Effect of tricaprin on the physical characteristics and in vitro release of etoposide from PLGA microspheres.

abstract：:The nanotopography and nanoscale geometry of the extra-cellular matrix (ECM) are important regulators of cell adhesion, motility and fate decision. However, unlike the sensing of matrix mechanics and ECM density, the molecular processes regulating the direct sensing of the ECM nanotopography and nanoscale geometry are...

journal_title：Biomaterials

authors： Di Cio S,Iskratsch T,Connelly JT,Gautrot JE

更新日期：2020-02-01 00:00:00

abstract：:Bioactive composites composed of hydroxyapatite containing glass (HA-G) as a coating and titanium (Ti) or titanium alloy implants as a substrate were prepared by the Cullet method. This method results in the HA-G coating layer on the substrate with a compositional gradient in HA concentration. The results of in vitro ...

journal_title：Biomaterials

authors： Yamada K,Imamura K,Itoh H,Iwata H,Maruno S

更新日期：2001-08-01 00:00:00

abstract：:The contraction of connective tissue cells may facilitate their production and maintenance of extracellular matrix architecture and can benefit healing through wound closure. However, aberrant cell contraction can result in pathological contracture. Implants may stimulate this process leading to contracture of the sur...

journal_title：Biomaterials

authors： Menard C,Mitchell S,Spector M

更新日期：2000-09-01 00:00:00

abstract：:The pathogenesis of osteoarthritis is mediated in part by inflammatory cytokines including interleukin-1 (IL-1), which promote degradation of articular cartilage and prevent human mesenchymal stem cell (MSC) chondrogenesis. In this study, we combined gene therapy and functional tissue engineering to develop engineered...

journal_title：Biomaterials

authors： Glass KA,Link JM,Brunger JM,Moutos FT,Gersbach CA,Guilak F

更新日期：2014-07-01 00:00:00

abstract：:We hypothesized that reduced stem stiffness of orthopaedic implants contributes to a high risk of loosening, since interface stresses and relative motions may exceed a tolerable range. To study this hypothesis, three types of load-bearing implant with different stiffnesses were inserted into the tibia of the goat. His...

journal_title：Biomaterials

authors： Buma P,van Loon PJ,Versleyen H,Weinans H,Slooff TJ,de Groot K,Huiskes R

更新日期：1997-09-01 00:00:00

abstract：:New crosslinked ionic polyurethanes and copolyurethanes were yielded by reaction of telechelic cis-1,4-oligoisoprenes, bearing a variable number of ammonium and hydroxy groups, with isocyanurate of isophorone diisocyanate (I-IPDI). Aiming for a comparative study, polyurethane elastomers based on non-ionic telechelic o...

journal_title：Biomaterials

authors： Kébir N,Campistron I,Laguerre A,Pilard JF,Bunel C,Jouenne T

更新日期：2007-10-01 00:00:00

abstract：:A 29 amino-acid peptide derived from the rabies virus glycoprotein (RVG29) was exploited as a ligand for efficient brain-targeting gene delivery. RVG29 was modified on polyamidoamine dendrimers (PAMAM) through bifunctional PEG, then complexed with DNA, yielding PAMAM-PEG-RVG29/DNA nanoparticles (NPs). The NPs were obs...

journal_title：Biomaterials

authors： Liu Y,Huang R,Han L,Ke W,Shao K,Ye L,Lou J,Jiang C

更新日期：2009-09-01 00:00:00

abstract：:Intercellular interactions in the cell microenvironment play a critical role in determining cell fate, but the effects of these interactions on pathways governing human embryonic stem cell (hESC) behavior have not been fully elucidated. We and others have previously reported that 3-D culture of hESCs affects cell fate...

journal_title：Biomaterials

authors： Azarin SM,Lian X,Larson EA,Popelka HM,de Pablo JJ,Palecek SP

更新日期：2012-03-01 00:00:00

abstract：:There is a growing demand for the production of a DNA biosensor with applications in medicine, the food industry, agriculture, veterinary science and environmental science. In this paper we describe methods for the optical and electrochemical detection of DNA using the enzyme horseradish peroxidase (EC 1.11.1.7) and g...

journal_title：Biomaterials

authors： Downs ME,Warner PJ,Turner AP,Fothergill JC

更新日期：1988-01-01 00:00:00

abstract：:In this study, a type of intracellular redox-triggered hollow mesoporous silica nanoreservoirs (HMSNs) with tumor specificity was developed in order to deliver anticancer drug (i.e., doxorubicin (DOX)) to the target tumor cells with high therapeutic efficiency and reduced side effects. Firstly, adamantanamine was graf...

journal_title：Biomaterials

authors： Luo Z,Hu Y,Cai K,Ding X,Zhang Q,Li M,Ma X,Zhang B,Zeng Y,Li P,Li J,Liu J,Zhao Y

