Microwave pumped high-efficient thermoacoustic tumor therapy with single wall carbon nanotubes.


:The ultra-short pulse microwave could excite to the strong thermoacoustic (TA) shock wave and deeply penetrate in the biological tissues. Based on this, we developed a novel deep-seated tumor therapy modality with mitochondria-targeting single wall carbon nanotubes (SWNTs) as microwave absorbing agents, which act efficiently to convert ultra-short microwave energy into TA shock wave and selectively destroy the targeted mitochondria, thereby inducing apoptosis in cancer cells. After the treatment of SWNTs (40 μg/mL) and ultra-short microwave (40 Hz, 1 min), 77.5% of cancer cells were killed and the vast majority were caused by apoptosis that initiates from mitochondrial damage. The orthotopic liver cancer mice were established as deep-seated tumor model to investigate the anti-tumor effect of mitochondria-targeting TA therapy. The results suggested that TA therapy could effectively inhibit the tumor growth without any observable side effects, while it was difficult to achieve with photothermal or photoacoustic therapy. These discoveries implied the potential application of TA therapy in deep-seated tumor models and should be further tested for development into a promising therapeutic modality for cancer treatment.






Wen L,Ding W,Yang S,Xing D




Has Abstract


2016-01-01 00:00:00












  • Biomimetic apatite formation on polyethylene photografted with vinyltrimethoxysilane and hydrolyzed.

    abstract::A photografting technique to produce functional groups of silanol able to induce apatite nucleation was attempted on polyethylene substrate for biomimetic formation of bone-mineral-like apatite layer on its surface. The polyethylene surface was subjected to vapor-phase photografting of vinyltrimethoxysilane and subseq...


    pub_type: 杂志文章


    authors: Kim HM,Uenoyama M,Kokubo T,Minoda M,Miyamoto T,Nakamura T

    更新日期:2001-09-01 00:00:00

  • Accelerated Achilles tendon healing by PDGF gene delivery with mesoporous silica nanoparticles.

    abstract::We report the ability of amino- and carboxyl-modified MCM-41 mesoporous silica nanoparticles (MSN) to deliver gene in vivo in rat Achilles tendons, despite their inefficiency to transfect primary tenocytes in culture. We show that luciferase activity lasted for at least 2 weeks in tendons injected with these MSN and a...


    pub_type: 杂志文章


    authors: Suwalski A,Dabboue H,Delalande A,Bensamoun SF,Canon F,Midoux P,Saillant G,Klatzmann D,Salvetat JP,Pichon C

    更新日期:2010-07-01 00:00:00

  • A model for recording mercury release from an amalgam surface.

    abstract::The release rate of mercury from a conventional, a dispersed phase or a spherical high copper content amalgam under static conditions in stimulated or artificial saliva has been measured and found to decrease approximately exponentially with time. A higher initial release rate was observed for mercury in stimulated sa...


    pub_type: 杂志文章


    authors: Brune D

    更新日期:1985-09-01 00:00:00

  • The effect of RGD fluorosurfactant polymer modification of ePTFE on endothelial cell adhesion, growth, and function.

    abstract::We have synthesized and characterized a novel peptide fluorosurfactant polymer (PFSP) modification that facilitates the adhesion and growth of endothelial cells on expanded polytetrafluoroetheylene (ePTFE) vascular graft material. This PFSP consists of a poly(vinyl amine) (PVAm) backbone with integrin binding Arg-Gly-...


    pub_type: 杂志文章


    authors: Larsen CC,Kligman F,Kottke-Marchant K,Marchant RE

    更新日期:2006-10-01 00:00:00

  • Technological issues for the development of more efficient calcium phosphate bone cements: a critical assessment.

    abstract::The first calcium phosphate cements (CPCs) were discovered in the 1980s. Two decades later, the interest for these materials is still rising. The goal of the present document is to review the most recent achievements in the field and to analyze future directions in research and development. ...


    pub_type: 杂志文章,评审


    authors: Bohner M,Gbureck U,Barralet JE

    更新日期:2005-11-01 00:00:00

  • The use of glass substrates with bi-functional silanes for designing micropatterned cell-secreted cytokine immunoassays.

    abstract::It is often desirable to sequester cells in specific locations on the surface and to integrate sensing elements next to the cells. In the present study, surfaces were fabricated so as to position cytokine sensing domains inside non-fouling poly(ethylene glycol) (PEG) hydrogel microwells. Our aim was to increase sensit...


