Surface-mediated transfection of a pDNA vector encoding short hairpin RNA to downregulate TGF-β1 expression for the prevention of in-stent restenosis.

abstract：:Chitin grafted with poly(acrylic acid) (chitin-PAA) was prepared with the aim of obtaining a hydrogel characteristic for wound dressing application. The chitin-PAA films were synthesized at various acrylic acid feed contents to investigate its effect on water sorption ability. Acrylic acid (AA) was first linked to chi...

journal_title：Biomaterials

authors： Tanodekaew S,Prasitsilp M,Swasdison S,Thavornyutikarn B,Pothsree T,Pateepasen R

更新日期：2004-03-01 00:00:00

abstract：:An increasing number of studies in cardiac cell therapy have provided encouraging results for cardiac repair. Adult stem cells may overcome ethical and availability concerns, with the additional advantages, in some cases, to allow autologous grafts to be performed. However, the major problems of cell survival, cell fa...

journal_title：Biomaterials

authors： Karam JP,Muscari C,Montero-Menei CN

更新日期：2012-08-01 00:00:00

abstract：:Programmed cell death-ligand 1 (PD-L1)-based immune checkpoint blockade therapy using the anti-PD-L1 antibody is effective for a subset of patients with advanced metastatic melanoma but about half of the patients do not respond to the therapy because of the tumor immunosuppressive microenvironment. Immunogenic cell de...

journal_title：Biomaterials

authors： Qiu N,Liu Y,Liu Q,Chen Y,Shen L,Hu M,Zhou X,Shen Y,Gao J,Huang L

更新日期：2020-12-17 00:00:00

abstract：:Resorbable calcium phosphate (CaP) biomaterials have demonstrated considerable efficacy in bone reconstructive surgery. Furthermore, bisphosphonates (BPs) are well known anti-resorptive agents largely used in clinical treatments for osteoporosis. An injectable BP-combined CaP matrix has been developed in order to biol...

journal_title：Biomaterials

authors： Verron E,Gauthier O,Janvier P,Pilet P,Lesoeur J,Bujoli B,Guicheux J,Bouler JM

更新日期：2010-10-01 00:00:00

abstract：:Reduced expression of autophagy regulators has been observed in pathological cartilage in humans and mice. The present study aimed to investigate the synergistic therapeutic effect of promotion of chondrocyte autophagy via exposure to sinomenium (SIN) encapsulated by chitosan microspheres (CM-SIN) and photo-crosslinke...

journal_title：Biomaterials

authors： Chen P,Xia C,Mei S,Wang J,Shan Z,Lin X,Fan S

更新日期：2016-03-01 00:00:00

abstract：:Si, Mg-substituted hydroxyapatites, alone and co-substituted, have been prepared to obtain biomaterials having an improved biocompatibility. From FT-IR, XRD and ICP analyses, it was confirmed that single phases of hydroxyapatite substituted by Si alone or co-substituted by Si, Mg. The XRD data indicated the absence of...

journal_title：Biomaterials

authors： Kim SR,Lee JH,Kim YT,Riu DH,Jung SJ,Lee YJ,Chung SC,Kim YH

更新日期：2003-04-01 00:00:00

abstract：:Electroconductive hydrogels (ECHs) are composite biomaterials that bring together the redox switching and electrical properties of inherently conductive electroactive polymers (CEPs) with the facile small molecule transport, high hydration levels and biocompatibility of cross-linked hydrogels. General methods for the ...

journal_title：Biomaterials

authors： Guiseppi-Elie A

更新日期：2010-04-01 00:00:00

abstract：:Motivated by the necessity to engineer appropriately stratified cartilage, the shear mechanics of layered, bovine chondrocyte-seeded 20mg/mL alginate scaffolds were investigated and related to the structure and biochemical composition. Chondrocyte-seeded alginate scaffolds were exposed to a calcium-chelating solution,...

journal_title：Biomaterials

authors： Lee CS,Gleghorn JP,Won Choi N,Cabodi M,Stroock AD,Bonassar LJ

更新日期：2007-07-01 00:00:00

abstract：:The adherence of five strains of Staphylococcus epidermidis and one strain of S. aureus to both untreated and Hydromer-coated silicone rubber cerebrospinal fluid shunts was studied in vitro using epifluorescent image analysis. All five strains of S. epidermidis showed similar levels of adherence to untreated shunts, w...

journal_title：Biomaterials

authors： Bridgett MJ,Davies MC,Denyer SP,Eldridge PR

更新日期：1993-02-01 00:00:00

abstract：:The present work assesses the potential of three-dimensional porous titanium scaffolds produced by a novel powder metallurgy process for applications in bone engineering through in vitro experimentation. Mouse MC3T3-E1 pre-osteoblasts were used to investigate the proliferation (DNA content), differentiation (alkaline ...

