Abstract：
:Thrombomodulin (TM) is a newly described endothelial cell associated protein that functions as a potent natural anticoagulant by converting thrombin from a procoagulant protease to an anticoagulant. In this study, the immobilization of hTM was investigated in detail using surface modified polymers. As the basis of immobilization, poly(acrylic acid) (PAAc) surface-grafted poly(ethylene) (PAAc-g-PE) film was used with the expectation of increasing the immobilization amount of hTM. The effect of the immobilization reaction on the hTM activities, and the comparison of the activities of the immobilized hTM with the free hTM, were studied.
journal_name
Biomaterialsjournal_title
Biomaterialsauthors
Kishida A,Ueno Y,Maruyama I,Akashi Mdoi
10.1016/0142-9612(94)90238-0subject
Has Abstractpub_date
1994-11-01 00:00:00pages
1170-4issue
14eissn
0142-9612issn
1878-5905pii
0142-9612(94)90238-0journal_volume
15pub_type
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