Microwave pumped high-efficient thermoacoustic tumor therapy with single wall carbon nanotubes.


:The ultra-short pulse microwave could excite to the strong thermoacoustic (TA) shock wave and deeply penetrate in the biological tissues. Based on this, we developed a novel deep-seated tumor therapy modality with mitochondria-targeting single wall carbon nanotubes (SWNTs) as microwave absorbing agents, which act efficiently to convert ultra-short microwave energy into TA shock wave and selectively destroy the targeted mitochondria, thereby inducing apoptosis in cancer cells. After the treatment of SWNTs (40 μg/mL) and ultra-short microwave (40 Hz, 1 min), 77.5% of cancer cells were killed and the vast majority were caused by apoptosis that initiates from mitochondrial damage. The orthotopic liver cancer mice were established as deep-seated tumor model to investigate the anti-tumor effect of mitochondria-targeting TA therapy. The results suggested that TA therapy could effectively inhibit the tumor growth without any observable side effects, while it was difficult to achieve with photothermal or photoacoustic therapy. These discoveries implied the potential application of TA therapy in deep-seated tumor models and should be further tested for development into a promising therapeutic modality for cancer treatment.






Wen L,Ding W,Yang S,Xing D




Has Abstract


2016-01-01 00:00:00












  • Dose-dependent effect of adipose-derived adult stem cells on vertical bone regeneration in rabbit calvarium.

    abstract::Previous in vivo studies have shown a limited potential for vertical bone regeneration using osteoconductive scaffolds alone. In the present study, we investigated whether the association of adipose-derived adult stem cells (ASCs) with anorganic bovine bone (ABB) scaffold improved bone formation and implant osseointeg...


    pub_type: 杂志文章


    authors: Pieri F,Lucarelli E,Corinaldesi G,Aldini NN,Fini M,Parrilli A,Dozza B,Donati D,Marchetti C

    更新日期:2010-05-01 00:00:00

  • Effect of lysozyme on the stability of polyester nanocapsules and nanoparticles: stabilization approaches.

    abstract::The efficacy of colloidal particles as drug carriers is closely related to their interaction with proteins and enzymes in different body fluids. In the present work, we analysed the interaction phenomenon between lysozyme (LZM), a positively charged enzyme that is highly concentrated in mucosas, and two different drug...


    pub_type: 杂志文章


    authors: Calvo P,Vila-Jato JL,Alonso MJ

    更新日期:1997-10-01 00:00:00

  • Assembly of upconversion nanophotosensitizer in vivo to achieve scatheless real-time imaging and selective photodynamic therapy.

    abstract::A perfect "off" to "on" switch of the therapeutic function is very important to minimize the phototoxicity of nanoplatforms assisted imaging-guided photodynamic therapy (PDT) of cancer. Current approaches rely on preloaded photosensitizers, where the off/on state of PDT is regulated by the sensitizing light of photose...


    pub_type: 杂志文章


    authors: Feng Y,Wu Y,Zuo J,Tu L,Que I,Chang Y,Cruz LJ,Chan A,Zhang H

    更新日期:2019-05-01 00:00:00

  • High throughput atmospheric pressure plasma-induced graft polymerization for identifying protein-resistant surfaces.

    abstract::Three critical aspects of searching for and understanding how to find highly resistant surfaces to protein adhesion are addressed here with specific application to synthetic membrane filtration. They include the (i) discovery of a series of previously unreported monomers from a large library of monomers with high prot...


    pub_type: 杂志文章


    authors: Gu M,Kilduff JE,Belfort G

    更新日期:2012-02-01 00:00:00

  • Water absorption, dimensional change and radial pressure in resin matrix dental restorative materials.

    abstract::The purpose of this work was to study the relationship between water absorption, dimensional change (swelling) under cavity constraint and radial stress generation in resin matrix dental restorative materials. Water absorption was determined on disc specimens whilst swelling was determined on samples of materials rest...


