A stimuli-responsive hydrogel for doxorubicin delivery.

Abstract:

:The goal of this study was to develop a polymeric carrier for delivery of anti-tumor drugs and sustained release of these agents in order to optimize anti-tumor activity while minimizing systemic effects. We used oligo(poly(ethylene glycol) fumarate) (OPF) hydrogels modified with small negatively charged molecules, sodium methacrylate (SMA), for delivery of doxorubicin (DOX). SMA at different concentrations was incorporated into the OPF hydrogel with a photo-crosslinking method. The resulting hydrogels exhibited sensitivity to the pH and ionic strength of the surrounding environment. Our results revealed that DOX was bound to the negatively charged hydrogel through electrostatic interaction and was released in a timely fashion with an ion-exchange mechanism. Release kinetics of DOX was directly correlated to the concentration of SMA in the hydrogel formulations. Anti-tumor activity of the released DOX was assessed using a human osteosarcoma cell line. Our data revealed that DOX released from the modified, charged hydrogels remained biologically active and had the capability to kill cancer cells. In contrast, control groups of unmodified OPF hydrogels with or without DOX did not exhibit any cytotoxicity. This study demonstrates the feasibility of using SMA-modified OPF hydrogels as a potential carrier for chemotherapeutic drugs for cancer treatments.

journal_name

Biomaterials

journal_title

Biomaterials

authors

Dadsetan M,Liu Z,Pumberger M,Giraldo CV,Ruesink T,Lu L,Yaszemski MJ

doi

10.1016/j.biomaterials.2010.06.054

subject

Has Abstract

pub_date

2010-11-01 00:00:00

pages

8051-62

issue

31

eissn

0142-9612

issn

1878-5905

pii

S0142-9612(10)00834-3

journal_volume

31

pub_type

杂志文章
  • Bulk, surface and blood-contacting properties of polyether polyurethanes modified with polydimethylsiloxane macroglycols.

    abstract::The bulk, surface and blood-contacting properties of a series of polyether polyurethanes, modified with three different polydimethylsiloxane (PDMS) macroglycol segments, were evaluated. The PDMS oligomers were terminated with hydroxy-tipped end groups of varying polarity. The effect of substituting the polytetramethyl...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/0142-9612(89)90005-7

    authors: Okkema AZ,Fabrizius DJ,Grasel TG,Cooper SL,Zdrahala RJ

    更新日期:1989-01-01 00:00:00

  • Induction of protein oxidation by cobalt and chromium ions in human U937 macrophages.

    abstract::Metal particles and ions from hip prostheses have the potential to induce the production of reactive oxygen species (ROS), making them prime suspects for disturbing the cellular balance of oxidants/antioxidants (redox state of the cell). To better understand the cellular effect of metal ions from metal-on-metal prosth...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/j.biomaterials.2004.11.019

    authors: Petit A,Mwale F,Tkaczyk C,Antoniou J,Zukor DJ,Huk OL

    更新日期:2005-07-01 00:00:00

  • Collection of neural inducing factors from PA6 cells using heparin solution and their immobilization on plastic culture dishes for the induction of neurons from embryonic stem cells.

    abstract::Embryonic stem (ES) cells have the ability to replicate themselves and differentiate into various mature cells. Recently, dopaminergic neurons were efficiently induced from ES cells using mouse stromal cells (PA6 cells) as a feeder cell layer. This simple procedure seems to be very efficient to obtain dopamine-releasi...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/j.biomaterials.2005.02.021

    authors: Yamazoe H,Murakami Y,Mizuseki K,Sasai Y,Iwata H

    更新日期:2005-10-01 00:00:00

  • Synthesis of polylactides with different molecular weights.