    pub_type: 杂志文章


    authors: Seo JH,Chen LJ,Verkhoturov SV,Schweikert EA,Revzin A

    更新日期:2011-08-01 00:00:00

  • Anti-Flt1 peptide - hyaluronate conjugate for the treatment of retinal neovascularization and diabetic retinopathy.

    abstract::Anti-angiogenic therapeutics has been investigated extensively for the treatment of retinal and choroidal vascular diseases, and diabetic retinopathy. Anti-Flt1 peptide of GNQWFI is an antagonistic peptide for vascular endothelial growth factor receptor 1 (VEGFR1 or Flt1) inhibiting VEGFR1-mediated endothelial cell mi...


    pub_type: 杂志文章


    authors: Oh EJ,Choi JS,Kim H,Joo CK,Hahn SK

    更新日期:2011-04-01 00:00:00

  • Polymeric microspheres as stabilizing anchors for oligonucleotide delivery to dendritic cells.

    abstract::The aim of this study is to evaluate a novel microspheric vector for delivery of oligonucleotides (ODN) into dendritic cells (DC). A requirement of decoy-based modulation of transcriptional activities in DC is that the ODN would have to accumulate inside the cell. Using an ex vivo DC culture model, we demonstrate that...


    pub_type: 杂志文章


    authors: Kovacs JR,Zheng Y,Shen H,Meng WS

    更新日期:2005-11-01 00:00:00

  • Effect of the size and surface charge of polymer microspheres on their phagocytosis by macrophage.

    abstract::Polystyrene and phenylated polyacrolein microspheres of different diameters, as well as modified cellulose microspheres with different surface charges, were prepared in order to study the size and surface charge effect on their phagocytosis by mouse peritoneal macrophages. It was found that the maximal phagocytosis of...


    pub_type: 杂志文章


    authors: Tabata Y,Ikada Y

    更新日期:1988-07-01 00:00:00

  • Tear and rupture of elastomeric dental impression materials.

    abstract::The curing time dependence of the tear energy, tensile strength and ultimate extension ratio of a range of characterized elastomeric impression materials was investigated. This variation of tensile strength and ultimate extension ratio was correlated with the development of the network structure. The tear energy showe...


    pub_type: 杂志文章


    authors: Cook WD,Liem F,Russo P,Scheiner M,Simkiss G,Woodruff P

    更新日期:1984-09-01 00:00:00

  • The effect of continuous wavy micropatterns on silicone substrates on the alignment of skeletal muscle myoblasts and myotubes.

    abstract::Tissue-engineered muscle is a viable option for tissue repair, though presently technologies are not developed enough to produce tissue in vitro identical to that in vivo. One important step in generating accurate engineered muscle is to mimic natural muscle architecture. Skeletal muscle is composed of fibrils whose o...


    pub_type: 杂志文章


    authors: Lam MT,Sim S,Zhu X,Takayama S

    更新日期:2006-08-01 00:00:00

  • Meniscal repair by fibrocartilage in the dog: characterization of the repair tissue and the role of vascularity.

    abstract::Lesions in the avascular part of 20 canine menisci were repaired by implantation of a porous polyurethane. Seven menisci were not repaired and served as controls. The repair tissue was characterized by biochemical and immunological analysis. The role of vascularity in healing was studied by perfusion of menisci with I...


    pub_type: 杂志文章


    authors: Klompmaker J,Veth RP,Jansen HW,Nielsen HK,de Groot JH,Pennings AJ,Kuijer R

    更新日期:1996-09-01 00:00:00

  • Debye function analysis and 2D imaging of nanoscaled engineered bone.

    abstract::The Debye Function Analysis of diffraction patterns from nanosized mineral crystals showing different average degrees of maturity was carried out on engineered bone samples. The analysis relied on a bivariate family of atomistic hydroxyapatite nanocrystal models and provided information about crystal structure, size a...


    pub_type: 杂志文章


    authors: Guagliardi A,Cedola A,Giannini C,Ladisa M,Cervellino A,Sorrentino A,Lagomarsino S,Cancedda R,Mastrogiacomo M

    更新日期:2010-11-01 00:00:00

  • The application of human bone marrow stromal cells and poly(dl-lactic acid) as a biological bone graft extender in impaction bone grafting.

    abstract::Concerns over disease transmission, high costs and limited supply have led to interest in synthetic grafts in the field of impaction bone grafting (IBG). Poly(DL-lactic acid) (PLA) grafts are attractive alternatives due to their biocompatibility, established safety and versatile manufacturing process. This study exami...


    pub_type: 杂志文章


    authors: Bolland BJ,Kanczler JM,Ginty PJ,Howdle SM,Shakesheff KM,Dunlop DG,Oreffo RO

