Engineered, self-assembled near-infrared photothermal agents for combined tumor immunotherapy and chemo-photothermal therapy.

abstract：:Synthetic small interfering RNA (siRNA) is a class of therapeutic entities that allow for specific silencing of target genes via RNA interference (RNAi) and comprise an enormous clinical potential for a variety of diseases, including cancer. However, efficient tissue-specific delivery of siRNA remains the major limita...

journal_title：Biomaterials

authors： Lee DJ,Kessel E,Edinger D,He D,Klein PM,Voith von Voithenberg L,Lamb DC,Lächelt U,Lehto T,Wagner E

更新日期：2016-01-01 00:00:00

abstract：:DNA vaccine is a milestone in contemporary vaccine development. It has considerably offset many shortcomings in conventional vaccines. Although DNA vaccines applied through 'traditional' high-pressure gene guns generally elicit high titers of protective immunity, such a practice however requires enormous investment in...

journal_title：Biomaterials

authors： Huang HN,Li TL,Chan YL,Chen CL,Wu CJ

更新日期：2009-10-01 00:00:00

abstract：:It is often desirable to sequester cells in specific locations on the surface and to integrate sensing elements next to the cells. In the present study, surfaces were fabricated so as to position cytokine sensing domains inside non-fouling poly(ethylene glycol) (PEG) hydrogel microwells. Our aim was to increase sensit...

journal_title：Biomaterials

authors： Seo JH,Chen LJ,Verkhoturov SV,Schweikert EA,Revzin A

更新日期：2011-08-01 00:00:00

abstract：:This paper describes a method of foaming a polymer system comprising poly(ethyl methacrylate)/tetrahydrofurfuryl methacrylate (PEMA/THFMA), characterisation of the resulting porosity and use of the foam for chondrocyte culture. The potential for this polymer system to support cartilage repair has been investigated pre...

journal_title：Biomaterials

authors： Barry JJ,Gidda HS,Scotchford CA,Howdle SM

更新日期：2004-08-01 00:00:00

abstract：:The limited intrinsic repair capacity of articular cartilage has stimulated continuing efforts to develop tissue engineered analogues. Matrices composed of type II collagen and chondroitin sulfate (CS), the major constituents of hyaline cartilage, may create an appropriate environment for the generation of cartilage-l...

journal_title：Biomaterials

authors： Pieper JS,van der Kraan PM,Hafmans T,Kamp J,Buma P,van Susante JL,van den Berg WB,Veerkamp JH,van Kuppevelt TH

更新日期：2002-08-01 00:00:00

abstract：:Measurements were made of the extremes in temperature which occur at different sites in the oral cavity during fluid intake. The results indicate that temperatures noted at the tooth surface, within the mouth, during fluid intake were less than the temperatures of the fluid imbibed. Variations in temperature were note...

journal_title：Biomaterials

authors： Longman CM,Pearson GJ

更新日期：1987-09-01 00:00:00

abstract：:Biomimetic materials are often capable of subtly affecting tissue development, regeneration and carcinogenesis due to their high similarity to natural tissues. Despite the benefit of using such materials in tissue engineering, their prospective use in cancer therapy has been neglected, particularly the functions and m...

journal_title：Biomaterials

authors： Li X,Wang Y,Chen Y,Zhou P,Wei K,Wang H,Wang J,Fang H,Zhang S

更新日期：2020-10-01 00:00:00

abstract：:Nitric oxide (NO) is widely known as an effective vasodilator at low concentrations. Drug delivery systems combined with NO can dilate blood vessels surrounding tumor tissues, and the drug accumulation in tumors is accelerated by the enhanced permeability and retention effect, leading to an improvement in the anti-tum...

journal_title：Biomaterials

authors： Kang Y,Kim J,Park J,Lee YM,Saravanakumar G,Park KM,Choi W,Kim K,Lee E,Kim C,Kim WJ

更新日期：2019-10-01 00:00:00

abstract：:Redox-sensitive non-viral delivery systems exploit intracellular reducing environment to improve the efficacy of the delivery of nucleic acids by selectively releasing the cargo in the subcellular space. Bcl-2 overexpression is frequently observed in human cancers and is closely associated with increased resistance to...

journal_title：Biomaterials

authors： Manickam DS,Hirata A,Putt DA,Lash LH,Hirata F,Oupický D

更新日期：2008-06-01 00:00:00

abstract：:Neural transplantation therapy using neural stem cells has received as potential treatments for neurodegenerative diseases. Indeed, this therapy is thought to be effective for replacement of degenerating neurons in restricted anatomical region. However, because injected neural stem cells integrate randomly into the ho...