    abstract::The synthesis of poly(lactic acid) through polycondensation of the lactic acid monomer gave weight average molecular weights (Mw) lower than 1.6 x 10(4), whereas ring-opening polymerization of lactides in bulk at 130 degrees C for 72 h using stannous octoate as catalyst in the concentration range from 0.003 to 0.8 wt%...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/s0142-9612(97)00076-8

    authors: Hyon SH,Jamshidi K,Ikada Y

    更新日期:1997-11-01 00:00:00

  • Treating metastatic triple negative breast cancer with CD44/neuropilin dual molecular targets of multifunctional nanoparticles.

    abstract::Metastasis of cancer makes up the vast majority of cancer-related deaths, and it usually initiates from tumor cells invasiveness and develops through tumor neovasculature. In this work, we have fabricated a CD44/neuropilin dual receptor-targeting nanoparticulate system (tLyP-1-HT NPs) with endogenous or FDA approved c...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/j.biomaterials.2017.05.022

    authors: Liang DS,Zhang WJ,Wang AT,Su HT,Zhong HJ,Qi XR

    更新日期:2017-08-01 00:00:00

  • Antibacterial activity of bactericide-immobilized filler for resin-based restoratives.

    abstract::This study examined the antibacterial activity of prepolymerized resin filler, in which the bactericide quaternary ammonium was immobilized. The experimental filler was prepared by grinding prepolymerized resin blocks of methacrylate monomers, silica particles, and the antibacterial monomer methacryloyloxydodecylpyrid...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/s0142-9612(03)00217-5

    authors: Imazato S,Ebi N,Takahashi Y,Kaneko T,Ebisu S,Russell RR

    更新日期:2003-09-01 00:00:00

  • Molecular imaging of a cancer-targeting theragnostics probe using a nucleolin aptamer- and microRNA-221 molecular beacon-conjugated nanoparticle.

    abstract::MicroRNAs (miRNA, miR) have been reported as cancer biomarkers that regulate tumor suppressor genes. Hence, simultaneous detecting and inhibiting of miRNA function will be useful as a cancer theragnostics probe to minimize side effects and invasiveness. In this study, we developed a cancer-targeting therangostics prob...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/j.biomaterials.2011.09.023

    authors: Kim JK,Choi KJ,Lee M,Jo MH,Kim S

    更新日期:2012-01-01 00:00:00

  • A mPEG-PLGA-b-PLL copolymer carrier for adriamycin and siRNA delivery.

    abstract::A amphiphilic block copolymer composed of conventional monomethoxy (polyethylene glycol)-poly (d,l-lactide-co-glycolide)-poly (l-lysine) (mPEG-PLGA-b-PLL) was synthesized. The chemical structure of this copolymer and its precursors was confirmed by Fourier Transform Infrared Spectroscopy (FTIR), (1)H Nuclear Magnetic ...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/j.biomaterials.2012.02.041

    authors: Liu P,Yu H,Sun Y,Zhu M,Duan Y

    更新日期:2012-06-01 00:00:00

  • An evaluation of the capacity of differently prepared demineralised bone matrices (DBM) and toxic residuals of ethylene oxide (EtOx) to provoke an inflammatory response in vitro.

    abstract::Demineralised bone matrix (DBM) is a form of allogeneic tissue graft widely used in oral and maxillofacial procedures. There is a long history of controversy relating to the suitability of ethylene oxide gas (EtOx) as a terminal sterilisation agent for this graft, relating to its effects on the clinical performance of...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/s0142-9612(00)00255-6

    authors: Lomas RJ,Gillan HL,Matthews JB,Ingham E,Kearney JN

    更新日期:2001-05-01 00:00:00

  • Porogens in the preparation of microporous hydrogels based on poly(ethylene oxides).

    abstract::To enable the synthesis of hydrogels containing microporosity, a family of pore generating additives (porogens) were synthesized from poly(ethylene glycols) (PEGs) with different molecular weights using naphthyl acetic acid. The products formed were characterized by UV-vis, differential scanning calorimetry and soluti...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/0142-9612(93)90206-h

    authors: Badiger MV,McNeill ME,Graham NB

    更新日期:1993-11-01 00:00:00

  • Redox-responsive nanocapsules for intracellular protein delivery.

