Self-assembling polystyrene-block-poly(ethylene oxide) copolymer surface coatings: resistance to protein and cell adhesion.

abstract：:The ability to restore heart function by replacement of diseased myocardium is one of the great challenges in biomaterials and regenerative medicine. Brown adipose derived stem cells (BADSCs) present a new source of cardiomyocytes to regenerate the myocardium after infarction. In this study, we explored an injectable ...

journal_title：Biomaterials

authors： Wang H,Shi J,Wang Y,Yin Y,Wang L,Liu J,Liu Z,Duan C,Zhu P,Wang C

更新日期：2014-04-01 00:00:00

abstract：:A novel technique has been developed for microstructural studies of bone. The spatial organizations of the mineral and collagen fibres in bone have been a matter of discussion for some time, with numerous diverse observations arising from various preparative techniques. In this latest investigation details of the mine...

journal_title：Biomaterials

authors： Green M,Isaac DH,Jenkins GM

更新日期：1985-05-01 00:00:00

abstract：:As peripheral arterial disease (PAD) results in muscle ischemia and neovascularization, it has been claimed that nanoparticles can passively accumulate in ischemic tissues through the enhanced permeability and retention (EPR) effect. At this time, a quantitative evaluation of the passive targeting capabilities of nano...

journal_title：Biomaterials

authors： England CG,Im HJ,Feng L,Chen F,Graves SA,Hernandez R,Orbay H,Xu C,Cho SY,Nickles RJ,Liu Z,Lee DS,Cai W

更新日期：2016-09-01 00:00:00

abstract：:Microcontact printing techniques were used to modify silicon substrates with arrays of hexagonal features of N1[3-(trimethoxysilyl) propyl]diethylenetriamine (DETA) surrounded by octadecyltrichlorosilane (OTS), which are hydrophilic, cell-adhesive and hydrophobic, non-adhesive organosilanes, respectively. In the prese...

journal_title：Biomaterials

authors： Kam L,Shain W,Turner JN,Bizios R

更新日期：1999-12-01 00:00:00

abstract：:Although PEGylated liposomes (PEG-LS) have been intensively studied as drug-delivery vehicles, the rigidity and the hydrophilic PEG corona of liposomal membranes often limits cellular uptake, resulting in insufficient drug delivery to target cells. Thus, it is necessary to develop a new type of lipid-based self-assemb...

journal_title：Biomaterials

authors： Saw PE,Yu M,Choi M,Lee E,Jon S,Farokhzad OC

更新日期：2017-04-01 00:00:00

abstract：:The channel of the viral DNA packaging motor allows dsDNA to enter the protein procapsid shell during maturation and to exit during infection. We recently showed that the bacteriophage phi29 DNA packaging motor exercises a one-way traffic property using a channel as a valve for dsDNA translocation. This raises a quest...

journal_title：Biomaterials

authors： Geng J,Fang H,Haque F,Zhang L,Guo P

更新日期：2011-11-01 00:00:00

abstract：:Nanoparticles, such as dendritic polymers, are currently investigated as excellent candidates for drug delivery vehicles. In this study, we report the preparation and characterization of mPEGylated peptide dendron-doxorubicin (dendron-DOX) conjugate based vehicle carrying 14.0 wt% (weight percent) of doxorubicin (DOX)...

journal_title：Biomaterials

authors： She W,Luo K,Zhang C,Wang G,Geng Y,Li L,He B,Gu Z

更新日期：2013-02-01 00:00:00

abstract：:The release of the anti-inflammatory agent dexamethasone (DEX) from nanoparticles of poly(lactic-co-glycolic acid) (PLGA) embedded in alginate hydrogel (HG) matrices was investigated. DEX-loaded PLGA nanoparticles were prepared using a solvent evaporation technique and were characterized for size, drug loading, and in...

journal_title：Biomaterials

authors： Kim DH,Martin DC

更新日期：2006-05-01 00:00:00

abstract：:Sub-micron particles of bioactive glass (SMBGs) with composition 85 mol% SiO(2) and 15 mol% CaO were synthesised and characterised. Bioactivity was demonstrated by the formation of calcium apatite following 5 days immersion in simulated body fluid (SBF). The effect of a 24 h exposure of SMBGs (100 μg/ml, 150 μg/ml, 20...

journal_title：Biomaterials

authors： Labbaf S,Tsigkou O,Müller KH,Stevens MM,Porter AE,Jones JR

更新日期：2011-02-01 00:00:00

abstract：:Porous nanostructure with its unique properties is found to be able to hold promise in drug delivery. We fabricated the one-dimensional titanium dioxide whiskers (TiO2 Ws) and designed a strategy to explore their drug delivery application and anti-tumor function combined with daunorubicin (DNR). We observed good bioco...

