Preparation of poly(ethylene glycol)-polystyrene block copolymers using photochemistry of dithiocarbamate as a reduced cell-adhesive coating material.

abstract：:In the design of parenteral delivery systems the modulation of the biodegradation of a polymer matrix represents a promising strategy to control drug release. We have investigated the degradation of ABA triblock copolymers, consisting of poly(lactide-co-glycolide) A-blocks and poly(oxyethylene) B-blocks, and PLG, poly...

journal_title：Biomaterials

authors： Witt C,Mäder K,Kissel T

更新日期：2000-05-01 00:00:00

abstract：:Mucus layer coating the vaginal epithelium represents a barrier for intravaginally delivered recombined adenoviral (rAd) vectors, but it could be overcome by proper polyethylene glycol (PEG) modification. Here we synthesized two cationic PEG derivatives, amino-(EO)n/(AGE)m-Cyss (APCs). The polymers contained neutral l...

journal_title：Biomaterials

authors： Xie Z,Ji Z,Zhang Z,Gong T,Sun X

更新日期：2014-09-01 00:00:00

abstract：:A class of designed self-assembling peptide nanofiber scaffolds with more than 99% water content has been shown to be a good biological material for cell culture. Here, we report the functionalization of one of these peptide scaffolds, RAD16-I (AcN-RADARADARADARADA-CONH2), by direct solid phase synthesis extension at ...

journal_title：Biomaterials

authors： Genové E,Shen C,Zhang S,Semino CE

更新日期：2005-06-01 00:00:00

abstract：:Riboflavin (Rf) and its metabolic analogs flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD) are essential for normal cellular growth and function. Their intracellular transport is regulated by the riboflavin carrier protein (RCP), which has been shown to be over-expressed by metabolically active cancer...

journal_title：Biomaterials

authors： Jayapaul J,Arns S,Lederle W,Lammers T,Comba P,Gätjens J,Kiessling F

更新日期：2012-12-01 00:00:00

abstract：:Inspired by nature's toughening mechanisms, we designed a new polyhedral oligomeric silsesquioxane (POSS)-derived hybrid glass (PHG) that has covalent interactions on the molecular scale between the inorganic POSS cage and organic phase. These features allow "elastic deformation" of the inorganic POSS cage in limited ...

journal_title：Biomaterials

authors： Zhou X,Sahai N,Qi L,Mankoci S,Zhao W

更新日期：2015-05-01 00:00:00

abstract：:The effect of surface characteristics on the interaction of sterically stabilized polystyrene particles with mouse peritoneal macrophages was studied using a range of poloxamers and poloxamine as coating agents. The coated particles were characterized in terms of thickness of coating layer, surface charge and critical...

journal_title：Biomaterials

authors： Illum L,Jacobsen LO,Müller RH,Mak E,Davis SS

更新日期：1987-03-01 00:00:00

abstract：:A procedure for preparing homogeneous chitosan gels by in situ molybdate cross-linking is described. The gels are obtained by dispersing solid MoO3 in a buffered chitosan solution and the polymer is cross-linked by formation of heavily negatively charged molybdate polyoxyanions. The resulting ionic gels are very trans...

journal_title：Biomaterials

authors： Draget KI,Vårum KM,Moen E,Gynnild H,Smidsrød O

更新日期：1992-01-01 00:00:00

abstract：:A series of mesoporous silica nanoparticles (MSNs) were synthesized using the co-structure directing method. A non-cytotoxic anionic surfactant, undec-1-en-11-yltetra(ethylene glycol) phosphate monoester surfactant (PMES), was used as a structure directing agent (SDA) together with aminopropyltrimethoxysilane that fun...

journal_title：Biomaterials

authors： Tsai CH,Vivero-Escoto JL,Slowing II,Fang IJ,Trewyn BG,Lin VS

更新日期：2011-09-01 00:00:00

abstract：:Multiwalled carbon nanotubes (MWCNTs) are cut short and grafted with polyethylenimine (PEI) for further covalent conjugation to fluorescein isothiocyanate (FITC) and prostate stem cell antigen (PSCA) monoclonal antibody (mAb). The in vitro and in vivo toxicity data reveal that the as-prepared CNT-PEI(FITC)-mAb has goo...

journal_title：Biomaterials

authors： Wu H,Shi H,Zhang H,Wang X,Yang Y,Yu C,Hao C,Du J,Hu H,Yang S

更新日期：2014-07-01 00:00:00

abstract：:Gold nanoparticles have been conceived as a radiosensitizer in cancer radiation therapy, but one of the important questions for primary drug screening is what size of gold nanoparticles can optimally enhance radiation effects. Herein, we perform in vitro and in vivo radiosensitization studies of 4.8, 12.1, 27.3, and 4...

