Mechanism of initial attachment of cells derived from human bone to commonly used prosthetic materials during cell culture.

abstract：:Monocytes/Macrophages have long been recognized as key players in inflammation and wound healing and are often employed in vitro to gain an understanding of the inflammatory response to biomaterials. Previous work has demonstrated a drastic decrease in primary monocyte adherent density on biomaterial surfaces coupled ...

journal_title：Biomaterials

authors： Waldeck H,Wang X,Joyce E,Kao WJ

更新日期：2012-01-01 00:00:00

abstract：:Tetragonal zirconia polycrystal (TZP) is a new interesting ceramic for the manufacture of medical devices. Its wide use in orthopedic and odontoiatric implants was limited till now by the high chemical and radiochemical impurities of the raw materials. Purification processes now available allow to obtain high purity c...

journal_title：Biomaterials

authors： Covacci V,Bruzzese N,Maccauro G,Andreassi C,Ricci GA,Piconi C,Marmo E,Burger W,Cittadini A

更新日期：1999-02-01 00:00:00

abstract：:Vaccination is an effective medical intervention for preventing disease. However, without an adjuvant, most subunit vaccines are poorly immunogenic. This work develops a bioinspired nanocomposite hyaluronic acid hydrogel system that incorporates N-trimethyl chitosan nanoparticles (TMC/NPs) that carry a model subunit v...

journal_title：Biomaterials

authors： Korupalli C,Pan WY,Yeh CY,Chen PM,Mi FL,Tsai HW,Chang Y,Wei HJ,Sung HW

更新日期：2019-09-01 00:00:00

abstract：:Beads of polytetrafluoroethylene were used to investigate adsorption of thrombin and the influence of the adsorbed protease on a subsequent deposition of fibrinogen. Adsorption of active thrombin was not detected by a specific fluorogenic substrate unless > 0.1 units/ml had been applied. Adsorption was considerably im...

journal_title：Biomaterials

authors： Schlosser E,Simler R,Hörmann H

更新日期：1993-04-01 00:00:00

abstract：:Interventional closure of intracardiac wall defects using occluder devices has evolved as a highly attractive treatment option. However, incomplete and delayed healing reactions often result in a major risk of residual defects, thromboembolism, or device fractures. Biodegradable living tissue engineered occluder membr...

journal_title：Biomaterials

authors： Weber B,Schoenauer R,Papadopulos F,Modregger P,Peter S,Stampanoni M,Mauri A,Mazza E,Gorelik J,Agarkova I,Frese L,Breymann C,Kretschmar O,Hoerstrup SP

更新日期：2011-12-01 00:00:00

abstract：:Copolymers of N-(2-hydroxypropyl)methacrylamide (HPMA) are prototypic and well-characterized polymeric drug carriers that have been broadly implemented in the delivery of anticancer therapeutics. To demonstrate that polymers, as liposomes, can be used for simultaneously delivering multiple chemotherapeutic agents to t...

journal_title：Biomaterials

authors： Lammers T,Subr V,Ulbrich K,Peschke P,Huber PE,Hennink WE,Storm G

更新日期：2009-07-01 00:00:00

abstract：:We report on the use of degradable polymer capsules as carriers for the delivery of oligopeptide antigens to professional antigen presenting cells (APCs). To achieve encapsulation, oligopeptide sequences were covalently linked to a negatively charged carrier polymer via biodegradable linkages and the resulting conjuga...

journal_title：Biomaterials

authors： Chong SF,Sexton A,De Rose R,Kent SJ,Zelikin AN,Caruso F

更新日期：2009-10-01 00:00:00

abstract：:This article reviews the controlled release of biologically active agents by the erosion or chemical degradation of a polymer matrix into which the agent is incorporated. Chemically bound active agents and work on steroid release from cholesterol implants are not covered. The mechanisms of polymer erosion discussed ar...

journal_title：Biomaterials

authors： Heller J

更新日期：1980-01-01 00:00:00

abstract：:We previously reported that modification of GALA peptide on the surface of liposomes enhanced fusion with endosomal membrane, and cytoplasmic release of encapsulated macromolecules. We report herein that an additional coating of GALA-modified liposomes with 2-methacryloyloxyethyl phosphorylcholine (MPC) polymer result...

journal_title：Biomaterials

authors： Ukawa M,Akita H,Masuda T,Hayashi Y,Konno T,Ishihara K,Harashima H

更新日期：2010-08-01 00:00:00

abstract：:The clinical application of calcium phosphate cements (CPCs) composed of tetracalcium phosphate and dicalcium phosphate anhydrous has been limited because of its longer setting time, so that we developed the CPC in which the setting time was shortened to approximately 10 min. Aiming at clinical application, we evaluat...

