Generation and simulated imaging of pseudo-scaffolds to aid characterisation by X-ray micro CT.

Abstract:

:In order to assess the suitability of polymer tissue scaffolds for use in regenerative medicine, methods to characterise scaffolds are needed. This requires the scaffold's structure to be determined for which X-ray microscopic computed tomography (X-ray micro CT) is widely used. However, because scaffolds are generally made of materials with low X-ray attenuating properties the images produced are far from ideal, which makes distinguishing scaffold material from the pores within it a non-trivial process. This paper presents a method for generating computer-simulated scaffolds that resemble the form of foamed polymer tissue scaffolds. Virtual images of the scaffold are then produced via a simulated X-ray micro CT process enabling the effect of varying the key parameters in the imaging process to be investigated. Here this is assessed via the calculated porosity of the sample, this being a simple measure of a scaffold's properties. Results highlight the difficulties in using X-ray micro CT to characterise scaffolds constructed from materials with low X-ray attenuating properties and suggest strategies that may be adopted in order to improve the quality of the images produced.

journal_name

Biomaterials

journal_title

Biomaterials

authors

Morris DE,Mather ML,Crowe JA

doi

10.1016/j.biomaterials.2009.04.035

subject

Has Abstract

pub_date

2009-09-01 00:00:00

pages

4233-46

issue

25

eissn

0142-9612

issn

1878-5905

pii

S0142-9612(09)00430-X

journal_volume

30

pub_type

杂志文章
  • Macrophage responses to silk.

    abstract::Silk fibers have potential biomedical applications beyond their traditional use as sutures. The physical properties of silk fibers and films make it a promising candidate for tissue engineering scaffold applications, particularly where high mechanical loads or tensile forces are applied or in cases where low rates of ...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/s0142-9612(03)00158-3

    authors: Panilaitis B,Altman GH,Chen J,Jin HJ,Karageorgiou V,Kaplan DL

    更新日期:2003-08-01 00:00:00

  • The brain tissue response to biodegradable poly(methylidene malonate 2.1.2)-based microspheres in the rat.

    abstract::The aim of this study was to follow the in vivo biodegradation as well as to appreciate the brain tissue response to poly(methylidene malonate 2.1.2) (PMM 2.1.2)-based microspheres implanted into the rat brain. Ninety-three adult Sprague-Dawley female rats were engaged in the study in which 54 underwent stereotactic i...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/j.biomaterials.2006.04.045

    authors: Fournier E,Passirani C,Colin N,Sagodira S,Menei P,Benoit JP,Montero-Menei CN

    更新日期:2006-10-01 00:00:00

  • Bone tissue engineering on amorphous carbonated apatite and crystalline octacalcium phosphate-coated titanium discs.

    abstract::Poor fixation of bone replacement implants, e.g. the artificial hip, in implantation sites with inferior bone quality and quantity may be overcome by the use of implants coated with a cultured living bone equivalent. In this study, we tested, respectively, amorphous carbonated apatite (CA)- and crystalline octacalcium...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/j.biomaterials.2005.01.057

    authors: Dekker RJ,de Bruijn JD,Stigter M,Barrere F,Layrolle P,van Blitterswijk CA

    更新日期:2005-09-01 00:00:00

  • The protective role of arjunolic acid against doxorubicin induced intracellular ROS dependent JNK-p38 and p53-mediated cardiac apoptosis.

    abstract::In spite of tremendous demand for the development and implementation of effective therapeutic strategies, limitations are still associated with doxorubicin-induced cardiotoxicity. Arjunolic acid (AA) has been shown to possess a multitude of biological functions. The purpose of the present study was to explore whether ...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/j.biomaterials.2011.03.048

    authors: Ghosh J,Das J,Manna P,Sil PC

    更新日期:2011-07-01 00:00:00

  • Injectable biodegradation-visual self-healing citrate hydrogel with high tissue penetration for microenvironment-responsive degradation and local tumor therapy.

    abstract::Local tumor therapy through injectable biodegradable hydrogels with controlled drug release has attracted much attention recently, due to their easy operation, low side effect and efficiency. However, most of the reported therapeutic hydrogel system showed a lack of biodegradation tracking and tumor environment-respon...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/j.biomaterials.2020.120301

    authors: Wang M,Chen M,Niu W,Winston DD,Cheng W,Lei B

    更新日期:2020-12-01 00:00:00

  • PEGylated TNF-related apoptosis-inducing ligand (TRAIL) for effective tumor combination therapy.

    abstract::Although PEGylated TNF-related apoptosis-inducing ligand (PEG-TRAIL) has good tumor cell specificity and stability, its therapeutic potential is restricted by the development of tumor cell resistance. The purpose of this study was to develop an effective combination therapy with sustained biological activity based on ...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/j.biomaterials.2011.07.051

    authors: Jiang HH,Kim TH,Lee S,Chen X,Youn YS,Lee KC

    更新日期:2011-11-01 00:00:00

  • Long-acting liposomal corneal anesthetics.

