Three-dimensional, soft neotissue arrays as high throughput platforms for the interrogation of engineered tissue environments.

abstract：:The ability of different calcium phosphate to activate the complement system is studied by crossed immunoelectrophoresis demonstrating conversion of C3 to C3b. Complement consumption is determined by a haemolytic assay CH50. Hydroxyapatite powders after sintering induce a significant conversion of C3 and reduction of ...

journal_title：Biomaterials

authors： Klein CP,de Groot K,van Kamp G

更新日期：1983-07-01 00:00:00

abstract：:6-O-Carboxymethylchitin (CM-chitin) was partially deacetylated by alkaline treatment, and the 30% deacetylated product was named CM-DA30 and used for the preparation of microspheres. An aqueous solution of CM-DA30 was added to hexane containing 1% (w/w) sorbitan sesquioleate and emulsified by stirring and sonication, ...

journal_title：Biomaterials

authors： Hata H,Onishi H,Machida Y

更新日期：2000-09-01 00:00:00

abstract：:This article is a review of recent developments of polymer-related stents mainly employed in the coronary arteries, including polymer-coated stents, biostable stents and biodegradable stents. Polymer paving is covered as well. The problems with the stents currently investigated and the development of new stents are di...

journal_title：Biomaterials

authors： Peng T,Gibula P,Yao KD,Goosen MF

更新日期：1996-04-01 00:00:00

abstract：:The human heart cannot regenerate after an injury. Lost cardiomyocytes are replaced by scar tissue resulting in reduced cardiac function causing high morbidity and mortality. One possible solution to this problem is cardiac tissue engineering. Here, we have investigated the suitability of non-mulberry silk protein fib...

journal_title：Biomaterials

authors： Patra C,Talukdar S,Novoyatleva T,Velagala SR,Mühlfeld C,Kundu B,Kundu SC,Engel FB

更新日期：2012-03-01 00:00:00

abstract：:To evaluate the biocompatibility of chemically and structurally modified polyurethane elastomers for use as blood vessel replacements, small squares of vascular prostheses were cultured in direct contact with endothelium from chick embryo aorta using an organotypic culture assay. The polyurethane materials tested were...

journal_title：Biomaterials

authors： Guidoin R,Sigot M,King M,Sigot-Luizard MF

更新日期：1992-01-01 00:00:00

abstract：:pH-sensitive degradable chimaeric polymersomes were developed based on asymmetric poly(ethylene glycol)-b-poly(2,4,6-trimethoxybenzylidene-1,1,1-tris(hydroxymethyl)ethane methacrylate)-b-poly(acrylic acid) (PEG-PTTMA-PAA) triblock copolymers for active loading as well as triggered intracellular release of hydrophilic ...

journal_title：Biomaterials

authors： Du Y,Chen W,Zheng M,Meng F,Zhong Z

更新日期：2012-10-01 00:00:00

abstract：:Inspired by nature's toughening mechanisms, we designed a new polyhedral oligomeric silsesquioxane (POSS)-derived hybrid glass (PHG) that has covalent interactions on the molecular scale between the inorganic POSS cage and organic phase. These features allow "elastic deformation" of the inorganic POSS cage in limited ...

journal_title：Biomaterials

authors： Zhou X,Sahai N,Qi L,Mankoci S,Zhao W

更新日期：2015-05-01 00:00:00

abstract：:The anterior cruciate ligament (ACL) is the most commonly injured intra-articular ligament of the knee, and limitations in existing reconstruction grafts have prompted an interest in tissue engineered solutions. Previously, we reported on a tissue-engineered ACL scaffold fabricated using a novel, three-dimensional bra...

journal_title：Biomaterials

authors： Lu HH,Cooper JA Jr,Manuel S,Freeman JW,Attawia MA,Ko FK,Laurencin CT

更新日期：2005-08-01 00:00:00

abstract：:Nanoparticle-induced endothelial cell (EC) dysfunction, due to the induction of inflammation and/or the activation of the coagulation system, is associated with pulmonary and ischemic cardiovascular diseases. Although it is contigent on several mechanisms, involving formation of reactive oxygen species and inflammator...

journal_title：Biomaterials

authors： Bauer AT,Strozyk EA,Gorzelanny C,Westerhausen C,Desch A,Schneider MF,Schneider SW

更新日期：2011-11-01 00:00:00

abstract：:For chronic non-viral gene therapy, biodegradable carriers with low cytotoxicity are essential. To create a series of non-toxic and biodegradable gene carriers, hyperbranched polymers based on 2,2-bis-(methylol)propionic acid (bis-MPA); (Boltorn H) were modified by introducing tertiary amines. The terminal OH groups w...

