Structure-biocompatibility relationship of dendritic polyglycerol derivatives.

abstract：:The generation of effective tissue engineered bone grafts requires efficient exchange of nutrients and mechanical stimulus. Bioreactors provide a manner in which this can be achieved. We have recently developed a biaxial rotating bioreactor with efficient fluidics through in-silico modeling. Here we investigated its p...

journal_title：Biomaterials

authors： Zhang ZY,Teoh SH,Chong WS,Foo TT,Chng YC,Choolani M,Chan J

更新日期：2009-05-01 00:00:00

abstract：:The bioactivity of plasma-sprayed hydroxyapatite (HA)/Ti-6Al-4V composite coatings was studied by soaking the coatings in simulated body fluid (SBF) for up to 8 weeks. This investigation was aimed at elucidating the biological behaviour of plasma-sprayed HA/Ti-6Al-4V composite coatings by analyzing the changes in chem...

journal_title：Biomaterials

authors： Gu YW,Khor KA,Cheang P

更新日期：2003-04-01 00:00:00

abstract：:Biomimetic strategies focusing on presenting short bioadhesive oligopeptides, including the arginine-glycine-aspartic acid (RGD) motif present in numerous adhesive proteins, on a non-fouling support have emerged as promising approaches to improve cellular activities and healing responses. Nevertheless, these bio-inspi...

journal_title：Biomaterials

authors： Petrie TA,Capadona JR,Reyes CD,García AJ

更新日期：2006-11-01 00:00:00

abstract：:Following an original synthesis route, we have prepared a single-component calcium phosphate apatite-like powder which settles and hardens when mixed with deionized water in an approximative 1.2 g:1 ml ratio. This paper describes the first physico-chemical studies and characterizations of the material. Observations of...

journal_title：Biomaterials

authors： Zoulgami M,Lucas A,Briard P,Gaudé J

更新日期：2001-07-01 00:00:00

abstract：:Tissue engineering combined with gene therapy represents a promising approach for bone regeneration. The Hypoxia-inducible factor-1α (HIF-1α) gene is a pivotal regulator of vascular reactivity and angiogenesis. Our recent study has showed that HIF-1α could promote osteogenesis of bone mesenchymal stem cells (BMSCs) us...

journal_title：Biomaterials

authors： Zou D,Zhang Z,He J,Zhu S,Wang S,Zhang W,Zhou J,Xu Y,Huang Y,Wang Y,Han W,Zhou Y,Wang S,You S,Jiang X,Huang Y

更新日期：2011-12-01 00:00:00

abstract：:The human heart cannot regenerate after an injury. Lost cardiomyocytes are replaced by scar tissue resulting in reduced cardiac function causing high morbidity and mortality. One possible solution to this problem is cardiac tissue engineering. Here, we have investigated the suitability of non-mulberry silk protein fib...

journal_title：Biomaterials

authors： Patra C,Talukdar S,Novoyatleva T,Velagala SR,Mühlfeld C,Kundu B,Kundu SC,Engel FB

更新日期：2012-03-01 00:00:00

abstract：:Poly(glycerol-sebacate) (PGS) is an elastomeric biodegradable polyester that could potentially be used to engineer blood vessels in vivo. However, its blood-material interactions are unknown. The objectives of this study were to: (a) fabricate PGS-based biphasic tubular scaffolds and (b) assess the blood compatibility...

journal_title：Biomaterials

authors： Motlagh D,Yang J,Lui KY,Webb AR,Ameer GA

更新日期：2006-08-01 00:00:00

abstract：:Understanding how engineered tissue scaffold architecture affects cell morphology, metabolism, phenotypic expression, as well as predicting material mechanical behavior has recently received increased attention. In the present study, an image-based analysis approach that provides an automated tool to characterize engi...

journal_title：Biomaterials

authors： D'Amore A,Stella JA,Wagner WR,Sacks MS

更新日期：2010-07-01 00:00:00

abstract：:The interest in gallium alloys as a replacement for amalgam has increased in recent years due to the risk of environmental pollution from amalgam. Alloy powders with compositions close to those for alloys of amalgam are mixed with a liquid gallium alloy. The mix is condensed into a prepared cavity in much the same way...

journal_title：Biomaterials

authors： Herø H,Simensen CJ,Jørgensen RB

更新日期：1996-07-01 00:00:00

abstract：:This paper is concerned with the entrapment of an enzyme within an aggregated metallic matrix and the development of a bioactive enzyme-metal composite. Whereas the use of organic polymers and metal oxides for the preparation of enzymatically active materials is well developed, the third principle enzyme-material comb...

journal_title：Biomaterials

authors： Ben-Knaz R,Avnir D

更新日期：2009-03-01 00:00:00

abstract：:The effective role of exosome delivering neurogenic microRNA (miRNA) enables to induce efficient differentiation process during neurogenesis. The microfludic system capable of visualizing the exosomal behavior such as secretion, migration, and uptake of individual exosomes can be used as a robust technique to understa...