    pub_type: 杂志文章


    authors: McCabe JF,Rusby S

    更新日期:2004-08-01 00:00:00

  • Retention of stemness and vasculogenic potential of human umbilical cord blood stem cells after repeated expansions on PES-nanofiber matrices.

    abstract::Despite recent advances in cardiovascular medicine, ischemic diseases remain a major cause of morbidity and mortality. Although stem cell-based therapies for the treatment of ischemic diseases show great promise, limited availability of biologically functional stem cells mired the application of stem cell-based therap...


    pub_type: 杂志文章


    authors: Joseph M,Das M,Kanji S,Lu J,Aggarwal R,Chakroborty D,Sarkar C,Yu H,Mao HQ,Basu S,Pompili VJ,Das H

    更新日期:2014-10-01 00:00:00

  • Encapsulation of individual living cells with enzyme responsive polymer nanoshell.

    abstract::Cell delivery in cell therapy is typically challenged by the low cell survival rate and immunological rejection during cells injection and circulation. Encapsulation of cells with semipermeable hydrogels or membranes can improve cell viability by resisting high shear force and inhibit immune response with the physical...


    pub_type: 杂志文章


    authors: Yang J,Yang Y,Kawazoe N,Chen G

    更新日期:2019-03-01 00:00:00

  • The mechanism of cell-damaging reactive oxygen generation by colloidal fullerenes.

    abstract::Because of the ability to induce cell death in certain conditions, the fullerenes (C(60)) are potential anticancer and toxic agents. The colloidal suspension of crystalline C(60) (nano-C(60), nC(60)) is extremely toxic, but the mechanisms of its cytotoxicity are not completely understood. By combining experimental ana...


    pub_type: 杂志文章


    authors: Markovic Z,Todorovic-Markovic B,Kleut D,Nikolic N,Vranjes-Djuric S,Misirkic M,Vucicevic L,Janjetovic K,Isakovic A,Harhaji L,Babic-Stojic B,Dramicanin M,Trajkovic V

    更新日期:2007-12-01 00:00:00

  • The promotion of angiogenesis by growth factors integrated with ECM proteins through coiled-coil structures.

    abstract::An appropriate method to bind extracellular matrix (ECM) proteins and growth factors using advanced protein engineering techniques has the potential to enhance cell proliferation and differentiation for tissue regeneration and repair. In this study we developed a method to co-immobilize non-covalently an ECM protein t...


    pub_type: 杂志文章


    authors: Assal Y,Mie M,Kobatake E

    更新日期:2013-04-01 00:00:00

  • Failure micromechanisms during uniaxial tensile fracture of conventional and highly crosslinked ultra-high molecular weight polyethylenes used in total joint replacements.

    abstract::Highly crosslinked UHMWPEs have demonstrated improved in vitro wear properties; however, there is concern regarding loss of fracture resistance and ductility. The goals of this study were to evaluate the micromechanisms of failure under uniaxial tension and to determine the effect of gamma radiation-induced crosslinki...


    pub_type: 杂志文章


    authors: Gencur SJ,Rimnac CM,Kurtz SM

    更新日期:2003-10-01 00:00:00

  • Self-protecting core-shell magnetic nanoparticles for targeted, traceable, long half-life delivery of BCNU to gliomas.

    abstract::The successful delivery of anti-cancer drugs relies on the simultaneous capability to actively target a specific location, a sufficient lifetime in the active form in the circulation, and traceability and quantification of drug distribution via in vivo medical imaging. Herein, a highly magnetic nanocarrier (HMNC) comp...


    pub_type: 杂志文章


    authors: Yang HW,Hua MY,Liu HL,Huang CY,Tsai RY,Lu YJ,Chen JY,Tang HJ,Hsien HY,Chang YS,Yen TC,Chen PY,Wei KC

    更新日期:2011-09-01 00:00:00

  • Composite mesh design for delivery of autologous mesenchymal stem cells influences mesh integration, exposure and biocompatibility in an ovine model of pelvic organ prolapse.

