Modulation of biological processes in the nucleus by delivery of DNA oligonucleotides conjugated with gold nanoparticles.

abstract：:In our previous study, a three-dimensional zein porous scaffold with a compressive Young's modulus of up to 86.6+/-19.9 MPa and a compressive strength of up to 11.8+/-1.7 MPa was prepared, and was suitable for culture of mesenchymal stem cells (MSCs) in vitro. In this study, we examined its tissue compatibility in a r...

journal_title：Biomaterials

authors： Wang HJ,Gong SJ,Lin ZX,Fu JX,Xue ST,Huang JC,Wang JY

更新日期：2007-09-01 00:00:00

abstract：:Previous in vivo studies have shown a limited potential for vertical bone regeneration using osteoconductive scaffolds alone. In the present study, we investigated whether the association of adipose-derived adult stem cells (ASCs) with anorganic bovine bone (ABB) scaffold improved bone formation and implant osseointeg...

journal_title：Biomaterials

authors： Pieri F,Lucarelli E,Corinaldesi G,Aldini NN,Fini M,Parrilli A,Dozza B,Donati D,Marchetti C

更新日期：2010-05-01 00:00:00

abstract：:Finding bioactive short peptides derived from proteins is a critical step to the advancement of tissue engineering and regenerative medicine, because the former maintains the functions of the latter without immunogenicity in biological systems. Here, we discovered a bioactive core nonapeptide sequence, PPFEGCIWN (resi...

journal_title：Biomaterials

authors： Yeo IS,Min SK,Kang HK,Kwon TK,Jung SY,Min BM

更新日期：2015-12-01 00:00:00

abstract：:Protein therapeutics targeting inflammatory mediators have shown great promise for the treatment of autoimmunities such as rheumatoid arthritis (RA). However, a significant challenge in this area has been their low in vivo stability and consequently their severely compromised therapeutic efficacy. One such therapeutic...

journal_title：Biomaterials

authors： Pasi S,Kant R,Gupta S,Surolia A

更新日期：2015-02-01 00:00:00

abstract：:Acute kidney injury (AKI) is associated with high mortality and morbidity with no effective treatment available at present, which greatly escalates the risk of chronic kidney disease. Nanotechnology-based drug delivery for targeting renal tubules offers a new strategy for AKI treatment but remains challenging due to t...

journal_title：Biomaterials

authors： Yu H,Lin T,Chen W,Cao W,Zhang C,Wang T,Ding M,Zhao S,Wei H,Guo H,Zhao X

更新日期：2019-10-01 00:00:00

abstract：:A type III glass-ionomer cement (Vidrion F), currently used as fast-setting lining material and fissure sealant, was implanted into rat dental alveolus immediately after tooth extraction and its biocompatibility was analysed in terms of incorporation into alveolar bone in the wound healing process. Histological and hi...

journal_title：Biomaterials

authors： Brentegani LG,Bombonato KF,Carvalho TL

更新日期：1997-01-01 00:00:00

abstract：:Drug hepatotoxicity testing requires in vitro hepatocyte culture to maintain the long-term and stable liver specific functions. We developed a drug testing platform based on laminar-flow immediate-overlay hepatocyte sandwich perfusion culture. The immediate-overlay sandwich (collagen-coated porous polymeric membrane a...

journal_title：Biomaterials

authors： Xia L,Ng S,Han R,Tuo X,Xiao G,Leo HL,Cheng T,Yu H

更新日期：2009-10-01 00:00:00

abstract：:The nanotopography and nanoscale geometry of the extra-cellular matrix (ECM) are important regulators of cell adhesion, motility and fate decision. However, unlike the sensing of matrix mechanics and ECM density, the molecular processes regulating the direct sensing of the ECM nanotopography and nanoscale geometry are...

journal_title：Biomaterials

authors： Di Cio S,Iskratsch T,Connelly JT,Gautrot JE

更新日期：2020-02-01 00:00:00

abstract：:Neonates with congenital diaphragmatic hernia often require surgical defect closure with a patch. Alternatives to native diaphragmatic tissue are critically needed for this paediatric surgery. The clinical efficacy of mesh patches is limited by complications associated with residual foreign material and by hernia recu...

journal_title：Biomaterials

authors： Zhang XY,Yanagi Y,Sheng Z,Nagata K,Nakayama K,Taguchi T

更新日期：2018-06-01 00:00:00

abstract：:Clinically used contrast agents for magnetic resonance imaging (MRI) suffer by the lack of specificity; short circulation time; and insufficient relaxivity. Here, a one-step combinatorial approach is described for the synthesis of magnetic lipid-polymer (hybrid) nanoparticles (MHNPs) encapsulating 5 nm ultra-small sup...

