Bioreactor based engineering of large-scale human cartilage grafts for joint resurfacing.

abstract：:IR-780 iodide is a near-infrared (NIR) fluorescence dye with higher and more stable fluorescence intensity than clinically applied dye indocyanine green (ICG). Meanwhile, IR-780 can be utilized in photothermal therapy with laser irradiation. IR-780 is an important theranostic agent but its lipophilicity limited its ap...

journal_title：Biomaterials

authors： Yue C,Liu P,Zheng M,Zhao P,Wang Y,Ma Y,Cai L

更新日期：2013-09-01 00:00:00

abstract：:Mesoporous silica nanoshell (MSN) coating has been demonstrated as a versatile surface modification strategy for various kinds of inorganic functional nanoparticles, such as gold nanorods (GNRs), to achieve not only improved nanoparticle stability but also concomitant drug loading capability. However, limited drug loa...

journal_title：Biomaterials

authors： Xu C,Chen F,Valdovinos HF,Jiang D,Goel S,Yu B,Sun H,Barnhart TE,Moon JJ,Cai W

更新日期：2018-05-01 00:00:00

abstract：:The FRP wires 0.5 mm in diameter with a multiple fiber structure were fabricated by drawing the fiber polymer complex at 250 degrees C for an esthetic, transparent orthodontic wire. Biocompatible CaO-P2O5-SiO2-Al2O3 (CPSA) glass fibers of 8-20 microm in diameter were oriented unidirectionally in the longitudinal direc...

journal_title：Biomaterials

authors： Imai T,Watari F,Yamagata S,Kobayashi M,Nagayama K,Toyoizumi Y,Nakamura S

更新日期：1998-12-01 00:00:00

abstract：:The object of this study was to develop a small experimental animal model for a systematic study of the interfacial phenomena between percutaneous implants and skin. Plasma-sprayed and dense hydroxyapatite test implants were inserted into the tibia and dorsum of guinea pigs and into the tibia and on the cranium of rab...

journal_title：Biomaterials

authors： Jansen JA,de Groot K

更新日期：1988-05-01 00:00:00

abstract：:To investigate the role that the micro/nano-environment plays on the differentiation pathway of bone marrow stromal cells (BMSCs) into osteoblasts, we employed a 2D substrate coated with turnip yellow mosaic virus (TYMV) particles. TYMV is a non-enveloped icosahedral plant virus which has an average diameter 28 nm and...

journal_title：Biomaterials

authors： Kaur G,Valarmathi MT,Potts JD,Wang Q

更新日期：2008-10-01 00:00:00

abstract：:Myocardial infarction (MI) leads to the mass death of cardiomyocytes accompanying with the unfavorable alternation of microenvironment, a fibrosis scar deprived of electrical communications, and the lack of blood supply in the infarcted myocardium. The three factors are inextricably intertwined and thus result in a co...

journal_title：Biomaterials

authors： Wang W,Tan B,Chen J,Bao R,Zhang X,Liang S,Shang Y,Liang W,Cui Y,Fan G,Jia H,Liu W

更新日期：2018-04-01 00:00:00

abstract：:The functionalization of polytetrafluoroethylene (PTFE) for human thrombomodulin (hTM) binding has been achieved by CO2 plasma activation and subsequent vapour phase graft polymerization of acrylic acid (AA). The PTFE surfaces after CO2 plasma treatment, AA grafting and hTM immobilization were characterized by attenua...

journal_title：Biomaterials

authors： Vasilets VN,Hermel G,König U,Werner C,Müller M,Simon F,Grundke K,Ikada Y,Jacobasch HJ

更新日期：1997-09-01 00:00:00

abstract：:The development of biocompatible photopolymerizing polymers for biomedical and tissue engineering applications has the potential to reduce the invasiveness and cost of biomaterial implants designed to repair or augment tissues. However, more information is needed about the cellular toxicity of the compounds and initia...

journal_title：Biomaterials

authors： Williams CG,Malik AN,Kim TK,Manson PN,Elisseeff JH

更新日期：2005-04-01 00:00:00

abstract：:Combined treatment using nonviral agent-mediated enzyme/prodrug therapy and immunotherapy had been proposed as a powerful alternative method of cancer therapy. The present study was aimed to evaluate the cytotoxicity in vitro and the therapeutic efficacy in vivo when the cytosine deaminase/5-fluorocytosine (CD/5-FC) a...

journal_title：Biomaterials

authors： Liang B,He ML,Chan CY,Chen YC,Li XP,Li Y,Zheng D,Lin MC,Kung HF,Shuai XT,Peng Y

更新日期：2009-08-01 00:00:00

abstract：:The sintering behavior of calcium pyrophosphate (CPP, Ca2P2O7)-doped beta-tricalcium phosphate [TCP, Ca3(PO4)2], prepared by solid state reaction, was investigated in-situ, using dilatometry. Pure beta-TCP undergoes phase transition to alpha-TCP at about 1200 degrees C; hence pure beta-TCP ceramics should be sintered ...

