Abstract：
:This article introduces novel biocompatible tissue adhesives that do not involve any chemical or biochemical reactions, during their application in vivo. The use of these new adhesives is based exclusively on their temperature-dependent rheological properties. Since biocompatibility and biodegradability are additional crucial attributes of tissue adhesives, the polymers were tailored so that they as well as their degradation products are non-toxic. Branched oligomers consisting of a core molecule and biodegradable chains bound to it were synthesized and the relationship between their composition and their adhesive properties under in vitro conditions, was investigated. The oligomers comprised trimethylolpropane as the trifunctional central molecule, while lactoyl and caprolactone units formed the biodegradable segments. Oligomers with glass transition temperatures in the 20-25 degrees C range, were found to perform better. A strong connection was found between the length of the PLA blocks, the glass transition temperature (T(g)) of the different materials and their Adhesive Failure Strength (AFS) at 37 degrees C. The remarkable flexibilizing effect of the caprolactone units incorporated along the PLA blocks, allowed to generate longer biodegradable chains and to improve, therefore, the adhesive strength of the oligomers, while keeping their T(g) within the appropriate temperature interval. The TMP(LA(16)-CL(2)-LA(16)-CL(2)-LA(16))(3) oligomer attained especially high AFS values under in vitro conditions.
journal_name
Biomaterialsjournal_title
Biomaterialsauthors
Cohn D,Lando Gdoi
10.1016/j.biomaterials.2004.01.040keywords:
subject
Has Abstractpub_date
2004-12-01 00:00:00pages
5875-84issue
27eissn
0142-9612issn
1878-5905pii
S014296120400081Xjournal_volume
25pub_type
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