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Development of in situ thermosensitive drug vehicles for glaucoma therapy.

Abstract：

:The goal of this research was to design thermosensitive drug vehicles for glaucoma therapy. Thermosensitive ophthalmic drop was prepared by mixing linear poly(N-isopropylacrylamide-g-2-hydroxyethyl methacrylate) (PNIPAAm-g-PHEMA), PNIPAAm-g-PHEMA gel particles and antiglaucoma drug. This produced polymeric eyedrop containing the drug epinephrine was a clear solution at room temperature which became a soft film after contacting the surface of cornea. The drug entrapped within the tangled polymer chains was therefore released progressively after topical application. Evaluation of the drug release responded as a function of crosslinking density and PHEMA macromer contents. The in vivo studies indicated that the intraocular pressure (IOP)-lowering effect for a polymeric eyedrop lasted for 26 h, which is significantly better than the effect of traditional eyedrop (8 h). Hence our investigations successfully prove that the thermosensitive polymeric eyedrop with ability of controlled drug release exhibits a greater potential for glaucoma therapy.

journal_name

Biomaterials

journal_title

Biomaterials

authors

Hsiue GH,Chang RW,Wang CH,Lee SH

doi

10.1016/s0142-9612(03)00035-8

keywords:

subject

Has Abstract

pub_date

2003-06-01 00:00:00

pages

2423-30

issue

13

eissn

0142-9612

issn

1878-5905

pii

S0142961203000358

journal_volume

24

pub_type

杂志文章

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