Abstract：
:The construction of tissue-engineered devices for medical applications is now possible in vitro using cell culture and bioreactors. Although methods of incorporating them back into the host are available, current constructs depend purely on diffusion which limits their potential. The absence of a vascular network capable of distributing oxygen and other nutrients within the tissue-engineered device is a major limiting factor in creating vascularised artificial tissues. Though bio-hybrid prostheses such as vascular bypass grafts and skin substitutes have already been developed and are being used clinically, the absence of a capillary bed linking the two systems remains the missing link. In this review, the different approaches currently being or that have been applied to vascularise tissues are identified and discussed.
journal_name
Biomaterialsjournal_title
Biomaterialsauthors
Kannan RY,Salacinski HJ,Sales K,Butler P,Seifalian AMdoi
10.1016/j.biomaterials.2004.07.006keywords:
subject
Has Abstractpub_date
2005-05-01 00:00:00pages
1857-75issue
14eissn
0142-9612issn
1878-5905pii
S0142-9612(04)00582-4journal_volume
26pub_type
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