journal_title：Biomaterials

authors： Reul R,Nguyen J,Kissel T

更新日期：2009-10-01 00:00:00

abstract：:It is well known that biomaterials play an important role in the regulation of adhesion and growth of a variety of cultured cell types. However, whether biomaterials are associated with the senescence of cultured cells is not known. The present work shows that the decrease of the hydrophobic property of poly (ethylene...

journal_title：Biomaterials

authors： Lou PJ,Chiu MY,Chou CC,Liao BW,Young TH

更新日期：2010-03-01 00:00:00

abstract：:Glioblastoma multiforme (GBM) is among the most aggressive cancers associated with massive infiltration of peritumoral parenchyma by migrating tumor cells. The infiltrative nature of GBM cells, the intratumoral heterogeneity concomitant with redundant signaling pathways likely underlie the inability of conventional an...

journal_title：Biomaterials

authors： Cosset E,Petty T,Dutoit V,Tirefort D,Otten-Hernandez P,Farinelli L,Dietrich PY,Preynat-Seauve O

更新日期：2016-11-01 00:00:00

abstract：:The ability to influence the direction of polymerization of a self-assembling biomolecular system has the potential to generate materials with extremely high anisotropy. In biological systems where highly-oriented cellular populations give rise to aligned and often load-bearing tissue such organized molecular scaffold...

journal_title：Biomaterials

authors： Saeidi N,Sander EA,Ruberti JW

更新日期：2009-12-01 00:00:00

abstract：:Dextran derivatives are biosynthetic polyanionic polymers which exert some of the heparin properties such as regulating the activity of several heparin-binding growth factors. Based on a reproducible synthetic procedure, we have synthesized a new generation of dextran derivatives named dextran methylcarboxylate benzyl...

journal_title：Biomaterials

authors： Vercoutter-Edouart AS,Dubreucq G,Vanhoecke B,Rigaut C,Renaux F,Dahri-Correia L,Lemoine J,Bracke M,Michalski JC,Correia J

更新日期：2008-05-01 00:00:00

abstract：:Isostatic compression has rarely been used to load calcium-phosphate biomaterials with therapeutic agents. This report, concerning four processes associating vancomycin, compares isostatic compression with wet granulation, a classical method. In the wet granulation study, vancomycin was associated with biphasic calciu...

journal_title：Biomaterials

authors： Gautier H,Merle C,Auget JL,Daculsi G

更新日期：2000-02-01 00:00:00

abstract：:Controlling cell orientation and morphology through topographical patterning is a phenomenon that is applicable to a wide variety of medical applications such as implants and tissue engineering scaffolds. Previous work in this field, termed contact guidance, has demonstrated the application of this cellular response o...

journal_title：Biomaterials

authors： Bettinger CJ,Orrick B,Misra A,Langer R,Borenstein JT

更新日期：2006-04-01 00:00:00

abstract：:The goal of this research was to design thermosensitive drug vehicles for glaucoma therapy. Thermosensitive ophthalmic drop was prepared by mixing linear poly(N-isopropylacrylamide-g-2-hydroxyethyl methacrylate) (PNIPAAm-g-PHEMA), PNIPAAm-g-PHEMA gel particles and antiglaucoma drug. This produced polymeric eyedrop con...

journal_title：Biomaterials

authors： Hsiue GH,Chang RW,Wang CH,Lee SH

更新日期：2003-06-01 00:00:00

abstract：:Human (h) pluripotent stem cells (PSC) such as embryonic stem cells (ESC) can be directed into cardiomyocytes (CMs), representing a potential unlimited cell source for disease modeling, cardiotoxicity screening and myocardial repair. Although the electrophysiology of single hESC-CMs is now better defined, their multi-...

journal_title：Biomaterials

authors： Wang J,Chen A,Lieu DK,Karakikes I,Chen G,Keung W,Chan CW,Hajjar RJ,Costa KD,Khine M,Li RA

更新日期：2013-11-01 00:00:00

abstract：:It is known that the organic molecules can provide an effective means to manipulate the surface properties of the biodegradable ceramic. There are two ways to modify the surface of the biodegradable ceramic by organic molecules. The first one is through surface adsorption but organic molecules will easily be washed ou...

journal_title：Biomaterials

authors： Dong GC,Sun JS,Yao CH,Jiang GJ,Huang CW,Lin FH

更新日期：2001-12-01 00:00:00

abstract：:Block copolymer prodrugs (BCPs) have attracted considerable attentions in clinical translation of nanomedicine owing to their self-assembly into well-defined core-shell nanoparticles for improved pharmacokinetics, stability in blood circulation without drug leakage, and optimized biodistribution. However, a cascade of...

journal_title：Biomaterials

authors： Ke W,Yin W,Zha Z,Mukerabigwi JF,Chen W,Wang Y,He C,Ge Z

更新日期：2018-02-01 00:00:00

abstract：:The present study provides in vivo trials of silicone rubber chambers filled with different concentrations of bilobalide (0, 50, 100, 200, 400 microM) to bridge a 15 mm sciatic nerve defect in rats. Collagen was also filled in the chambers to prevent the bilobalide from leakage. Histological and electrophysiological t...