    abstract::Direct delivery of proteins to the cytosol of cells holds tremendous potential in biological and medical applications. Engineering vehicles for escorting proteins to the cytosol in a controlled release fashion has thus generated considerable interest. We report here the preparation of redox-responsive single-protein n...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/j.biomaterials.2011.03.060

    authors: Zhao M,Biswas A,Hu B,Joo KI,Wang P,Gu Z,Tang Y

    更新日期:2011-08-01 00:00:00

  • The inhibition of postinfarct ventricle remodeling without polycythaemia following local sustained intramyocardial delivery of erythropoietin within a supramolecular hydrogel.

    abstract::Erythropoietin (EPO) can protect myocardium from ischemic injury, but it also plays an important role in promoting polycythaemia, the potential for thrombo-embolic complications. Local sustained delivery of bioactive agents directly to impaired tissues using biomaterials is an approach to limit systemic toxicity and i...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/j.biomaterials.2009.04.033

    authors: Wang T,Jiang XJ,Lin T,Ren S,Li XY,Zhang XZ,Tang QZ

    更新日期:2009-09-01 00:00:00

  • Multilayer polypeptide nanoscale coatings incorporating IL-12 for the prevention of biomedical device-associated infections.

    abstract::Biomedical device-associated infection is one of the most common and problematic complications faced by millions of patients worldwide. The current antibiotic therapy strategies face challenges, the most serious of which is antibiotic resistance. Studies have shown that the systemic level of interleukin 12 (IL-12) dec...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/j.biomaterials.2009.01.042

    authors: Li B,Jiang B,Boyce BM,Lindsey BA

    更新日期:2009-05-01 00:00:00

  • Nanocarriers with ultrahigh chromophore loading for fluorescence bio-imaging and photodynamic therapy.

    abstract::We describe the design of original nanocarriers that allows for ultrahigh chromophore loading while maintaining the photo-activity of each individual molecule. They consist in shells of charged biocompatible polymers grafted on gold nanospheres. The self-organization of extended polymer chains results from repulsive c...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/j.biomaterials.2013.07.032

    authors: Navarro JR,Lerouge F,Cepraga C,Micouin G,Favier A,Chateau D,Charreyre MT,Lanoë PH,Monnereau C,Chaput F,Marotte S,Leverrier Y,Marvel J,Kamada K,Andraud C,Baldeck PL,Parola S

    更新日期:2013-11-01 00:00:00

  • pH-dependent modulation of fibroblast adhesion on multilayers composed of poly(ethylene imine) and heparin.

    abstract::Adhesion of tissue cells is a prerequisite for their growth and differentiation but prevents also apoptosis. Here the layer-by-layer technique (LbL) was used to design multilayer structures of poly(ethylene imine) (PEI) and heparin (HEP) on glass as model biomaterial to control the adhesion of primary human dermal fib...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/j.biomaterials.2009.06.014

    authors: Niepel MS,Peschel D,Sisquella X,Planell JA,Groth T

    更新日期:2009-10-01 00:00:00

  • Hydrolytic degradation of devices based on poly(DL-lactic acid) size-dependence.

    abstract::The hydrolytic degradation of aliphatic polyesters derived from lactic and glycolic acids (PLA/GA polymers) has been previously shown to proceed heterogeneously in the case of large size devices, the rate of degradation being greater inside than at the surface. A qualitative model based on diffusion-reaction phenomena...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/0142-9612(95)93258-f

    authors: Grizzi I,Garreau H,Li S,Vert M

    更新日期:1995-03-01 00:00:00

  • Re-assessing the enhanced permeability and retention effect in peripheral arterial disease using radiolabeled long circulating nanoparticles.

