The complement cascade at the Utah microelectrode-tissue interface.

abstract：:Titanium (Ti) osseointegration is critical for the success of dental and orthopedic implants. Previous studies have shown that surface roughness at the micro- and submicro-scales promotes osseointegration by enhancing osteoblast differentiation and local factor production. Only relatively recently have the effects of ...

journal_title：Biomaterials

authors： Gittens RA,McLachlan T,Olivares-Navarrete R,Cai Y,Berner S,Tannenbaum R,Schwartz Z,Sandhage KH,Boyan BD

更新日期：2011-05-01 00:00:00

abstract：:Aberrant regulation of angiogenesis supply sufficient oxygen and nutrients to exacerbate tumor progression and metastasis. Taking this hallmark of cancer into account, reported here is a self-monitoring and triple-collaborative therapy system by auto-fluorescent polymer nanotheranostics which could be concurrently aga...

journal_title：Biomaterials

authors： Shao L,Li Q,Zhao C,Lu J,Li X,Chen L,Deng X,Ge G,Wu Y

更新日期：2019-02-01 00:00:00

abstract：:Transcutaneous immunization (TCI) is an attractive vaccination method compared with conventional injectable vaccines because it is easier to administer without pain. We developed a dissolving microneedle patch (MicroHyala, MH) made of hyaluronic acid and showed that transcutaneous vaccination using MH induced a strong...

journal_title：Biomaterials

authors： Hirobe S,Azukizawa H,Hanafusa T,Matsuo K,Quan YS,Kamiyama F,Katayama I,Okada N,Nakagawa S

更新日期：2015-07-01 00:00:00

abstract：:Cell delivery in cell therapy is typically challenged by the low cell survival rate and immunological rejection during cells injection and circulation. Encapsulation of cells with semipermeable hydrogels or membranes can improve cell viability by resisting high shear force and inhibit immune response with the physical...

journal_title：Biomaterials

authors： Yang J,Yang Y,Kawazoe N,Chen G

更新日期：2019-03-01 00:00:00

abstract：:Thrombomodulin (TM) is a newly described endothelial cell associated protein that functions as a potent natural anticoagulant by converting thrombin from a procoagulant protease to an anticoagulant. In this study, the immobilization of hTM was investigated in detail using surface modified polymers. As the basis of imm...

journal_title：Biomaterials

authors： Kishida A,Ueno Y,Maruyama I,Akashi M

更新日期：1994-11-01 00:00:00

abstract：:In this study, we used deoxyribozyme (DNAzyme) functionalized gold nanoparticles (AuNPs) to catalytically silence tumor necrosis factor-α (TNF-α) in vivo as a potential therapeutic for myocardial infarction (MI). Using primary macrophages as a model, we demonstrated 50% knockdown of TNF-α, which was not attainable usi...

journal_title：Biomaterials

authors： Somasuntharam I,Yehl K,Carroll SL,Maxwell JT,Martinez MD,Che PL,Brown ME,Salaita K,Davis ME

更新日期：2016-03-01 00:00:00

abstract：:Surface properties of implanted biomaterials can cause fibrotic tissue reactions by stimulating differentiation of host fibroblasts into contractile myofibroblasts. Silk fibroin (SF) protein has been used as biomaterial in pure and blended form. however, its effect on myofibroblast differentiation remains elusive. We ...

journal_title：Biomaterials

authors： Acharya C,Hinz B,Kundu SC

更新日期：2008-12-01 00:00:00

abstract：:This work exploits the thermal responsive phase behavior of hydroxypropylcellulose to produce 3D interconnected macroporous hydrogels in aqueous environment. Hydroxypropylcellulose was modified with allyl isocyanate, and their temperature mediated phase behavior was studied as a function of degree of modification (DS)...

journal_title：Biomaterials

authors： Yue Z,Wen F,Gao S,Ang MY,Pallathadka PK,Liu L,Yu H

更新日期：2010-11-01 00:00:00

abstract：:microRNA-124 (miR-124), the most abundant miRNA of the CNS, was recently shown to modulate the polarization of activated microglia and infiltrating macrophages towards the anti-inflammatory M2 phenotype and protect neurons in various ways after brain disease. In ischemic stroke, microglia and macrophages of a detrimen...

journal_title：Biomaterials

authors： Hamzei Taj S,Kho W,Riou A,Wiedermann D,Hoehn M

更新日期：2016-06-01 00:00:00

abstract：:Gd3+-based contrast agents monopolize in the clinical MR imaging-based diagnosis of hepatic tumors, however, the inherent toxicity by the released Gd3+-ions triggered an urgent demand for safer alternatives. Here, we demonstrate hollow manganese silicate nanoparticles (HMS), which exert burst-release of Mn2+-ions by s...

