Control of smooth muscle cell proliferation by ferrous iron.

abstract：:Glucose oxidase was immobilized into photographic gelatin hardened by chromium(III) sulphate. The enzyme-gelatin mixture was coated on polyester film strips which allowed easy and simple handling during assays. The effect of gelatin and cross-linker concentrations on water content and enzymatic activity was studied. T...

journal_title：Biomaterials

authors： Elçin YM,Akbulut U

更新日期：1992-01-01 00:00:00

abstract：:A PCL/hydrogel construct that would mimic the structural organization, biochemistry and anatomy of meniscus was engineered. The compressive (380 ± 40 kPa) and tensile modulus (18.2 ± 0.9 MPa) of the PCL scaffolds were increased significantly when constructs were printed with a shifted design and circumferential strand...

journal_title：Biomaterials

authors： Bahcecioglu G,Bilgen B,Hasirci N,Hasirci V

更新日期：2019-10-01 00:00:00

abstract：:Retinal pigment epithelial (RPE) cellular morphology and function are vital to the health of the retina. In age-related macular degeneration, RPE dysfunction and changes in Bruch's membrane occur. Thus, a potential cure is a dual-layer biomimetic transplant consisting of a layer of healthy RPE cells cultured on a supp...

journal_title：Biomaterials

authors： Lee CJ,Fishman HA,Bent SF

更新日期：2007-04-01 00:00:00

abstract：:For clinical application of human embryonic stem cells (hESCs), it is critical to develop hESC culture techniques that completely exclude the use of animal feeder cells, mitotic inhibition, and enzyme treatments used in conventional hESC culture systems. Toward this goal, we attempted to maintain hESCs and induced plu...

journal_title：Biomaterials

authors： Hwang ST,Kang SW,Lee SJ,Lee TH,Suh W,Shim SH,Lee DR,Taite LJ,Kim KS,Lee SH

更新日期：2010-11-01 00:00:00

abstract：:Dextran derivatives are biosynthetic polyanionic polymers which exert some of the heparin properties such as regulating the activity of several heparin-binding growth factors. Based on a reproducible synthetic procedure, we have synthesized a new generation of dextran derivatives named dextran methylcarboxylate benzyl...

journal_title：Biomaterials

authors： Vercoutter-Edouart AS,Dubreucq G,Vanhoecke B,Rigaut C,Renaux F,Dahri-Correia L,Lemoine J,Bracke M,Michalski JC,Correia J

更新日期：2008-05-01 00:00:00

abstract：:Vaccination is an effective medical intervention for preventing disease. However, without an adjuvant, most subunit vaccines are poorly immunogenic. This work develops a bioinspired nanocomposite hyaluronic acid hydrogel system that incorporates N-trimethyl chitosan nanoparticles (TMC/NPs) that carry a model subunit v...

journal_title：Biomaterials

authors： Korupalli C,Pan WY,Yeh CY,Chen PM,Mi FL,Tsai HW,Chang Y,Wei HJ,Sung HW

更新日期：2019-09-01 00:00:00

abstract：:Frequent outbreaks and the rapid global spread of infectious diseases have increased the urgent need for massive vaccination especially in countries with limited resources. Intranasal vaccination facilitates the mass vaccination via needle-free delivery of vaccine through nasal mucosal surfaces. Inspired by the strong...

journal_title：Biomaterials

authors： Wang X,Yang D,Li S,Xu X,Qin CF,Tang R

更新日期：2016-11-01 00:00:00

abstract：:Porous biomaterials designed to support cellular infiltration and tissue formation play a critical role in implant fixation and engineered tissue repair. The purpose of this Leading Opinion Paper is to advocate the use of high resolution 3D imaging techniques as a tool to quantify extracellular matrix formation and va...

journal_title：Biomaterials

authors： Guldberg RE,Duvall CL,Peister A,Oest ME,Lin AS,Palmer AW,Levenston ME

更新日期：2008-10-01 00:00:00

abstract：:At high concentrations, manganese (Mn) promotes cellular neurodevelopment but causes toxicity. Here, we report that Mn ion at high concentrations can be delivered to pheochromocytoma 12 (PC12) cells using gold nanoparticles (AuNPs) to enhance cellular neurodevelopment without toxicity. Mn(2+) release from AuNPs was de...

journal_title：Biomaterials

authors： Bhang SH,Han J,Jang HK,Noh MK,La WG,Yi M,Kim WS,Kwon YK,Yu T,Kim BS

更新日期：2015-07-01 00:00:00

abstract：:Titanium and its alloys are widely used in load-bearing implants as a result of their excellent mechanical properties and corrosion resistance. In order to improve their performances with respect to osseointegration, the use of bioactive coatings has been suggested. Polypyrrole (PPy) has been chosen as coating polymer...

