Two-dimensional nanosheets with high curcumin loading content for multimodal imaging-guided combined chemo-photothermal therapy.

Abstract:

:Nowadays, two-dimensional (2D) nanomaterials with many fascinating physicochemical properties have drawn extensive attention as drug delivery platforms for cancer theranostics. Nevertheless, current existing 2D nanomaterial-based drug delivery systems normally undergo the bottlenecks of hash preparation process, low drug loading content and unsatisfactory therapeutic outcome. Herein, we developed a novel nanoparticles-induced assemble strategy to construct 2D nanosheets with ultra-high curcumin loading content of 59.6 % and excellent stability in water. Furthermore, a distinct photothermal effect and multimodal imaging property after polydopamine coating could be obtained, thereby leading to precise and efficient ablation of tumor in combination of curcumin-induced chemotherapy. More importantly, the design principle of our work offers novel facile strategy to assemble metal-binding drugs into 2D nanomedicine with high drug content and well-defined shapes.

journal_name

Biomaterials

journal_title

Biomaterials

authors

Liu F,Lin L,Zhang Y,Sheng S,Wang Y,Xu C,Tian H,Chen X

doi

10.1016/j.biomaterials.2019.119470

subject

Has Abstract

pub_date

2019-12-01 00:00:00

pages

119470

eissn

0142-9612

issn

1878-5905

pii

S0142-9612(19)30569-1

journal_volume

223

pub_type

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