    abstract::As peripheral arterial disease (PAD) results in muscle ischemia and neovascularization, it has been claimed that nanoparticles can passively accumulate in ischemic tissues through the enhanced permeability and retention (EPR) effect. At this time, a quantitative evaluation of the passive targeting capabilities of nano...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/j.biomaterials.2016.05.018

    authors: England CG,Im HJ,Feng L,Chen F,Graves SA,Hernandez R,Orbay H,Xu C,Cho SY,Nickles RJ,Liu Z,Lee DS,Cai W

    更新日期:2016-09-01 00:00:00

  • Roles of bone scintigraphy and resonance frequency analysis in evaluating osseointegration of endosseous implant.

    abstract::The purpose of this study is to analyze the roles of two non-invasive techniques, bone scintigraphy and resonance frequency analysis (RFA), in the osseointegration assessment. Sixty implants with sandblasted/acid-etched (SA) or machined (MA) surface were placed into the distal femur condyles of 30 rabbits. At 1, 2, 4,...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/j.biomaterials.2007.10.021

    authors: Zhou Y,Jiang T,Qian M,Zhang X,Wang J,Shi B,Xia H,Cheng X,Wang Y

    更新日期:2008-02-01 00:00:00

  • An electrochemical glucose biosensor exploiting a polyaniline grafted multiwalled carbon nanotube/perfluorosulfonate ionomer-silica nanocomposite.

    abstract::A glucose biosensor was fabricated with loading of glucose oxidase (GOx) into a new organic-inorganic hybrid nanocomposite. The preparation involves formation of silica network into a Nafion (perfluorosulfonate ionomer) and subsequent loading of polyaniline grafted multiwalled carbon nanotubes (MWNT-g-PANI) onto Nafio...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/j.biomaterials.2009.07.047

    authors: Gopalan AI,Lee KP,Ragupathy D,Lee SH,Lee JW

    更新日期:2009-10-01 00:00:00

  • A free-standing multilayer film as a novel delivery carrier of platelet lysates for potential wound-dressing applications.

    abstract::Great efforts have been made to develop suitable bioactive constructs that release growth factors (GFs) in a controlled manner for tissue-regeneration applications. Platelet lysates (PLs) are an affordable source of multiple GFs and other proteins, and show great potential in the wound-healing process. Herein, poly-l-...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/j.biomaterials.2020.120138

    authors: Tang Q,Lim T,Wei XJ,Wang QY,Xu JC,Shen LY,Zhu ZZ,Zhang CQ

    更新日期:2020-10-01 00:00:00

  • An cell-assembly derived physiological 3D model of the metabolic syndrome, based on adipose-derived stromal cells and a gelatin/alginate/fibrinogen matrix.

    abstract::One of the major obstacles in drug discovery is the lack of in vitro three-dimensional (3D) models that can capture more complex features of a disease.Here we established a in vitro physiological model of the metabolic syndrome (MS) using cell-assembly technique (CAT), which can assemble cells into designated places t...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/j.biomaterials.2010.01.111

    authors: Xu M,Wang X,Yan Y,Yao R,Ge Y

    更新日期:2010-05-01 00:00:00

  • Fabrication of PLGA scaffolds using soft lithography and microsyringe deposition.

    abstract::Construction of biodegradable, three-dimensional scaffolds for tissue engineering has been previously described using a variety of molding and rapid prototyping techniques. In this study, we report and compare two methods for fabricating poly(DL-lactide-co-glycolide) (PLGA) scaffolds with feature sizes of approximatel...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/s0142-9612(03)00052-8

    authors: Vozzi G,Flaim C,Ahluwalia A,Bhatia S

    更新日期:2003-06-01 00:00:00

  • Volumetric interpretation of protein adsorption: competition from mixtures and the Vroman effect.

    abstract::A Vroman-like exchange of different proteins adsorbing from a concentrated mixture to the same hydrophobic adsorbent surface is shown to arise naturally from the selective pressure imposed by a fixed interfacial-concentration capacity (w/v, mg/mL) for which protein molecules compete. A size (molecular weight, MW) disc...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/j.biomaterials.2006.09.006

    authors: Noh H,Vogler EA

    更新日期:2007-01-01 00:00:00

  • Alginate hydrogels as synthetic extracellular matrix materials.

