Creating polymer hydrogel microfibres with internal alignment via electrical and mechanical stretching.

abstract：:The majority of epithelia in our organism perform barrier functions on being exposed to different fluids at the luminal and basal sides. To simulate this natural situation under in vitro conditions for biomaterial testing and tissue engineering the epithelia have to withstand mechanical and fluid stress over a prolong...

journal_title：Biomaterials

authors： Schumacher K,Strehl R,de VU,Minuth WW

更新日期：2002-02-01 00:00:00

abstract：:Tissue engineering strategies for repairing and regenerating articular cartilage face critical challenges to recapitulate the dynamic and complex biochemical microenvironment of native tissues. One approach to mimic the biochemical complexity of articular cartilage is through the use of recombinant bacterial collagens...

journal_title：Biomaterials

authors： Parmar PA,Skaalure SC,Chow LW,St-Pierre JP,Stoichevska V,Peng YY,Werkmeister JA,Ramshaw JA,Stevens MM

更新日期：2016-08-01 00:00:00

abstract：:Nitric oxide is a cell signaling molecule that can be a potent inducer of cell death in cancers at elevated concentrations. However, NO is also toxic to normal tissues and chronic exposure at low levels can induce tumor growth. We have designed a polymeric carrier system to deliver nitric oxide locoregionally to tumor...

journal_title：Biomaterials

authors： Duan S,Cai S,Yang Q,Forrest ML

更新日期：2012-04-01 00:00:00

abstract：:The dynamic regulation of integrin-binding peptides is crucial for chondrogenic differentiation. Here, we revealed the feasibility for flexible modification of RGD by embedding a large molecular weight and slightly charged (isoelectric point, 6-6.25) RGD-chimeric protein (CBD-RGD) with cellulose-binding domain (CBD) i...

journal_title：Biomaterials

authors： Chang JC,Hsu SH,Chen DC

更新日期：2009-10-01 00:00:00

abstract：:The immobilization of cells within alginate-poly-l-lysine-alginate (APA) microcapsules has been demonstrated to be an effective technology design for long term delivery of therapeutic products. Despite promising advances, biosafety aspects still remain to be improved. Here, we describe a complete characterization of t...

journal_title：Biomaterials

authors： Santos E,Larzabal L,Calvo A,Orive G,Pedraz JL,Hernández RM

更新日期：2013-01-01 00:00:00

abstract：:Micro-computed tomography (micro-CT) is an emerging imaging modality, due to the low cost of the imagers as well as their efficiency in establishing high-resolution (1-100 μm) three-dimensional images of small laboratory animals and facilitating rapid, structural and functional in vivo visualization. However use of a ...

journal_title：Biomaterials

authors： Li X,Anton N,Zuber G,Zhao M,Messaddeq N,Hallouard F,Fessi H,Vandamme TF

更新日期：2013-01-01 00:00:00

abstract：:Conventional amputation prosthetics are problematic because they rely on the stump-socket interface for attachment. Intraosseous transcutaneous amputation prostheses (ITAP) could solve these problems; however they rely on the integrity of the soft tissue-implant interface as a barrier to exogenous agents, and in the p...

journal_title：Biomaterials

authors： Pendegrass CJ,Goodship AE,Blunn GW

更新日期：2006-08-01 00:00:00

abstract：:Local signals from tissue-specific extracellular matrix (ECM) microenvironments, including matrix adhesive ligand, mechanical elasticity and micro-scale geometry, are known to instruct a variety of stem cell differentiation processes. Likewise, these signals converge to provide multifaceted, mechanochemical cues for h...

journal_title：Biomaterials

authors： Floren M,Tan W

更新日期：2015-08-01 00:00:00

abstract：:Given that vascular endothelial growth factor (VEGF) and placental growth factor (PIGF), over-expressed in breast cancer cells and M2-like tumor-associated macrophages (M2-TAMs) within tumor microenvironment (TME), work synergistically and independently in mediating tumor progression and immunosuppression, combinatori...

journal_title：Biomaterials

authors： Song Y,Tang C,Yin C

更新日期：2018-12-01 00:00:00

abstract：:Dual-functional liposomes with pH-responsive cell-penetrating peptide (CPP) and active targeting hyaluronic acid (HA) were fabricated for tumor-targeted drug delivery. A series of synthetic tumor pH-triggered CPPs rich in arginines and histidines were screened by comparing tumor cellular uptake efficiency at pH 6.4 wi...

journal_title：Biomaterials

authors： Jiang T,Zhang Z,Zhang Y,Lv H,Zhou J,Li C,Hou L,Zhang Q

更新日期：2012-12-01 00:00:00

abstract：:The development of electrospun ultrafine fibres from biodegradable and biocompatible polymers has created exciting opportunities for biomedical applications. Fibre meshes with high surface area, suitable porosity and stiffness have been produced. Despite desirable structural and topographical properties, for most synt...