journal_title：Biomaterials

authors： De Giglio E,Guascito MR,Sabbatin L,Zambonin G

更新日期：2001-10-01 00:00:00

abstract：:Boiling diluted alkali incubation was found to be an effective way to prepare bioactive Ti6Al4V surfaces, whether polished or not, as indicated in vitro after immersion in two different supersaturated calcification solutions (SCSs). The induction of calcium phosphate (Ca-P) precipitation from the SCSs is most probably...

journal_title：Biomaterials

authors： Wen HB,de Wijn JR,Cui FZ,de Groot K

更新日期：1998-01-01 00:00:00

abstract：:The commercial availability of peptides and proteins and their advantages as therapeutic agents have been the basis for tremendous efforts in designing delivery systems for such agents. The protection of these agents from biological fluids and physiological interactions is crucial for the treatment efficacy. One such ...

journal_title：Biomaterials

authors： Torres-Lugo M,Peppas NA

更新日期：2000-06-01 00:00:00

abstract：:Nanotherapeutics have been investigated for years, but only modest survival benefits were observed clinic. This is partially attributed to the short and rapid elimination of nanodrug after intravenous administration. In this study, a long circulation single wall carbon nanotube (SWCNT) complex was successfully fabrica...

journal_title：Biomaterials

authors： Xie L,Wang G,Zhou H,Zhang F,Guo Z,Liu C,Zhang X,Zhu L

更新日期：2016-10-01 00:00:00

abstract：:The degradation behavior of the absorbable coating may have significant impacts to the short and long-term safety of the drug eluting stent (DES). A poly(lactide-co-glycolide) (PLGA) polymer coating containing sirolimus on stent surface was studied when stents were expanded to 3.0 mm. In vitro and in vivo degradation ...

journal_title：Biomaterials

authors： Xi T,Gao R,Xu B,Chen L,Luo T,Liu J,Wei Y,Zhong S

更新日期：2010-07-01 00:00:00

abstract：:Atherosclerotic plaques are cholesterol-induced inflammatory niches accumulating in the vascular sub-endothelial space. Cellular and extracellular composition of human plaques is maneuvered by local inflammation that leads to alterations in the original vascular microenvironment and to the recruitment of an invading f...

journal_title：Biomaterials

authors： Mallone A,Stenger C,Von Eckardstein A,Hoerstrup SP,Weber B

更新日期：2018-01-01 00:00:00

abstract：:The water absorption characteristics of resins, upon which many composite filling materials are based, have been studied. In general, the equilibrium uptake is less than that predicted from the water absorption of composite filling materials, if it is assumed that the polymer alone absorbs the water. Also, whereas the...

journal_title：Biomaterials

authors： Braden M,Davy KW

更新日期：1986-11-01 00:00:00

abstract：:Cell labeling using magnetic nanoparticles is an increasingly used approach in noninvasive behavior tracking, in vitro separation of cancer stem cells (CSCs), and CSC-based research in cancer therapy. However, the impact of magnetic labeling on the biological properties of targeted CSCs, such as self-renewal, prolifer...

journal_title：Biomaterials

authors： Wang X,Wei F,Liu A,Wang L,Wang JC,Ren L,Liu W,Tu Q,Li L,Wang J

更新日期：2012-05-01 00:00:00

abstract：:Therapeutic options to treat primary glioblastoma (GBM) tumors are scarce. GBM tumors with epidermal growth factor receptor (EGFR) mutations, in particular a constitutively active EGFRvIII mutant, have extremely poor clinical outcomes. GBM tumors with concurrent EGFR amplification and active phosphatase and tensin hom...

journal_title：Biomaterials

authors： Pedron S,Wolter GL,Chen JE,Laken SE,Sarkaria JN,Harley BAC

更新日期：2019-10-01 00:00:00

abstract：:Covalent antithrombin-heparin complex (ATH) was covalently grafted to a polycarbonate urethane (Corethane) endoluminal graft (a kind gift of Corvita Corporation) after being activated using 0.3% m/m NaOCl in 0.15 M phosphate pH 6.0. ATH graft density (1.98 x 10(-7) mol/m2) was 6 times the maximum amount of unfractiona...

journal_title：Biomaterials

authors： Klement P,Du YJ,Berry L,Andrew M,Chan AK

更新日期：2002-01-01 00:00:00

abstract：:To develop a polymer-anticancer drug conjugate, we employed gelatin nanoparticles (GPs) as carriers of cisplatin (CDDP) with anticipated improved therapeutic effect and reduced side effects. The anticancer activities of CDDP-incorporated in GPs (GP-Pt) with biotinylated-EGF (bEGF) modification (GP-Pt-bEGF) were studie...