journal_title：Biomaterials

authors： Ryu HS,Youn HJ,Hong KS,Chang BS,Lee CK,Chung SS

更新日期：2002-02-01 00:00:00

abstract：:The photodynamic activity of a carrier-sensitizer system consisting of heterotopic colloidal nanoparticles (diameter 100-1000 nm) of a cationic amphiphilic cyclodextrin, heptakis(2-omega-amino-O-oligo(ethylene oxide)-6-hexylthio)-beta-CD (SC6CDNH2) encapsulating the anionic 5,10,15,20-tetrakis(4-sulfonatophenyl)-21H,2...

journal_title：Biomaterials

authors： Sortino S,Mazzaglia A,Monsù Scolaro L,Marino Merlo F,Valveri V,Sciortino MT

更新日期：2006-08-01 00:00:00

abstract：:As a chronic and lifelong disease, obesity not only significant impairs health but also dramatically shortens life span (at least 10 years). Obesity requires a life-long effort for the successful treatment because a number of abnormalities would appear in the development of obesity. Nanomaterials possess large specifi...

journal_title：Biomaterials

authors： Li J,Cha R,Luo H,Hao W,Zhang Y,Jiang X

更新日期：2019-12-01 00:00:00

abstract：:The efficient generation of integration- and xeno-free iPSCs is a prerequisite for their use in clinical applications. Furthermore, non-invasiveness of somatic cell acquisition for iPSC generation is another factor to consider. In this study, we established a practical, simple, and convenient method to generate integr...

journal_title：Biomaterials

authors： Lee KI,Kim HT,Hwang DY

更新日期：2014-09-01 00:00:00

abstract：:Achieving and maintaining safe and reliable lineage specific differentiation of stem cells is important for clinical translation of tissue engineering strategies. In an effort to circumvent the multitude of problems arising from the usage of growth factors and growth factor delivery systems, we have explored the use o...

journal_title：Biomaterials

authors： Huang CC,Narayanan R,Alapati S,Ravindran S

更新日期：2016-12-01 00:00:00

abstract：:The widespread use of synthetic transvaginal polypropylene mesh for treating Pelvic Organ Prolapse (POP) has been curtailed due to serious adverse effects highlighted in 2008 and 2011 FDA warnings and subsequent legal action. We are developing new synthetic mesh to deliver endometrial mesenchymal stem cells (eMSC) to ...

journal_title：Biomaterials

authors： Emmerson S,Mukherjee S,Melendez-Munoz J,Cousins F,Edwards SL,Karjalainen P,Ng M,Tan KS,Darzi S,Bhakoo K,Rosamilia A,Werkmeister JA,Gargett CE

更新日期：2019-12-01 00:00:00

abstract：:Bone morphogenetic protein-2/absorbable collagen sponge (BMP-2/ACS) implants have been approved for clinical use to induce bone regeneration. We previously showed that exaggerated inflammation characterized by elevated level of inflammatory cytokines including TNF-α, IL-1β, and IL-6 has been shown to inhibit BMP-2/ACS...

journal_title：Biomaterials

authors： Huang RL,Chen G,Wang W,Herller T,Xie Y,Gu B,Li Q

更新日期：2015-10-01 00:00:00

abstract：:Covalent immobilization of cell-adhesive proteins such as collagen and fibronectin on to the surface of poly(vinyl alcohol) hydrogel was investigated by using diisocyanates, polyisocyanates, and cyanogen bromide. It was found that 0.5 and 12 micrograms/cm2 of collagen were immobilized on to the surface by using hexame...

journal_title：Biomaterials

authors： Kobayashi H,Ikada Y

更新日期：1991-10-01 00:00:00

abstract：:Hydrogels have been widely used as artificial cell niche to mimic extracellular matrix with tunable properties. However, changing biochemical cues in hydrogels developed-to-date would often induce simultaneous changes in mechanical properties, which do not support mechanistic studies on stem cell-niche interactions. H...

journal_title：Biomaterials

authors： Tong X,Yang F

更新日期：2014-02-01 00:00:00

abstract：:Substitution with carboxylic and benzylamine sulphonated groups conferred on dextran both antithrombic activity and the capacity to inhibit formation of the amplification C3 convertase of complement. In dextrans substituted with carboxylic groups (greater than 40%), a high content of sulphonate (greater than 10%) resu...

journal_title：Biomaterials

authors： Mauzac M,Maillet F,Jozefonvicz J,Kazatchkine MD

更新日期：1985-01-01 00:00:00

abstract：:Water uptake characteristics of BisGMA-based composites incorporating untreated and surface-treated hydroxyapatite (HA) with a silane coupling agent have been investigated. The water absorption and desorption behaviour of these composites obeyed the classical diffusion theory. The diffusion coefficients of the composi...

