Transmucosal delivery systems for calcitonin: a review.

abstract：:Poly(ether-ether-ketone) (PEEK)s are a group of polymeric biomaterials with excellent mechanical properties and chemical stability. In the present study, we demonstrate the fabrication of an antibiofouling and highly hydrophilic high-density nanometer-scaled layer on the surface of PEEK by photo-induced graft polymeri...

journal_title：Biomaterials

authors： Kyomoto M,Moro T,Takatori Y,Kawaguchi H,Nakamura K,Ishihara K

更新日期：2010-02-01 00:00:00

abstract：:Tissue-engineering technology employing genetically-modified mesenchymal stem cells combined with proper scaffolds represents a promising strategy for bone regeneration. Elucidating the underlying mechanisms that govern the osteogenesis of mesenchymal stem cells will give deeper insights into the regulatory patterns, ...

journal_title：Biomaterials

authors： Xie Q,Wang Z,Zhou H,Yu Z,Huang Y,Sun H,Bi X,Wang Y,Shi W,Gu P,Fan X

更新日期：2016-01-01 00:00:00

abstract：:We present here an easy method to modify the surface chemistry of polymeric microcapsules of perfluorooctyl bromide used as ultrasound contrast agents (UCAs). Capsules were obtained by a solvent emulsification-evaporation process with phospholipids incorporated in the organic phase before emulsification. Several phosp...

journal_title：Biomaterials

authors： Díaz-López R,Tsapis N,Libong D,Chaminade P,Connan C,Chehimi MM,Berti R,Taulier N,Urbach W,Nicolas V,Fattal E

更新日期：2009-03-01 00:00:00

abstract：:A tissue-engineered substitute that facilitates large-volume regeneration of the subcutaneous adipose tissue layer is needed for reconstructive plastic surgery. Towards this goal, we describe the in vitro culture of primary human adipose-derived stem cells (ASC) seeded into placental decellular matrix (PDM) and cross-...

journal_title：Biomaterials

authors： Flynn LE,Prestwich GD,Semple JL,Woodhouse KA

更新日期：2008-04-01 00:00:00

abstract：:The non-specific interaction between nanoparticles (NPs) and plasma proteins occurs immediately after NPs enter the blood, resulting in the formation of the protein corona that thereafter replaces the original NPs and becomes what the organs and cells really see. Consequently, the in vivo fate of NPs and the biologica...

journal_title：Biomaterials

authors： Peng Q,Zhang S,Yang Q,Zhang T,Wei XQ,Jiang L,Zhang CL,Chen QM,Zhang ZR,Lin YF

更新日期：2013-11-01 00:00:00

abstract：:Personalized oncology significantly relies on the development of cancer theranostic agents to integrate cancer therapeutics and diagnostics. Current most common strategy for development of such multifunctional agents requires multistep chemical conjugation with cancer targeted ligands, contrast agents and therapeutic ...

journal_title：Biomaterials

authors： Luo S,Tan X,Qi Q,Guo Q,Ran X,Zhang L,Zhang E,Liang Y,Weng L,Zheng H,Cheng T,Su Y,Shi C

更新日期：2013-03-01 00:00:00

abstract：:Most urgent health problems are related to a blood vessel formation failure. The use of stem cells from different sources or species for both in vitro and in vivo engineering of endothelium does not necessarily imply their direct commitment towards a vascular phenotype. In the present study, we used human amniotic flu...

journal_title：Biomaterials

authors： Mirabella T,Cilli M,Carlone S,Cancedda R,Gentili C

更新日期：2011-05-01 00:00:00

abstract：:A homogeneous glycidyl acrylate polymer (GAP) has been grafted on to polytetrafluoroethylene (PTFE) and polyethylene (PE) using a modified plasma glow discharge technique with glycidyl acrylate. The polymeric layer appears to be extremely stable to acidic media and to common organic solvents. The modified surface can ...

journal_title：Biomaterials

authors： Tanfani F,Durrani AA,Kojima M,Chapman D

更新日期：1990-10-01 00:00:00

abstract：:Beads of polytetrafluoroethylene were used to investigate adsorption of thrombin and the influence of the adsorbed protease on a subsequent deposition of fibrinogen. Adsorption of active thrombin was not detected by a specific fluorogenic substrate unless > 0.1 units/ml had been applied. Adsorption was considerably im...

journal_title：Biomaterials

authors： Schlosser E,Simler R,Hörmann H

更新日期：1993-04-01 00:00:00

abstract：:We investigated the morphological effect of phase-separated block copolymer surfaces composed of poly(2-methacryloyloxyethyl phosphorylcholine (MPC)) (PMPC) and poly(dimethylsiloxane) (PDMS) on protein adsorption and cell adhesion behavior. We observed three different types of phase-separated surface morphologies by T...

