Regulation of metastatic ability and drug resistance in pulmonary adenocarcinoma by matrix rigidity via activating c-Met and EGFR.

abstract：:Poly(epsilon-caprolactone) (PCL)/continuous bioglass fibre composite was prepared using the monomer transfer moulding technique coupled with a surface initiated polymerisation. The bioglass fibres were surface treated with an amine ended silane in order to initiate polymerisation of epsilon-caprolactone from the fibre...

journal_title：Biomaterials

authors： Jiang G,Evans ME,Jones IA,Rudd CD,Scotchford CA,Walker GS

更新日期：2005-05-01 00:00:00

abstract：:The construction of tissue-engineered devices for medical applications is now possible in vitro using cell culture and bioreactors. Although methods of incorporating them back into the host are available, current constructs depend purely on diffusion which limits their potential. The absence of a vascular network capa...

journal_title：Biomaterials

authors： Kannan RY,Salacinski HJ,Sales K,Butler P,Seifalian AM

更新日期：2005-05-01 00:00:00

abstract：:We analysed tissues harvested during 24 retrievals of hip joint prostheses, with one or both articular components made of alumina. We describe the morphology of wear particles, measure their size and analyse their chemical composition. We relate histopathological aspects to the parameters that characterize ceramic wea...

journal_title：Biomaterials

authors： Pizzoferrato A,Stea S,Sudanese A,Toni A,Nigrisoli M,Gualtieri G,Squarzoni S

更新日期：1993-07-01 00:00:00

abstract：:By taking advantage of the excessively upregulated expression of neuropilin (NRP) on the surface of both glioma cells and endothelial cells of angiogenic blood vessels, the ligand of NRP with high affinity - tLyp-1 peptide, which also contains a CendR motif ((R/K)XX(R/K)), was functionalized to the surface of PEG-PLA ...

journal_title：Biomaterials

authors： Hu Q,Gao X,Gu G,Kang T,Tu Y,Liu Z,Song Q,Yao L,Pang Z,Jiang X,Chen H,Chen J

更新日期：2013-07-01 00:00:00

abstract：:The clinical application of cancer radiotherapy is critically impeded by hypoxia-induced radioresistance, insufficient DNA damage, and multiple DNA repair mechanisms. Herein we demonstrate a dual-hyperthermia strategy to potentiate radiotherapy by relieving tumor hypoxia and preventing irradiation-induced DNA damage r...

journal_title：Biomaterials

authors： Li Q,Hang L,Jiang W,Dou J,Xiao L,Tang X,Yao Y,Wang Y

更新日期：2020-10-01 00:00:00

abstract：:The water absorption characteristics of resins, upon which many composite filling materials are based, have been studied. In general, the equilibrium uptake is less than that predicted from the water absorption of composite filling materials, if it is assumed that the polymer alone absorbs the water. Also, whereas the...

journal_title：Biomaterials

authors： Braden M,Davy KW

更新日期：1986-11-01 00:00:00

abstract：:It is widely accepted that implant surface factors affect the quality of the bone-to-implant interface. Recent additional treatments superimposed on moderately rough cpTitanium surface provide further enhancement of bone-to-implant contact. The aim of this study was to compare osteoinductive and bone-specific gene exp...

journal_title：Biomaterials

authors： Guo J,Padilla RJ,Ambrose W,De Kok IJ,Cooper LF

更新日期：2007-12-01 00:00:00

abstract：:Impaction grafting using morsellised allograft bone restores bone stock, but carries the potential for transmission of infection. Synthetic bone graft substitutes can eliminate this risk but may, however, influence outcome. In this study we tested the hypothesis that a 50/50 mix of hydroxyapatite and allograft does no...

journal_title：Biomaterials

authors： Aulakh TS,Jayasekera N,Kuiper JH,Richardson JB

更新日期：2009-03-01 00:00:00

abstract：:Calcium phosphate coatings were deposited by pulsed laser ablation with a radiation of 355 nm from a Nd:YAG laser. All the coatings were obtained at the same conditions, but deposition was stopped after different number of pulses to get coatings with different thickness. The influence of thickness in the structural an...

journal_title：Biomaterials

authors： Fernández-Pradas JM,Clèries L,Sardin G,Morenza JL

更新日期：2002-05-01 00:00:00

abstract：:Photodynamic therapy (PDT) is a new therapeutic approach for the palliative treatment of malignant bile duct obstruction. In this study, we designed photosensitizer-embedded self-expanding nonvascular metal stent (PDT-stent) which allows repeatable photodynamic treatment of cholangiocarcinoma without systemic injectio...