journal_title：Biomaterials

authors： Aryal S,Key J,Stigliano C,Ananta JS,Zhong M,Decuzzi P

更新日期：2013-10-01 00:00:00

abstract：:Polyelectrolyte complexes (PEC) were prepared from chitosan as the polycation and several synthesized functional anion polysaccharides, and their effects on cell attachment, morphology, proliferation and differentiation were estimated using normal human osteoblasts (NHOst). After a 1-week incubation, PEC made from pol...

journal_title：Biomaterials

authors： Nagahata M,Nakaoka R,Teramoto A,Abe K,Tsuchiya T

更新日期：2005-09-01 00:00:00

abstract：:Suture materials may interact with immune competent cells and thereby affect localized immunity. Macrophages are central to the inflammatory response and coordinate wound healing. They are also involved in the clearance of foreign material, bacteria and malignant cells. We studied the influence of soluble factors asso...

journal_title：Biomaterials

authors： Uff CR,Scott AD,Pockley AG,Phillips RK

更新日期：1995-03-01 00:00:00

abstract：:Human umbilical cord vein segments have been used as vessel substitutes for damaged or occluded arteries, as aorto-coronary by-passes and as arterio-venous fistulae for dialysis. The Dardik-Biograft fixed with glutaraldehyde and the Mindich-Bioflow, fixed with ethanol and dialdehyde starch, are commercially available....

journal_title：Biomaterials

authors： Guidoin R,Marois M,Martin L,Noël HP,Laroche F,Gosselin CO,Côté R,Bénichoux R,Blais P

更新日期：1980-04-01 00:00:00

abstract：:There is currently no effective treatment for the retinal disorders caused by retinal pigment epithelium (RPE) degeneration. Transplantation of allografts is the main strategy towards correction of this malady. Tissue engineering could offer hope and involve the use of biodegradable polymeric templates to replace dise...

journal_title：Biomaterials

authors： Tezcaner A,Bugra K,Hasirci V

更新日期：2003-11-01 00:00:00

abstract：:Forty squares of tissue, 40 mm X 40 mm, were harvested from bovine pericardium fixed in glutaraldehyde free of tension. Two parallel dumb-bell specimens were excised from each square. In 20 pairs of adjacent samples, two 1 mm cuts were introduced into one of the samples at the centre of the dumb-bell. The other 20 pai...

journal_title：Biomaterials

authors： Crofts CE,Trowbridge EA

更新日期：1989-05-01 00:00:00

abstract：:High-throughput screening techniques for cellular response are often unable to account for several factors present in the in vivo environment, many of which have been shown to modulate cellular response to the screened parameter. Culture in three-dimensional biomaterials and active mechanical stimulation are two such ...

journal_title：Biomaterials

authors： Moraes C,Wang G,Sun Y,Simmons CA

更新日期：2010-01-01 00:00:00

abstract：:Wounded tissues and cells may be treated with growth factors and specific genes for the purpose of tissue repair and regeneration. To deliver specific genes into tissues and cells, this study presents the use of fabricated poly (DL-lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) complexed with the cationic polymer...

journal_title：Biomaterials

authors： Park JS,Yang HN,Woo DG,Jeon SY,Park KH

更新日期：2013-01-01 00:00:00

abstract：:In this work, the in vitro interaction of cerebellar granule neurons prepared from 7-day-old Wistar rats and poly ethylene-co-vinyl alcohol (EVAL) membranes was investigated. Cells were cultured in smooth and particulate EVAL membranes for up to 7 days. Particulate membranes were prepared by using 1-octanol to precipi...

journal_title：Biomaterials

authors： Young TH,Lin CW,Cheng LP,Hsieh CC

更新日期：2001-07-01 00:00:00

abstract：:Platelet-derived growth factor BB (PDGF-BB) was an important inductive factor during wound healing, but the lack of efficient delivery system limited its clinical application. Here, a peptide of seven amino acids was firstly utilized to engineer PDGF-BB to construct a collagen-targeting system. This peptide functioned...

journal_title：Biomaterials

authors： Lin H,Chen B,Sun W,Zhao W,Zhao Y,Dai J

更新日期：2006-11-01 00:00:00

abstract：:A series of segmented polydimethylsiloxane (PDMS) polyurea-urethanes was synthesized based on hexane diisocyanate modified polyether-PDMS soft segments. The hard segments consisted of 4,4'-methylene diphenylene diisocyanate, which was chain extended with 1,4-butanediol. The effect of chemical composition of the polyet...