    abstract::Eye drops producing long-acting ocular anesthesia would be desirable for corneal pain management. Here we present liposome-based formulations to achieve very long ocular anesthetic effect after a single eye drop instillation. The liposomes were functionalized with succinyl-Concanavalin A (sConA-Lip), which can bind co...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/j.biomaterials.2018.07.054

    authors: Zhan C,Santamaria CM,Wang W,McAlvin JB,Kohane DS

    更新日期:2018-10-01 00:00:00

  • Live cell imaging of mouse intestinal organoids reveals heterogeneity in their oxygenation.

    abstract::Intestinal organoids are widely applied in stem cell research, regenerative medicine, toxicology, pharmacology, and host-microbe interactions research. The variability of oxidative metabolism for stem and differentiated cell types constituting organoid is known to be important but so far it has not been studied in det...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/j.biomaterials.2017.08.043

    authors: Okkelman IA,Foley T,Papkovsky DB,Dmitriev RI

    更新日期:2017-11-01 00:00:00

  • Skeletal repair in rabbits with calcium phosphate cements incorporated phosphorylated chitin.

    abstract::The effects of phosphorylated chitin (P-chitin) on the tissue responses to two kinds of calcium phosphate cements (CPCs) were investigated using experimental rabbits. One of them consisting of monocalcium phosphate monohydrate, calcium oxide, 1 M phosphate buffer (pH: 7.4) and different amounts of P-chitin (CPC-I or P...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/s0142-9612(02)00205-3

    authors: Wang X,Ma J,Feng Q,Cui F

    更新日期:2002-12-01 00:00:00

  • Chemical and physical properties of a hydrogel wound dressing.

    abstract::Geliperm hydrogel provides optimal physiological conditions for wound healing. The material is composed of two interlaced networks, one of polyacrylamide and one of agar, and contains about 96% firmly bound water. It is supplied in smooth, elastic, transparent sheets which are impermeable to bacteria but permeable to ...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/0142-9612(86)90092-x

    authors: Kickhöfen B,Wokalek H,Scheel D,Ruh H

    更新日期:1986-01-01 00:00:00

  • Vitrification of intact human articular cartilage.

    abstract::Articular cartilage injuries do not heal and large defects result in osteoarthritis with major personal and socioeconomic costs. Osteochondral transplantation is an effective treatment for large joint defects but its use is limited by the inability to store cartilage for long periods of time. Cryopreservation/vitrific...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/j.biomaterials.2012.05.007

    authors: Jomha NM,Elliott JA,Law GK,Maghdoori B,Forbes JF,Abazari A,Adesida AB,Laouar L,Zhou X,McGann LE

    更新日期:2012-09-01 00:00:00

  • Effect of PVA-AA on dentine bonding of HEMA.

    abstract::PVA-AA, an esterification product of poly(vinyl alcohol) and acryloyl chloride, was synthesized and tested for its dentine bonding ability as an additive to 2-hydroxyethyl methacrylate (HEMA). The dentine bonding strength increased significantly by increasing the concentration of PVA-AA in HEMA. The dentine tensile bo...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/s0142-9612(96)00142-1

    authors: Gung YW,Kuo SM,Wang YJ

    更新日期:1997-02-01 00:00:00

  • Bioactive glass ceramics: properties and applications.

    abstract::Heat treatment of an MgO-CaO-SiO2-P2O5 glass gave a glass ceramic containing crystalline apatite (Ca10(PO4)6O,F2] and beta-wollastonite (CaO,SiO2) in an MgO-CaO-SiO2 glassy matrix. It showed bioactivity and a fairly high mechanical strength which decreased only slowly, even under load-bearing conditions in the body. I...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/0142-9612(91)90194-f

    authors: Kokubo T

    更新日期:1991-03-01 00:00:00

  • Skeletal muscle derived stem cells microintegrated into a biodegradable elastomer for reconstruction of the abdominal wall.

    abstract::A variety of techniques have been applied to generate tissue engineered constructs, where cells are combined with degradable scaffolds followed by a period of in vitro culture or direct implantation. In the current study, a cellularized scaffold was generated by concurrent deposition of electrospun biodegradable elast...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/j.biomaterials.2016.10.029

    authors: Takanari K,Hashizume R,Hong Y,Amoroso NJ,Yoshizumi T,Gharaibeh B,Yoshida O,Nonaka K,Sato H,Huard J,Wagner WR

    更新日期:2017-01-01 00:00:00

  • The effects of covalently immobilized hyaluronic acid substrates on the adhesion, expansion, and differentiation of embryonic stem cells for in vitro tissue engineering.

