Branched polyesters based on poly[vinyl-3-(dialkylamino)alkylcarbamate-co-vinyl acetate-co-vinyl alcohol]-graft-poly(d,l-lactide-co-glycolide): effects of polymer structure on cytotoxicity.

abstract：:Nanocarrier for augmenting the efficacy of reactive oxygen species (ROS) by tumor microenvironment (TME) has become an emerging strategy for cancer treatment. Herein, a smart biodegradable drug delivery nanoplatform with mitochondrial-targeted ability, pH-responsive drug release and enzyme-like catalytic function is d...

journal_title：Biomaterials

authors： An J,Hu YG,Cheng K,Li C,Hou XL,Wang GL,Zhang XS,Liu B,Zhao YD,Zhang MZ

更新日期：2020-03-01 00:00:00

abstract：:The phenomenon of light-induced cell detachment is reported. Mouse calvaria-derived, pre-osteoblastic (MC3T3-E1) cells were cultured on a TiO(2) nanodot-coated quartz substrate. After 20 min of UV365 illumination, over 90% of the cells would detach from the surface. Moreover, intact cell sheets could be obtained in th...

journal_title：Biomaterials

authors： Hong Y,Yu M,Weng W,Cheng K,Wang H,Lin J

更新日期：2013-01-01 00:00:00

abstract：:Combined and targeted therapy have been extensively employed to achieve more effective elimination of tumor tissues. In this study, biocompatible multifunctional lipid-coated calcium phosphate nanoparticles (LCP NPs) were designed and constructed as an efficient targeted delivery system for combined gene/photothermal ...

journal_title：Biomaterials

authors： Tang J,Li B,Howard CB,Mahler SM,Thurecht KJ,Wu Y,Huang L,Xu ZP

更新日期：2019-09-01 00:00:00

abstract：:In order to assess the suitability of polymer tissue scaffolds for use in regenerative medicine, methods to characterise scaffolds are needed. This requires the scaffold's structure to be determined for which X-ray microscopic computed tomography (X-ray micro CT) is widely used. However, because scaffolds are generall...

journal_title：Biomaterials

authors： Morris DE,Mather ML,Crowe JA

更新日期：2009-09-01 00:00:00

abstract：:Hydrogel materials that display inherent activity against bacteria can be used to directly treat accessible wounds to prevent or kill existing infection. Hydrogels composed of self-assembling β-hairpin peptides, having a high content of arginine, were found to be extremely effective at killing both gram-positive and g...

journal_title：Biomaterials

authors： Veiga AS,Sinthuvanich C,Gaspar D,Franquelim HG,Castanho MA,Schneider JP

更新日期：2012-12-01 00:00:00

abstract：:Acute trauma or trauma associated with occlusal disturbance can produce tooth crack or fracture. Although several methods are proposed to treat the defect, however, the prognosis is generally poor. If the fusion of a tooth fracture by laser is possible, it will offer an alternative to extraction or at least serve as a...

journal_title：Biomaterials

authors： Lin CP,Tseng YC,Lin FH,Liao JD,Lan WH

更新日期：2001-03-01 00:00:00

abstract：:The systemic administration of immunosuppressive and anti-inflammatory drugs is routinely employed in organ transplantation to minimize graft rejection and improve graft survival. Localized drug delivery has the potential to improve transplant outcomes by providing sustained exposure to efficacious drug concentrations...

journal_title：Biomaterials

authors： Chang CA,Akinbobuyi B,Quintana JM,Yoshimatsu G,Naziruddin B,Kane RR

更新日期：2018-03-01 00:00:00

abstract：:The protective role of different dentine fractions and of dentine slices in moderating the cytotoxicity of zinc oxide eugenol (ZOE) was investigated. The collagen fraction of dentine powder provided increased protection over intact powder. Slices of dentine offered greater protection probably by providing a physical b...

journal_title：Biomaterials

authors： Meryon SD,Jakeman KJ

更新日期：1986-11-01 00:00:00

abstract：:DNA vaccine is a milestone in contemporary vaccine development. It has considerably offset many shortcomings in conventional vaccines. Although DNA vaccines applied through 'traditional' high-pressure gene guns generally elicit high titers of protective immunity, such a practice however requires enormous investment in...

journal_title：Biomaterials

authors： Huang HN,Li TL,Chan YL,Chen CL,Wu CJ

更新日期：2009-10-01 00:00:00

abstract：:Effective real-time and long-time in vivo imaging for flap perfusion requires bright and stable imaging agents whose emissions can effectively penetrate live tissues without photobleaching. Compared to the standard imaging agent today - intraoperative indocyanine green (ICG), quantum dots (QDs) is a more attractive al...