journal_title：Biomaterials

authors： Kato-Negishi M,Tsuda Y,Onoe H,Takeuchi S

更新日期：2010-12-01 00:00:00

abstract：:Facile assembly of intelligent DNA nanoobjects with the ability to exert in situ visualization of intracellular microRNAs (miRNAs) has long been concerned in the fields of DNA nanotechnology and basic medical study. Here, we present a driving primer (DP)-triggered polymerization-mediated metastable assembly (PMA) stra...

journal_title：Biomaterials

authors： Xu J,Wu ZS,Wang Z,Le J,Zheng T,Jia L

更新日期：2017-03-01 00:00:00

abstract：:Semiconductor quantum dots and upconversion nanoparticles have been broadly used for live cell imaging due to their color tunability and photostability etc. However, these inorganic materials often contain heavy metals and potentially have metabolism problems. To overcome these issues, herein, we report a type of orga...

journal_title：Biomaterials

authors： Xu R,Huang L,Wei W,Chen X,Zhang X,Zhang X

更新日期：2016-07-01 00:00:00

abstract：:Nanoparticles have been widely used for delivering various chemical and biomolecular drugs, such as anti-cancer drugs and therapeutic proteins. Among nanoparticles, protein nanoparticles have advantages of non-cytotoxicity and biodegradability. In this study, a recombinant 30Kc19 protein was applied to human serum alb...

journal_title：Biomaterials

authors： Lee HJ,Park HH,Kim JA,Park JH,Ryu J,Choi J,Lee J,Rhee WJ,Park TH

更新日期：2014-02-01 00:00:00

abstract：:Endothelial cells derived from the bovine pulmonary artery (line CPAE, CCL 209, American Tissue Culture Collection, Rockville, MD, USA) were cultured on pristine or fluorine ion-irradiated polystyrene (5 x 10(12) or 5 x 10(14) F ions/cm2, 150 keV). At 24-h post-seeding interval, the number of cells which adhered to th...

journal_title：Biomaterials

authors： Bacáková L,Mares V,Lisá V,Svorcík V

更新日期：2000-06-01 00:00:00

abstract：:G-rich oligonucleotides tend to fall into kinetically trapped unstable structures because of their conformational polymorphism. Nucleic acid chaperones accelerate association of nucleic acids assemblies into the thermodynamically most stable conformations by decreasing the energy barrier for breakage or re-assembly of...

journal_title：Biomaterials

authors： Moriyama R,Shimada N,Kano A,Maruyama A

更新日期：2011-10-01 00:00:00

abstract：:Following our recent report of attractive antibacterial properties of a designed amphiphilic peptide, A(9)K, we have investigated its antitumor activities by examining the modes of its action against different mammalian cell types. The peptide strongly inhibited the growth of cancerous HeLa cells and human promyelocyt...

journal_title：Biomaterials

authors： Xu H,Chen CX,Hu J,Zhou P,Zeng P,Cao CH,Lu JR

更新日期：2013-04-01 00:00:00

abstract：:Hydroxyapatite ceramics with zirconia dispersion from fine powders synthesized hydrothermally were post-sintered at 1000-1300 degrees C under 200 MPa of argon for 1 h without capsules, after normal sintering in air at 1200 degrees C for 3 h. Densification was most significant with post-sintering at 1200 degrees C. Fra...

journal_title：Biomaterials

authors： Ioku K,Yoshimura M,Somiya S

更新日期：1990-01-01 00:00:00

abstract：:Induced pluripotent stem (iPS) cells have been generated from various somatic cells; however, a major restriction of the technology is the use of potentially harmful genome-integrating viral DNAs. Here, without a viral vector, we generated iPS cells from fibroblasts using a non-viral magnetic nanoparticle-based transf...

journal_title：Biomaterials

authors： Lee CH,Kim JH,Lee HJ,Jeon K,Lim H,Choi Hy,Lee ER,Park SH,Park JY,Hong S,Kim S,Cho SG

更新日期：2011-10-01 00:00:00

abstract：:Peel bond strength and tensile bond strength between three polyvinylsiloxane denture soft liners and a heat-cured acrylic resin denture base were measured using two adhesive systems. The soft lining materials differed only in regard of their filler content and compliance. The values of bond strength and mode of failur...

journal_title：Biomaterials

authors： McCabe JF,Carrick TE,Kamohara H

更新日期：2002-03-01 00:00:00

abstract：:Experimental and histological studies on the reaction of surrounding gingiva to permucosal implants of dense calcium hydroxyapatite were carried out in dogs. Epithelial attachment and connection of supra-alveolar collagen fibres to the implant surface seemed to form a biological seal around implants similar to that ar...

