Abstract：
:Drug carrier particles composed of poly(ethylene glycol)-co-poly(sebacic acid) (PEG-PSA) have been shown capable of efficient aerosolization into model lungs and the ability to rapidly penetrate human mucus. Here, we develop PEG-PSA particles (Etop/PEG-PSA) that encapsulate up to 40% etoposide by weight in a one step process, release it continuously for 6 days in vitro, and maintain its cytotoxic activity against a human lung tumor cell line in vitro. We further show that Etop/PEG-PSA injected intratumorally effectively suppress human lung tumor growth in a xenograft mouse model, with 100% survival after 31 days. In contrast, 0% survival was observed by day 24 in animals that received free etoposide (either intratumoral or intraperitoneal administration) or placebo particles intratumorally. These findings support PEG-PSA as a drug delivery platform for improved local therapy of cancer.
journal_name
Biomaterialsjournal_title
Biomaterialsauthors
Tang BC,Fu J,Watkins DN,Hanes Jdoi
10.1016/j.biomaterials.2009.09.033subject
Has Abstractpub_date
2010-01-01 00:00:00pages
339-44issue
2eissn
0142-9612issn
1878-5905pii
S0142-9612(09)00963-6journal_volume
31pub_type
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