journal_title：Biomaterials

authors： Li Q,Wang X,Lu X,Tian H,Jiang H,Lv G,Guo D,Wu C,Chen B

更新日期：2009-09-01 00:00:00

abstract：:Multifunctional nanoparticles integrated with imaging modalities (such as magnetic resonance and optical) and therapeutic drugs are promising candidates for future cancer diagnostics and therapy. While targeted drug delivery and imaging of tumor cells have been the major focus in engineering nanoparticle probes, no ex...

journal_title：Biomaterials

authors： Mitra RN,Doshi M,Zhang X,Tyus JC,Bengtsson N,Fletcher S,Page BD,Turkson J,Gesquiere AJ,Gunning PT,Walter GA,Santra S

更新日期：2012-02-01 00:00:00

abstract：:A series of hydrogels composed of varying fractions of dodecyl methacrylate (DM) and 2,3-dihydroxypropyl methacrylate (GM) were prepared using ethylene glycol dimethacrylate (EGDMA) as the cross-linking agent. The study found that for a series of gels with the same monomer ratio, bulk hydration could be controlled by ...

journal_title：Biomaterials

authors： Haigh R,Rimmer S,Fullwood NJ

更新日期：2000-04-01 00:00:00

abstract：:The carboxymethylcellulose-gelatine carrier system was investigated for invertase immobilization. Chromium (III) acetate, chromium (III) sulphate and potassium chromium (III) sulphate were used as cross-linking agents. Effect of carboxymethylcellulose-gelatine ratio and cross-linker concentration on immobilized enzyme...

journal_title：Biomaterials

authors： Emregül E,Sungur S,Akbulut U

更新日期：1996-07-01 00:00:00

abstract：:A biocompatible hydrogel of poly[N-(2-hydroxypropyl)methacrylamide] (PHPMA) which includes the cell-adhesive region of fibronectin Arg-Gly-Asp was synthesized and its structure, rheological and dielectric properties were characterized. The ability of a PHPMA-RGD hydrogel to promote tissue regeneration and support axon...

journal_title：Biomaterials

authors： Woerly S,Pinet E,de Robertis L,Van Diep D,Bousmina M

更新日期：2001-05-01 00:00:00

abstract：:Metal sensitivity (MS) reactions to implant metals represent a rare but well-documented complication following total joint arthroplasty (TJA). Although 20-25% of post-TJA patients develop MS, only a few highly susceptible patients (< 1%) exhibit symptoms. Whether surgeons should perform screening for MS is currently a...

journal_title：Biomaterials

authors： Niki Y,Matsumoto H,Otani T,Yatabe T,Kondo M,Yoshimine F,Toyama Y

更新日期：2005-03-01 00:00:00

abstract：:Recent advances in nanoparticle systems for improved drug delivery display a great potential for the administration of active molecules. Generally, the lipid systems presented the advantage of their low toxicity due to their composition of physiological lipids compared to polymeric particles. The physico-chemical stab...

journal_title：Biomaterials

authors： Heurtault B,Saulnier P,Pech B,Proust JE,Benoit JP

更新日期：2003-10-01 00:00:00

abstract：:Implantation of synthetic material, including vascular grafts, pacemakers, etc. results in the foreign body reaction and the formation of multinucleated giant cells (MGCs) at the exterior surface of the implant. Despite the long-standing premise that fusion of mononucleated macrophages results in the formation of MGCs...

journal_title：Biomaterials

authors： Faust JJ,Christenson W,Doudrick K,Ros R,Ugarova TP

更新日期：2017-06-01 00:00:00

abstract：:Pancreatic islet transplantation is one of the most promising strategies for patients suffering from type 1 diabetes mellitus, but several therapeutic immunosuppressive medications must be administered simultaneously to protect transplanted islets in the long-term, and these expose patients to the risk of serious comp...

journal_title：Biomaterials

authors： Yun Lee D,Hee Nam J,Byun Y

更新日期：2007-04-01 00:00:00

abstract：:We report the ability of amino- and carboxyl-modified MCM-41 mesoporous silica nanoparticles (MSN) to deliver gene in vivo in rat Achilles tendons, despite their inefficiency to transfect primary tenocytes in culture. We show that luciferase activity lasted for at least 2 weeks in tendons injected with these MSN and a...

journal_title：Biomaterials

authors： Suwalski A,Dabboue H,Delalande A,Bensamoun SF,Canon F,Midoux P,Saillant G,Klatzmann D,Salvetat JP,Pichon C

更新日期：2010-07-01 00:00:00

abstract：:This study examined the engineering and true axial stress-strain behavior of smooth cylindrical and shallow and deep notched cylindrical test specimens, under applied axial tensile loading using non-contacting methods, of both conventional and highly crosslinked ultra-high molecular weight polyethylenes (UHMWPEs). The...