    abstract::We investigated the in vitro effects of the molecular weight (MW) of hyaluronic acid (HA) on the maintenance of the pluripotency and proliferation of murine embryonic stem (ES) cells. High (1000 kDa) or low (4-8 kDa) MW HA was derivatized using an ultraviolet-reactive compound, 4-azidoaniline, and the derivative was i...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/j.biomaterials.2011.07.083

    authors: Joddar B,Kitajima T,Ito Y

    更新日期:2011-11-01 00:00:00

  • Comparative proteomic analysis of endothelial cells progenitor cells derived from cord blood- and peripheral blood for cell therapy.

    abstract::Vasculopathy due to ischemia in damaged tissues is a major cause of morbidity and mortality. To treat these conditions, endothelial progenitor cells (EPCs) from various sources, such as umbilical cord or peripheral blood, have been the focus of the regenerative medicine field due to their proliferative and vasculogeni...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/j.biomaterials.2012.11.017

    authors: Kim J,Jeon YJ,Kim HE,Shin JM,Chung HM,Chae JI

    更新日期:2013-02-01 00:00:00

  • On the role of the actin cytoskeleton and nucleus in the biomechanical response of spread cells.

    abstract::Micropipette aspiration (MA) has been used extensively in biomechanical investigations of un-adhered cells suspended in media. In the current study, a custom MA system is developed to aspirate substrate adhered spread cells. Additionally, the system facilitates immuno-fluorescent staining of aspirated cells to investi...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/j.biomaterials.2014.01.056

    authors: Reynolds NH,Ronan W,Dowling EP,Owens P,McMeeking RM,McGarry JP

    更新日期:2014-04-01 00:00:00

  • Electrospun degradable polyesterurethane membranes: potential scaffolds for skeletal muscle tissue engineering.

    abstract::Skeletal muscle tissue engineering represents an attractive approach to overcome problems associated with autologous transfer of muscle tissue and provides a valid alternative in muscle regeneration enhancement. The aim of this study was to investigate the suitability, as scaffold for skeletal muscle tissue engineerin...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/j.biomaterials.2004.11.035

    authors: Riboldi SA,Sampaolesi M,Neuenschwander P,Cossu G,Mantero S

    更新日期:2005-08-01 00:00:00

  • Chitosan-poly(acrylic) acid polyionic complex: in vivo study to demonstrate prolonged gastric retention.

    abstract::The aim of this study was to develop a chitosan-poly(acrylic) acid based controlled drug release system for gastric antibiotic delivery. Different mixtures of amoxicillin (A), chitosan (CS), and poly(acrylic) acid (PAA) were employed to obtain these polyionic complexes. A non-invasive method was employed for determini...

    journal_title:Biomaterials

    pub_type: 临床试验,杂志文章

    doi:10.1016/s0142-9612(03)00579-9

    authors: Torrado S,Prada P,de la Torre PM,Torrado S

    更新日期:2004-02-01 00:00:00

  • Quantitative analysis of the resorption and osteoconduction process of a calcium phosphate cement and its mechanical effect for screw fixation.

    abstract::The clinical application of calcium phosphate cements (CPCs) composed of tetracalcium phosphate and dicalcium phosphate anhydrous has been limited because of its longer setting time, so that we developed the CPC in which the setting time was shortened to approximately 10 min. Aiming at clinical application, we evaluat...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/s0142-9612(03)00422-8

    authors: Hoshikawa A,Fukui N,Fukuda A,Sawamura T,Hattori M,Nakamura K,Oda H

    更新日期:2003-12-01 00:00:00

  • Assessment of genetic damage by methyl methacrylate employing in vitro mammalian test system.

    abstract::Methyl methacrylate (MMA) is a volatile liquid widely used in the manufacture of acrylic polymers. In modern dentistry, MMA is the mainstream material in denture bases. MMA has been implicated as primary irritant and sensitizer, which can cause allergic eczematous reaction on the oral mucosa as well as skin. To date, ...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/s0142-9612(03)00132-7

    authors: Yang HW,Chou LS,Chou MY,Chang YC

    更新日期:2003-08-01 00:00:00

  • Glucose & oxygen exhausting liposomes for combined cancer starvation and hypoxia-activated therapy.

    abstract::Starvation therapy to slow down the tumor growth by cutting off its energy supply has been proposed to be an alternative therapeutic strategy for cancer treatment. Herein, glucose oxidase (GOx) is loaded into stealth liposomes and act as the glucose and oxygen elimination agent to trigger the conversion of glucose and...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/j.biomaterials.2018.02.004

    authors: Zhang R,Feng L,Dong Z,Wang L,Liang C,Chen J,Ma Q,Zhang R,Chen Q,Wang Y,Liu Z