更新日期：2014-09-01 00:00:00

abstract：:A liposomal system with surface lactoferrin (Lf) was developed for delivering neuron growth factor (NGF) across the blood-brain barrier (BBB) and improving the viability of neuron-like SK-N-MC cells with deposited β-amyloid peptide (Aβ). The Lf-grafted liposomes carrying NGF (Lf/NGF-liposomes) were applied to a monola...

journal_title：Biomaterials

authors： Kuo YC,Wang CT

更新日期：2014-07-01 00:00:00

abstract：:Stem cell transplantation is a promising therapeutic strategy for acute or chronic ischemic cardiomyopathy. A major limitation to efficacy in cell transplantation is the low efficiency of retention and engraftment, due at least in part to significant early "wash-out" of cells from coronary blood flow and heart contrac...

journal_title：Biomaterials

authors： Vandergriff AC,Hensley TM,Henry ET,Shen D,Anthony S,Zhang J,Cheng K

更新日期：2014-10-01 00:00:00

abstract：:Low molecular weight polyurethanes with sites for metal complexation were synthesized. The -SO(2) and the -COOH groups were incorporated into the polyurethane chain by the reactions of tri-functional monomers, 4,4'-bis(hydroxyphenyl)sulfone and 4,4'-bis(hydroxyphenyl) valeric acid with hexa-methylene di-isocyanate (HM...

journal_title：Biomaterials

authors： Acharya V,Prabha CR,Narayanamurthy C

更新日期：2004-08-01 00:00:00

abstract：:Menisci are one of the most commonly injured parts of the knee with a limited healing potential. This study focuses on fabrication and characterization of biomimetic surfaces for meniscal tissue engineering. To achieve this, a combination of hyaluronic acid/chitosan (HA/CH) mutilayers with covalently immobilized major...

journal_title：Biomaterials

authors： Tan GK,Dinnes DL,Butler LN,Cooper-White JJ

更新日期：2010-08-01 00:00:00

abstract：:Alzheimer's disease (AD) is characterized by the loss of neurogenesis and excessive induction of apoptosis. The induction of neurogenesis and inhibition of apoptosis may be a promising therapeutic approach to combating the disease. Celecoxib (CB), a cyclooxygenase-2 specific inhibitor, could offer neuroprotection. Spe...

journal_title：Biomaterials

authors： Guo JW,Guan PP,Ding WY,Wang SL,Huang XS,Wang ZY,Wang P

更新日期：2017-11-01 00:00:00

abstract：:Topographical cues, independent of biochemistry, generated by the extracellular matrix may have significant effects upon cellular behavior. Studies have documented that substratum topography has direct effects on the ability of cells to orient themselves, migrate, and produce organized cytoskeletal arrangements. Basem...

journal_title：Biomaterials

authors： Flemming RG,Murphy CJ,Abrams GA,Goodman SL,Nealey PF

更新日期：1999-03-01 00:00:00

abstract：:The limited intrinsic repair capacity of articular cartilage has stimulated continuing efforts to develop tissue engineered analogues. Matrices composed of type II collagen and chondroitin sulfate (CS), the major constituents of hyaline cartilage, may create an appropriate environment for the generation of cartilage-l...

journal_title：Biomaterials

authors： Pieper JS,van der Kraan PM,Hafmans T,Kamp J,Buma P,van Susante JL,van den Berg WB,Veerkamp JH,van Kuppevelt TH

更新日期：2002-08-01 00:00:00

abstract：:Thermosensitive hydrogels based on poly(γ-ethyl-L-glutamate)-poly(ethylene glycol)-poly(γ-ethyl-L-glutamate) triblock copolymers (PELG-PEG-PELG) were prepared for localized and sustained delivery of anticancer drugs. The polypeptide-based hydrogels showed much lower critical gelation concentration than the traditional...

journal_title：Biomaterials

authors： Cheng Y,He C,Ding J,Xiao C,Zhuang X,Chen X

更新日期：2013-12-01 00:00:00

abstract：:To minimize the cytotoxicity of poly (2-(dimethylamino) ethyl methacrylate) (PDMAEMA) as a gene delivery vector, we synthesized PEGylated PDMAEMA by atom transfer radical polymerization (ATRP). Here we report its effects on transfection efficiency in vitro delivered with a GFP expression plasmid and immunogenicity in ...

journal_title：Biomaterials

authors： Qiao Y,Huang Y,Qiu C,Yue X,Deng L,Wan Y,Xing J,Zhang C,Yuan S,Dong A,Xu J

更新日期：2010-01-01 00:00:00

abstract：:Injectable, biodegradable scaffolds are important biomaterials for tissue engineering and drug delivery. Hydrogels derived from natural polysaccharides are ideal scaffolds as they resemble the extracellular matrices of tissues comprised of various glycosaminoglycans (GAGs). Here, we report a new class of biocompatible...

