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Specific role of polysorbate 80 coating on the targeting of nanoparticles to the brain.

Abstract：

:It was reported that nanoparticles with polysorbate 80 (Tween 80, T-80) coating represented tools used for delivering drugs to brain. Nevertheless, disputations were once aroused for some complications. Aimed to have a better understanding of the specific role of T-80 coating on nanoparticles and simplify the problem, the direct observation of brain targeting combined with in vivo experiments was carried out in this work using the model nanoparticles (MNPs). The presence of a complex composed by the model loading, T-80 and nanoparticles was found in the preparation of MNPs. The result was further supported by some surface properties of MNPs. Being bound to nanoparticles that were overcoated by T-80 later, was necessary for the loading to be delivered to brain. Partial coverage was enough for T-80 coating to play a specific role in brain targeting. It seemed that brain targeting of nanoparticles was concerned with the interaction between T-80 coating and brain micro-vessel endothelial cells. Therefore, the specific role of T-80 coating on nanoparticles in brain targeting was confirmed.

journal_name

Biomaterials

journal_title

Biomaterials

authors

Sun W,Xie C,Wang H,Hu Y

doi

10.1016/j.biomaterials.2003.09.087

keywords:

subject

Has Abstract

pub_date

2004-07-01 00:00:00

pages

3065-71

issue

15

eissn

0142-9612

issn

1878-5905

pii

S014296120300855X

journal_volume

25

pub_type

杂志文章

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