journal_title：Biomaterials

authors： Hoshikawa A,Fukui N,Fukuda A,Sawamura T,Hattori M,Nakamura K,Oda H

更新日期：2003-12-01 00:00:00

abstract：:In order to evaluate degradation kinetics and biocompatibility of a resorbable poly(D,L-lactic acid) (PDLLA) plug for total cemented hip prostheses, an experimental in vitro and in vivo study was carried out. Degradation rate studies were performed in Ringer solution and after in vivo plug implantation in the femoral ...

journal_title：Biomaterials

authors： Giardino R,Fini M,Aldini NN,Giavaresi G,Rocca M,Orienti L,de Lollis A,Fambri L

更新日期：1997-07-01 00:00:00

abstract：:The aim of this work was to develop a new type of D-alpha-tocopheryl polyethylene glycol 1000 succinate mono-ester (TPGS) coated multi-functional (theranostic) liposomes, which contain both docetaxel and quantum dots (QDs) for cancer imaging and therapy. Non-targeting and folate receptor targeting TPGS coated theranos...

journal_title：Biomaterials

authors： Muthu MS,Kulkarni SA,Raju A,Feng SS

更新日期：2012-04-01 00:00:00

abstract：:Biomimetic strategies focusing on presenting short bioadhesive oligopeptides, including the arginine-glycine-aspartic acid (RGD) motif present in numerous adhesive proteins, on a non-fouling support have emerged as promising approaches to improve cellular activities and healing responses. Nevertheless, these bio-inspi...

journal_title：Biomaterials

authors： Petrie TA,Capadona JR,Reyes CD,García AJ

更新日期：2006-11-01 00:00:00

abstract：:Neurotrophic factors therapy requires their precise delivery to the targeted neuronal population. For this purpose, a wide range of strategies have been developed, and among them the stereotaxic implantation of biodegradable microparticles. To assess the in vivo activity of NGF-releasing PLGA microspheres, unloaded an...

journal_title：Biomaterials

authors： Péan JM,Menei P,Morel O,Montero-Menei CN,Benoit JP

更新日期：2000-10-01 00:00:00

abstract：:In spite of tremendous demand for the development and implementation of effective therapeutic strategies, limitations are still associated with doxorubicin-induced cardiotoxicity. Arjunolic acid (AA) has been shown to possess a multitude of biological functions. The purpose of the present study was to explore whether ...

journal_title：Biomaterials

authors： Ghosh J,Das J,Manna P,Sil PC

更新日期：2011-07-01 00:00:00

abstract：:To investigate the role that the micro/nano-environment plays on the differentiation pathway of bone marrow stromal cells (BMSCs) into osteoblasts, we employed a 2D substrate coated with turnip yellow mosaic virus (TYMV) particles. TYMV is a non-enveloped icosahedral plant virus which has an average diameter 28 nm and...

journal_title：Biomaterials

authors： Kaur G,Valarmathi MT,Potts JD,Wang Q

更新日期：2008-10-01 00:00:00

abstract：:We have investigated the interface between bone and hydroxyapatite (HA) chronically implanted in man. By light microscopy, HA appeared to bind directly to bone without intervening fibrous tissue. By transmission electron microscopy, two patterns were noted: (1) HA either bound directly to bone; or (2) electron-dense m...

journal_title：Biomaterials

authors： Oguchi H,Ishikawa K,Mizoue K,Seto K,Eguchi G

更新日期：1995-01-01 00:00:00

abstract：:Long-term (8 and 24 month) reactions of the (hypo) dermis of the guinea pig to solid and porous (50 vol%) acrylic implants and four human biopsies from porous subcutaneous acrylic implants were studied light microscopically. The solid implants were encapsulated by dense connective tissue. Mobility was evidenced by the...

journal_title：Biomaterials

authors： van Mullem PJ,Vaandrager JM,Nicolai JP,de Wijn JR

更新日期：1990-07-01 00:00:00

abstract：:Xenogeneic extracellular matrix (ECM) can be harvested and configured to function as a bioscaffold for tissue and organ reconstruction. The mechanical properties of the ECM vary depending upon the tissue from which it is harvested. Likewise, the manufacturing steps required to develop ECMs into medical grade devices w...

journal_title：Biomaterials

authors： Freytes DO,Badylak SF,Webster TJ,Geddes LA,Rundell AE

更新日期：2004-05-01 00:00:00

abstract：:Lower back pain is mainly caused by intervertebral disc degeneration, in which calcification is frequently involved. Here novel nanofibrous spongy microspheres (NF-SMS) are used to carry rabbit bone marrow mesenchymal stromal cells (MSCs) to regenerate nucleus pulposus tissues. NF-SMS are shown to significantly enhanc...