    更新日期:2018-04-01 00:00:00

  • A review of nanocarriers for the delivery of small interfering RNA.

    abstract::Increasing knowledge about molecular mechanisms of endogenous RNA interference (RNAi) and small interfering RNAs (siRNAs) has been incorporated into innovative nucleic acid medicines for treatment of diseases such as cancers. Although RNAi and siRNA have the potential to become powerful therapeutic drugs, their delive...

    journal_title:Biomaterials

    pub_type: 杂志文章,评审

    doi:10.1016/j.biomaterials.2012.06.068

    authors: Kesharwani P,Gajbhiye V,Jain NK

    更新日期:2012-10-01 00:00:00

  • Microarray analyses to quantify advantages of 2D and 3D hydrogel culture systems in maintaining the native valvular interstitial cell phenotype.

    abstract::Valvular interstitial cells (VICs) actively maintain and repair heart valve tissue; however, persistent activation of VICs to a myofibroblast phenotype can lead to aortic stenosis. To better understand and quantify how microenvironmental cues influence VIC phenotype and myofibroblast activation, we compared expression...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/j.biomaterials.2015.09.035

    authors: Mabry KM,Payne SZ,Anseth KS

    更新日期:2016-01-01 00:00:00

  • Intracellular self-assembly based multi-labeling of key viral components: Envelope, capsid and nucleic acids.

    abstract::Envelope, capsid and nucleic acids are key viral components that are all involved in crucial events during virus infection. Thus simultaneous labeling of these key components is an indispensable prerequisite for monitoring comprehensive virus infection process and dissecting virus infection mechanism. Baculovirus was ...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/j.biomaterials.2016.04.038

    authors: Wen L,Lin Y,Zhang ZL,Lu W,Lv C,Chen ZL,Wang HZ,Pang DW

    更新日期:2016-08-01 00:00:00

  • Calcium phosphate apatites with variable Ca/P atomic ratio II. Calcination and sintering.

    abstract::The calcination and natural sintering of calcium deficient hydroxyapatite powders Ca(10-x)(PO4)(6-x)(HPO4)x(OH)(2-x) (with 0 < or = x < or = 1) were studied. For temperature below 700 degrees C, particle coalescence occurs without densification. The particle coalescence is associated with a reduction of the specific s...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/s0142-9612(01)00219-8

    authors: Raynaud S,Champion E,Bernache-Assollant D

    更新日期:2002-02-01 00:00:00

  • Poly(glycerol-dodecanoate), a biodegradable polyester for medical devices and tissue engineering scaffolds.

    abstract::In this paper we describe the mechanical and biological features of a thermosetting polyester synthesized from glycerol and dodecanedioic acid named Poly-Glycerol-Dodecanoate (PGD). This polymer shows a glass transition temperature (T(g)) around 32 degrees C, and this accounts for its mechanical properties. At room te...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/j.biomaterials.2009.08.021

    authors: Migneco F,Huang YC,Birla RK,Hollister SJ

    更新日期:2009-11-01 00:00:00

  • In vitro degradation of pH-sensitive hydrogels containing aromatic azo bonds.

    abstract::Biodegradable and pH-sensitive hydrogels containing azoaromatic moieties were synthesized from the same polymeric precursors by two synthetic methods, namely a polymer-polymer reaction and cross-linking of polymeric precursors. The effect of the synthetic route employed and the detailed network structure on in vitro d...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/s0142-9612(97)00007-0

    authors: Ghandehari H,Kopecková P,Kopecek J

    更新日期:1997-06-01 00:00:00

  • The significance of pore microarchitecture in a multi-layered elastomeric scaffold for contractile cardiac muscle constructs.

    abstract::Multi-layered poly(glycerol-sebacate) (PGS) scaffolds with controlled pore microarchitectures were fabricated, combined with heart cells, and cultured with perfusion to engineer contractile cardiac muscle constructs. First, one-layered (1L) scaffolds with accordion-like honeycomb shaped pores and elastomeric mechanica...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/j.biomaterials.2010.11.032

    authors: Park H,Larson BL,Guillemette MD,Jain SR,Hua C,Engelmayr GC Jr,Freed LE

    更新日期:2011-03-01 00:00:00

  • Three-dimensional piezoelectric fibrous scaffolds selectively promote mesenchymal stem cell differentiation.

    abstract::The discovery of electric fields in biological tissues has led to efforts in developing technologies utilizing electrical stimulation for therapeutic applications. Native tissues, such as cartilage and bone, exhibit piezoelectric behavior, wherein electrical activity can be generated due to mechanical deformation. Yet...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/j.biomaterials.2017.09.024

    authors: Damaraju SM,Shen Y,Elele E,Khusid B,Eshghinejad A,Li J,Jaffe M,Arinzeh TL

    更新日期:2017-12-01 00:00:00