In vivo biocompatibility and mechanical properties of porous zein scaffolds.

Abstract:

:In our previous study, a three-dimensional zein porous scaffold with a compressive Young's modulus of up to 86.6+/-19.9 MPa and a compressive strength of up to 11.8+/-1.7 MPa was prepared, and was suitable for culture of mesenchymal stem cells (MSCs) in vitro. In this study, we examined its tissue compatibility in a rabbit subcutaneous implantation model; histological analysis revealed a good tissue response and degradability. To improve its mechanical property (especially the brittleness), the scaffolds were prepared using the club-shaped mannitol as the porogen, and stearic acid or oleic acid was added. The scaffolds obtained had an interconnected tubular pore structure, 100-380 microm in pore size, and about 80% porosity. The maximum values of the compressive strength and modulus, the tensile strength and modulus, and the flexural strength and modulus were obtained at the lowest porosity, reaching 51.81+/-8.70 and 563.8+/-23.4 MPa; 3.91+/-0.86 and 751.63+/-58.85 MPa; and 17.71+/-3.02 and 514.39+/-19.02 MPa, respectively. Addition of 15% stearic acid or 20% oleic acid did not affect the proliferation and osteogenic differentiation of MSCs, and a successful improvement of mechanical properties, especially the brittleness of the zein scaffold could be achieved.

journal_name

Biomaterials

journal_title

Biomaterials

authors

Wang HJ,Gong SJ,Lin ZX,Fu JX,Xue ST,Huang JC,Wang JY

doi

10.1016/j.biomaterials.2007.05.017

subject

Has Abstract

pub_date

2007-09-01 00:00:00

pages

3952-64

issue

27

eissn

0142-9612

issn

1878-5905

pii

S0142-9612(07)00416-4

journal_volume

28

pub_type

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