journal_title：Biomaterials

authors： Sobieraj MC,Kurtz SM,Rimnac CM

更新日期：2005-06-01 00:00:00

abstract：:The objective of the study was to examine the effect of alkali ion release, pH control and buffer capacity on the expression of the osteoblastic phenotype. In addition we determined the importance of modifications of the surface of porous bioactive glass (BG) on the activity of rat calvaria osteoblasts in vitro. We fo...

journal_title：Biomaterials

authors： el-Ghannam A,Ducheyne P,Shapiro IM

更新日期：1997-02-01 00:00:00

abstract：:With respect to the effect of material factors on calcium phosphate biomaterial-induced osteogenesis, the osteoinductive property of two kinds of porous hydroxyapatite ceramics, which were made by different producers, was investigated in dorsal muscles of dogs. One hydroxyapatite ceramic (S-HA), macroporous implants w...

journal_title：Biomaterials

authors： Yuan H,Kurashina K,de Bruijn JD,Li Y,de Groot K,Zhang X

更新日期：1999-10-01 00:00:00

abstract：:Gd3+-based contrast agents monopolize in the clinical MR imaging-based diagnosis of hepatic tumors, however, the inherent toxicity by the released Gd3+-ions triggered an urgent demand for safer alternatives. Here, we demonstrate hollow manganese silicate nanoparticles (HMS), which exert burst-release of Mn2+-ions by s...

journal_title：Biomaterials

authors： Kim JG,Jang MS,Kumari N,Choi JK,Im GH,Kwon T,Lee JH,Lee WJ,Lee IS

更新日期：2020-02-01 00:00:00

abstract：:Programmable hydrogels are defined as hydrogels that are able to change their properties and functions periodically, reversibly and/or sequentially on demand. They are different from those responsive hydrogels whose changes are passive or cannot be stopped or reversed once started and vice versa. The purpose of this r...

journal_title：Biomaterials

authors： Wang Y

更新日期：2018-09-01 00:00:00

abstract：:Surface protein modification with poly(ethylene glycol) (PEG) can inhibit acute thrombosis on damaged vascular and biomaterial surfaces by blocking surface protein-platelet interactions. However, the feasibility of employing protein reactive PEGs to limit intravascular and biomaterial thrombosis in vivo is contingent ...

journal_title：Biomaterials

authors： Xu H,Kaar JL,Russell AJ,Wagner WR

更新日期：2006-06-01 00:00:00

abstract：:The aim of this study was to evaluate the physical-chemical properties, in vivo biocompatibility and antimicrobial activity of bioactive glasses (BG) used as a controlled release device for tetracycline hydrochloride and an inclusion complex formed by tetracycline and beta-cyclodextrin at 1:1 molar ratio. The BG as we...

journal_title：Biomaterials

authors： Domingues ZR,Cortés ME,Gomes TA,Diniz HF,Freitas CS,Gomes JB,Faria AM,Sinisterra RD

更新日期：2004-01-01 00:00:00

abstract：:Particle-associated periprosthetic osteolysis remains a major issue in joint replacement. Ongoing bone loss resulting from wear particle-induced inflammation is accompanied by continued attempts at bone repair. Previously we showed that mesenchymal stem cells (MSCs) are recruited systemically to bone exposed to contin...

journal_title：Biomaterials

authors： Gibon E,Yao Z,Rao AJ,Zwingenberger S,Batke B,Valladares R,Smith RL,Biswal S,Gambhir SS,Goodman SB

更新日期：2012-05-01 00:00:00

abstract：:Valvular interstitial cells (VICs) actively maintain and repair heart valve tissue; however, persistent activation of VICs to a myofibroblast phenotype can lead to aortic stenosis. To better understand and quantify how microenvironmental cues influence VIC phenotype and myofibroblast activation, we compared expression...

journal_title：Biomaterials

authors： Mabry KM,Payne SZ,Anseth KS

更新日期：2016-01-01 00:00:00

abstract：:We report a new template-directed method for the fabrication of hydroxyapatite (HAp) sponges by using amino-acid-coated HAp nanoparticles dispersed within a viscous polysaccharide (dextran sulfate) matrix, and describe the use of these materials for the viability and proliferation of human bone marrow stromal cells. T...

journal_title：Biomaterials

authors： Gonzalez-McQuire R,Green D,Walsh D,Hall S,Chane-Ching JY,Oreffo RO,Mann S

更新日期：2005-11-01 00:00:00

abstract：:This animal experiment compared the regenerative processes within defined bony defects of the porcine skull after delivery of routinely utilized bone graft materials: anorganic bone matrix (ABM) and an identical ABM carrying the cell binding peptide P-15. Particulated autogenous bone was used as a control group. The c...

journal_title：Biomaterials

authors： Thorwarth M,Schultze-Mosgau S,Wehrhan F,Kessler P,Srour S,Wiltfang J,Andreas Schlegel K

更新日期：2005-10-01 00:00:00