journal_title：Biomaterials

authors： Oh HJ,Shin Y,Chung S,Hwang DW,Lee DS

更新日期：2017-01-01 00:00:00

abstract：:An ideal scaffold that provides a combination of suitable mechanical properties along with biological signals is required for successful ligament/tendon regeneration in mesenchymal stem cell-based tissue engineering strategies. Among the various fibre-based scaffolds that have been used, hybrid fibrous scaffolds compr...

journal_title：Biomaterials

authors： Sahoo S,Toh SL,Goh JC

更新日期：2010-04-01 00:00:00

abstract：:One of the main issues in orthopaedic implant design is the fabrication of scaffolds that closely mimic the biomechanical properties of the surrounding bone. This research reports on a multi-stage rapid prototyping technique that was successfully developed to produce porous titanium scaffolds with fully interconnected...

journal_title：Biomaterials

authors： Ryan GE,Pandit AS,Apatsidis DP

更新日期：2008-09-01 00:00:00

abstract：:The aim of this study was to evaluate the in vivo response following implantation into a rat model of three innovative hyaluronan derivatives for clinical use: HYAFF 7, HYAFF 11 and HYAFF 11p75 (respectively, the 100% ethyl ester, 100% and 75% benzyl esters). The tissue reaction evoked by films of these new biomateria...

journal_title：Biomaterials

authors： Campoccia D,Hunt JA,Doherty PJ,Zhong SP,O'Regan M,Benedetti L,Williams DF

更新日期：1996-05-01 00:00:00

abstract：:Polymers have been used to deliver therapeutic agents in a range of medical devices with drug eluting stents being the most widespread current application. Although polymers enable controlled release of a therapeutic agent, the polymeric surface has been reported to provide suboptimal biocompatibility and haemocompati...

journal_title：Biomaterials

authors： Simmons A,Padsalgikar AD,Ferris LM,Poole-Warren LA

更新日期：2008-07-01 00:00:00

abstract：:Drug carrier particles composed of poly(ethylene glycol)-co-poly(sebacic acid) (PEG-PSA) have been shown capable of efficient aerosolization into model lungs and the ability to rapidly penetrate human mucus. Here, we develop PEG-PSA particles (Etop/PEG-PSA) that encapsulate up to 40% etoposide by weight in a one step ...

journal_title：Biomaterials

authors： Tang BC,Fu J,Watkins DN,Hanes J

更新日期：2010-01-01 00:00:00

abstract：:A tissue-engineered bone has become a viable alternative to autologous bone for bone augmentation in atrophy alveolar ridge. The aim of the present study was to evaluate porous beta-tricalcium phosphate (beta-TCP) combined with autologous osteoblasts to augment edentulous alveolar ridge in a canine model. Autologous o...

journal_title：Biomaterials

authors： Wang S,Zhang Z,Zhao J,Zhang X,Sun X,Xia L,Chang Q,Ye D,Jiang X

更新日期：2009-05-01 00:00:00

abstract：:Although synergistic therapy for tumors has displayed significant promise for effective treatment of cancer, developing a simple and effective strategy to build a multi-functional nanoplatform is still a huge challenge. By virtue of the characteristics of tumor microenvironment, such as hypoxia, slight acidity and H2O...

journal_title：Biomaterials

authors： Wang M,Chang M,Chen Q,Wang D,Li C,Hou Z,Lin J,Jin D,Xing B

更新日期：2020-09-01 00:00:00

abstract：:Retinal ischemia is a major cause of vision loss and impairment and a common underlying mechanism associated with diseases such as glaucoma, diabetic retinopathy, and central retinal artery occlusion. The regenerative capacity of the diseased human retina is limited. Our previous studies have shown the neuroprotective...

journal_title：Biomaterials

authors： Mathew B,Ravindran S,Liu X,Torres L,Chennakesavalu M,Huang CC,Feng L,Zelka R,Lopez J,Sharma M,Roth S

更新日期：2019-03-01 00:00:00

abstract：:Decellularized adipose tissue (DAT) has shown promise as an adipogenic bioscaffold for soft tissue augmentation and reconstruction. The objective of the current study was to investigate the effects of allogeneic adipose-derived stem/stromal cells (ASCs) on in vivo fat regeneration in DAT bioscaffolds using an immunoco...

journal_title：Biomaterials

authors： Han TT,Toutounji S,Amsden BG,Flynn LE

更新日期：2015-12-01 00:00:00

abstract：:The interfacial membrane harvested from failed joint replacements contains particulate debris from the materials used for the implant. To define the tissue response to particulate titanium alloy and hydroxyapatite (HA) alone, 16 mature New Zealand white rabbits were divided into 2 groups of 8 rabbits. Using sterile te...