    abstract::The widespread use of synthetic transvaginal polypropylene mesh for treating Pelvic Organ Prolapse (POP) has been curtailed due to serious adverse effects highlighted in 2008 and 2011 FDA warnings and subsequent legal action. We are developing new synthetic mesh to deliver endometrial mesenchymal stem cells (eMSC) to ...


    pub_type: 杂志文章


    authors: Emmerson S,Mukherjee S,Melendez-Munoz J,Cousins F,Edwards SL,Karjalainen P,Ng M,Tan KS,Darzi S,Bhakoo K,Rosamilia A,Werkmeister JA,Gargett CE

    更新日期:2019-12-01 00:00:00

  • Generation and simulated imaging of pseudo-scaffolds to aid characterisation by X-ray micro CT.

    abstract::In order to assess the suitability of polymer tissue scaffolds for use in regenerative medicine, methods to characterise scaffolds are needed. This requires the scaffold's structure to be determined for which X-ray microscopic computed tomography (X-ray micro CT) is widely used. However, because scaffolds are generall...


    pub_type: 杂志文章


    authors: Morris DE,Mather ML,Crowe JA

    更新日期:2009-09-01 00:00:00

  • The fibrotic response of primary liver spheroids recapitulates in vivo hepatic stellate cell activation.

    abstract::A major obstacle in the development of efficient therapies for progressive liver fibrosis is the lack of representative in vitro models of liver fibrosis to aid in understanding the mechanisms of the disease and to promote the development of pharmaceuticals. Our aim was to develop a relevant in vitro mouse liver fibro...


    pub_type: 杂志文章


    authors: Mannaerts I,Eysackers N,Anne van Os E,Verhulst S,Roosens T,Smout A,Hierlemann A,Frey O,Leite SB,van Grunsven LA

    更新日期:2020-12-01 00:00:00

  • Tolerance induction by surface immobilization of Jagged-1 for immunoprotection of pancreatic islets.

    abstract::Although transplantation of pancreatic islets is a promising approach for treatment of type 1 diabetes mellitus, the engraftment efficiency of these islets is limited by host immune responses. Extensive efforts have been made to immunoisolate these islets by introducing barriers on the islet surface. To date, these ba...


    pub_type: 杂志文章


    authors: Izadi Z,Hajizadeh-Saffar E,Hadjati J,Habibi-Anbouhi M,Ghanian MH,Sadeghi-Abandansari H,Ashtiani MK,Samsonchi Z,Raoufi M,Moazenchi M,Izadi M,Nejad ASSH,Namdari H,Tahamtani Y,Ostad SN,Akbari-Javar H,Baharvand H

    更新日期:2018-11-01 00:00:00

  • Dual-drug delivery system based on hydrogel/micelle composites.

    abstract::We present a dual-drug delivery system (DDDS) of hydrogel/polypeptide micelle composites in this work. The DDDS was constructed from aspirin (Asp) dispersed poly(vinyl alcohol) (PVA) or Chitosan (CS)/PVA hydrogel and doxorubicin (DOX) loaded poly(L-glutamic acid)-b-poly(propylene oxide)-b-poly(L-glutamic acid) (GPG) m...


    pub_type: 杂志文章


    authors: Wei L,Cai C,Lin J,Chen T

    更新日期:2009-05-01 00:00:00

  • Electrodeposited platinum-iridium coating improves in vivo recording performance of chronically implanted microelectrode arrays.

    abstract::Reliable single unit neuron recordings from chronically implanted microelectrode arrays (MEAs) are essential tools in the field of neural engineering. However, following implantation, MEAs undergo a foreign body response that functionally isolates them from the brain and reduces the useful longevity of the array. We t...


    pub_type: 杂志文章


    authors: Cassar IR,Yu C,Sambangi J,Lee CD,Whalen JJ 3rd,Petrossians A,Grill WM

    更新日期:2019-06-01 00:00:00

  • An overview of tissue and whole organ decellularization processes.