journal_title：Biomaterials

authors： Zhang XD,Wu D,Shen X,Chen J,Sun YM,Liu PX,Liang XJ

更新日期：2012-09-01 00:00:00

abstract：:Inflammatory bowel disease (IBD) is a chronic inflammatory gastrointestinal disorder that affects more than 1 million individuals in the USA. Local therapy with enema formulations, such as micronized budesonide (Entocort®), is a common strategy for treating patients with distally active IBD. However, we hypothesize th...

journal_title：Biomaterials

authors： Date AA,Halpert G,Babu T,Ortiz J,Kanvinde P,Dimitrion P,Narayan J,Zierden H,Betageri K,Musmanno O,Wiegand H,Huang X,Gumber S,Hanes J,Ensign LM

更新日期：2018-12-01 00:00:00

abstract：:The functionalization of polytetrafluoroethylene (PTFE) for human thrombomodulin (hTM) binding has been achieved by CO2 plasma activation and subsequent vapour phase graft polymerization of acrylic acid (AA). The PTFE surfaces after CO2 plasma treatment, AA grafting and hTM immobilization were characterized by attenua...

journal_title：Biomaterials

authors： Vasilets VN,Hermel G,König U,Werner C,Müller M,Simon F,Grundke K,Ikada Y,Jacobasch HJ

更新日期：1997-09-01 00:00:00

abstract：:We have recently reported on an ultrafast degrading tyrosine-derived terpolymer that degrades and resorbs within hours, and is suitable for use in cortical neural prosthetic applications. Here we further characterize this polymer, and describe a new tyrosine-derived fast degrading terpolymer in which the poly(ethylene...

journal_title：Biomaterials

authors： Lewitus DY,Smith KL,Shain W,Bolikal D,Kohn J

更新日期：2011-08-01 00:00:00

abstract：:The engineering of living tissues in vivo requires new concepts in cell culture technology. In contrast to conventional cell cultures, the development of tissues depends on a three-dimensional arrangement of cells and the formation or synthesis of an appropriate extracellular matrix. Special emphasis is given to the m...

journal_title：Biomaterials

authors： Sittinger M,Bujia J,Rotter N,Reitzel D,Minuth WW,Burmester GR

更新日期：1996-02-01 00:00:00

abstract：:Tissue engineering of the cornea could overcome shortages of donor corneas for transplantation and improve quality. Our aim was to grow an endothelial layer on a substratum suitable for transplant. Silkworm (Bombyx mori) fibroin was prepared as 5 μm thick transparent membranes. The B4G12 cell line was used to assess a...

journal_title：Biomaterials

authors： Madden PW,Lai JN,George KA,Giovenco T,Harkin DG,Chirila TV

更新日期：2011-06-01 00:00:00

abstract：:pH-triggered lipid-membranes designed from biophysical principles are evaluated in the form of targeted liposomal doxorubicin with the aim to ultimately better control the growth of vascularized tumors. We compare the antitumor efficacy of anti-HER2/neu pH-triggered lipid vesicles encapsulating doxorubicin to the anti...

journal_title：Biomaterials

authors： Bandekar A,Karve S,Chang MY,Mu Q,Rotolo J,Sofou S

更新日期：2012-06-01 00:00:00

abstract：:Cancer vaccines are designed to elicit an endogenous adaptive immune response that can successfully recognize and eliminate residual or recurring tumors. Such approaches can potentially overcome shortcomings of passive immunotherapies by generating long-lived therapeutic effects and immune memory while limiting system...

journal_title：Biomaterials

authors： Shukla S,Myers JT,Woods SE,Gong X,Czapar AE,Commandeur U,Huang AY,Levine AD,Steinmetz NF

更新日期：2017-03-01 00:00:00

abstract：:The authors aimed to develop a liquid material for embolization of aneurysms. In vitro and in vivo performances of the new embolic material were examined by cell culture and using an aneurysm model made in common carotid arteries (CCAs) of adult rats. Engineered protein ProNectin F (PnF), which contains 13 sites of an...

journal_title：Biomaterials

authors： Ohyama T,Ko IK,Miura A,Iwata H,Taki W

更新日期：2004-08-01 00:00:00

abstract：:Peripheral nerve injuries often lead to incomplete recovery and contribute to significant disability to approximately 360,000 people in the USA each year. Stem cell therapy holds significant promise for peripheral nerve regeneration, but maintenance of stem cell viability and differentiation potential in vivo are stil...

journal_title：Biomaterials

authors： Du J,Zhen G,Chen H,Zhang S,Qing L,Yang X,Lee G,Mao HQ,Jia X

更新日期：2018-10-01 00:00:00

abstract：:The maximum capacity of a hydrophobic adsorbent is interpreted in terms of square or hexagonal (cubic and face-centered-cubic, FCC) interfacial packing models of adsorbed blood proteins in a way that accommodates experimental measurements by the solution-depletion method and quartz-crystal-microbalance (QCM) for the h...

journal_title：Biomaterials

authors： Kao P,Parhi P,Krishnan A,Noh H,Haider W,Tadigadapa S,Allara DL,Vogler EA