journal_title：Biomaterials

authors： Feng S,Chen J,Wo Y,Li Y,Chen S,Zhang Y,Zhang W

更新日期：2016-10-01 00:00:00

abstract：:Brain tissue inflammatory responses, including neuronal loss and gliosis at the neural electrode/tissue interface, limit the recording stability and longevity of neural probes. The neural adhesion molecule L1 specifically promotes neurite outgrowth and neuronal survival. In this study, we covalently immobilized L1 on ...

journal_title：Biomaterials

authors： Azemi E,Lagenaur CF,Cui XT

更新日期：2011-01-01 00:00:00

abstract：:Elucidation of relationship among cellular uptake, localization and biological activities of metal complexes could make great breakthrough in the understanding of their action mechanisms and provide useful information for rational design of metal-based anticancer drugs. Iron(II) complexes have emerged as potential ant...

journal_title：Biomaterials

authors： Chen J,Luo Z,Zhao Z,Xie L,Zheng W,Chen T

更新日期：2015-12-01 00:00:00

abstract：:Recent advances in biomaterial surface engineering have shown that surface biomechanical, spatial and topographical properties can elicit control over fundamental biological processes such as cell shape, proliferation, differentiation and apoptosis. Along these lines, we have very recently shown that the self-assembly...

journal_title：Biomaterials

authors： George PA,Quinn K,Cooper-White JJ

更新日期：2010-02-01 00:00:00

abstract：:Polyelectrolyte complexes (PEC) were prepared from chitosan as the polycation and several synthesized functional anion polysaccharides, and their effects on cell attachment, morphology, proliferation and differentiation were estimated using normal human osteoblasts (NHOst). After a 1-week incubation, PEC made from pol...

journal_title：Biomaterials

authors： Nagahata M,Nakaoka R,Teramoto A,Abe K,Tsuchiya T

更新日期：2005-09-01 00:00:00

abstract：:Three one-week controlled-release methadone formulations: polylactic acid microspheres (F-PLA) and poly(lactide-co-glycolide) microspheres (F-PLGA) with 24 and 30% methadone content, respectively, and an implant of 50:50 poly(lactide-co-glycolide): methadone, were evaluated in vitro and in vivo. The implant released t...

journal_title：Biomaterials

authors： Negrin CM,Delgado A,Llabrés M,Evora C

更新日期：2001-03-01 00:00:00

abstract：:Hydrogels, chemically cross-linked or physically entangled, have found a number of applications as novel delivery vehicles of drugs and cells. However, the narrow ranges of degradation rates and mechanical strength currently available from many hydrogels limits their applications. We have hypothesized that utilization...

journal_title：Biomaterials

authors： Lee KY,Bouhadir KH,Mooney DJ

更新日期：2004-06-01 00:00:00

abstract：:Autophagy has attracted a great deal of research interest in tumor therapy in recent years. An attempt was made in this direction and now we report that iron oxide NPs synthesized by us selectively induce autophagy in cancer cells (A549) and not in normal cells (IMR-90). It was also noteworthy that autophagy correlate...

journal_title：Biomaterials

authors： Khan MI,Mohammad A,Patil G,Naqvi SA,Chauhan LK,Ahmad I

更新日期：2012-02-01 00:00:00

abstract：:Vaccination is an effective medical intervention for preventing disease. However, without an adjuvant, most subunit vaccines are poorly immunogenic. This work develops a bioinspired nanocomposite hyaluronic acid hydrogel system that incorporates N-trimethyl chitosan nanoparticles (TMC/NPs) that carry a model subunit v...

journal_title：Biomaterials

authors： Korupalli C,Pan WY,Yeh CY,Chen PM,Mi FL,Tsai HW,Chang Y,Wei HJ,Sung HW

更新日期：2019-09-01 00:00:00

abstract：:Alginate/aminopropyl-silicate/alginate (Alg/AS/Alg) membrane was prepared on Ca-alginate gel beads by a sol-gel process. The membrane has identical to Si-O-Si identical to bonds as well as electrostatic bonds between amino groups of AS and carboxyl groups of alginate. Permeability and stability were investigated for t...

journal_title：Biomaterials

authors： Sakai S,Ono T,Ijima H,Kawakami K

更新日期：2002-11-01 00:00:00

abstract：:A surface graft polymer with one or two phosphorylcholine (PC) polarheads at the terminus of the growing chain end was prepared by sequential reactions on a glass substrate. The dithiocarbamate group covalently bound to glass surfaces was derivatized with one or two PC groups and then irradiated with ultraviolet light...

