A graphene-based platform for induced pluripotent stem cells culture and differentiation.

Abstract:

:Induced pluripotent stem cells (iPSCs) hold great promise as a cell source for regenerative medicine yet its culture, maintenance of pluripotency and induction of differentiation remain challenging. Conversely, graphene (G) and graphene oxide (GO) have captured tremendous interests in the fields of materials science, physics, chemistry and nanotechnology. Here we report on that G and GO can support the mouse iPSCs culture and allow for spontaneous differentiation. Intriguingly, G and GO surfaces led to distinct cell proliferation and differentiation characteristics. In comparison with the glass surface, iPSCs cultured on the G surface exhibited similar degrees of cell adhesion and proliferation while iPSCs on the GO surface adhered and proliferated at a faster rate. Moreover, G favorably maintained the iPSCs in the undifferentiated state while GO expedited the differentiation. The iPSCs cultured on both G and GO surfaces spontaneously differentiated into ectodermal and mesodermal lineages without significant disparity, but G suppressed the iPSCs differentiation towards the endodermal lineage whereas GO augmented the endodermal differentiation. These data collectively demonstrated that the different surface properties of G and GO governed the iPSCs behavior and implicate the potentials of graphene-based materials as a platform for iPSCs culture and diverse applications.

journal_name

Biomaterials

journal_title

Biomaterials

authors

Chen GY,Pang DW,Hwang SM,Tuan HY,Hu YC

doi

10.1016/j.biomaterials.2011.09.071

subject

Has Abstract

pub_date

2012-01-01 00:00:00

pages

418-27

issue

2

eissn

0142-9612

issn

1878-5905

pii

S0142-9612(11)01147-1

journal_volume

33

pub_type

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