journal_title：Biomaterials

authors： Seo JH,Matsuno R,Takai M,Ishihara K

更新日期：2009-10-01 00:00:00

abstract：:Previous in vivo studies have shown a limited potential for vertical bone regeneration using osteoconductive scaffolds alone. In the present study, we investigated whether the association of adipose-derived adult stem cells (ASCs) with anorganic bovine bone (ABB) scaffold improved bone formation and implant osseointeg...

journal_title：Biomaterials

authors： Pieri F,Lucarelli E,Corinaldesi G,Aldini NN,Fini M,Parrilli A,Dozza B,Donati D,Marchetti C

更新日期：2010-05-01 00:00:00

abstract：:An oxidizing treatment of carbon fibres in boiling nitric acid leads to significant changes in the chemical state of their surface. As a result of the chemical treatment on a hydrophobic carbon surface, hydrophilic domains are formed and phenolic, carbonyl and carboxyl groups appear. In this work the intensity of phag...

journal_title：Biomaterials

authors： Czajkowska B,Błazewicz M

更新日期：1997-01-01 00:00:00

abstract：:The urgent needs of functional arterial replacements for curing the vascular system diseases have been proposed for many years. However, an ideal small-diameter vascular scaffold, which is nonthrombogenic, minimizes intimal hyperplasia, matches the mechanical properties of natural vessels, and supports neovascular tis...

journal_title：Biomaterials

authors： Han F,Jia X,Dai D,Yang X,Zhao J,Zhao Y,Fan Y,Yuan X

更新日期：2013-10-01 00:00:00

abstract：:Physicochemical features of a cell nanoenvironment exert important influence on stem cell behavior and include the influence of matrix elasticity and topography on differentiation processes. The presence of growth factors such as TGF-β and BMPs on these matrices provides chemical cues and thus plays vital role in dire...

journal_title：Biomaterials

authors： Das RK,Zouani OF

更新日期：2014-07-01 00:00:00

abstract：:To investigate the role that the micro/nano-environment plays on the differentiation pathway of bone marrow stromal cells (BMSCs) into osteoblasts, we employed a 2D substrate coated with turnip yellow mosaic virus (TYMV) particles. TYMV is a non-enveloped icosahedral plant virus which has an average diameter 28 nm and...

journal_title：Biomaterials

authors： Kaur G,Valarmathi MT,Potts JD,Wang Q

更新日期：2008-10-01 00:00:00

abstract：:This study examined the engineering and true axial stress-strain behavior of smooth cylindrical and shallow and deep notched cylindrical test specimens, under applied axial tensile loading using non-contacting methods, of both conventional and highly crosslinked ultra-high molecular weight polyethylenes (UHMWPEs). The...

journal_title：Biomaterials

authors： Sobieraj MC,Kurtz SM,Rimnac CM

更新日期：2005-06-01 00:00:00

abstract：:Poly(γ-4-((2-(piperidin-1-yl)ethyl)aminomethyl)benzyl-l-glutamate) (PPABLG), a cationic helical polypeptide, has been recently developed by us as an effective non-viral gene delivery vector. In attempts to elucidate the effect of molecular architecture on the gene delivery efficiencies and thereby identify a potential...

journal_title：Biomaterials

authors： Yin L,Song Z,Kim KH,Zheng N,Tang H,Lu H,Gabrielson N,Cheng J

更新日期：2013-03-01 00:00:00

abstract：:Sol-gel derived porous silica carriers for the controlled release of proteins were synthesized using a room temperature process. The materials are intended to serve as both substrates for bone growth as well as to allow incorporated proteins such as growth factors to diffuse out and stimulate cell function and tissue ...

journal_title：Biomaterials

authors： Santos EM,Radin S,Ducheyne P

更新日期：1999-09-01 00:00:00

abstract：:We compared the osteogenic response in porous alumni (Al) and hydroxyapatite coated porous alumni ceramic (HA/Al) by grafting rat bone marrow cells with these implants subcutaneously in the back of syngeneic rats. The ceramics did not show any bone formation without marrow, but did when combined with marrow cells. The...

journal_title：Biomaterials

authors： Takaoka T,Okumura M,Ohgushi H,Inoue K,Takakura Y,Tamai S

更新日期：1996-08-01 00:00:00

abstract：:A nanocarrier delivery system that can simultaneously deliver a chemotherapeutic drug and siRNA to the tumor is emerging as a promising treatment strategy for cancer treatment. In this study, a multifunctional PHD/PPF/siRNA complexes was developed by one-step assembly of prefunctionalized polymers: PEI-HZ-DOX (PHD) an...