journal_title：Biomaterials

authors： Chen YS,Liu CJ,Cheng CY,Yao CH

更新日期：2004-02-01 00:00:00

abstract：:Construction of biodegradable, three-dimensional scaffolds for tissue engineering has been previously described using a variety of molding and rapid prototyping techniques. In this study, we report and compare two methods for fabricating poly(DL-lactide-co-glycolide) (PLGA) scaffolds with feature sizes of approximatel...

journal_title：Biomaterials

authors： Vozzi G,Flaim C,Ahluwalia A,Bhatia S

更新日期：2003-06-01 00:00:00

abstract：:Recent advances in efficient microRNA (miRNA) delivery techniques using brain-targeted nanoparticles offer critical information for understanding the functional role of miRNAs in vivo, and for supporting targeted gene therapy in terms of treating miRNA-associated neurological diseases. Here, we report the rabies virus...

journal_title：Biomaterials

authors： Hwang DW,Son S,Jang J,Youn H,Lee S,Lee D,Lee YS,Jeong JM,Kim WJ,Lee DS

更新日期：2011-07-01 00:00:00

abstract：:Quinacrine and related heterocyclic compounds have antiprion activity. Since the infectious pathogen of prion diseases is composed of multimeric PrP(Sc) assemblies, we hypothesized that this antiprion property could be enhanced by attaching multiple quinacrine-derived chloroquinoline or acridine moieties to a scaffold...

journal_title：Biomaterials

authors： Mays CE,Joy S,Li L,Yu L,Genovesi S,West FG,Westaway D

更新日期：2012-10-01 00:00:00

abstract：:Infection constitutes a major risk for implant failure, but the reasons why biomaterial sites are more vulnerable than normal tissue are not fully elucidated. In this study, a soft tissue infection model was developed, allowing the analysis of cellular and molecular responses in each of the sub-compartments of the imp...

journal_title：Biomaterials

authors： Svensson S,Trobos M,Hoffman M,Norlindh B,Petronis S,Lausmaa J,Suska F,Thomsen P

更新日期：2015-02-01 00:00:00

abstract：:Transcutaneous immunization (TCI) is an attractive vaccination method compared with conventional injectable vaccines because it is easier to administer without pain. We developed a dissolving microneedle patch (MicroHyala, MH) made of hyaluronic acid and showed that transcutaneous vaccination using MH induced a strong...

journal_title：Biomaterials

authors： Hirobe S,Azukizawa H,Hanafusa T,Matsuo K,Quan YS,Kamiyama F,Katayama I,Okada N,Nakagawa S

更新日期：2015-07-01 00:00:00

abstract：:Checkpoint blocking antibodies that interfere in the PD-1/PD-L1 axis provide effective cancer immunotherapy for tumors that are immune inflamed or induced to become "hot". It has also been demonstrated that a small molecule inhibitor of the signaling hub kinase GSK3 can interfere in the PD-1/PD-L1 axis in T-cells by s...

journal_title：Biomaterials

authors： Allen SD,Liu X,Jiang J,Liao YP,Chang CH,Nel AE,Meng H

更新日期：2020-12-28 00:00:00

abstract：:Chronic implantation of microelectrodes into the cortex has been shown to lead to inflammatory gliosis and neuronal loss in the microenvironment immediately surrounding the probe, a hypothesized cause of neural recording failure. Caspase-1 (aka Interleukin 1β converting enzyme) is known to play a key role in both infl...

journal_title：Biomaterials

authors： Kozai TD,Li X,Bodily LM,Caparosa EM,Zenonos GA,Carlisle DL,Friedlander RM,Cui XT

更新日期：2014-12-01 00:00:00

abstract：:Plaque-induced lesions can produce peri-implant bone loss with ultimate implant loss. Although the peri-implant tissues seem to be more resistant than the periodontal ones to plaque and calculus, they can produce a more extensive spread of the infection to the deeper tissues around implants. The case of a 45-year-old ...

journal_title：Biomaterials

authors： Piattelli A,Cosci F,Scarano A,Trisi P

更新日期：1995-08-01 00:00:00

abstract：:The N-terminal 200 amino acid residues of topoisomerase I (TopoN) is highly positive in charge and has DNA binding activity, without DNA sequence and topological specificity. Here, a fusion protein (6 x His-PTD-TopoN) containing a hexahistidine (6 x His) tag, a membrane penetration domain and TopoN (amino acid 3-200) ...

journal_title：Biomaterials

authors： Chen YA,Kuo HC,Chen YM,Huang SY,Liu YR,Lin SC,Yang HL,Chen TY

更新日期：2011-06-01 00:00:00