Abstract：
:Previous in vivo studies have shown a limited potential for vertical bone regeneration using osteoconductive scaffolds alone. In the present study, we investigated whether the association of adipose-derived adult stem cells (ASCs) with anorganic bovine bone (ABB) scaffold improved bone formation and implant osseointegration in a vertical guided bone regeneration model. Two pre-formed titanium domes were placed on the calvaria of 12 rabbits. Four treatment modalities were evenly distributed among the 24 domes: ABB alone, and ABB containing 3 x 10(5), 3 x 10(6), or 3 x 10(7) cells/graft. After 1 month, the domes were removed and one titanium implant was placed into each augmented site. One month after the second operation, the animals were killed and biopsy specimens were examined by histomorphometric and micro-CT analyses. Results indicated that at all concentrations, the ASC-loaded groups showed significantly more new bone formation and higher mean values of bone-implant contact and bone density inside threads than the ABB group. Furthermore, ASCs demonstrated a dose-response relationship, with the highest dose chosen inducing more robust bone regeneration. This study suggests that the delivery of ASCs on ABB might effectively increase vertical bone regeneration and implant osseointegration, versus ABB alone.
journal_name
Biomaterialsjournal_title
Biomaterialsauthors
Pieri F,Lucarelli E,Corinaldesi G,Aldini NN,Fini M,Parrilli A,Dozza B,Donati D,Marchetti Cdoi
10.1016/j.biomaterials.2010.01.066subject
Has Abstractpub_date
2010-05-01 00:00:00pages
3527-35issue
13eissn
0142-9612issn
1878-5905pii
S0142-9612(10)00098-0journal_volume
31pub_type
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