journal_title：Biomaterials

authors： Dong DW,Xiang B,Gao W,Yang ZZ,Li JQ,Qi XR

更新日期：2013-07-01 00:00:00

abstract：:At the present time, three poly(ortho ester) systems have been described. The first one was developed at the Alza Corporation and is prepared by the transesterification reaction between a diol and diethoxytetrahydrofuran. It is currently marketed under the trade name of Alzamer. A second poly(ortho ester) system, deve...

journal_title：Biomaterials

authors： Heller J

更新日期：1990-11-01 00:00:00

abstract：:Highly oriented hydroxyapatite coatings (HACs) were obtained on titanium substrates through a radio-frequency thermal plasma spraying (TPS) method. XRD patterns showed that the HACs had crystallites with [001] preferred orientation vertical to the coating's surface. XRD results also indicated that tetracalcium phospha...

journal_title：Biomaterials

authors： Inagaki M,Kameyama T

更新日期：2007-07-01 00:00:00

abstract：:Vasculopathy due to ischemia in damaged tissues is a major cause of morbidity and mortality. To treat these conditions, endothelial progenitor cells (EPCs) from various sources, such as umbilical cord or peripheral blood, have been the focus of the regenerative medicine field due to their proliferative and vasculogeni...

journal_title：Biomaterials

authors： Kim J,Jeon YJ,Kim HE,Shin JM,Chung HM,Chae JI

更新日期：2013-02-01 00:00:00

abstract：:This study was undertaken to evaluate the role of collagen matrix to enhance platelet-rich plasma (PRP) effects on pro-inflammatory cytokine-induced arthritic model. We have previously demonstrated the highly regenerative roles of PRP to restore disc degeneration and osteoporosis. In this study, PRP modulated by colla...

journal_title：Biomaterials

authors： Wu CC,Chen WH,Zao B,Lai PL,Lin TC,Lo HY,Shieh YH,Wu CH,Deng WP

更新日期：2011-09-01 00:00:00

abstract：:A human-human oligodendroglial cell line MO3.13 was chosen in this study to model the loss of oligodendrocytes that occurs during episodes of multiple sclerosis. The influence of mercuric chloride (HgCl(2)) upon cell viability specifically the mode of cell death, whether by an active apoptotic mechanism or passive nec...

journal_title：Biomaterials

authors： Issa Y,Watts DC,Duxbury AJ,Brunton PA,Watson MB,Waters CM

更新日期：2003-03-01 00:00:00

abstract：:Local tumor therapy through injectable biodegradable hydrogels with controlled drug release has attracted much attention recently, due to their easy operation, low side effect and efficiency. However, most of the reported therapeutic hydrogel system showed a lack of biodegradation tracking and tumor environment-respon...

journal_title：Biomaterials

authors： Wang M,Chen M,Niu W,Winston DD,Cheng W,Lei B

更新日期：2020-12-01 00:00:00

abstract：:A number of neurodegenerative disorders may potentially be treated by the delivery of therapeutic genes to neurons. Nonviral gene delivery systems, however, typically provide low transfection efficiency in post-mitotic differentiated neurons. To uncover mechanistic reasons for this observation, we compared gene transf...

journal_title：Biomaterials

authors： Suk JS,Suh J,Choy K,Lai SK,Fu J,Hanes J

更新日期：2006-10-01 00:00:00

abstract：:The functionalization of polytetrafluoroethylene (PTFE) for human thrombomodulin (hTM) binding has been achieved by CO2 plasma activation and subsequent vapour phase graft polymerization of acrylic acid (AA). The PTFE surfaces after CO2 plasma treatment, AA grafting and hTM immobilization were characterized by attenua...

journal_title：Biomaterials

authors： Vasilets VN,Hermel G,König U,Werner C,Müller M,Simon F,Grundke K,Ikada Y,Jacobasch HJ

更新日期：1997-09-01 00:00:00

abstract：:Dextran T40 was modified with carboxylic, benzylamide and benzylamine-sulphonated groups (samples 1-10). The polymers were incubated with dextranase and the decrease of molecular weight was determined by high performance size exclusion chromatography. It was shown that the higher the substitution of dextrans, the lowe...

journal_title：Biomaterials

authors： Crepon B,Jozefonvicz J,Chytry V,Rihová B,Kopecek J

更新日期：1991-08-01 00:00:00

abstract：:Polyethylene terephthalate (PET), ethylene-vinyl alcohol copolymer (EVOH) and Nylon 6 in plate form were treated with silane-coupling agents, a titanium alkoxide-alcohol solution and a hot HCl solution to form a thin crystalline titanium oxide layer. When placed in a simulated body fluid with ion concentrations nearly...

journal_title：Biomaterials

authors： Balas F,Kawashita M,Nakamura T,Kokubo T

更新日期：2006-03-01 00:00:00