Abstract：
:Polydispersed poly(L-lactic acid) (PLLA) membranes comprised of blends of monodispersed PLLA of weight average molecular weight of 82,500 and 7600 were fabricated to investigate the effect of polydispersity on degradation characteristics. The PLLA blends exhibited large spherulites of high molecular weight chains embedded in a low molecular weight matrix. During degradation in phosphate buffer at pH 7.4 and 37 degrees C for 28 d, the release rate of lactic acid increased as the percentage of the low molecular weight component in the blend was increased. For low molecular weight compositions larger than 50%, voids were created in the degrading blends due to the degradation of low molecular weight chains and the concurrent dissolution of lactic acid, and also the release of undegraded particles of high molecular weight. These studies demonstrate the feasibility of modulating lactic acid release during in vivo degradation of PLLA implants by adjusting the polymer polydispersity.
journal_name
Biomaterialsjournal_title
Biomaterialsauthors
von Recum HA,Cleek RL,Eskin SG,Mikos AGdoi
10.1016/0142-9612(95)98816-wsubject
Has Abstractpub_date
1995-04-01 00:00:00pages
441-7issue
6eissn
0142-9612issn
1878-5905pii
014296129598816Wjournal_volume
16pub_type
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