Abstract：
:Liposome is one of the most commonly used drug delivery systems in the world, due to its excellent biocompatibility, satisfactory ability in controlling drug release, and passive targeting capability. However, some drawbacks limit the application of liposomes in clinical, such as problems in transporting, storing, and difficulties in maintaining the drug concentration in the local area. Scaffolds usually are used as implants to supply certain mechanical supporting to the defective area or utilized as diagnosis and imaging methods. But, in general, unmodified scaffolds show limited abilities in promoting tissue regeneration and treating diseases. Therefore, liposome-scaffold composite systems are designed to take advantages of both liposomes' biocompatibility and scaffolds' strength to provide a novel system that is more suitable for clinical applications. This review introduces and discusses different types of liposomes and scaffolds, and also the application of liposome-scaffold composite systems in different diseases, such as cancer, diabetes, skin-related diseases, infection and human immunodeficiency virus, and in tissue regeneration like bone, teeth, spinal cord and wound healing.
journal_name
Biomaterialsjournal_title
Biomaterialsauthors
Cheng R,Liu L,Xiang Y,Lu Y,Deng L,Zhang H,Santos HA,Cui Wdoi
10.1016/j.biomaterials.2019.119706subject
Has Abstractpub_date
2020-02-01 00:00:00pages
119706eissn
0142-9612issn
1878-5905pii
S0142-9612(19)30824-5journal_volume
232pub_type
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