    abstract::Biologic scaffold materials composed of extracellular matrix (ECM) are typically derived by processes that involve decellularization of tissues or organs. Preservation of the complex composition and three-dimensional ultrastructure of the ECM is highly desirable but it is recognized that all methods of decellularizati...


    pub_type: 杂志文章,评审


    authors: Crapo PM,Gilbert TW,Badylak SF

    更新日期:2011-04-01 00:00:00

  • In vitro bone metastasis dwelling in a 3D bioengineered niche.

    abstract::Bone is the most frequent metastasis site for breast cancer. As well as dramatically increasing disease burden, bone metastases are also an indicator of poor prognosis. One of the main challenges in investigating bone metastasis in breast cancer is engineering in vitro models that replicate the features of in vivo bon...


    pub_type: 杂志文章


    authors: Han W,El Botty R,Montaudon E,Malaquin L,Deschaseaux F,Espagnolle N,Marangoni E,Cottu P,Zalcman G,Parrini MC,Assayag F,Sensebe L,Silberzan P,Vincent-Salomon A,Dutertre G,Roman-Roman S,Descroix S,Camonis J

    更新日期:2020-12-24 00:00:00

  • Gel spinning of silk tubes for tissue engineering.

    abstract::Tubular vessels for tissue engineering are typically fabricated using a molding, dipping, or electrospinning technique. While these techniques provide some control over inner and outer diameters of the tube, they lack the ability to align the polymers or fibers of interest throughout the tube. This is an important asp...


    pub_type: 杂志文章


    authors: Lovett ML,Cannizzaro CM,Vunjak-Novakovic G,Kaplan DL

    更新日期:2008-12-01 00:00:00

  • Wet-adhesive, haemostatic and antimicrobial bilayered composite nanosheets for sealing and healing soft-tissue bleeding wounds.

    abstract::Healing soft-tissue wounds with an irregular, complicated topography in a bleeding environment demands the development of a dressing that is wet-adhesive, haemostatic, and antibacterial. To meet this unmet demand, we designed a flexible nanosheet (~77 nm thick) made of two layers, one is the antibacterial and haemosta...


    pub_type: 杂志文章


    authors: Xuan C,Hao L,Liu X,Zhu Y,Yang H,Ren Y,Wang L,Fujie T,Wu H,Chen Y,Shi X,Mao C

    更新日期:2020-09-01 00:00:00

  • iNGR-modified PEG-PLGA nanoparticles that recognize tumor vasculature and penetrate gliomas.

    abstract::A major cross-cutting problem for glioma therapy is the poor extravasation and penetration of the payload drug in target glioma parenchyma. Here, to overcome these obstacles, a tumor vessel recognizing and tumor penetrating system is developed by functionalizating the poly (ethyleneglycol)-poly (L-lactic-co-glycolic a...


    pub_type: 杂志文章


    authors: Kang T,Gao X,Hu Q,Jiang D,Feng X,Zhang X,Song Q,Yao L,Huang M,Jiang X,Pang Z,Chen H,Chen J

    更新日期:2014-05-01 00:00:00

  • Two-dimensional nanosheets with high curcumin loading content for multimodal imaging-guided combined chemo-photothermal therapy.

    abstract::Nowadays, two-dimensional (2D) nanomaterials with many fascinating physicochemical properties have drawn extensive attention as drug delivery platforms for cancer theranostics. Nevertheless, current existing 2D nanomaterial-based drug delivery systems normally undergo the bottlenecks of hash preparation process, low d...


    pub_type: 杂志文章


    authors: Liu F,Lin L,Zhang Y,Sheng S,Wang Y,Xu C,Tian H,Chen X

    更新日期:2019-12-01 00:00:00

  • Implantation of porous acrylic cement in soft tissues: an animal and human biopsy histological study.

    abstract::Long-term (8 and 24 month) reactions of the (hypo) dermis of the guinea pig to solid and porous (50 vol%) acrylic implants and four human biopsies from porous subcutaneous acrylic implants were studied light microscopically. The solid implants were encapsulated by dense connective tissue. Mobility was evidenced by the...


