Abstract:
:Reactive oxygen species (ROS) have been shown to play crucial roles in regulating various cellular functions, e.g. focal adhesion (FA) dynamics and cell migration upon growth factor stimulation. However, it is not clear how ROS are regulated at subcellular FA sites to impact cell migration. We have developed a biosensor capable of monitoring ROS production at FA sites in live cells with high sensitivity and specificity, utilizing fluorescence resonance energy transfer (FRET). The results revealed that platelet derived growth factor (PDGF) can induce ROS production at FA sites, which is mediated by Rac1 activation. In contrast, integrins, specifically integrin αvβ3, inhibits this local ROS production. The RhoA activity can mediate this inhibitory role of integrins in regulating ROS production. Therefore, PDGF and integrin αvβ3 coordinate to have an antagonistic effect in the ROS production at FA sites to regulate cell adhesion and migration.
journal_name
Biomaterialsjournal_title
Biomaterialsauthors
Lin LJ,Grimme JM,Sun J,Lu S,Gai L,Cropek DM,Wang Ydoi
10.1016/j.biomaterials.2013.01.092subject
Has Abstractpub_date
2013-05-01 00:00:00pages
3807-15issue
15eissn
0142-9612issn
1878-5905pii
S0142-9612(13)00147-6journal_volume
34pub_type
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