journal_title：Biomaterials

authors： Duque Sánchez L,Brack N,Postma A,Pigram PJ,Meagher L

更新日期：2016-11-01 00:00:00

abstract：:This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy. ...

journal_title：Biomaterials

authors： Kyle S,McPherson MJ,Aggeli A,Ingham E

更新日期：2011-07-01 00:00:00

abstract：:Engineered nanomaterials are known to exhibit diverse and sometimes unexpected biological effects. Fullerene nanoparticles have been reported to specifically bind to and elicit persistent activation of hippocampal Ca(2+)/calmodulin-dependent protein kinase II (CaMKII), a multimeric intracellular serine/threonine kinas...

journal_title：Biomaterials

authors： Chen L,Miao Y,Chen L,Xu J,Wang X,Zhao H,Shen Y,Hu Y,Bian Y,Shen Y,Chen J,Zha Y,Wen LP,Wang M

更新日期：2014-11-01 00:00:00

abstract：:Pancreatic islet transplantation is one of the most promising strategies for patients suffering from type 1 diabetes mellitus, but several therapeutic immunosuppressive medications must be administered simultaneously to protect transplanted islets in the long-term, and these expose patients to the risk of serious comp...

journal_title：Biomaterials

authors： Yun Lee D,Hee Nam J,Byun Y

更新日期：2007-04-01 00:00:00

abstract：:There is extensive experimental and surgical experience with the use of bone tissue to fill defects in the skeleton, to bridge non-union sites, and to pack defects in bone created from cyst curettage. DP-bioactive glass with a chemical composition of Na2O 8.4%, SiO2 39.6%, P2O5 12% and CaO 40% has been reported as an ...

journal_title：Biomaterials

authors： Lin FH,Lin CC,Liu HC,Huang YY,Wang CY,Lu CM

更新日期：1994-10-01 00:00:00

abstract：:Osteoarthritis (OA) is a progressively degenerative disease that is accompanied by articular cartilage deterioration, sclerosis of the underlying bone and ultimately joint destruction. Although therapeutic medicine and surgical treatment are done to alleviate the symptoms of OA, it is difficult to restore normal carti...

journal_title：Biomaterials

authors： Kim SJ,Kim JE,Kim SH,Kim SJ,Jeon SJ,Kim SH,Jung Y

更新日期：2016-01-01 00:00:00

abstract：:Development of biochips containing living cells for biodetection, drug screening and tissue engineering applications is limited by a lack of reconfigurable material interfaces and actuators. Here we describe a new class of nanostructured magnetizable materials created with a femtosecond laser surface etching technique...

journal_title：Biomaterials

authors： Polte TR,Shen M,Karavitis J,Montoya M,Pendse J,Xia S,Mazur E,Ingber DE

更新日期：2007-06-01 00:00:00

abstract：:Melanoma inhibitory activity (MIA), also referred to as cartilage derived retinoic acid-sensitive protein (CD-RAP), is detected physiologically in cartilage tissue and pathologically in malignant melanomas. To measure MIA/CD-RAP quantitatively we developed a sensitive ELISA system. Recently, we described diagnostic ap...

journal_title：Biomaterials

authors： Bosserhoff AK,Buettner R

更新日期：2003-08-01 00:00:00

abstract：:Multilayer nanofilms, formed by the layer-by-layer (LbL) adsorption of positively and negatively charged polyelectrolytes, are promising substrates for tissue engineering. We investigate here the attachment and function of hepatic cells on multilayer films in terms of film composition, terminal layer, rigidity, charge...

journal_title：Biomaterials

authors： Wittmer CR,Phelps JA,Lepus CM,Saltzman WM,Harding MJ,Van Tassel PR

更新日期：2008-10-01 00:00:00

abstract：:The aim of this study was to characterize a nasally delivered bioadhesive liposome using an inactivated H5N3 virus as a model antigen. Bioadhesive liposomes were developed using tremella (T) or xanthan gum (XG) as the bioadhesive polysaccharide. Using chickens as the target animal, we evaluated whether delivery of a b...

journal_title：Biomaterials

authors： Chiou CJ,Tseng LP,Deng MC,Jiang PR,Tasi SL,Chung TW,Huang YY,Liu DZ

更新日期：2009-10-01 00:00:00

abstract：:Wounded tissues and cells may be treated with growth factors and specific genes for the purpose of tissue repair and regeneration. To deliver specific genes into tissues and cells, this study presents the use of fabricated poly (DL-lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) complexed with the cationic polymer...