    更新日期:2008-08-01 00:00:00

  • Antitumor efficacy following the intracellular and interstitial release of liposomal doxorubicin.

    abstract::pH-triggered lipid-membranes designed from biophysical principles are evaluated in the form of targeted liposomal doxorubicin with the aim to ultimately better control the growth of vascularized tumors. We compare the antitumor efficacy of anti-HER2/neu pH-triggered lipid vesicles encapsulating doxorubicin to the anti...


    pub_type: 杂志文章


    authors: Bandekar A,Karve S,Chang MY,Mu Q,Rotolo J,Sofou S

    更新日期:2012-06-01 00:00:00

  • A superoxide dismutase/catalase mimetic nanomedicine for targeted therapy of inflammatory bowel disease.

    abstract::Oxidative stress, resulting from excessive generation of reactive oxygen species (ROS), plays a pivotal role in the initiation and progression of inflammatory bowel disease (IBD). To develop an efficacious and safe nanotherapy against IBD, we designed and developed a superoxide dismutase/catalase mimetic nanomedicine ...


    pub_type: 杂志文章


    authors: Zhang Q,Tao H,Lin Y,Hu Y,An H,Zhang D,Feng S,Hu H,Wang R,Li X,Zhang J

    更新日期:2016-10-01 00:00:00

  • Biocompatibility of the Vascugraft: evaluation of a novel polyester urethane vascular substitute by an organotypic culture technique.

    abstract::To evaluate the biocompatibility of chemically and structurally modified polyurethane elastomers for use as blood vessel replacements, small squares of vascular prostheses were cultured in direct contact with endothelium from chick embryo aorta using an organotypic culture assay. The polyurethane materials tested were...


    pub_type: 杂志文章


    authors: Guidoin R,Sigot M,King M,Sigot-Luizard MF

    更新日期:1992-01-01 00:00:00

  • Characterizing multicomponent adsorbed protein films using electron spectroscopy for chemical analysis, time-of-flight secondary ion mass spectrometry, and radiolabeling: capabilities and limitations.

    abstract::Characterization of complex adsorbed protein films is a critical aspect of biomaterials science, particularly in understanding the in vivo response to biomaterials. The surface analysis techniques electron spectroscopy for chemical analysis (ESCA) and time-of-flight secondary ion mass spectrometry (ToF-SIMS) are parti...


    pub_type: 杂志文章


    authors: Wagner MS,Horbett TA,Castner DG

    更新日期:2003-05-01 00:00:00

  • Graphene oxide covalently grafted upconversion nanoparticles for combined NIR mediated imaging and photothermal/photodynamic cancer therapy.

    abstract::Theranostics, the integration of diagnostics and therapies, has become a new concept in the battles with various major diseases such as cancer. Here, we report a multifunctional nanoplatform, which is developed by covalently grafting core-shell structured upconversion nanoparticles (UCNPs) with nanographene oxide (NGO...


    pub_type: 杂志文章


    authors: Wang Y,Wang H,Liu D,Song S,Wang X,Zhang H

    更新日期:2013-10-01 00:00:00

  • Developing bioactive composite materials for tissue replacement.

    abstract::A variety of bioactive composites have been investigated over the last two decades as substitute materials for diseased or damaged tissues in the human body. In this paper, the rationale and strategy of developing these composites are given. Major factors influencing the production and performance of bioactive composi...


    pub_type: 杂志文章,评审


    authors: Wang M

    更新日期:2003-06-01 00:00:00

  • The cellular response to transglutaminase-cross-linked collagen.

    abstract::Collagen, type I, is a highly abundant natural protein material which has been cross-linked by a variety of methods including chemical agents, physical heating and UV irradiation with the aim of enhancing its physical characteristics such as mechanical strength, thermal stability, resistance to proteolytic breakdown, ...


    pub_type: 杂志文章


    authors: Chau DY,Collighan RJ,Verderio EA,Addy VL,Griffin M

    更新日期:2005-11-01 00:00:00

  • The proliferation and differentiation of placental-derived multipotent cells into smooth muscle cells on fibrillar collagen.

    abstract::Type I collagen constitutes a major portion of the extracellular matrix (ECM) in arterial wall and it is the major substrate for cell growth and differentiation. The goal of this study was to evaluate the differentiation and proliferation of placenta-derived multipotent cells (PDMCs) on polymerized type I collagen fib...


