Abstract：
:Acute and chronic wounds affect millions and are associated with billions of dollars in healthcare costs. The use of healing markers, biochemical cues from biocompatible matrices and materials, and their correlation with wound healing has the potential to generate valuable diagnostic, prognostic, and therapeutic information. In this study, we developed a collagen-dextran oxygen-sensing biocomposite scaffold membrane in which a phosphorescent oxygen sensor was incorporated to monitor physiological oxygen using in vivo phosphorescence imaging in a preclinical mouse model of wound healing. The oxygen-sensing biocomposite scaffold membrane enabled the noninvasive and longitudinal monitoring of oxygenation changes in vivo in an approach compatible with commercially available preclinical in vivo imaging system instruments. This study provides a new and novel capability where a biocomposite material can serve as a biocompatible, biodegradable theranostic platform to promote and assess tissue oxygenation during wound healing.
journal_name
Biomaterialsjournal_title
Biomaterialsauthors
Roussakis E,Ortines RV,Pinsker BL,Mooers CT,Evans CL,Miller LS,Calderón-Colón Xdoi
10.1016/j.biomaterials.2019.05.007subject
Has Abstractpub_date
2019-08-01 00:00:00pages
17-27eissn
0142-9612issn
1878-5905pii
S0142-9612(19)30271-6journal_volume
212pub_type
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