journal_title：Biomaterials

authors： Kurashina K,de Lange GL,de Putter C,de Groot K

更新日期：1984-07-01 00:00:00

abstract：:A two-layer hydroxyapatite (HA)/HA+TiO(2) bond coat composite coating (HTH coating) on titanium was fabricated by plasma spraying. The HA+TiO(2) bond coat (HTBC) consists of 50 vol% HA and 50 vol% TiO(2) (HT). The microstructural characterization of the HTH coatings before and after heat treatment was conducted by usi...

journal_title：Biomaterials

authors： Lu YP,Li MS,Li ST,Wang ZG,Zhu RF

更新日期：2004-08-01 00:00:00

abstract：:The protective role of different dentine fractions and of dentine slices in moderating the cytotoxicity of zinc oxide eugenol (ZOE) was investigated. The collagen fraction of dentine powder provided increased protection over intact powder. Slices of dentine offered greater protection probably by providing a physical b...

journal_title：Biomaterials

authors： Meryon SD,Jakeman KJ

更新日期：1986-11-01 00:00:00

abstract：:Craniofacial skeletal muscle is composed of approximately 60 muscles, which have critical functions including food uptake, eye movements and facial expressions. Although craniofacial muscles have significantly different embryonic origin, most current skeletal muscle differentiation protocols using human induced plurip...

journal_title：Biomaterials

authors： Kim E,Wu F,Wu X,Choo HJ

更新日期：2020-07-01 00:00:00

abstract：:An urgent unmet need exists for early-stage treatment of spinal cord injury (SCI). Currently methylprednisolone is the only therapeutic agent used in clinics, for which the efficacy is controversial and the side effect is well-known. We demonstrated functional restoration of injured spinal cord by self-assembled nanop...

journal_title：Biomaterials

authors： Wu W,Lee SY,Wu X,Tyler JY,Wang H,Ouyang Z,Park K,Xu XM,Cheng JX

更新日期：2014-02-01 00:00:00

abstract：:Human adipose-derived stem cells (hADSCs) were purified from a suspension of human adipose tissue cells (stromal vascular fraction) by the conventional culture method and by membrane filtration through polyurethane (PU) foam membranes. hADSCs can be obtained from a suspension of human adipose tissue cells using the me...

journal_title：Biomaterials

authors： Wu CH,Lee FK,Suresh Kumar S,Ling QD,Chang Y,Chang Y,Wang HC,Chen H,Chen DC,Hsu ST,Higuchi A

更新日期：2012-11-01 00:00:00

abstract：:Compression, tension and torsion tests were designed and completed successfully on a brushite and a precipitated hydroxyapatite cement in moist condition. Elastic and strength properties were measured for these three loading cases. For each cement, the full set of strength data was fitted to an isotropic Tsai-Wu crite...

journal_title：Biomaterials

authors： Charrière E,Terrazzoni S,Pittet C,Mordasini PH,Dutoit M,Lemaître J,Zysset PH

更新日期：2001-11-01 00:00:00

abstract：:A technique for preparing micropatterns and gradients of proteins on polymeric substrates has been developed in this work. Peroxides were generated on the substrate surface by UV preirradiation and they initiated graft polymerization of acrylic acid (AA) onto the surface upon a second UV irradiation. Micropatterns and...

journal_title：Biomaterials

authors： Li B,Ma Y,Wang S,Moran PM

更新日期：2005-05-01 00:00:00

abstract：:We have developed an ion-sensing nanoparticle that is comprised of a superparamagnetic iron oxide (SPIO) core encapsulated with a porous silica shell. The latter can be readily anchored with ligands capable of coordinating with positron-emitting metal. Evidently, this nanoparticle has a great potential for use in cell...

journal_title：Biomaterials

authors： Patel D,Kell A,Simard B,Deng J,Xiang B,Lin HY,Gruwel M,Tian G

更新日期：2010-04-01 00:00:00

abstract：:We have synthesized a series of coumarins (1-3) that can emit fluorescence in a turn-on manner through a Michael-type reaction with thiol-containing compounds. The only difference among the coumarins is the position of a carboxyl group on its benzene ring moiety near the double-bond conjugated coumarin. Their selectiv...

journal_title：Biomaterials

authors： Jung HS,Pradhan T,Han JH,Heo KJ,Lee JH,Kang C,Kim JS

更新日期：2012-11-01 00:00:00

abstract：:A series of latex particles, having different sizes and surface structures, were prepared and the dependence of phagocytosis of latex particles by leucocytes on the particle size and surface potential was investigated by measuring the oxygen consumption of leucocytes. Most of the phagocytic behaviour in the initial st...

journal_title：Biomaterials

authors： Kawaguchi H,Koiwai N,Ohtsuka Y,Miyamoto M,Sasakawa S

更新日期：1986-01-01 00:00:00