journal_title：Biomaterials

authors： Tseng CL,Su WY,Yen KC,Yang KC,Lin FH

更新日期：2009-07-01 00:00:00

abstract：:To realize a fast and selective capture of nano drug vehicles (NDVs) by malignant tumors, an instant affinity switchable NDV based on pH-sensitive surface protonation was prepared. This NDV is prepared from a zwitterionic polymer system with an ultra resistant poly(carboxybetaine) (pCB) shell and sulfo groups near a h...

journal_title：Biomaterials

authors： Wang Z,Ma G,Zhang J,Yuan Z,Wang L,Bernards M,Chen S

更新日期：2015-09-01 00:00:00

abstract：:We describe a novel approach to process bioceramic microparticles and poly(diol citrates) into bioceramic-elastomer composites for potential use in orthopedic surgery. The composite consists of the biodegradable elastomer poly(1,8-octanediol-citrate) (POC) and the bioceramic hydroxyapatite (HA). The objective of this ...

journal_title：Biomaterials

authors： Qiu H,Yang J,Kodali P,Koh J,Ameer GA

更新日期：2006-12-01 00:00:00

abstract：:New combination therapy strategy, which takes the advantages of co-delivery two or more therapeutic agents in one nanocarrier platform, has been widely used in the clinic and achieved immense popularity in cancer treatment. Here, we have rationally developed a multifunctional platform using a self-assembly strategy to...

journal_title：Biomaterials

authors： Tao Y,Ju E,Liu Z,Dong K,Ren J,Qu X

更新日期：2014-08-01 00:00:00

abstract：:The development of synthetic hydrogels analogs for the extracellular matrix has proven a useful and important tool to study the role of specific signals on biological outcomes in vitro and to serve as scaffolds for tissue repair. Although the importance of physical properties (e.g. microstructure and stiffness) in the...

journal_title：Biomaterials

authors： Darling NJ,Hung YS,Sharma S,Segura T

更新日期：2016-09-01 00:00:00

abstract：:We show here, that the proapoptotic peptide, KLAKLAKKLAKLAK (KLA), which by itself does not penetrate cell membranes, can do so when fused to a protein transduction domain derived from NH(2)-terminus of translationally controlled tumor protein (TCTP-PTD, MIIYRDLISH). Once inside the cell, the conjugated KLA exerts its...

journal_title：Biomaterials

authors： Kim HY,Kim S,Youn H,Chung JK,Shin DH,Lee K

更新日期：2011-08-01 00:00:00

abstract：:Adipose-derived stem cells (ASCs) have valuable applications in regenerative medicine, but maintaining the stemness of ASCs during in vitro culture is still a challenging issue. In this study, human ASCs spontaneously formed three-dimensional spheroids on chitosan films. Most ASCs within the spheroid were viable, and ...

journal_title：Biomaterials

authors： Cheng NC,Wang S,Young TH

更新日期：2012-02-01 00:00:00

abstract：:Biological heart prostheses present medium and long-term problems, owing to progressive deterioration and calcification of the tissue. To study the latter problem, we compared the effectiveness of anticalcification treatments in calf pericardium samples implanted into female Wistar rats after the following procedures:...

journal_title：Biomaterials

authors： Jorge-Herrero E,Gutiérrez MP,Castillo-Olivares JL

更新日期：1991-03-01 00:00:00

abstract：:Duchenne Muscular Dystrophy (DMD) is a fatal genetic disorder currently having no cure. Here we report that culture substrates patterned with nanogrooves and functionalized with Matrigel (or laminin) present an engineered cell microenvironment to allow myotubes derived from non-diseased, less-affected DMD, and severel...

journal_title：Biomaterials

authors： Xu B,Magli A,Anugrah Y,Koester SJ,Perlingeiro RCR,Shen W

更新日期：2018-11-01 00:00:00

abstract：:The successful delivery of anti-cancer drugs relies on the simultaneous capability to actively target a specific location, a sufficient lifetime in the active form in the circulation, and traceability and quantification of drug distribution via in vivo medical imaging. Herein, a highly magnetic nanocarrier (HMNC) comp...

journal_title：Biomaterials

authors： Yang HW,Hua MY,Liu HL,Huang CY,Tsai RY,Lu YJ,Chen JY,Tang HJ,Hsien HY,Chang YS,Yen TC,Chen PY,Wei KC

更新日期：2011-09-01 00:00:00

abstract：:In this paper we report a new method that permitted for the first time to selectively track a polysaccharide-based hydrogel on bone tissue explants, several weeks after its implantation. The hydrogel, which was developed for bone healing and tissue engineering, was labelled with a ruthenium complex and implanted into ...

journal_title：Biomaterials

authors： Laïb S,Fellah BH,Fatimi A,Quillard S,Vinatier C,Gauthier O,Janvier P,Petit M,Bujoli B,Bohic S,Weiss P

更新日期：2009-03-01 00:00:00