    pub_type: 杂志文章


    authors: van Mullem PJ,Vaandrager JM,Nicolai JP,de Wijn JR

    更新日期:1990-07-01 00:00:00

  • Bone formation within alumina tubes: effect of calcium, manganese, and chromium dopants.

    abstract::Alumina tubes (1.3mm outer diameter, 0.6mm inner diameter, 15 mm length) doped with Ca, Mn, or Cr at nominal concentrations of 0.5 and 5.0 mol% were implanted into femoral medullary canals of female rats for 16 weeks. Tissue formation within tubes was determined by histology and histomorphometry. Addition of Ca to alu...


    pub_type: 杂志文章


    authors: Pabbruwe MB,Standard OC,Sorrell CC,Howlett CR

    更新日期:2004-09-01 00:00:00

  • Intrinsic catalytic activity of Au nanoparticles with respect to hydrogen peroxide decomposition and superoxide scavenging.

    abstract::Gold nanoparticles have received a great deal of interest due to their unique optical and catalytic properties and biomedical applications. Developing applications as well as assessing associated risks requires an understanding of the interactions between Au nanoparticles (NPs) and biologically active substances. In t...


    pub_type: 杂志文章


    authors: He W,Zhou YT,Wamer WG,Hu X,Wu X,Zheng Z,Boudreau MD,Yin JJ

    更新日期:2013-01-01 00:00:00

  • A stimuli-responsive hydrogel for doxorubicin delivery.

    abstract::The goal of this study was to develop a polymeric carrier for delivery of anti-tumor drugs and sustained release of these agents in order to optimize anti-tumor activity while minimizing systemic effects. We used oligo(poly(ethylene glycol) fumarate) (OPF) hydrogels modified with small negatively charged molecules, so...


    pub_type: 杂志文章


    authors: Dadsetan M,Liu Z,Pumberger M,Giraldo CV,Ruesink T,Lu L,Yaszemski MJ

    更新日期:2010-11-01 00:00:00

  • Phospholipid decoration of microcapsules containing perfluorooctyl bromide used as ultrasound contrast agents.

    abstract::We present here an easy method to modify the surface chemistry of polymeric microcapsules of perfluorooctyl bromide used as ultrasound contrast agents (UCAs). Capsules were obtained by a solvent emulsification-evaporation process with phospholipids incorporated in the organic phase before emulsification. Several phosp...


    pub_type: 杂志文章


    authors: Díaz-López R,Tsapis N,Libong D,Chaminade P,Connan C,Chehimi MM,Berti R,Taulier N,Urbach W,Nicolas V,Fattal E

    更新日期:2009-03-01 00:00:00

  • Localized inhibition of platelets and platelet derived growth factor by a matrix targeted glycan mimetic significantly attenuates liver fibrosis.

    abstract::New therapeutic strategies are needed for the growing unmet clinical needs in liver disease and fibrosis. Platelet activation and PDGF activity are recognized as important therapeutic targets; however, no therapeutic approach has yet addressed these two upstream drivers of liver fibrosis. We therefore designed a matri...


    pub_type: 杂志文章


    authors: Kabra H,Walimbe T,Stuart K,Indey C,Jalgaonkar S,Ikwa E,Skurnac T,Chen J,Woolley A,Snead NM,Bachtell N,Leeming DJ,Karsdal M,Prestwich G,Panitch A,Paderi J

    更新日期:2020-11-17 00:00:00

  • Calcification of soft tissue employed in the construction of heart valve prostheses: study of different chemical treatments.

    abstract::Biological heart prostheses present medium and long-term problems, owing to progressive deterioration and calcification of the tissue. To study the latter problem, we compared the effectiveness of anticalcification treatments in calf pericardium samples implanted into female Wistar rats after the following procedures:...


    pub_type: 杂志文章


    authors: Jorge-Herrero E,Gutiérrez MP,Castillo-Olivares JL

    更新日期:1991-03-01 00:00:00