Abstract:
:Adoptive cell transfer of targeted chimeric antigen receptor (CAR) T cells has emerged as a highly promising cancer therapy. The pharmacodynamic action or CAR T cells is closely related to their pharmacokinetic profile; because of this as well as the risk of non-specific action, it is important to monitor their biodistribution and fate following infusion. To this end, we developed a dual-modal PET/near infrared fluorescent (NIRF) nanoparticle-based imaging agent for non-genomic labeling of human CAR T cells. Since the PET/NIRF nanoparticles did not affect cell viability or cytotoxic functionality and enabled long-term whole-body CAR T cell tracking using PET and NIRF in an ovarian peritoneal carcinomatosis model, this platform is a viable imaging technology to be applied in other cancer models.
journal_name
Biomaterialsjournal_title
Biomaterialsauthors
Harmsen S,Medine EI,Moroz M,Nurili F,Lobo J,Dong Y,Turkekul M,Pillarsetty NVK,Ting R,Ponomarev V,Akin O,Aras Odoi
10.1016/j.biomaterials.2020.120630subject
Has Abstractpub_date
2020-12-23 00:00:00pages
120630eissn
0142-9612issn
1878-5905pii
S0142-9612(20)30877-2journal_volume
269pub_type
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