Abstract:
:Nowadays, two-dimensional (2D) nanomaterials with many fascinating physicochemical properties have drawn extensive attention as drug delivery platforms for cancer theranostics. Nevertheless, current existing 2D nanomaterial-based drug delivery systems normally undergo the bottlenecks of hash preparation process, low drug loading content and unsatisfactory therapeutic outcome. Herein, we developed a novel nanoparticles-induced assemble strategy to construct 2D nanosheets with ultra-high curcumin loading content of 59.6 % and excellent stability in water. Furthermore, a distinct photothermal effect and multimodal imaging property after polydopamine coating could be obtained, thereby leading to precise and efficient ablation of tumor in combination of curcumin-induced chemotherapy. More importantly, the design principle of our work offers novel facile strategy to assemble metal-binding drugs into 2D nanomedicine with high drug content and well-defined shapes.
journal_name
Biomaterialsjournal_title
Biomaterialsauthors
Liu F,Lin L,Zhang Y,Sheng S,Wang Y,Xu C,Tian H,Chen Xdoi
10.1016/j.biomaterials.2019.119470subject
Has Abstractpub_date
2019-12-01 00:00:00pages
119470eissn
0142-9612issn
1878-5905pii
S0142-9612(19)30569-1journal_volume
223pub_type
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