Micropatterned polymer substrates control alignment of proliferating Schwann cells to direct neuronal regeneration.

abstract：:Unhealed chronic wounds often deteriorate into multiple infection with several kinds of bacteria and excessive proteolytic wound exudate and remains one of the common healthcare issues. Here, the functional and antimicrobial hydrogel and cryogel biomaterials were prepared from glycol chitosan and a novel biodegradable...

journal_title：Biomaterials

authors： Chen TY,Wen TK,Dai NT,Hsu SH

更新日期：2020-12-16 00:00:00

abstract：:The rate of change of pH of aqueous lactic acid at pH 4.2-4.5 (i.e. a little below that of active caries in vivo) in contact with disks of various commercial glass-ionomer cements has been determined in two configurations. In the first of them, a thin film set-up, 20 microl of solution was spread across the surface of...

journal_title：Biomaterials

authors： Nicholson JW,Aggarwal A,Czarnecka B,Limanowska-Shaw H

更新日期：2000-10-01 00:00:00

abstract：:Optimal nano-sized drug carrier requires long blood circulation, selective extravasation, and efficient cell uptake. Here we develop a charge-convertible nanoplatform based on Pt(IV) prodrug loaded NaYF4:Yb,Tm upconversion nanoparticles (UCNs), followed by coating a layer of PEG-PAH-DMMA polymer (UCNs-Pt(IV)@PEG-PAH-D...

journal_title：Biomaterials

authors： Xu J,Kuang Y,Lv R,Yang P,Li C,Bi H,Liu B,Yang D,Dai Y,Gai S,He F,Xing B,Lin J

更新日期：2017-06-01 00:00:00

abstract：:Resorbable calcium phosphate (CaP) biomaterials have demonstrated considerable efficacy in bone reconstructive surgery. Furthermore, bisphosphonates (BPs) are well known anti-resorptive agents largely used in clinical treatments for osteoporosis. An injectable BP-combined CaP matrix has been developed in order to biol...

journal_title：Biomaterials

authors： Verron E,Gauthier O,Janvier P,Pilet P,Lesoeur J,Bujoli B,Guicheux J,Bouler JM

更新日期：2010-10-01 00:00:00

abstract：:Cancer stem cells (CSCs) play pivotal roles in cancer metastasis, and strategies targeting cancer stemness may greatly reduce cancer metastasis and improve patients' survival. The canonical Wnt/β-catenin pathway plays critical roles in CSC generation and maintenance as well as in normal stem cells. Non-specifically su...

journal_title：Biomaterials

authors： Li Y,Xiao Y,Lin HP,Reichel D,Bae Y,Lee EY,Jiang Y,Huang X,Yang C,Wang Z

更新日期：2019-01-01 00:00:00

abstract：:In order to develop a more effective self-etching primer, with a longer lasting shelf life, we designed a self-etching primer comprised of methacrylamide, N-methacryloyl glycine, NMGly. In this study, the hydrolytic stability of the amide portion in the NMGly was examined. The difference in the hydrolytic stability be...

journal_title：Biomaterials

authors： Nishiyama N,Suzuki K,Yoshida H,Teshima H,Nemoto K

更新日期：2004-03-01 00:00:00

abstract：:Silver nanoparticles (AgNPs) have anti-cancer effect. However, whether and how these particles could inhibit the growth of acute myeloid leukemia (AML) cells is unclear. In the present study, we prepared AgNPs with various sizes and investigated their cytotoxic effect on AML cells. We found that AgNPs could inhibit th...

journal_title：Biomaterials

authors： Guo D,Zhu L,Huang Z,Zhou H,Ge Y,Ma W,Wu J,Zhang X,Zhou X,Zhang Y,Zhao Y,Gu N

更新日期：2013-10-01 00:00:00

abstract：:A series of latex particles, having different sizes and surface structures, were prepared and the dependence of phagocytosis of latex particles by leucocytes on the particle size and surface potential was investigated by measuring the oxygen consumption of leucocytes. Most of the phagocytic behaviour in the initial st...

journal_title：Biomaterials

authors： Kawaguchi H,Koiwai N,Ohtsuka Y,Miyamoto M,Sasakawa S

更新日期：1986-01-01 00:00:00

abstract：:This study designs a pH-sensitive nanoparticle carrier of methotrexate (MTX) and combretastatin A4 (CA4) based on pullulan for the combination therapy against hepatocellular carcinoma (HCC). Briefly, N-urocanyl pullulan (URPA) with the degree of substitution (DS) of 5.2% was synthesized and then conjugated with MTX to...

journal_title：Biomaterials

authors： Wang Y,Chen H,Liu Y,Wu J,Zhou P,Wang Y,Li R,Yang X,Zhang N

更新日期：2013-09-01 00:00:00

abstract：:As a chronic and lifelong disease, obesity not only significant impairs health but also dramatically shortens life span (at least 10 years). Obesity requires a life-long effort for the successful treatment because a number of abnormalities would appear in the development of obesity. Nanomaterials possess large specifi...

