Abstract:
:We have developed an ion-sensing nanoparticle that is comprised of a superparamagnetic iron oxide (SPIO) core encapsulated with a porous silica shell. The latter can be readily anchored with ligands capable of coordinating with positron-emitting metal. Evidently, this nanoparticle has a great potential for use in cell tracking with magnetic resonance (MR) imaging and positron emission tomography (PET). Herein we report the synthesis, surface functionalization and characterization of the magnetic nanoparticle-based probes and evaluate their cell-labeling efficacy, cytotoxicity and relaxivity in comparison to one of the most commonly utilized MRI contrast agents, Feridex.
journal_name
Biomaterialsjournal_title
Biomaterialsauthors
Patel D,Kell A,Simard B,Deng J,Xiang B,Lin HY,Gruwel M,Tian Gdoi
10.1016/j.biomaterials.2009.12.025subject
Has Abstractpub_date
2010-04-01 00:00:00pages
2866-73issue
10eissn
0142-9612issn
1878-5905pii
S0142-9612(09)01384-2journal_volume
31pub_type
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