Abstract:
:The effect of surface characteristics on the interaction of sterically stabilized polystyrene particles with mouse peritoneal macrophages was studied using a range of poloxamers and poloxamine as coating agents. The coated particles were characterized in terms of thickness of coating layer, surface charge and critical flocculation temperature. The relative phagocytic uptake was found to decrease with increasing adsorbed layer thickness i.e. longer hydrophilic polymer chains of the coating agent and consequently a greater steric stabilization effect.
journal_name
Biomaterialsjournal_title
Biomaterialsauthors
Illum L,Jacobsen LO,Müller RH,Mak E,Davis SSdoi
10.1016/0142-9612(87)90099-8subject
Has Abstractpub_date
1987-03-01 00:00:00pages
113-7issue
2eissn
0142-9612issn
1878-5905pii
0142-9612(87)90099-8journal_volume
8pub_type
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