journal_title：Biomaterials

authors： Li J,Cha R,Luo H,Hao W,Zhang Y,Jiang X

更新日期：2019-12-01 00:00:00

abstract：:Human cell therapy applications in tissue engineering, such as the ex vivo production of hematopoietic cells for transplantation, have recently entered the clinic. Although considerable effort has been focused on the development of biological processes to generate therapeutic cells, little has been published on the de...

journal_title：Biomaterials

authors： Koller MR,Palsson MA,Manchel I,Maher RJ,Palsson BO

更新日期：1998-11-01 00:00:00

abstract：:Chitosan-based nanofibers with an average fiber diameter controllable from a few microns down to approximately 40 nm and a narrow size distribution were fabricated by electrospinning solutions containing chitosan, polyethylene oxide (PEO), and Triton X-100. Rheological study showed a strong dependence of spinnability ...

journal_title：Biomaterials

authors： Bhattarai N,Edmondson D,Veiseh O,Matsen FA,Zhang M

更新日期：2005-11-01 00:00:00

abstract：:Photoacoustic tomography (PAT) also referred to as optoacoustic tomography (OAT) is a hybrid imaging modality that employs nonionizing optical radiation and ultrasonic detection. Here, we describe the application of a new class of optical contrast agents based on mesoscopic hollow gold nanospheres (HAuNS) to PAT. HAuN...

journal_title：Biomaterials

authors： Lu W,Huang Q,Ku G,Wen X,Zhou M,Guzatov D,Brecht P,Su R,Oraevsky A,Wang LV,Li C

更新日期：2010-03-01 00:00:00

abstract：:Cell labeling using magnetic nanoparticles is an increasingly used approach in noninvasive behavior tracking, in vitro separation of cancer stem cells (CSCs), and CSC-based research in cancer therapy. However, the impact of magnetic labeling on the biological properties of targeted CSCs, such as self-renewal, prolifer...

journal_title：Biomaterials

authors： Wang X,Wei F,Liu A,Wang L,Wang JC,Ren L,Liu W,Tu Q,Li L,Wang J

更新日期：2012-05-01 00:00:00

abstract：:Glioma is still hard to be treated due to their complex microenvironment. In this study, a gold nanoparticle-based delivery system was developed. The system, An-PEG-DOX-AuNPs, was loaded with doxorubicin (DOX) through hydrazone, an acid-responsive linker, and was functionalized with angiopep-2, a specific ligand of lo...

journal_title：Biomaterials

authors： Ruan S,Yuan M,Zhang L,Hu G,Chen J,Cun X,Zhang Q,Yang Y,He Q,Gao H

更新日期：2015-01-01 00:00:00

abstract：:A major goal of bone tissue engineering is to design better scaffold configuration and materials to better control osteoblast behavior. Nanoporous architecture has been shown to significantly affect cellular response. In this work, nanoporous alumina membranes were fabricated by a two-step anodization method to invest...

journal_title：Biomaterials

authors： Popat KC,Leary Swan EE,Mukhatyar V,Chatvanichkul KI,Mor GK,Grimes CA,Desai TA

更新日期：2005-08-01 00:00:00

abstract：:This study was conducted to determine the interaction of individual corrosion products from biodegradable iron stents with cells from the adjacent tissue. The response of human umbilical venous smooth muscle cells (SMCs) to an excess of ferrous ions was investigated in a cell culture model at the phenotypic and at the...

journal_title：Biomaterials

authors： Mueller PP,May T,Perz A,Hauser H,Peuster M

更新日期：2006-04-01 00:00:00

abstract：:An independent assessment was performed of the results of woven carbon implants of mesh or rods into articular cartilage defects performed by two surgeons in the knees of 96 patients. Eight had symptomatic osteochondritis, 31 had chondromalacia patellae and 57 had early osteoarthritis. They were reviewed up to 5 yr af...

journal_title：Biomaterials

authors： Pongor P,Betts J,Muckle DS,Bentley G

更新日期：1992-01-01 00:00:00

abstract：:The oriented attachment of hydroxyapatite (HAP) nanorods was achieved through a hydrothermal treatment. The nanorods were arranged in order along the c-axis of the HAP. These formed ca. 3.5 slip-shaped pores between the rods. High-resolution transmission electron (HRTEM) also revealed that single crystals of HAP may g...

journal_title：Biomaterials

authors： Chen JD,Wang YJ,Wei K,Zhang SH,Shi XT

更新日期：2007-05-01 00:00:00

abstract：:High-throughput screening techniques for cellular response are often unable to account for several factors present in the in vivo environment, many of which have been shown to modulate cellular response to the screened parameter. Culture in three-dimensional biomaterials and active mechanical stimulation are two such ...

