Abstract:
:A simple route for synthesizing nano-sized beta-tricalcium phosphate (beta-TCP) at room temperature has been developed in methanol solvent. The phase evolution from CaHPO4, intermediate amorphous calcium phosphate (ACP) phases (including ACP1 and ACP2 with different structures) to final beta-TCP with increasing aging time was observed. The formation of beta-TCP phase is favored due to the incorporation of carbonate which can suppress the transformation of ACP1 phase. High-resolution transmission electron microscopy image along [1-100] zone axis of beta-TCP reveals two types of lattice fringes (straight and wavy fringes) in beta-TCP structure due to structural imperfection. Furthermore, the observations of abnormal diffraction intensity and superlattice diffraction in selected-area diffraction patterns further confirm the chemical order-disorder characteristics in beta-TCP structure and can be used to elucidate the resorbability of beta-TCP in either in vivo or in vitro environment due to the imperfection in beta-TCP crystal.
journal_name
Biomaterialsjournal_title
Biomaterialsauthors
Bow JS,Liou SC,Chen SYdoi
10.1016/j.biomaterials.2003.10.046keywords:
subject
Has Abstractpub_date
2004-07-01 00:00:00pages
3155-61issue
16eissn
0142-9612issn
1878-5905pii
S0142961203008883journal_volume
25pub_type
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