journal_title：Biomaterials

authors： Bae BC,Yang SG,Jeong S,Lee DH,Na K,Kim JM,Costamagna G,Kozarek RA,Isayama H,Deviere J,Seo DW,Nageshwar Reddy D

更新日期：2014-10-01 00:00:00

abstract：:The effect of anodization on passive dissolution of titanium was studied by measuring titanium levels in peritoneal leukocytes and tissues of laboratory animals with titanium plates implanted into the peritoneal cavity. Fifteen Sprague-Dawley rats were assigned randomly to three treatment groups of five animals. One g...

journal_title：Biomaterials

authors： Jorgenson DS,Centeno JA,Mayer MH,Topper MJ,Nossov PC,Mullick FG,Manson PN

更新日期：1999-04-01 00:00:00

abstract：:Wounded tissues and cells may be treated with growth factors and specific genes for the purpose of tissue repair and regeneration. To deliver specific genes into tissues and cells, this study presents the use of fabricated poly (DL-lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) complexed with the cationic polymer...

journal_title：Biomaterials

authors： Park JS,Yang HN,Woo DG,Jeon SY,Park KH

更新日期：2013-01-01 00:00:00

abstract：:A-B-type block copolymers, consisting of polystyrene (PST) or poly(methyl methacrylate) (PMMA) forming segment (A) and poly(gamma-benzyl L-glutamate) (P[Glu(OBzl)]) segment (B), were synthesized and the thrombus formation on these block copolymer films was investigated in relation to the adsorption of plasma proteins ...

journal_title：Biomaterials

authors： Mori A,Ito Y,Sisido M,Imanishi Y

更新日期：1986-09-01 00:00:00

abstract：:The bulk, surface and blood-contacting properties of a series of polyether polyurethanes, modified with three different polydimethylsiloxane (PDMS) macroglycol segments, were evaluated. The PDMS oligomers were terminated with hydroxy-tipped end groups of varying polarity. The effect of substituting the polytetramethyl...

journal_title：Biomaterials

authors： Okkema AZ,Fabrizius DJ,Grasel TG,Cooper SL,Zdrahala RJ

更新日期：1989-01-01 00:00:00

abstract：:Biological surface engineering using synthetic biological materials has a great potential for advances in our understanding of complex biological phenomena. We developed a simple system to engineer biologically relevant surfaces using a combination of self-assembling oligopeptide monolayers and microcontact printing (...

journal_title：Biomaterials

authors： Zhang S,Yan L,Altman M,Lässle M,Nugent H,Frankel F,Lauffenburger DA,Whitesides GM,Rich A

更新日期：1999-07-01 00:00:00

abstract：:Bioactive glass granules were implanted in the tibiae of rabbits in order to determine the pathway of the silicon released from bioactive glass in vivo. We traced and quantified the silicon released by obtaining 24-h urine samples and blood samples for up to 7 months after implantation. Bone tissue as well as the foll...

journal_title：Biomaterials

authors： Lai W,Garino J,Ducheyne P

更新日期：2002-01-01 00:00:00

abstract：:Magnesium (Mg), a potential biodegradable material, has recently received increasing attention due to its unique antibacterial property. However, rapid corrosion in the physiological environment and potential toxicity limit clinical applications. In order to improve the corrosion resistance meanwhile not compromise th...

journal_title：Biomaterials

authors： Qin H,Zhao Y,An Z,Cheng M,Wang Q,Cheng T,Wang Q,Wang J,Jiang Y,Zhang X,Yuan G

更新日期：2015-06-01 00:00:00

abstract：:Reconstruction of the genitourinary tract, using engineered urological tissues, requires a mechanically stable biodegradable and biocompatible scaffold and cultured cells. Such engineered autologous tissue would have many clinical implications. In this study a highly porous biodegradable polyesterurethane-foam, DegraP...

journal_title：Biomaterials

authors： Danielsson C,Ruault S,Simonet M,Neuenschwander P,Frey P

更新日期：2006-03-01 00:00:00

abstract：:Autophagy has attracted a great deal of research interest in tumor therapy in recent years. An attempt was made in this direction and now we report that iron oxide NPs synthesized by us selectively induce autophagy in cancer cells (A549) and not in normal cells (IMR-90). It was also noteworthy that autophagy correlate...

journal_title：Biomaterials

authors： Khan MI,Mohammad A,Patil G,Naqvi SA,Chauhan LK,Ahmad I

更新日期：2012-02-01 00:00:00

abstract：:A newly developed bone equivalent hydroxyapatite was derived from veterinary bone (VHAP). Sections of 1 cm of six rabbit mandibles were equally replaced by this VHAP graft. Radiological studies by X-ray were performed pre-operatively, immediately, and 1, 2 and 3 months post-operatively. The graft host-bone interface w...

