Abstract：
:Dibutyryl chitin (DBC) is a modified chitin carrying butyryl groups at 3 and 6 positions; its peculiarity is that it dissolves promptly in common solvents, while being insoluble in aqueous systems. The high biocompatibility of dibutyryl chitin in the form of films and non-wovens has been demonstrated for human, chick and mouse fibroblasts by the Viability/Cytotoxicity assay, In situ Cell Proliferation assay, Neutral Red Retention assay, Lactate Dehydrogenase Release assay, MTS cytotoxicity assay, and scanning electron microscopy. DBC was hardly degradable by lysozyme, amylase, collagenase, pectinase and cellulase over the observation period of 48 days at room temperature, during which no more than 1.33% by weight of the DBC filaments (0.3 mm diameter) was released to the aqueous medium. DBC non-wovens were incorporated into 5-methylpyrrolidinone chitosan solution and submitted to freeze-drying to produce a reinforced wound dressing material. The latter was tested in vivo in full thickness wounds in rats. The insertion of 4x4 mm pieces did not promote any adverse effect on the healing process, as shown histologically. DBC is therefore suitable for contacting intact and wounded human tissues.
journal_name
Biomaterialsjournal_title
Biomaterialsauthors
Muzzarelli RA,Guerrieri M,Goteri G,Muzzarelli C,Armeni T,Ghiselli R,Cornelissen Mdoi
10.1016/j.biomaterials.2005.03.006keywords:
subject
Has Abstractpub_date
2005-10-01 00:00:00pages
5844-54issue
29eissn
0142-9612issn
1878-5905pii
S0142-9612(05)00225-5journal_volume
26pub_type
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