journal_title：Biomaterials

authors： Matsuda T,Kaneko M,Ge S

更新日期：2003-11-01 00:00:00

abstract：:The major problem in skin grafting is that tissue-engineered skin grafts after their transplantation are initially entirely dependent on diffusion. Since this process is slow and inefficient, nutrients, growth factors, and oxygen will insufficiently be supplied and the regenerating graft will undergo a physiological c...

journal_title：Biomaterials

authors： Klar AS,Güven S,Biedermann T,Luginbühl J,Böttcher-Haberzeth S,Meuli-Simmen C,Meuli M,Martin I,Scherberich A,Reichmann E

更新日期：2014-06-01 00:00:00

abstract：:There are many ways to influence cell activities, and biomaterials with functional groups attached is an attractive method that clearly has the ability to modulate cell behavior. The evidence is clear that biomaterials, with or without growth factors and cells, have resulted in numerous products for the regenerative m...

journal_title：Biomaterials

authors： Ratcliffe A

更新日期：2011-06-01 00:00:00

abstract：:Bioactive coatings for neural electrodes that are tailored for cell interactions have the potential to produce superior implants with improved charge transfer capabilities. In this study synthetically produced anionically modified laminin peptides DEDEDYFQRYLI and DCDPGYIGSR were used to dope poly(3,4-ethylenedioxythi...

journal_title：Biomaterials

authors： Green RA,Lovell NH,Poole-Warren LA

更新日期：2009-08-01 00:00:00

abstract：:In this paper we report a method for biomaterial surface modification that utilizes the self-assembly of block copolymers of poly(styrene-block-ethylene oxide) (PS-PEO) to generate micro-phase separated surfaces with varying density PEO domains. These PS-PEO self-assembled surfaces showed a significant reduction in pr...

journal_title：Biomaterials

authors： George PA,Donose BC,Cooper-White JJ

更新日期：2009-05-01 00:00:00

abstract：:Lung fibrosis is a poor prognostic factor for pulmonary adenocarcinoma, and the effect of a rigid microenvironment on cancer behavior is unclear. We cultured A549 cells on matrices of 0.2, 2, and 25 kPa to mimic the rigidities of normal lung parenchyma, progressive fibrotic change, and lung fibrosis, respectively. Lun...

journal_title：Biomaterials

authors： Chang CC,Hsieh TL,Tiong TY,Hsiao CH,Ji AT,Hsu WT,Lee OK,Ho JH

更新日期：2015-08-01 00:00:00

abstract：:Cell sheet technology has emerged as an important tissue engineering approach. Adipose-derived stem cells (ASCs) have valuable applications in regenerative medicine, but their stemness and differentiation capabilities in the cell sheet format have not been well investigated. In this study, we found that l-ascorbate 2-...

journal_title：Biomaterials

authors： Yu J,Tu YK,Tang YB,Cheng NC

更新日期：2014-04-01 00:00:00

abstract：:A bilayer artificial skin composed of a silicone sheet and a collagen sponge sheet was developed by us in 1986, modifying Yannas and Burke's technique. It was used in experimental animals and clinically, both with success; but the artificial skin was inconvenient for clinical use in terms of disinfection and preservat...

journal_title：Biomaterials

authors： Matsuda K,Suzuki S,Isshiki N,Ikada Y

更新日期：1993-10-01 00:00:00

abstract：:Irradiated, thermally stabilized, highly cross-linked UHMWPE bearings have demonstrated superior wear performance and improved in vitro oxidation resistance compared with terminally gamma-sterilized bearings, yet retrieval analysis reveals unanticipated in vivo oxidation in these materials despite fewer or no measurab...

journal_title：Biomaterials

authors： Reinitz SD,Currier BH,Levine RA,Van Citters DW

更新日期：2014-05-01 00:00:00

abstract：:Introducing drugs into gene delivery systems to fabricate co-delivery systems for synergy therapy has become a promising strategy for tumor therapy. In this study, a dual responsive co-delivery system RHD/p53 was fabricated to enhance the antitumor efficacy with a low dose of doxorubicin (DOX). The reducible branched ...

journal_title：Biomaterials

authors： Chen S,Lei Q,Li SY,Qin SY,Jia HZ,Cheng YJ,Zhang XZ

更新日期：2016-06-01 00:00:00

abstract：:It has been demonstrated that using cultured chondrocytes that have been seeded onto various biomatrices can enhance the quality of the articular cartilage repair tissue. As tissue-engineering becomes increasingly more complex there is a need to understand how a specific biomaterial may influence gene expression. In t...

journal_title：Biomaterials

authors： Saldanha V,Grande DA

更新日期：2000-12-01 00:00:00