Abstract：
:Porous biomaterials designed to support cellular infiltration and tissue formation play a critical role in implant fixation and engineered tissue repair. The purpose of this Leading Opinion Paper is to advocate the use of high resolution 3D imaging techniques as a tool to quantify extracellular matrix formation and vascular ingrowth within porous biomaterials and objectively compare different strategies for functional tissue regeneration. An initial over-reliance on qualitative evaluation methods may have contributed to the false perception that developing effective tissue engineering technologies would be relatively straightforward. Moreover, the lack of comparative studies with quantitative metrics in challenging pre-clinical models has made it difficult to determine which of the many available strategies to invest in or use clinically for companies and clinicians, respectively. This paper will specifically illustrate the use of microcomputed tomography (micro-CT) imaging with and without contrast agents to nondestructively quantify the formation of bone, cartilage, and vasculature within porous biomaterials.
journal_name
Biomaterialsjournal_title
Biomaterialsauthors
Guldberg RE,Duvall CL,Peister A,Oest ME,Lin AS,Palmer AW,Levenston MEdoi
10.1016/j.biomaterials.2008.06.018subject
Has Abstractpub_date
2008-10-01 00:00:00pages
3757-61issue
28eissn
0142-9612issn
1878-5905pii
S0142-9612(08)00430-4journal_volume
29pub_type
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