journal_title：Biomaterials

authors： Lim F,Yang CZ,Cooper SL

更新日期：1994-05-01 00:00:00

abstract：:Six routinely packaged commercially pure titanium dental implants (three commercial brands) were analysed using secondary ion mass spectrometry to examine the outermost surface layer. The aim of the analysis was to compare the surface purity (99.95%) of the implants with the substrate metal, common to all three brands...

journal_title：Biomaterials

authors： Edwards BN,Gold BR

更新日期：1992-01-01 00:00:00

abstract：:The goal of this study was to develop a polymeric carrier for delivery of anti-tumor drugs and sustained release of these agents in order to optimize anti-tumor activity while minimizing systemic effects. We used oligo(poly(ethylene glycol) fumarate) (OPF) hydrogels modified with small negatively charged molecules, so...

journal_title：Biomaterials

authors： Dadsetan M,Liu Z,Pumberger M,Giraldo CV,Ruesink T,Lu L,Yaszemski MJ

更新日期：2010-11-01 00:00:00

abstract：:We developed a strategy to formulate supraparamagnetic iron oxides (SPIOs) in nanoparticles (NPs) of biodegradable copolymer made up of poly(lactic acid) (PLA) and d-alpha-tocopherol polyethylene glycol 1000 succinate (TPGS) for medical imaging by magnetic resonance imaging (MRI) of high contrast and low side effects....

journal_title：Biomaterials

authors： Prashant C,Dipak M,Yang CT,Chuang KH,Jun D,Feng SS

更新日期：2010-07-01 00:00:00

abstract：:Induced pluripotent stem cells (iPSCs) hold great promise as a cell source for regenerative medicine yet its culture, maintenance of pluripotency and induction of differentiation remain challenging. Conversely, graphene (G) and graphene oxide (GO) have captured tremendous interests in the fields of materials science, ...

journal_title：Biomaterials

authors： Chen GY,Pang DW,Hwang SM,Tuan HY,Hu YC

更新日期：2012-01-01 00:00:00

abstract：:The calcination and natural sintering of calcium deficient hydroxyapatite powders Ca(10-x)(PO4)(6-x)(HPO4)x(OH)(2-x) (with 0 < or = x < or = 1) were studied. For temperature below 700 degrees C, particle coalescence occurs without densification. The particle coalescence is associated with a reduction of the specific s...

journal_title：Biomaterials

authors： Raynaud S,Champion E,Bernache-Assollant D

更新日期：2002-02-01 00:00:00

abstract：:The rate of change of pH of aqueous lactic acid at pH 4.2-4.5 (i.e. a little below that of active caries in vivo) in contact with disks of various commercial glass-ionomer cements has been determined in two configurations. In the first of them, a thin film set-up, 20 microl of solution was spread across the surface of...

journal_title：Biomaterials

authors： Nicholson JW,Aggarwal A,Czarnecka B,Limanowska-Shaw H

更新日期：2000-10-01 00:00:00

abstract：:Cancer vaccines are designed to elicit an endogenous adaptive immune response that can successfully recognize and eliminate residual or recurring tumors. Such approaches can potentially overcome shortcomings of passive immunotherapies by generating long-lived therapeutic effects and immune memory while limiting system...

journal_title：Biomaterials

authors： Shukla S,Myers JT,Woods SE,Gong X,Czapar AE,Commandeur U,Huang AY,Levine AD,Steinmetz NF

更新日期：2017-03-01 00:00:00

abstract：:Metronomic chemotherapy, which is defined as a low-dose and frequent administration of cytotoxic drugs without drug-free breaks, has been recently emerged as an alternative to traditional MTD therapy and has shown therapeutic benefit in breast cancer patients in numbers of clinical studies. Unlike MTD, metronomic chem...

journal_title：Biomaterials

authors： Chung SW,Kim GC,Kweon S,Lee H,Choi JU,Mahmud F,Chang HW,Kim JW,Son WC,Kim SY,Byun Y

更新日期：2018-11-01 00:00:00

abstract：:Using the material technique recently developed by us, we prepared a micropattern on poly(ethylene glycol) (PEG) hydrogel to keep background resistant to cell adhesion for a long time, which made examination of differentiation of localized stem cells available. Our micropattern designed in this paper prevented or ensu...

journal_title：Biomaterials

authors： Tang J,Peng R,Ding J

更新日期：2010-03-01 00:00:00

abstract：:A new diamond ATR FTIR method has been developed to quantify the processes occurring in the resin-modified glass-ionomer cement (RMGIC). Fuji II LC (Improved), at 1 mm depth from the cement/water interface. With Fuji II LC (Improved) various changes in the spectra due to 90% monomer polymerisation were observed within...

journal_title：Biomaterials

authors： Young AM

更新日期：2002-08-01 00:00:00