journal_title：Biomaterials

authors： Kim JG,Jang MS,Kumari N,Choi JK,Im GH,Kwon T,Lee JH,Lee WJ,Lee IS

更新日期：2020-02-01 00:00:00

abstract：:Membranes of 75% and 100% benzyl hyaluronate esters (percentage of total carboxylate groups esterified) were prepared and their water vapour, oxygen and carbon dioxide transmission rates determined. The values of these properties were compared with the values obtained for several commercial wound dressings under the s...

journal_title：Biomaterials

authors： Ruiz-Cardona L,Sanzgiri YD,Benedetti LM,Stella VJ,Topp EM

更新日期：1996-08-01 00:00:00

abstract：:The purpose of this study is to analyze the roles of two non-invasive techniques, bone scintigraphy and resonance frequency analysis (RFA), in the osseointegration assessment. Sixty implants with sandblasted/acid-etched (SA) or machined (MA) surface were placed into the distal femur condyles of 30 rabbits. At 1, 2, 4,...

journal_title：Biomaterials

authors： Zhou Y,Jiang T,Qian M,Zhang X,Wang J,Shi B,Xia H,Cheng X,Wang Y

更新日期：2008-02-01 00:00:00

abstract：:The adhesion of osteoblasts to substrates is mediated through proteins that have adsorbed to the substrate, providing integrins on the cell membrane with ligands to connect to. The integrins regulate cell behavior through bi-directional signaling pathways. This critical review has the purpose to consider the research ...

journal_title：Biomaterials

authors： Siebers MC,ter Brugge PJ,Walboomers XF,Jansen JA

更新日期：2005-01-01 00:00:00

abstract：:Single-stranded oligonucleotide-conjugated lipids (ssDNA-PEG-lipids) that associate with the cell membrane confer to the cell an artificial adhesive capability via sequence-specific hybridization to complementary oligonucleotides, forming bonds of double stranded oligonucleotides (dsDNA). Such artificial tethers permi...

journal_title：Biomaterials

authors： Hoffecker IT,Takemoto N,Arima Y,Iwata H

更新日期：2015-01-01 00:00:00

abstract：:The aim of this work was to develop a new type of D-alpha-tocopheryl polyethylene glycol 1000 succinate mono-ester (TPGS) coated multi-functional (theranostic) liposomes, which contain both docetaxel and quantum dots (QDs) for cancer imaging and therapy. Non-targeting and folate receptor targeting TPGS coated theranos...

journal_title：Biomaterials

authors： Muthu MS,Kulkarni SA,Raju A,Feng SS

更新日期：2012-04-01 00:00:00

abstract：:Pancreatic cancer is predicted to be the second leading cause of cancer-related death by 2025. The best chemotherapy only extends survival by an average of 18 weeks. The extensive fibrotic stroma surrounding the tumor curbs therapeutic options as chemotherapy drugs cannot freely penetrate the tumor. RNA interference (...

journal_title：Biomaterials

authors： Kokkinos J,Ignacio RMC,Sharbeen G,Boyer C,Gonzales-Aloy E,Goldstein D,Australian Pancreatic Cancer Genome Initiative Apgi,McCarroll JA,Phillips PA

更新日期：2020-05-01 00:00:00

abstract：:Small-diameter vascular grafts made of biomedical polytetrafluoroethylene (PTFE) suffer from the poor long-term patency rate originating from thrombosis and intimal hyperplasia, which can be ascribed to the insufficient endothelialization and chronic inflammation of the materials. Hence, bio-functionalization of PTFE ...

journal_title：Biomaterials

authors： Gao A,Hang R,Li W,Zhang W,Li P,Wang G,Bai L,Yu XF,Wang H,Tong L,Chu PK

更新日期：2017-09-01 00:00:00

abstract：:Controlled delivery of bioactive molecules to modulate or control biological processes has a number of clinical applications. The present study reports a delivery system which was designed to deliver growth factors locally to a fracture site. Ethylene vinyl acetate copolymer (EVAc), bovine serum albumin (BSA) and plat...

journal_title：Biomaterials

authors： Walsh WR,Kim HD,Jong YS,Valentini RF

更新日期：1995-11-01 00:00:00

abstract：:Water uptake characteristics of BisGMA-based composites incorporating untreated and surface-treated hydroxyapatite (HA) with a silane coupling agent have been investigated. The water absorption and desorption behaviour of these composites obeyed the classical diffusion theory. The diffusion coefficients of the composi...