journal_title：Biomaterials

authors： Park JS,Yang HN,Woo DG,Jeon SY,Park KH

更新日期：2013-01-01 00:00:00

abstract：:Tetragonal zirconia polycrystal (TZP) is a new interesting ceramic for the manufacture of medical devices. Its wide use in orthopedic and odontoiatric implants was limited till now by the high chemical and radiochemical impurities of the raw materials. Purification processes now available allow to obtain high purity c...

journal_title：Biomaterials

authors： Covacci V,Bruzzese N,Maccauro G,Andreassi C,Ricci GA,Piconi C,Marmo E,Burger W,Cittadini A

更新日期：1999-02-01 00:00:00

abstract：:A cross-linking method for collagen-based biomaterials was developed using the water-soluble carbodiimide 1-ethyl-3-(3-dimethyl aminopropyl)carbodiimide hydrochloride (EDC). Cross-linking using EDC involves the activation of carboxylic acid groups to give O-acylisourea groups, which form cross-links after reaction wit...

journal_title：Biomaterials

authors： Olde Damink LH,Dijkstra PJ,van Luyn MJ,van Wachem PB,Nieuwenhuis P,Feijen J

更新日期：1996-04-01 00:00:00

abstract：:Restoration of tissue integrity and tissue function of wounded skin are both essential for wound repair and regeneration, while synergistic promotion of the two remains elusive. Since elevated reactive oxygen species (ROS) production in the injured site has been implicated in triggering a set of deleterious effects su...

journal_title：Biomaterials

authors： Wu H,Li F,Wang S,Lu J,Li J,Du Y,Sun X,Chen X,Gao J,Ling D

更新日期：2018-01-01 00:00:00

abstract：:Control of the precise location and extent of cellular attachment and proliferation, and of tissue outgrowth is important in a number of biomedical applications, including biomaterials and tissue engineered medical devices. Here we describe a method to control and direct the location and define boundaries of tissue gr...

journal_title：Biomaterials

authors： Thissen H,Johnson G,Hartley PG,Kingshott P,Griesser HJ

更新日期：2006-01-01 00:00:00

abstract：:A amphiphilic block copolymer composed of conventional monomethoxy (polyethylene glycol)-poly (d,l-lactide-co-glycolide)-poly (l-lysine) (mPEG-PLGA-b-PLL) was synthesized. The chemical structure of this copolymer and its precursors was confirmed by Fourier Transform Infrared Spectroscopy (FTIR), (1)H Nuclear Magnetic ...

journal_title：Biomaterials

authors： Liu P,Yu H,Sun Y,Zhu M,Duan Y

更新日期：2012-06-01 00:00:00

abstract：:Parkinson's disease (PD) is one of the most common neurodegenerative diseases. Activins are members of the superfamily of transforming growth factors and have many potential neuroprotective effects. Herein, at the first place, we verified activin B's neuroprotective role in a PD model, and revealed that activin B's fa...

journal_title：Biomaterials

authors： Li J,Darabi M,Gu J,Shi J,Xue J,Huang L,Liu Y,Zhang L,Liu N,Zhong W,Zhang L,Xing M,Zhang L

更新日期：2016-09-01 00:00:00

abstract：:The objective of this study was to investigate the adhesion, spreading and extracellular matrix synthesis of temporomandibular joint (TMJ) derived cells on non-absorbable scaffold materials to ultimately provide a durable stress-absorbent framework within tissue-engineered disc transplants. Scaffolds were prepared by ...

journal_title：Biomaterials

authors： Springer IN,Fleiner B,Jepsen S,Açil Y

更新日期：2001-09-01 00:00:00

abstract：:The goal of this research was to design thermosensitive drug vehicles for glaucoma therapy. Thermosensitive ophthalmic drop was prepared by mixing linear poly(N-isopropylacrylamide-g-2-hydroxyethyl methacrylate) (PNIPAAm-g-PHEMA), PNIPAAm-g-PHEMA gel particles and antiglaucoma drug. This produced polymeric eyedrop con...

journal_title：Biomaterials

authors： Hsiue GH,Chang RW,Wang CH,Lee SH

更新日期：2003-06-01 00:00:00

abstract：:Platinum nanoparticle-doped chitosan (CHIT) solution can be easily prepared by treating the CHIT solution with aqueous H2PtCl6 solution followed by chemical reduction of Pt(IV) with NaBH4. Multiwalled carbon nanotubes (MWCNT) are then dispersed in the nanoparticle-doped solution. The resulting Pt-CNT-CHIT material bri...

journal_title：Biomaterials

authors： Yang M,Yang Y,Yang H,Shen G,Yu R

更新日期：2006-01-01 00:00:00