtz SM,Villarraga ML,Zhao K,Edidin AA

更新日期：2005-06-01 00:00:00

abstract：:Natural biopolymer based multifunctional nanomaterials are perfect candidates for multimodality imaging and therapeutic applications. Conventional methods of building multimodal imaging probe require either cross-linking manners to increase its in vivo stability or attach a target module to realize targeted imaging. I...

journal_title：Biomaterials

authors： Yang M,Fan Q,Zhang R,Cheng K,Yan J,Pan D,Ma X,Lu A,Cheng Z

更新日期：2015-11-01 00:00:00

abstract：:Inspired by nature's toughening mechanisms, we designed a new polyhedral oligomeric silsesquioxane (POSS)-derived hybrid glass (PHG) that has covalent interactions on the molecular scale between the inorganic POSS cage and organic phase. These features allow "elastic deformation" of the inorganic POSS cage in limited ...

journal_title：Biomaterials

authors： Zhou X,Sahai N,Qi L,Mankoci S,Zhao W

更新日期：2015-05-01 00:00:00