更新日期：2011-02-01 00:00:00

abstract：:Neuromuscular circuits (NMCs) are vital for voluntary movement, and effective models of NMCs are needed to understand the pathogenesis of, as well as to identify effective treatments for, multiple diseases, including Duchenne's muscular dystrophy and amyotrophic lateral sclerosis. Microfluidics are ideal for recapitul...

journal_title：Biomaterials

authors： Bellmann J,Goswami RY,Girardo S,Rein N,Hosseinzadeh Z,Hicks MR,Busskamp V,Pyle AD,Werner C,Sterneckert J

更新日期：2019-12-01 00:00:00

abstract：:Poly(epsilon-caprolactone) (PCL)/continuous bioglass fibre composite was prepared using the monomer transfer moulding technique coupled with a surface initiated polymerisation. The bioglass fibres were surface treated with an amine ended silane in order to initiate polymerisation of epsilon-caprolactone from the fibre...

journal_title：Biomaterials

authors： Jiang G,Evans ME,Jones IA,Rudd CD,Scotchford CA,Walker GS

更新日期：2005-05-01 00:00:00

abstract：:Metal particles and ions from hip prostheses have the potential to induce the production of reactive oxygen species (ROS), making them prime suspects for disturbing the cellular balance of oxidants/antioxidants (redox state of the cell). To better understand the cellular effect of metal ions from metal-on-metal prosth...

journal_title：Biomaterials

authors： Petit A,Mwale F,Tkaczyk C,Antoniou J,Zukor DJ,Huk OL

更新日期：2005-07-01 00:00:00

abstract：:Load-bearing tissues, like bone, can be replaced by engineered tissues or tissue constructs. For the success of this treatment, a profound understanding is needed of the mechanical properties of both the native bone tissue and the construct. Also, the interaction between mechanical loading and bone regeneration and ad...

journal_title：Biomaterials

authors： Jaecques SV,Van Oosterwyck H,Muraru L,Van Cleynenbreugel T,De Smet E,Wevers M,Naert I,Vander Sloten J

更新日期：2004-04-01 00:00:00

abstract：:In order to evaluate degradation kinetics and biocompatibility of a resorbable poly(D,L-lactic acid) (PDLLA) plug for total cemented hip prostheses, an experimental in vitro and in vivo study was carried out. Degradation rate studies were performed in Ringer solution and after in vivo plug implantation in the femoral ...

journal_title：Biomaterials

authors： Giardino R,Fini M,Aldini NN,Giavaresi G,Rocca M,Orienti L,de Lollis A,Fambri L

更新日期：1997-07-01 00:00:00

abstract：:Nanocarriers possess advanced physicochemical properties that improve bioavailability, enhance cellular dynamics, and control targetability in drug delivery. In particular, dendritic polyglycerol is a promising new biocompatible scaffold for drug delivery. The present explores the structure-biocompatibility relationsh...

journal_title：Biomaterials

authors： Khandare J,Mohr A,Calderón M,Welker P,Licha K,Haag R

更新日期：2010-05-01 00:00:00

abstract：:The calcination and natural sintering of calcium deficient hydroxyapatite powders Ca(10-x)(PO4)(6-x)(HPO4)x(OH)(2-x) (with 0 < or = x < or = 1) were studied. For temperature below 700 degrees C, particle coalescence occurs without densification. The particle coalescence is associated with a reduction of the specific s...

journal_title：Biomaterials

authors： Raynaud S,Champion E,Bernache-Assollant D

更新日期：2002-02-01 00:00:00

abstract：:Films made of poly (3-hydroxybutyrate) (PHB), poly(3-hydroxybutyrate- co-3-hydroxyhexanoate) (PHBHHx) consisting of 5%, 12% and 20% hydroxyhexanoate (HHx), respectively, were evaluated for biomedical application in comparison with poly (L-Lactide) (PLA). With the increase of HHx content in PHBHHx, the polymer surface ...

journal_title：Biomaterials

authors： Wang YW,Yang F,Wu Q,Cheng YC,Yu PH,Chen J,Chen GQ

更新日期：2005-03-01 00:00:00

abstract：:Clinically used contrast agents for magnetic resonance imaging (MRI) suffer by the lack of specificity; short circulation time; and insufficient relaxivity. Here, a one-step combinatorial approach is described for the synthesis of magnetic lipid-polymer (hybrid) nanoparticles (MHNPs) encapsulating 5 nm ultra-small sup...

journal_title：Biomaterials

authors： Aryal S,Key J,Stigliano C,Ananta JS,Zhong M,Decuzzi P

更新日期：2013-10-01 00:00:00

abstract：:The carboxymethylcellulose-gelatine carrier system was investigated for invertase immobilization. Chromium (III) acetate, chromium (III) sulphate and potassium chromium (III) sulphate were used as cross-linking agents. Effect of carboxymethylcellulose-gelatine ratio and cross-linker concentration on immobilized enzyme...

journal_title：Biomaterials

authors： Emregül E,Sungur S,Akbulut U

更新日期：1996-07-01 00:00:00