journal_title：Biomaterials

authors： Tan H,Chu CR,Payne KA,Marra KG

更新日期：2009-05-01 00:00:00

abstract：:Skeletal muscle is a highly organized tissue in which the extracellular matrix (ECM) is composed of highly-aligned cables of collagen with nanoscale feature sizes, and provides structural and functional support to muscle fibers. As such, the transplantation of disorganized tissues or the direct injection of cells into...

journal_title：Biomaterials

authors： Yang HS,Ieronimakis N,Tsui JH,Kim HN,Suh KY,Reyes M,Kim DH

更新日期：2014-02-01 00:00:00

abstract：:Two types of isoelastic endosseous dental implants were produced and their functionality was tested. One type consisted of a porous sintered TiTa30 alloy, the other had a special surface structure consisting of titanium wire loops. Their mechanical properties were optimized by the production parameter (sintering and d...

journal_title：Biomaterials

authors： Breme J,Biehl V,Schulte W,d'Hoedt B,Donath K

更新日期：1993-10-01 00:00:00

abstract：:Bioengineering of whole hearts using human embryonic stem cells (hESCs)-derived cardiovascular progenitor cells (CPCs) and natural matrices is a promising approach to overcome organ donor shortage threatening millions of patients awaiting for heart transplantation. Here, we developed a novel strategy for generation of...

journal_title：Biomaterials

authors： Rajabi S,Pahlavan S,Ashtiani MK,Ansari H,Abbasalizadeh S,Sayahpour FA,Varzideh F,Kostin S,Aghdami N,Braun T,Baharvand H

更新日期：2018-02-01 00:00:00

abstract：:The anterior cruciate ligament (ACL) is the most commonly injured intra-articular ligament of the knee, and limitations in existing reconstruction grafts have prompted an interest in tissue engineered solutions. Previously, we reported on a tissue-engineered ACL scaffold fabricated using a novel, three-dimensional bra...

journal_title：Biomaterials

authors： Lu HH,Cooper JA Jr,Manuel S,Freeman JW,Attawia MA,Ko FK,Laurencin CT

更新日期：2005-08-01 00:00:00

abstract：:Microcontact printed polymeric substrates were evaluated for their ability to control Schwann cell attachment and direct proliferation, as Schwann cell guidance is a crucial factor in directing peripheral nerve regeneration. Elastomeric stamps of poly(dimethylsiloxane) were "inked" with laminin, a permissive protein f...

journal_title：Biomaterials

authors： Schmalenberg KE,Uhrich KE

更新日期：2005-04-01 00:00:00

abstract：:Stem cell-based gene therapies, wherein stem cells are genetically engineered to express therapeutic molecules, have shown tremendous potential for cancer applications owing to their innate ability to home to tumors. However, traditional stem cell-based gene therapies are hampered by our current inability to control w...

journal_title：Biomaterials

authors： Yin PT,Shah S,Pasquale NJ,Garbuzenko OB,Minko T,Lee KB

更新日期：2016-03-01 00:00:00

abstract：:Physicochemical features of a cell nanoenvironment exert important influence on stem cell behavior and include the influence of matrix elasticity and topography on differentiation processes. The presence of growth factors such as TGF-β and BMPs on these matrices provides chemical cues and thus plays vital role in dire...

journal_title：Biomaterials

authors： Das RK,Zouani OF

更新日期：2014-07-01 00:00:00

abstract：:A photografting technique to produce functional groups of silanol able to induce apatite nucleation was attempted on polyethylene substrate for biomimetic formation of bone-mineral-like apatite layer on its surface. The polyethylene surface was subjected to vapor-phase photografting of vinyltrimethoxysilane and subseq...

journal_title：Biomaterials

authors： Kim HM,Uenoyama M,Kokubo T,Minoda M,Miyamoto T,Nakamura T

更新日期：2001-09-01 00:00:00

abstract：:We have developed an ion-sensing nanoparticle that is comprised of a superparamagnetic iron oxide (SPIO) core encapsulated with a porous silica shell. The latter can be readily anchored with ligands capable of coordinating with positron-emitting metal. Evidently, this nanoparticle has a great potential for use in cell...

journal_title：Biomaterials

authors： Patel D,Kell A,Simard B,Deng J,Xiang B,Lin HY,Gruwel M,Tian G

更新日期：2010-04-01 00:00:00

abstract：:New therapeutic strategies are needed for the growing unmet clinical needs in liver disease and fibrosis. Platelet activation and PDGF activity are recognized as important therapeutic targets; however, no therapeutic approach has yet addressed these two upstream drivers of liver fibrosis. We therefore designed a matri...

journal_title：Biomaterials

authors： Kabra H,Walimbe T,Stuart K,Indey C,Jalgaonkar S,Ikwa E,Skurnac T,Chen J,Woolley A,Snead NM,Bachtell N,Leeming DJ,Karsdal M,Prestwich G,Panitch A,Paderi J

更新日期：2020-11-17 00:00:00