journal_title：Biomaterials

authors： Abdel-Fattah WI,Osiris WG,Mohamed SS,Khalil MR

更新日期：1994-06-01 00:00:00

abstract：:Realizing the potential of human pluripotent stem cell (hPSC)-based therapy requires the development of defined scalable culture systems with efficient expansion, differentiation and isolation protocols. We report an engineered 3D microfiber system that efficiently supports long-term hPSCs self-renewal under chemicall...

journal_title：Biomaterials

authors： Lu HF,Narayanan K,Lim SX,Gao S,Leong MF,Wan AC

更新日期：2012-03-01 00:00:00

abstract：:Duchenne Muscular Dystrophy (DMD) is a fatal genetic disorder currently having no cure. Here we report that culture substrates patterned with nanogrooves and functionalized with Matrigel (or laminin) present an engineered cell microenvironment to allow myotubes derived from non-diseased, less-affected DMD, and severel...

journal_title：Biomaterials

authors： Xu B,Magli A,Anugrah Y,Koester SJ,Perlingeiro RCR,Shen W

更新日期：2018-11-01 00:00:00

abstract：:Carbon nanotube (CNT) possesses excellent properties as a drug carrier. To overcome the challenge of drug functionalization with CNT, we have developed a lipid-drug approach for efficient drug loading onto CNT, in which a long chain lipid molecule is conjugated to the drug molecule so that the lipid-drug can be loaded...

journal_title：Biomaterials

authors： Shao W,Paul A,Zhao B,Lee C,Rodes L,Prakash S

更新日期：2013-12-01 00:00:00

abstract：:A comparative in vitro assessment of 4 types of tubing representative of the materials currently used in cardiopulmonary bypass (CPB) procedures was conducted under static conditions using liquid extracts of the materials or direct contact with fresh human blood or serum. The parameters monitored were biomarkers of co...

journal_title：Biomaterials

authors： Harmand MF,Briquet F

更新日期：1999-09-01 00:00:00

abstract：:Gelatin and dextran were blended and crosslinked to form enzymatically degradable interpenetrating polymeric networks (IPNs) as materials for degradable implants. Several crosslinking methods were investigated including treatment with glyceraldehyde, thermal hardening, and chelation of dextran by divalent metal cation...

journal_title：Biomaterials

authors： Kosmala JD,Henthorn DB,Brannon-Peppas L

更新日期：2000-10-01 00:00:00

abstract：:The adsorption of bovine serum albumin (BSA) on to titanium powder has been studied as a function of protein concentration and pH, and in the presence of calcium and phosphate ions. Isotherm data have shown that the adsorption process does not follow the Langmuir model (inflection points). The maximum adsorption (Adma...

journal_title：Biomaterials

authors： Wassell DT,Embery G

更新日期：1996-05-01 00:00:00

abstract：:New therapeutic strategies are needed for the growing unmet clinical needs in liver disease and fibrosis. Platelet activation and PDGF activity are recognized as important therapeutic targets; however, no therapeutic approach has yet addressed these two upstream drivers of liver fibrosis. We therefore designed a matri...

journal_title：Biomaterials

authors： Kabra H,Walimbe T,Stuart K,Indey C,Jalgaonkar S,Ikwa E,Skurnac T,Chen J,Woolley A,Snead NM,Bachtell N,Leeming DJ,Karsdal M,Prestwich G,Panitch A,Paderi J

更新日期：2020-11-17 00:00:00

abstract：:The synthesis of a new potential anti-thrombogenic polymer is described. Limited halogenation of an aryloxy-substituted polyphosphazene, followed by quaternization with triethylamine yielded a polymer capable of forming polyelectrolyte complexes with sodium heparin. The results of preliminary clotting tests with bovin...

journal_title：Biomaterials

authors： Neenan TX,Allcock HR

更新日期：1982-04-01 00:00:00

abstract：:We have prepared a fraction of commercial fetal calf serum whose major component comprises proteins of apparent molecular mass 65-80 kDa. These preparations elicit cell spreading responses in serum-free medium at concentrations similar to those reported for human vitronectin. In addition, we have identified (by a prot...

journal_title：Biomaterials

authors： Lydon MJ,Foulger CA

更新日期：1988-11-01 00:00:00

abstract：:Understanding how nanovectors transport DNA molecules through cell membranes is of great importance in gene therapy. In this paper, we systematically investigate the mechanism of cellular uptake of cationic polymeric nanovectors containing DNA molecules through dissipative particle dynamics simulations. Our results sh...

journal_title：Biomaterials

authors： Ding HM,Ma YQ

更新日期：2013-11-01 00:00:00