journal_title：Biomaterials

authors： St-Pierre JP,Gauthier M,Lefebvre LP,Tabrizian M

更新日期：2005-12-01 00:00:00

abstract：:The application of poly(hydroxybutyrate-co-hydroxyhexanoate) (PHBHHx) for sustained and controlled delivery of hydrophilic insulin was made possible by preparing insulin phospholipid complex loaded biodegradable PHBHHx nanoparticles (INS-PLC-NPs). The INS-PLC-NPs produced by a solvent evaporation method showed a spher...

journal_title：Biomaterials

authors： Peng Q,Zhang ZR,Gong T,Chen GQ,Sun X

更新日期：2012-02-01 00:00:00

abstract：:Tubular vessels for tissue engineering are typically fabricated using a molding, dipping, or electrospinning technique. While these techniques provide some control over inner and outer diameters of the tube, they lack the ability to align the polymers or fibers of interest throughout the tube. This is an important asp...

journal_title：Biomaterials

authors： Lovett ML,Cannizzaro CM,Vunjak-Novakovic G,Kaplan DL

更新日期：2008-12-01 00:00:00

abstract：:Hydrogels, chemically cross-linked or physically entangled, have found a number of applications as novel delivery vehicles of drugs and cells. However, the narrow ranges of degradation rates and mechanical strength currently available from many hydrogels limits their applications. We have hypothesized that utilization...

journal_title：Biomaterials

authors： Lee KY,Bouhadir KH,Mooney DJ

更新日期：2004-06-01 00:00:00

abstract：:Myocardial infarction (MI) leads to the mass death of cardiomyocytes accompanying with the unfavorable alternation of microenvironment, a fibrosis scar deprived of electrical communications, and the lack of blood supply in the infarcted myocardium. The three factors are inextricably intertwined and thus result in a co...

journal_title：Biomaterials

authors： Wang W,Tan B,Chen J,Bao R,Zhang X,Liang S,Shang Y,Liang W,Cui Y,Fan G,Jia H,Liu W

更新日期：2018-04-01 00:00:00

abstract：:Mesoporous silica (MPS), synthesized via the supramolecular polymer templating method, is one of the most attractive nanomaterials for biomedical applications, such as drug delivery systems, labeling, and tissue engineering. The significant difference between MPS and general silica (colloidal silica) is the pore archi...

journal_title：Biomaterials

authors： Lee S,Yun HS,Kim SH

更新日期：2011-12-01 00:00:00

abstract：:A PCL/hydrogel construct that would mimic the structural organization, biochemistry and anatomy of meniscus was engineered. The compressive (380 ± 40 kPa) and tensile modulus (18.2 ± 0.9 MPa) of the PCL scaffolds were increased significantly when constructs were printed with a shifted design and circumferential strand...

journal_title：Biomaterials

authors： Bahcecioglu G,Bilgen B,Hasirci N,Hasirci V

更新日期：2019-10-01 00:00:00

abstract：:High-throughput screening techniques for cellular response are often unable to account for several factors present in the in vivo environment, many of which have been shown to modulate cellular response to the screened parameter. Culture in three-dimensional biomaterials and active mechanical stimulation are two such ...

journal_title：Biomaterials

authors： Moraes C,Wang G,Sun Y,Simmons CA

更新日期：2010-01-01 00:00:00

abstract：:This study examines the early shrinkage behaviour of dental composite resins, and in particular the interfacial stresses around the margins of a composite restoration. The development of stresses at the restoration-tooth interface can have a detrimental effect on the longevity of a restoration. The influence of this i...

journal_title：Biomaterials

authors： Ensaff H,O'Doherty DM,Jacobsen PH

更新日期：2001-12-01 00:00:00

abstract：:Safety and high efficacy of vectors are essential requirements for gene therapy. To address these challenges, poly(carboxy betaine methacrylate ethyl ester)-poly(carboxy betaine methacrylate) (PCBMAEE-PCBMA) diblock copolymers were synthesized to form core-shell vector for gene delivery. The hydrophobic PCBMAEE segmen...

journal_title：Biomaterials

authors： Zhang J,Wang Z,Lin W,Chen S

更新日期：2014-09-01 00:00:00

abstract：:The magnetic resonance (MR) functionalities of pullulan-conjugated gadolinium diethylene triamine pentaacetate (Gd-DTPA-Pullulan) as a new hepatocyte-specific contrast agent were evaluated. Pullulan, which specifically accumulates on hepatocytes via asialoglycoprotein receptors, was chemically linked with Gd-DTPA. Gd-...

journal_title：Biomaterials

authors： Yim H,Yang SG,Jeon YS,Park IS,Kim M,Lee DH,Bae YH,Na K

更新日期：2011-08-01 00:00:00

abstract：:The human heart cannot regenerate after an injury. Lost cardiomyocytes are replaced by scar tissue resulting in reduced cardiac function causing high morbidity and mortality. One possible solution to this problem is cardiac tissue engineering. Here, we have investigated the suitability of non-mulberry silk protein fib...