journal_title：Biomaterials

authors： Feng G,Zhang Z,Dang M,Rambhia KJ,Ma PX

更新日期：2020-10-01 00:00:00

abstract：:A type III glass-ionomer cement (Vidrion F), currently used as fast-setting lining material and fissure sealant, was implanted into rat dental alveolus immediately after tooth extraction and its biocompatibility was analysed in terms of incorporation into alveolar bone in the wound healing process. Histological and hi...

journal_title：Biomaterials

authors： Brentegani LG,Bombonato KF,Carvalho TL

更新日期：1997-01-01 00:00:00

abstract：:The aim of this study is to evaluate a novel microspheric vector for delivery of oligonucleotides (ODN) into dendritic cells (DC). A requirement of decoy-based modulation of transcriptional activities in DC is that the ODN would have to accumulate inside the cell. Using an ex vivo DC culture model, we demonstrate that...

journal_title：Biomaterials

authors： Kovacs JR,Zheng Y,Shen H,Meng WS

更新日期：2005-11-01 00:00:00

abstract：:Immune checkpoint blocking (ICB) antibodies have shown great success in the clinic, but their low response rate in patients with immunosuppressive cold tumors remains a huge challenge. Inspired by the capability of immunogenic cell death (ICD) to convert tumors from cold to hot, we developed a corn-like Au/Ag nanorod ...

journal_title：Biomaterials

authors： Jin L,Shen S,Huang Y,Li D,Yang X

更新日期：2021-01-01 00:00:00

abstract：:Developing repair strategies for osteochondral tissue presents complex challenges due to its interfacial nature and complex zonal structure, consisting of subchondral bone, intermediate calcified cartilage and the superficial cartilage regions. In this study, the long term ability of a multi-layered biomimetic collage...

journal_title：Biomaterials

authors： Levingstone TJ,Ramesh A,Brady RT,Brama PAJ,Kearney C,Gleeson JP,O'Brien FJ

更新日期：2016-05-01 00:00:00

abstract：:Poly(L-lactide) (PLLA) with an extremely high molecular weight (Mv up to 1 X 10(6)) was synthesized at a low catalyst concentration (0.015 wt%) and temperatures between 100-110 degrees C. Besides good mechanical properties the as-polymerized PLLA exhibited a microporous structure. Plates and screws of this material we...

journal_title：Biomaterials

authors： Leenslag JW,Pennings AJ,Bos RR,Rozema FR,Boering G

更新日期：1987-01-01 00:00:00

abstract：:The ageing behaviour of ultra-high molecular weight polyethylene (UHMWPE) has been studied following gamma irradiation (25 or 40 kGy) in air. Accelerated ageing procedures used elevated temperature (70 degrees C) and/or pressurised oxygen (5bar). Shelf-aged UHMWPE was also studied. The variation in surface density and...

journal_title：Biomaterials

authors： Buchanan FJ,Shipway PH

更新日期：2002-01-01 00:00:00

abstract：:A cardiomyocyte-targeted Fas siRNA delivery system was developed using prostaglandin E(2) (PGE(2))-modified siRNA polyplexes formed by a reducible poly(amido amine) to inhibit cardiomyocyte apoptosis. PGE(2), which was used as a specific ligand for cardiomyocyte targeting, was conjugated to the terminal-end of the sen...

journal_title：Biomaterials

authors： Kim SH,Jeong JH,Ou M,Yockman JW,Kim SW,Bull DA

更新日期：2008-11-01 00:00:00

abstract：:Membranes of 75% and 100% benzyl hyaluronate esters (percentage of total carboxylate groups esterified) were prepared and their water vapour, oxygen and carbon dioxide transmission rates determined. The values of these properties were compared with the values obtained for several commercial wound dressings under the s...

journal_title：Biomaterials

authors： Ruiz-Cardona L,Sanzgiri YD,Benedetti LM,Stella VJ,Topp EM

更新日期：1996-08-01 00:00:00

abstract：:We report the ability of amino- and carboxyl-modified MCM-41 mesoporous silica nanoparticles (MSN) to deliver gene in vivo in rat Achilles tendons, despite their inefficiency to transfect primary tenocytes in culture. We show that luciferase activity lasted for at least 2 weeks in tendons injected with these MSN and a...

journal_title：Biomaterials

authors： Suwalski A,Dabboue H,Delalande A,Bensamoun SF,Canon F,Midoux P,Saillant G,Klatzmann D,Salvetat JP,Pichon C

更新日期：2010-07-01 00:00:00

abstract：:Skeletal muscle is a highly organized tissue in which the extracellular matrix (ECM) is composed of highly-aligned cables of collagen with nanoscale feature sizes, and provides structural and functional support to muscle fibers. As such, the transplantation of disorganized tissues or the direct injection of cells into...

journal_title：Biomaterials

authors： Yang HS,Ieronimakis N,Tsui JH,Kim HN,Suh KY,Reyes M,Kim DH

更新日期：2014-02-01 00:00:00