journal_title：Biomaterials

authors： Santos C,Clarke RL,Braden M,Guitian F,Davy KW

更新日期：2002-04-01 00:00:00

abstract：:A genetically encoded Förster Resonance Energy Transfer (FRET)-based biosensor that continuously monitors matrix metalloproteinase 9 (MMP-9) activity was developed. MMP-9 is an extracellularly acting endopeptidase with a prominent role in development, learning and memory, cancer metastasis, and stroke. To assess the b...

journal_title：Biomaterials

authors： Stawarski M,Rutkowska-Wlodarczyk I,Zeug A,Bijata M,Madej H,Kaczmarek L,Wlodarczyk J

更新日期：2014-02-01 00:00:00

abstract：:The objective of this study was to investigate the adhesion, spreading and extracellular matrix synthesis of temporomandibular joint (TMJ) derived cells on non-absorbable scaffold materials to ultimately provide a durable stress-absorbent framework within tissue-engineered disc transplants. Scaffolds were prepared by ...

journal_title：Biomaterials

authors： Springer IN,Fleiner B,Jepsen S,Açil Y

更新日期：2001-09-01 00:00:00

abstract：:Bone morphogenetic proteins (BMPs) are known to induce diverse differentiation fates in human embryonic stem cells (hESCs). In the present study, we compared the potency at which BMP5, BMP10 and BMP13, which are members of distinct BMP subgroups due to differences in sequential and structural homology, induce differen...

journal_title：Biomaterials

authors： Lichtner B,Knaus P,Lehrach H,Adjaye J

更新日期：2013-12-01 00:00:00

abstract：:Four commercial hydroxyapatites (both natural and synthetic) were tested to assess transformations of the chemical and crystalline structure following variation of temperature from 20 to 1600 degrees C. The thermal behaviour of hydroxyapatite is relevant for biomedical applications such as plasma spraying of metallic ...

journal_title：Biomaterials

authors： Locardi B,Pazzaglia UE,Gabbi C,Profilo B

更新日期：1993-05-01 00:00:00

abstract：:The interest in gallium alloys as a replacement for amalgam has increased in recent years due to the risk of environmental pollution from amalgam. Alloy powders with compositions close to those for alloys of amalgam are mixed with a liquid gallium alloy. The mix is condensed into a prepared cavity in much the same way...

journal_title：Biomaterials

authors： Herø H,Simensen CJ,Jørgensen RB

更新日期：1996-07-01 00:00:00

abstract：:Large-scale expansion of highly functional adult human mesenchymal stem cells (aMSCs) remains technologically challenging as aMSCs lose self renewal capacity and multipotency during traditional long-term culture and their quality/quantity declines with donor age and disease. Identification of culture conditions enabli...

journal_title：Biomaterials

authors： Ng CP,Sharif AR,Heath DE,Chow JW,Zhang CB,Chan-Park MB,Hammond PT,Chan JK,Griffith LG

更新日期：2014-04-01 00:00:00

abstract：:The flexural strength of five glass ionomers was measured at intervals ranging from 1 h to 3 months after mixing. The pattern of change in flexural strength is material-specific with two water-activated materials having significantly higher long-term flexural strengths than the others. This may be attributable to the ...

journal_title：Biomaterials

authors： Pearson GJ,Atkinson AS

更新日期：1991-09-01 00:00:00

abstract：:The purpose of this study was to quantify and compare the amount of water absorbed by six commercially available resin-modified glass ionomer cements and to investigate the possible influence of time and resin content on water sorption. The materials evaluated included Variglass used as a restoration, base and liner; ...

journal_title：Biomaterials

authors： Yap AU

更新日期：1996-10-01 00:00:00

abstract：:Hydroxyapatite (HA) and beta-tricalcium phosphate (TCP) were studied by computer graphics with a personal computer. Crystal models of fluoridated hydroxyapatite and fluorapatite, in which F- ions are substituted into some or all OH- positions, were also drawn. Data on the structural coordinates of the hydroxyapatite a...

journal_title：Biomaterials

authors： Okazaki M,Sato M

更新日期：1990-10-01 00:00:00

abstract：:The aim of this study was to determine the biocompatibility and osteoconductive potential of a high-strength canasite glass ceramic. Glass-ceramic rods were produced using the lost-wax casting technique and implanted in the mid-shafts rabbit femurs. Implants were harvested at 4, 13 and 22 weeks and prepared for light ...

journal_title：Biomaterials

authors： da Rocha Barros VM,Salata LA,Sverzut CE,Xavier SP,van Noort R,Johnson A,Hatton PV

更新日期：2002-07-01 00:00:00