journal_title：Biomaterials

authors： Patra C,Talukdar S,Novoyatleva T,Velagala SR,Mühlfeld C,Kundu B,Kundu SC,Engel FB

更新日期：2012-03-01 00:00:00

abstract：:Tissue-engineered muscle is a viable option for tissue repair, though presently technologies are not developed enough to produce tissue in vitro identical to that in vivo. One important step in generating accurate engineered muscle is to mimic natural muscle architecture. Skeletal muscle is composed of fibrils whose o...

journal_title：Biomaterials

authors： Lam MT,Sim S,Zhu X,Takayama S

更新日期：2006-08-01 00:00:00

abstract：:Adhesion of tissue cells is a prerequisite for their growth and differentiation but prevents also apoptosis. Here the layer-by-layer technique (LbL) was used to design multilayer structures of poly(ethylene imine) (PEI) and heparin (HEP) on glass as model biomaterial to control the adhesion of primary human dermal fib...

journal_title：Biomaterials

authors： Niepel MS,Peschel D,Sisquella X,Planell JA,Groth T

更新日期：2009-10-01 00:00:00

abstract：:Mucoadhesive properties of several polymers, such as sodium alginate, hydroxypropylmethyl cellulose, scleroglucan, xanthan gum, polyacrylic acid (Carbopol), and poly co-(methyl vinyl ether-maleic anhydride) (Gantrez), have been investigated by comparing a thermodynamical and a mechanical approach. Surface properties o...

journal_title：Biomaterials

authors： Esposito P,Colombo I,Lovrecich M

更新日期：1994-02-01 00:00:00

abstract：:Right femoral, cortical bone osteotomies of 42 rabbits were fixed with fibrillated, self-reinforced (SR) poly-L-lactide (PLLA) rods, 4.5 mm in diameter. Follow-up times were from 3 to 48 wk. None of the rods broke during this period. There was one non-union at three weeks and one non-union at 12 weeks. Radiographic, h...

journal_title：Biomaterials

authors： Manninen MJ,Pohjonen T

更新日期：1993-01-01 00:00:00

abstract：:The long-term patency rates of vascular grafts and stents are limited by the lack of surface endothelialisation of the implanted materials. We have previously reported that GRGDS and WQPPRARI peptide micropatterns increase the endothelialisation of prosthetic materials in vitro. To investigate the mechanisms by which ...

journal_title：Biomaterials

authors： Hoesli CA,Garnier A,Juneau PM,Chevallier P,Duchesne C,Laroche G

更新日期：2014-01-01 00:00:00

abstract：:The aim of this study was to evaluate the bacterial adherence to biodegradable self-reinforced polyglycolic acid (SR-PGA) and self-reinforced poly-DL-lactic acid (SR-PLA 96) spiral stents in vitro. They are used as temporary urethral stents in urology. Gold-plated metal wire, polyurethane and latex were used as contro...

journal_title：Biomaterials

authors： Pétas A,Vuopio-Varkila J,Siitonen A,Välimaa T,Talja M,Taari K

更新日期：1998-04-01 00:00:00

abstract：:To avoid the overheating effect of excitation light and improve the efficacy of photodynamic therapy (PDT) of upconversion nanoplatform, a novel nanoprobe based on 808 nm-excited upconversion nanocomposites (T-UCNPs@Ce6@mSiO2) with low heating effect and deep penetration has been successfully constructed for targeted ...

journal_title：Biomaterials

authors： Zeng L,Pan Y,Zou R,Zhang J,Tian Y,Teng Z,Wang S,Ren W,Xiao X,Zhang J,Zhang L,Li A,Lu G,Wu A

更新日期：2016-10-01 00:00:00

abstract：:In order to overcome the problem of rapid clearance of the polysaccharide hyaluronic acid (Hyal) in the treatment of osteoarthritis (OA), a 50% cross-linked Hyal hydrogel (Hyal 50%) was synthesised. The 50% refers to the amount of COOH groups of the polysaccharide involved in the cross-linking reaction. i.e. 50% of th...

journal_title：Biomaterials

authors： Barbucci R,Lamponi S,Borzacchiello A,Ambrosio L,Fini M,Torricelli P,Giardino R

更新日期：2002-12-01 00:00:00

abstract：:Thrombomodulin (TM) is a newly described endothelial cell-associated protein that functions as a potent natural anticoagulant by converting thrombin from a procoagulant protease to an anticoagulant. In this study, focussing on the application of TM for biomedical materials, recombinant human TM (hTM) was immobilized o...

journal_title：Biomaterials

authors： Kishida A,Ueno Y,Fukudome N,Yashima E,Maruyama I,Akashi M

更新日期：1994-08-01 00:00:00