journal_title：Biomaterials

authors： Goodman SB,Davidson JA,Fornasier VL

更新日期：1993-08-01 00:00:00

abstract：:The FRP wires 0.5 mm in diameter with a multiple fiber structure were fabricated by drawing the fiber polymer complex at 250 degrees C for an esthetic, transparent orthodontic wire. Biocompatible CaO-P2O5-SiO2-Al2O3 (CPSA) glass fibers of 8-20 microm in diameter were oriented unidirectionally in the longitudinal direc...

journal_title：Biomaterials

authors： Imai T,Watari F,Yamagata S,Kobayashi M,Nagayama K,Toyoizumi Y,Nakamura S

更新日期：1998-12-01 00:00:00

abstract：:Despite being increasingly used as artificial enzymes, little has been known for the origin of the pH-switchable peroxidase-like and catalase-like activities of metals. Using calculations and experiments, we report the mechanisms for both activities and their pH-switchability for metals Au, Ag, Pd and Pt. The calculat...

journal_title：Biomaterials

authors： Li J,Liu W,Wu X,Gao X

更新日期：2015-04-01 00:00:00

abstract：:Morphological changes of human polymorphonuclear neutrophils (PMN) adhering to hydrophilic (glass) and hydrophobic (FEP-Teflon, polyethylene, polypropylene) surfaces were studied in a parallel-plate flow chamber at the light and scanning electron microscopical levels. The PMN were exposed to a shear stress of 0.19 Pa ...

journal_title：Biomaterials

authors： Tomczok J,Sliwa-Tomczok W,Klein CL,van Kooten TG,Kirkpatrick CJ

更新日期：1996-07-01 00:00:00

abstract：:The non-specific interaction between nanoparticles (NPs) and plasma proteins occurs immediately after NPs enter the blood, resulting in the formation of the protein corona that thereafter replaces the original NPs and becomes what the organs and cells really see. Consequently, the in vivo fate of NPs and the biologica...

journal_title：Biomaterials

authors： Peng Q,Zhang S,Yang Q,Zhang T,Wei XQ,Jiang L,Zhang CL,Chen QM,Zhang ZR,Lin YF

更新日期：2013-11-01 00:00:00

abstract：:Local contact stresses at the bone-cement interface are thought to play an important role in the initiation of component loosening. A reduced-modulus bone cement can lower these local contact stresses. The viscoelastic properties of such a cement raised the question of long term subsidence of the implant system. In th...

journal_title：Biomaterials

authors： Yetkinler DN,Litsky AS

更新日期：1998-09-01 00:00:00

abstract：:The N-terminal 200 amino acid residues of topoisomerase I (TopoN) is highly positive in charge and has DNA binding activity, without DNA sequence and topological specificity. Here, a fusion protein (6 x His-PTD-TopoN) containing a hexahistidine (6 x His) tag, a membrane penetration domain and TopoN (amino acid 3-200) ...

journal_title：Biomaterials

authors： Chen YA,Kuo HC,Chen YM,Huang SY,Liu YR,Lin SC,Yang HL,Chen TY

更新日期：2011-06-01 00:00:00

abstract：:Hepatocytes are anchorage-dependent cells sensitive to microenvironment; the control of the physicochemical properties of the extra-cellular matrices may be useful to the maintenance of hepatocyte functions in vitro for various applications. In a microcapsule-based 3-D hepatocyte culture microenvironment, we could con...

journal_title：Biomaterials

authors： Ng S,Wu YN,Zhou Y,Toh YE,Ho ZZ,Chia SM,Zhu JH,Mao HQ,Yu H

更新日期：2005-06-01 00:00:00

abstract：:A procedure for preparing homogeneous chitosan gels by in situ molybdate cross-linking is described. The gels are obtained by dispersing solid MoO3 in a buffered chitosan solution and the polymer is cross-linked by formation of heavily negatively charged molybdate polyoxyanions. The resulting ionic gels are very trans...

journal_title：Biomaterials

authors： Draget KI,Vårum KM,Moen E,Gynnild H,Smidsrød O

更新日期：1992-01-01 00:00:00

abstract：:Regeneration of the damaged myocardium is one of the most challenging fronts in the field of tissue engineering due to the limited capacity of adult heart tissue to heal and to the mechanical and structural constraints of the cardiac tissue. In this study we demonstrate that an engineered acellular scaffold comprising...

journal_title：Biomaterials

authors： Serpooshan V,Zhao M,Metzler SA,Wei K,Shah PB,Wang A,Mahmoudi M,Malkovskiy AV,Rajadas J,Butte MJ,Bernstein D,Ruiz-Lozano P

更新日期：2013-12-01 00:00:00