    abstract::Alginate hydrogels are used extensively in cell encapsulation, cell transplantation, and tissue engineering applications. Alginates possess many favorable properties required in biomaterials, but are unable to specifically interact with mammalian cells. We have therefore covalently modified alginate polysaccharides wi...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/s0142-9612(98)00107-0

    authors: Rowley JA,Madlambayan G,Mooney DJ

    更新日期:1999-01-01 00:00:00

  • Biocompatibility and biodegradation of different hyaluronan derivatives (Hyaff) implanted in rats.

    abstract::Hyaluronan (HL), a naturally occurring glycosaminoglycan, has been chemically modified through the esterification of its carboxylic groups with different types of alcohol. The physico-chemical properties of these new biopolymers allow the preparation of many biomaterials which may be used in several medical applicatio...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/0142-9612(93)90160-4

    authors: Benedetti L,Cortivo R,Berti T,Berti A,Pea F,Mazzo M,Moras M,Abatangelo G

    更新日期:1993-12-01 00:00:00

  • Excess polycation mediates efficient chitosan-based gene transfer by promoting lysosomal release of the polyplexes.

    abstract::The optimal ratio of the polycation's amine to DNA phosphate group (N:P) for efficient polymer-based transfection always employs excess polycation versus DNA. Most of the excess polycation remains free in solution, unassociated with the polyplexes, but is essential for efficient transfection. The mechanism by which ex...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/j.biomaterials.2011.03.010

    authors: Thibault M,Astolfi M,Tran-Khanh N,Lavertu M,Darras V,Merzouki A,Buschmann MD

    更新日期:2011-07-01 00:00:00

  • Theranostic biocomposite scaffold membrane.

    abstract::Acute and chronic wounds affect millions and are associated with billions of dollars in healthcare costs. The use of healing markers, biochemical cues from biocompatible matrices and materials, and their correlation with wound healing has the potential to generate valuable diagnostic, prognostic, and therapeutic infor...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/j.biomaterials.2019.05.007

    authors: Roussakis E,Ortines RV,Pinsker BL,Mooers CT,Evans CL,Miller LS,Calderón-Colón X

    更新日期:2019-08-01 00:00:00

  • Characterizing the modification of surface proteins with poly(ethylene glycol) to interrupt platelet adhesion.

    abstract::Surface protein modification with poly(ethylene glycol) (PEG) can inhibit acute thrombosis on damaged vascular and biomaterial surfaces by blocking surface protein-platelet interactions. However, the feasibility of employing protein reactive PEGs to limit intravascular and biomaterial thrombosis in vivo is contingent ...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/j.biomaterials.2006.01.012

    authors: Xu H,Kaar JL,Russell AJ,Wagner WR

    更新日期:2006-06-01 00:00:00

  • Electrical stimulation and piezoelectric biomaterials for bone tissue engineering applications.

    abstract::Bioelectrical phenomenon in natural bone has been well recognized for its role in bone development and fracture healing. For example, the piezoelectricity induced modulation in cellular functionality assists in the repair and regeneration of bone tissue. Against this backdrop, we review here the origin of dielectric a...

    journal_title:Biomaterials

    pub_type: 杂志文章,评审

    doi:10.1016/j.biomaterials.2020.120280

    authors: Khare D,Basu B,Dubey AK

    更新日期:2020-11-01 00:00:00

  • Generation of craniofacial myogenic progenitor cells from human induced pluripotent stem cells for skeletal muscle tissue regeneration.

    abstract::Craniofacial skeletal muscle is composed of approximately 60 muscles, which have critical functions including food uptake, eye movements and facial expressions. Although craniofacial muscles have significantly different embryonic origin, most current skeletal muscle differentiation protocols using human induced plurip...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/j.biomaterials.2020.119995

    authors: Kim E,Wu F,Wu X,Choo HJ

    更新日期:2020-07-01 00:00:00