journal_title：Biomaterials

authors： Santos C,Clarke RL,Braden M,Guitian F,Davy KW

更新日期：2002-04-01 00:00:00

abstract：:We have designed a dual-aptamer complex specific to both prostate-specific membrane antigens (PSMA) (+) and (-) prostate cancer cells. In the complex, an A10 RNA aptamer targeting PSMA (+) cells and a DUP-1 peptide aptamer specific to PSMA (-) cells were conjugated through streptavidin. Doxorubicin-loaded onto the ste...

journal_title：Biomaterials

authors： Min K,Jo H,Song K,Cho M,Chun YS,Jon S,Kim WJ,Ban C

更新日期：2011-03-01 00:00:00

abstract：:Degradable poly(anhydride ester) implants in which the polymer backbone breaks down into salicylic acid (SA) were investigated. In this preliminary work, local release of SA from the poly(anhydride esters), thus classified as 'active polymers', on healthy bone and tissue was evaluated in vivo using a mouse model. Degr...

journal_title：Biomaterials

authors： Erdmann L,Macedo B,Uhrich KE

更新日期：2000-12-01 00:00:00

abstract：:Novel collagen scaffolds possessing predefined and reproducible internal channels with widths of 135 microm and greater have been produced. The process employed to make the collagen scaffold utilises a sacrificial mould, manufactured using solid freeform fabrication technology, and critical point drying technique. A c...

journal_title：Biomaterials

authors： Sachlos E,Reis N,Ainsley C,Derby B,Czernuszka JT

更新日期：2003-04-01 00:00:00

abstract：:The incidence of Parkinson's disease (PD), the second most common neurodegenerative disorder, has increased exponentially as the global population continues to age. Although the etiological factors contributing to PD remain uncertain, its average incidence rate is reported to be 1% of the global population older than ...

journal_title：Biomaterials

authors： Karthivashan G,Ganesan P,Park SY,Lee HW,Choi DK

更新日期：2020-02-01 00:00:00

abstract：:Characterization of complex adsorbed protein films is a critical aspect of biomaterials science, particularly in understanding the in vivo response to biomaterials. The surface analysis techniques electron spectroscopy for chemical analysis (ESCA) and time-of-flight secondary ion mass spectrometry (ToF-SIMS) are parti...

journal_title：Biomaterials

authors： Wagner MS,Horbett TA,Castner DG

更新日期：2003-05-01 00:00:00

abstract：:There are many ways to influence cell activities, and biomaterials with functional groups attached is an attractive method that clearly has the ability to modulate cell behavior. The evidence is clear that biomaterials, with or without growth factors and cells, have resulted in numerous products for the regenerative m...

journal_title：Biomaterials

authors： Ratcliffe A

更新日期：2011-06-01 00:00:00

abstract：:Demineralised bone matrix (DBM) is a form of allogeneic tissue graft widely used in oral and maxillofacial procedures. There is a long history of controversy relating to the suitability of ethylene oxide gas (EtOx) as a terminal sterilisation agent for this graft, relating to its effects on the clinical performance of...

journal_title：Biomaterials

authors： Lomas RJ,Gillan HL,Matthews JB,Ingham E,Kearney JN

更新日期：2001-05-01 00:00:00

abstract：:Because tissues are characterized by a well-defined three-dimensional arrangement of cells, tissue engineering scaffolds that facilitate the organization and differentiation of new tissue will have improved performance in comparison to scaffolds that only provide surfaces for cell attachment and growth. We hypothesize...

journal_title：Biomaterials

authors： Koegler WS,Griffith LG

更新日期：2004-06-01 00:00:00

abstract：:Titiania nanotubes have large potential in medical implant applications but their tissue compatibility is still controversial. Since the sterilization methods may impact the biocompatibility of titania nanotubes and be the source of the controversy, we investigate the influence of three commonly used sterilization met...

journal_title：Biomaterials

authors： Zhao L,Mei S,Wang W,Chu PK,Wu Z,Zhang Y

更新日期：2010-03-01 00:00:00

abstract：:Temperature-responsive polymers are attractive candidates for applications related to injectable delivery of biologically active therapeutics, such as stem cells. In this study, we evaluate the potential of thermosensitive hydroxybutyl chitosan (HBC) as a biomaterial for the culture of human mesenchymal stem cells (hM...

journal_title：Biomaterials

authors： Dang JM,Sun DD,Shin-Ya Y,Sieber AN,Kostuik JP,Leong KW

更新日期：2006-01-01 00:00:00

abstract：:Culture of seeded osteoblastic cells in three-dimensional osteoconductive scaffolds in vitro is a promising approach to produce an osteoinductive material for repair of bone defects. However, culture of cells in scaffolds sufficiently large to bridge critical-sized defects is a challenge for tissue engineers. Diffusio...

journal_title：Biomaterials

authors： Goldstein AS,Juarez TM,Helmke CD,Gustin MC,Mikos AG

更新日期：2001-06-01 00:00:00