journal_title：Biomaterials

authors： Moraes C,Wang G,Sun Y,Simmons CA

更新日期：2010-01-01 00:00:00

abstract：:Biodegradable polyurethanes are typically prepared from polyester polyols, aliphatic diisocyanates and chain extenders. We have developed a degradable chain extender (DCE) based on dl-lactic acid and ethylene glycol to accelerate hard segment degradation. Three series of polyurethane elastomers were synthesised to inv...

journal_title：Biomaterials

authors： Tatai L,Moore TG,Adhikari R,Malherbe F,Jayasekara R,Griffiths I,Gunatillake PA

更新日期：2007-12-01 00:00:00

abstract：:A variety of bioactive composites have been investigated over the last two decades as substitute materials for diseased or damaged tissues in the human body. In this paper, the rationale and strategy of developing these composites are given. Major factors influencing the production and performance of bioactive composi...

journal_title：Biomaterials

authors： Wang M

更新日期：2003-06-01 00:00:00

abstract：:There is a great clinical need for tissue engineered blood vessels that could be used to replace or bypass damaged arteries. The success of such grafts will depend strongly on their ability to mimic the cellular and matrix organization found in native arteries, but currently available cell scaffolds such as electrospu...

journal_title：Biomaterials

authors： McClendon MT,Stupp SI

更新日期：2012-08-01 00:00:00

abstract：:Engineering extracellular matrices that utilize the body's natural healing capacity enable the progression of regenerative therapies. Fibrin, widely used as a surgical sealant, is one such matrix that may be augmented by the addition of protein factors to promote cell infiltration and differentiation. The thrombin-cat...

journal_title：Biomaterials

authors： Soon AS,Stabenfeldt SE,Brown WE,Barker TH

更新日期：2010-03-01 00:00:00

abstract：:Dextran derivatives are biosynthetic polyanionic polymers which exert some of the heparin properties such as regulating the activity of several heparin-binding growth factors. Based on a reproducible synthetic procedure, we have synthesized a new generation of dextran derivatives named dextran methylcarboxylate benzyl...

journal_title：Biomaterials

authors： Vercoutter-Edouart AS,Dubreucq G,Vanhoecke B,Rigaut C,Renaux F,Dahri-Correia L,Lemoine J,Bracke M,Michalski JC,Correia J

更新日期：2008-05-01 00:00:00

abstract：:The production profile of interleukin 1 (IL-1) from mouse peritoneal macrophages (M phi) was determined following their incubation with poly(DL-lactic acid) (PDLLA) granules containing ovalbumin (OVA). Upon incubation, M phi produced IL-1 at a significantly high rate compared with those incubated with OVA in the free ...

journal_title：Biomaterials

authors： Nakaoka R,Tabata Y,Ikada Y

更新日期：1996-12-01 00:00:00

abstract：:In previous papers, we have described the preparation and heparin-like properties of insoluble modified polystyrene resins. We now report results obtained with amino acid sulphamide resins that are virtually devoid of sulphonate groups and with resins bearing both sulphonate groups as well as amino acid sulphamides wi...

journal_title：Biomaterials

authors： Fougnot C,Dupillier MP,Jozefowicz M

更新日期：1983-04-01 00:00:00

abstract：:Cationic solid lipid nanoparticles (cSLNs) are promising nanoparticles for controlled drug delivery. Increasing surface charge and/or reducing PEG density enhance cellular uptake of cSLNs in vitro, but for unknown reasons fail to improve drug delivery in vivo. Herein, we show that cSLNs present a risk for systemic pla...

journal_title：Biomaterials

authors： Wu X,Chen H,Wu C,Wang J,Zhang S,Gao J,Wang H,Sun T,Yang YG

更新日期：2018-02-01 00:00:00

abstract：:Poly(trimethylene carbonate) (PTMC) with molecular weights greater than 100 kg/mol is known to degrade readily in vivo while PTMC of less than 70 kg/mol is resistant to degradation. The reason for the molecular weight dependent degradation rate of PTMC is unclear, and may be due to differences in macrophage behavior o...

journal_title：Biomaterials

authors： Vyner MC,Li A,Amsden BG

更新日期：2014-11-01 00:00:00

abstract：:Personalized oncology significantly relies on the development of cancer theranostic agents to integrate cancer therapeutics and diagnostics. Current most common strategy for development of such multifunctional agents requires multistep chemical conjugation with cancer targeted ligands, contrast agents and therapeutic ...

journal_title：Biomaterials

authors： Luo S,Tan X,Qi Q,Guo Q,Ran X,Zhang L,Zhang E,Liang Y,Weng L,Zheng H,Cheng T,Su Y,Shi C

更新日期：2013-03-01 00:00:00