    pub_type: 杂志文章


    authors: Chou MT,Chang SN,Ke C,Chang HI,Sung ML,Kuo HC,Chen CN

    更新日期:2010-05-01 00:00:00

  • A bFGF-releasing silk/PLGA-based biohybrid scaffold for ligament/tendon tissue engineering using mesenchymal progenitor cells.

    abstract::An ideal scaffold that provides a combination of suitable mechanical properties along with biological signals is required for successful ligament/tendon regeneration in mesenchymal stem cell-based tissue engineering strategies. Among the various fibre-based scaffolds that have been used, hybrid fibrous scaffolds compr...


    pub_type: 杂志文章


    authors: Sahoo S,Toh SL,Goh JC

    更新日期:2010-04-01 00:00:00

  • CaproGlu: Multifunctional tissue adhesive platform.

    abstract::Driven by the clinical need for a strong tissue adhesive with elastomeric material properties, a departure from legacy crosslinking chemistries was sought as a multipurpose platform for tissue mending. A fresh approach to bonding wet substrates has yielded a synthetic biomaterial that overcomes the drawbacks of free-r...


    pub_type: 杂志文章


    authors: Djordjevic I,Pokholenko O,Shah AH,Wicaksono G,Blancafort L,Hanna JV,Page SJ,Nanda HS,Ong CB,Chung SR,Chin AYH,McGrouther D,Choudhury MM,Li F,Teo JS,Lee LS,Steele TWJ

    更新日期:2020-11-01 00:00:00

  • Rapid 3D bioprinting of decellularized extracellular matrix with regionally varied mechanical properties and biomimetic microarchitecture.

    abstract::Hepatocellular carcinoma (HCC), as the fifth most common malignant cancer, develops and progresses mostly in a cirrhotic liver where stiff nodules are separated by fibrous bands. Scaffolds that can provide a 3D cirrhotic mechanical environment with complex native composition and biomimetic architecture are necessary f...


    pub_type: 杂志文章


    authors: Ma X,Yu C,Wang P,Xu W,Wan X,Lai CSE,Liu J,Koroleva-Maharajh A,Chen S

    更新日期:2018-12-01 00:00:00

  • Characterization of interfaces in human calcified tissue.

    abstract::Thermostimulated current spectroscopy has been applied to the investigation of molecular mobility in human calcified tissue. A comparative study of extracts at various stages of demineralization is presented. The response of an organic-mineral complex interphase has been identified. ...


    pub_type: 杂志文章


    authors: Martin M,Lamure A,Lacabanne C,Betin C,Harmand MF

    更新日期:1990-07-01 00:00:00

  • Theranostic biocomposite scaffold membrane.

    abstract::Acute and chronic wounds affect millions and are associated with billions of dollars in healthcare costs. The use of healing markers, biochemical cues from biocompatible matrices and materials, and their correlation with wound healing has the potential to generate valuable diagnostic, prognostic, and therapeutic infor...


    pub_type: 杂志文章


    authors: Roussakis E,Ortines RV,Pinsker BL,Mooers CT,Evans CL,Miller LS,Calderón-Colón X

    更新日期:2019-08-01 00:00:00

  • Gene transfection in complex media using PCBMAEE-PCBMA copolymer with both hydrolytic and zwitterionic blocks.

    abstract::Safety and high efficacy of vectors are essential requirements for gene therapy. To address these challenges, poly(carboxy betaine methacrylate ethyl ester)-poly(carboxy betaine methacrylate) (PCBMAEE-PCBMA) diblock copolymers were synthesized to form core-shell vector for gene delivery. The hydrophobic PCBMAEE segmen...


    pub_type: 杂志文章


    authors: Zhang J,Wang Z,Lin W,Chen S

    更新日期:2014-09-01 00:00:00

  • Stability of some soluble alginate solutions.

    abstract::The stability of some water alginates against bacterial degradation was studied. The study was based on viscosity and pH measurements of some typical alginate solutions, containing suitable additives during an extended time period (222 days). ...


    pub_type: 杂志文章


    authors: Polyzois GL,Andreopoulos AG

    更新日期:1985-01-01 00:00:00

  • Enhanced cell survival of melanocyte spheroids in serum starvation condition.

    abstract::Autologous melanocyte transplantation for vitiligo treatment by use of melanocyte suspension has drawbacks including cell damage in cell preparation and transportation, difficult manipulation and low engraftment rate in acral vitiligious lesions. We have proposed the concept of cellular patch as an alternative solutio...


    pub_type: 杂志文章


    authors: Lin SJ,Jee SH,Hsiao WC,Yu HS,Tsai TF,Chen JS,Hsu CJ,Young TH

    更新日期:2006-03-01 00:00:00